FI950893A0 - Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina - Google Patents
Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreinaInfo
- Publication number
- FI950893A0 FI950893A0 FI950893A FI950893A FI950893A0 FI 950893 A0 FI950893 A0 FI 950893A0 FI 950893 A FI950893 A FI 950893A FI 950893 A FI950893 A FI 950893A FI 950893 A0 FI950893 A0 FI 950893A0
- Authority
- FI
- Finland
- Prior art keywords
- pct
- hydroxy
- derivatives
- nhch2
- sch2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929218334A GB9218334D0 (en) | 1992-08-28 | 1992-08-28 | Heterocyclic compounds |
PCT/GB1993/001802 WO1994005660A1 (en) | 1992-08-28 | 1993-08-24 | Quinuclidine derivatives as squalene synthase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
FI950893A FI950893A (fi) | 1995-02-27 |
FI950893A0 true FI950893A0 (fi) | 1995-02-27 |
Family
ID=10721113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI950893A FI950893A0 (fi) | 1992-08-28 | 1995-02-27 | Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina |
Country Status (13)
Country | Link |
---|---|
US (1) | US5714496A (fi) |
EP (1) | EP0656897B1 (fi) |
JP (1) | JPH08502731A (fi) |
AT (1) | ATE161843T1 (fi) |
AU (1) | AU4969193A (fi) |
CA (2) | CA2143430A1 (fi) |
DE (1) | DE69316224D1 (fi) |
FI (1) | FI950893A0 (fi) |
GB (2) | GB9218334D0 (fi) |
IL (1) | IL106797A0 (fi) |
TW (1) | TW231293B (fi) |
WO (1) | WO1994005660A1 (fi) |
ZA (1) | ZA936201B (fi) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5385912A (en) * | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
DE69208877T2 (de) * | 1991-05-31 | 1996-07-25 | Pfizer | Chinuclidinderivate |
IL109451A0 (en) * | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
DE4417837A1 (de) * | 1994-05-20 | 1995-11-23 | Basf Ag | Substituierte 3-Phenylpyrazole |
GB9412145D0 (en) * | 1994-06-17 | 1994-08-10 | Zeneca Ltd | Heterocycles |
AU7871498A (en) * | 1996-12-20 | 1998-07-17 | Novo Nordisk A/S | A method of treating hypercholesterolemia and related disorders |
US6472528B1 (en) * | 1999-08-10 | 2002-10-29 | Neurocrine Biosciences, Inc. | Synthesis of substituted pyrazolopyrimidines |
EP1217001B1 (en) * | 1999-09-28 | 2005-12-07 | Eisai Co., Ltd. | Quinuclidine compounds and drugs containing the same as the active ingredient |
EP1315493A4 (en) * | 2000-08-21 | 2007-12-05 | Univ Georgetown | 2-3-DISUBSTITUTED QUINUCLIDINS AS MONOAMINE CARRIER MODULATORS AND THERAPEUTIC AND DIAGNOSTIC METHODS BASED THEREON |
EP1375496B1 (en) | 2001-03-27 | 2007-07-04 | Eisai R&D Management Co., Ltd. | N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient |
NZ532283A (en) | 2001-10-17 | 2005-06-24 | Ucb S | Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors |
GB0127731D0 (en) * | 2001-11-20 | 2002-01-09 | Coin Controls | Coin handling apparatus |
EP1506205B1 (en) * | 2002-05-07 | 2008-07-16 | Neurosearch A/S | Novel azacyclic ethynyl derivatives |
SI1587821T1 (sl) * | 2002-12-19 | 2009-02-28 | Scripps Research Inst | Sestavki in postopki za stabiliziranje transtiretina in zaviranje napaäśnega zvijanja transtiretina |
KR101176670B1 (ko) | 2004-03-25 | 2012-08-23 | 메모리 파마슈티칼스 코포레이션 | 인다졸, 벤조티아졸, 벤조이소티아졸, 벤즈이속사졸, 및그의 제조법 및 용도 |
WO2005112913A1 (en) | 2004-05-20 | 2005-12-01 | The Scripps Research Institute | Transthyretin stabilization |
