FI950893A0 - Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina - Google Patents

Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina

Info

Publication number
FI950893A0
FI950893A0 FI950893A FI950893A FI950893A0 FI 950893 A0 FI950893 A0 FI 950893A0 FI 950893 A FI950893 A FI 950893A FI 950893 A FI950893 A FI 950893A FI 950893 A0 FI950893 A0 FI 950893A0
Authority
FI
Finland
Prior art keywords
pct
hydroxy
derivatives
nhch2
sch2
Prior art date
Application number
FI950893A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950893A7 (fi
Inventor
George Robert Brown
Keith Blakeney Mallion
Paul Robert Owen Whittamore
David Robert Brittain
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI950893A7 publication Critical patent/FI950893A7/fi
Publication of FI950893A0 publication Critical patent/FI950893A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI950893A 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina FI950893A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds
PCT/GB1993/001802 WO1994005660A1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors

Publications (2)

Publication Number Publication Date
FI950893A7 FI950893A7 (fi) 1995-02-27
FI950893A0 true FI950893A0 (fi) 1995-02-27

Family

ID=10721113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950893A FI950893A0 (fi) 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina

Country Status (13)

Country Link
US (1) US5714496A (https=)
EP (1) EP0656897B1 (https=)
JP (1) JPH08502731A (https=)
AT (1) ATE161843T1 (https=)
AU (1) AU4969193A (https=)
CA (2) CA2143430A1 (https=)
DE (1) DE69316224D1 (https=)
FI (1) FI950893A0 (https=)
GB (2) GB9218334D0 (https=)
IL (1) IL106797A0 (https=)
TW (1) TW231293B (https=)
WO (1) WO1994005660A1 (https=)
ZA (1) ZA936201B (https=)

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GB9412145D0 (en) * 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
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DE60220997T2 (de) * 2001-03-27 2008-03-13 Eisai R&D Management Co., Ltd. N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
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EP1735306A2 (en) 2004-03-25 2006-12-27 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
WO2005113523A1 (en) * 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
US7772271B2 (en) * 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) * 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) * 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019831A1 (en) * 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
WO2006019832A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
US8410109B2 (en) 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
SI2346837T1 (sl) 2008-06-26 2015-05-29 Resverlogix Corporation Postopki pripravljanja kinazolinonskih derivatov
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
KR101913109B1 (ko) 2009-03-18 2018-10-31 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
CA2851996C (en) 2011-11-01 2020-01-07 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
US8859553B2 (en) * 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

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Also Published As

Publication number Publication date
ATE161843T1 (de) 1998-01-15
CA2143430A1 (en) 1994-03-17
IL106797A0 (en) 1993-12-08
EP0656897A1 (en) 1995-06-14
GB9317153D0 (en) 1993-10-06
GB9218334D0 (en) 1992-10-14
CA2104981A1 (en) 1994-03-01
DE69316224D1 (de) 1998-02-12
WO1994005660A1 (en) 1994-03-17
JPH08502731A (ja) 1996-03-26
ZA936201B (en) 1994-02-28
EP0656897B1 (en) 1998-01-07
FI950893A7 (fi) 1995-02-27
US5714496A (en) 1998-02-03
TW231293B (https=) 1994-10-01
AU4969193A (en) 1994-03-29

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Legal Events

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