GB9218334D0 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
GB9218334D0
GB9218334D0 GB929218334A GB9218334A GB9218334D0 GB 9218334 D0 GB9218334 D0 GB 9218334D0 GB 929218334 A GB929218334 A GB 929218334A GB 9218334 A GB9218334 A GB 9218334A GB 9218334 D0 GB9218334 D0 GB 9218334D0
Authority
GB
United Kingdom
Prior art keywords
pct
hydroxy
nhch2
sch2
alkylcarbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB929218334A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB929218334A priority Critical patent/GB9218334D0/en
Publication of GB9218334D0 publication Critical patent/GB9218334D0/en
Priority to GB939317153A priority patent/GB9317153D0/en
Priority to AU49691/93A priority patent/AU4969193A/en
Priority to EP93919477A priority patent/EP0656897B1/en
Priority to CA002143430A priority patent/CA2143430A1/en
Priority to AT93919477T priority patent/ATE161843T1/de
Priority to PCT/GB1993/001802 priority patent/WO1994005660A1/en
Priority to DE69316224T priority patent/DE69316224D1/de
Priority to JP6506955A priority patent/JPH08502731A/ja
Priority to ZA936201A priority patent/ZA936201B/xx
Priority to US08/392,928 priority patent/US5714496A/en
Priority to IL106797A priority patent/IL106797A0/xx
Priority to MX9305200A priority patent/MX9305200A/es
Priority to CA002104981A priority patent/CA2104981A1/en
Priority to TW082107086A priority patent/TW231293B/zh
Priority to FI950893A priority patent/FI950893A0/fi
Priority to NO950756A priority patent/NO950756D0/no
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GB929218334A 1992-08-28 1992-08-28 Heterocyclic compounds Pending GB9218334D0 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds
GB939317153A GB9317153D0 (en) 1992-08-28 1993-08-18 Heterocyclic compounds
EP93919477A EP0656897B1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
JP6506955A JPH08502731A (ja) 1992-08-28 1993-08-24 スクアレンシンターゼ阻害剤としてのキヌクリジン誘導体
ZA936201A ZA936201B (en) 1992-08-28 1993-08-24 Heterocyclic compounds
CA002143430A CA2143430A1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
AT93919477T ATE161843T1 (de) 1992-08-28 1993-08-24 Chinuclidine derivate als squalen synthase inhibitoren
PCT/GB1993/001802 WO1994005660A1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
DE69316224T DE69316224D1 (de) 1992-08-28 1993-08-24 Chinuclidine derivate als squalen synthase inhibitoren
AU49691/93A AU4969193A (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
US08/392,928 US5714496A (en) 1992-08-28 1993-08-25 Quinuclidine derivatives as squalene synthase inhibitors
IL106797A IL106797A0 (en) 1992-08-28 1993-08-25 Heterocyclic compounds
MX9305200A MX9305200A (es) 1992-08-28 1993-08-27 Compuestos heterociclicos
CA002104981A CA2104981A1 (en) 1992-08-28 1993-08-27 Heterocyclic compounds
TW082107086A TW231293B (https=) 1992-08-28 1993-08-31
FI950893A FI950893A0 (fi) 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina
NO950756A NO950756D0 (no) 1992-08-28 1995-02-27 Kinuklidinderivater som squalensyntetase-inhibitorer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
GB9218334D0 true GB9218334D0 (en) 1992-10-14

Family

ID=10721113

Family Applications (2)

Application Number Title Priority Date Filing Date
GB929218334A Pending GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds
GB939317153A Pending GB9317153D0 (en) 1992-08-28 1993-08-18 Heterocyclic compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB939317153A Pending GB9317153D0 (en) 1992-08-28 1993-08-18 Heterocyclic compounds

Country Status (13)

Country Link
US (1) US5714496A (https=)
EP (1) EP0656897B1 (https=)
JP (1) JPH08502731A (https=)
AT (1) ATE161843T1 (https=)
AU (1) AU4969193A (https=)
CA (2) CA2143430A1 (https=)
DE (1) DE69316224D1 (https=)
FI (1) FI950893A0 (https=)
GB (2) GB9218334D0 (https=)
IL (1) IL106797A0 (https=)
TW (1) TW231293B (https=)
WO (1) WO1994005660A1 (https=)
ZA (1) ZA936201B (https=)

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US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
UA27776C2 (uk) * 1991-05-31 2000-10-16 Пфайзер Інк. Похідні хінуклідину та їх фармацевтично прийнятні солі, що є антагоністами речовини р у ссавців, фармацевтична композиція, що має антагоністичну дію на речовину р у ссавців
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
DE4417837A1 (de) * 1994-05-20 1995-11-23 Basf Ag Substituierte 3-Phenylpyrazole
GB9412145D0 (en) * 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
WO1998027983A1 (en) * 1996-12-20 1998-07-02 Novo Nordisk A/S A method of treating hypercholesterolemia and related disorders
US6472528B1 (en) * 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
NZ517788A (en) * 1999-09-28 2003-11-28 Eisai Co Ltd Quinuclidine compounds and drugs containing the same as the active ingredient
EP1315493A4 (en) * 2000-08-21 2007-12-05 Univ Georgetown 2-3-DISUBSTITUTED QUINUCLIDINS AS MONOAMINE CARRIER MODULATORS AND THERAPEUTIC AND DIAGNOSTIC METHODS BASED THEREON
DE60220997T2 (de) * 2001-03-27 2008-03-13 Eisai R&D Management Co., Ltd. N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
CN1571787A (zh) * 2001-10-17 2005-01-26 Ucb公司 奎宁环衍生物、制备它们的方法和它们作为m2和/或m3毒蕈碱受体抑制剂的用途
GB0127731D0 (en) * 2001-11-20 2002-01-09 Coin Controls Coin handling apparatus
CN100522976C (zh) * 2002-05-07 2009-08-05 神经研究公司 氮杂环乙炔基衍生物
CA2800237C (en) * 2002-12-19 2016-05-17 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
EP1735306A2 (en) 2004-03-25 2006-12-27 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
WO2005113523A1 (en) * 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
US7772271B2 (en) * 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) * 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) * 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019831A1 (en) * 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
WO2006019832A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
US8410109B2 (en) 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
SI2346837T1 (sl) 2008-06-26 2015-05-29 Resverlogix Corporation Postopki pripravljanja kinazolinonskih derivatov
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
KR101913109B1 (ko) 2009-03-18 2018-10-31 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
CA2851996C (en) 2011-11-01 2020-01-07 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
US8859553B2 (en) * 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

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US3405134A (en) * 1965-08-17 1968-10-08 Colgate Palmolive Co Quinuclidyl esters of aromatic acids
NL6715600A (https=) * 1966-12-02 1968-06-04
US3534053A (en) * 1967-05-24 1970-10-13 American Home Prod Quinuclidine derivatives
US3763168A (en) * 1968-09-09 1973-10-02 Sterling Drug Inc N-(3-quinuclidinyl) acylanilides
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US3725410A (en) * 1970-07-15 1973-04-03 American Home Prod 3-aminomethyl-3-quinuclidinols
US3679690A (en) * 1971-03-18 1972-07-25 Sterling Drug Inc Certain n-(pyridyl) propionanilides
FR2183565B1 (https=) * 1972-05-10 1975-12-26 Cerm Cent Europ Rech Mauvernay
CA1014958A (en) * 1973-10-05 1977-08-02 Jacques Moleyre .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
US4038402A (en) * 1974-03-05 1977-07-26 Mikhail Emmanuilovich Kaminka Method of effecting antihistaminic, antiserotonin and antiallergic actions
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
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CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
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US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
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DE8817121U1 (de) * 1988-11-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Quinuclidine
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Also Published As

Publication number Publication date
ATE161843T1 (de) 1998-01-15
CA2143430A1 (en) 1994-03-17
IL106797A0 (en) 1993-12-08
EP0656897A1 (en) 1995-06-14
GB9317153D0 (en) 1993-10-06
CA2104981A1 (en) 1994-03-01
DE69316224D1 (de) 1998-02-12
WO1994005660A1 (en) 1994-03-17
JPH08502731A (ja) 1996-03-26
ZA936201B (en) 1994-02-28
EP0656897B1 (en) 1998-01-07
FI950893A7 (fi) 1995-02-27
FI950893A0 (fi) 1995-02-27
US5714496A (en) 1998-02-03
TW231293B (https=) 1994-10-01
AU4969193A (en) 1994-03-29

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Legal Events

Date Code Title Description
730A Proceeding under section 30 patents act 1977