US7868037B2 (en) * | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) * | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) * | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
BRPI0511834A (pt) * | 2004-07-14 | 2008-01-08 | Ptc Therapeutics Inc | métodos por tratar hepatite c |
WO2006019832A1 (en) * | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
EP2332527A3 (en) | 2004-10-20 | 2011-11-16 | Resverlogix Corp. | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases |
AU2006275514B2 (en) | 2005-07-29 | 2012-04-05 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
WO2008034016A2 (en) * | 2006-09-15 | 2008-03-20 | Foldrx Pharmaceuticals, Inc. | Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins |
PT2118074E (pt) | 2007-02-01 | 2014-03-20 | Resverlogix Corp | Compostos para a prevenção e tratamento de doenças cardiovasculares |
CA2711103C (en) | 2008-06-26 | 2016-08-09 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
CA2747417C (en) | 2009-01-08 | 2017-01-03 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
CA3146333A1 (en) | 2009-03-18 | 2010-09-23 | Resverlogix Corp. | Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents |
LT2421533T (lt) | 2009-04-22 | 2018-12-27 | Resverlogix Corp. | Nauji priešuždegiminiai agentai |
CN103781770B (zh) | 2011-09-16 | 2016-04-13 | 辉瑞公司 | 转甲状腺素蛋白解离抑制剂的固体形式 |
JP5992049B2 (ja) | 2011-11-01 | 2016-09-14 | レスバーロジックス コーポレイション | 置換されたキナゾリノンのための経口速放性製剤 |
US8859553B2 (en) * | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
WO2016147053A1 (en) | 2015-03-13 | 2016-09-22 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3405134A (en) * | 1965-08-17 | 1968-10-08 | Colgate Palmolive Co | Quinuclidyl esters of aromatic acids |
NL6715600A (fi) * | 1966-12-02 | 1968-06-04 | ||
US3534053A (en) * | 1967-05-24 | 1970-10-13 | American Home Prod | Quinuclidine derivatives |
US3763168A (en) * | 1968-09-09 | 1973-10-02 | Sterling Drug Inc | N-(3-quinuclidinyl) acylanilides |
US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
US3725410A (en) * | 1970-07-15 | 1973-04-03 | American Home Prod | 3-aminomethyl-3-quinuclidinols |
US3679690A (en) * | 1971-03-18 | 1972-07-25 | Sterling Drug Inc | Certain n-(pyridyl) propionanilides |
FR2183565B1 (fi) * | 1972-05-10 | 1975-12-26 | Cerm Cent Europ Rech Mauvernay | |
CA1014958A (en) * | 1973-10-05 | 1977-08-02 | Jacques Moleyre | .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES |
SU495310A1 (ru) * | 1974-03-05 | 1975-12-15 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе | Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени |
US4038402A (en) * | 1974-03-05 | 1977-07-26 | Mikhail Emmanuilovich Kaminka | Method of effecting antihistaminic, antiserotonin and antiallergic actions |
US4599344A (en) * | 1984-10-31 | 1986-07-08 | Schering A.G. | Quinuclidines and quinuclidinium salts as antiarrhythmic agents |
CH667657A5 (de) * | 1985-01-07 | 1988-10-31 | Sandoz Ag | Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine. |
NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
IL88156A (en) * | 1987-11-13 | 1997-02-18 | Novo Nordisk As | Azacyclic compounds their preparation and pharmaceutical compositions containing them |
EP0322182A3 (en) * | 1987-12-22 | 1992-01-02 | Beecham Group Plc | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
DK730588A (da) * | 1988-02-03 | 1989-08-04 | Asta Pharma Ag | Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel |
NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
US5242914A (en) * | 1988-04-01 | 1993-09-07 | Sankyo Company, Limited | 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics |
NO168304C (no) * | 1988-04-01 | 1992-02-05 | Sankyo Co | Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater |
US5286864A (en) * | 1988-11-22 | 1994-02-15 | Boehringer Ingelheim Kg | Quinuclidines, their use as medicaments and processes for their preparation |
DE8817121U1 (fi) * | 1988-11-22 | 1993-02-04 | Boehringer Ingelheim Kg, 6507 Ingelheim, De | |
GB8918061D0 (en) * | 1989-08-08 | 1989-09-20 | Merck Sharp & Dohme | Therapeutic agents |
DE4116582A1 (de) * | 1990-05-19 | 1991-11-21 | Boehringer Ingelheim Kg | Bicyclische 1-aza-cycloalkane |
YU84791A (sh) * | 1990-05-19 | 1994-06-10 | Boehringer Ingelheim Kg. | Biciklicni 1-aza-cikloalkalni |
ZA92278B (en) * | 1991-02-01 | 1992-10-28 | Akzo Nv | 3-quinuclidine derivatives |
US5385912A (en) * | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
AU1752792A (en) * | 1991-03-08 | 1992-10-06 | Rhone-Poulenc Rorer International (Holdings) Inc. | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
US5135935A (en) * | 1991-05-17 | 1992-08-04 | Merck & Co., Inc. | Squalene synthetase inhibitors |
GB9127279D0 (en) * | 1991-12-23 | 1992-02-19 | Ici Plc | Heterocyclic derivatives |
GB9201749D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Plc | Medicaments |
GB9202443D0 (en) * | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
GB9211796D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Heterocyclic derivatives |
-
1992
- 1992-08-28 GB GB929218334A patent/GB9218334D0/en active Pending
-
1993
- 1993-08-18 GB GB939317153A patent/GB9317153D0/en active Pending
- 1993-08-24 JP JP6506955A patent/JPH08502731A/ja active Pending
- 1993-08-24 CA CA002143430A patent/CA2143430A1/en not_active Abandoned
- 1993-08-24 AU AU49691/93A patent/AU4969193A/en not_active Abandoned
- 1993-08-24 WO PCT/GB1993/001802 patent/WO1994005660A1/en active IP Right Grant
- 1993-08-24 AT AT93919477T patent/ATE161843T1/de not_active IP Right Cessation
- 1993-08-24 ZA ZA936201A patent/ZA936201B/xx unknown
- 1993-08-24 EP EP93919477A patent/EP0656897B1/en not_active Expired - Lifetime
- 1993-08-24 DE DE69316224T patent/DE69316224D1/de not_active Expired - Lifetime
- 1993-08-25 IL IL106797A patent/IL106797A0/xx unknown
- 1993-08-25 US US08/392,928 patent/US5714496A/en not_active Expired - Fee Related
- 1993-08-27 CA CA002104981A patent/CA2104981A1/en not_active Abandoned
- 1993-08-31 TW TW082107086A patent/TW231293B/zh active
-
1995
- 1995-02-27 FI FI950893A patent/FI950893A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI950893A (fi) | 1995-02-27 |
US5714496A (en) | 1998-02-03 |
GB9218334D0 (en) | 1992-10-14 |
ZA936201B (en) | 1994-02-28 |
ATE161843T1 (de) | 1998-01-15 |
CA2143430A1 (en) | 1994-03-17 |
DE69316224D1 (de) | 1998-02-12 |
CA2104981A1 (en) | 1994-03-01 |
EP0656897A1 (en) | 1995-06-14 |
GB9317153D0 (en) | 1993-10-06 |
WO1994005660A1 (en) | 1994-03-17 |
EP0656897B1 (en) | 1998-01-07 |
JPH08502731A (ja) | 1996-03-26 |
AU4969193A (en) | 1994-03-29 |
TW231293B (fi) | 1994-10-01 |
IL106797A0 (en) | 1993-12-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |