FI950485L - Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina - Google Patents

Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina Download PDF

Info

Publication number
FI950485L
FI950485L FI950485A FI950485A FI950485L FI 950485 L FI950485 L FI 950485L FI 950485 A FI950485 A FI 950485A FI 950485 A FI950485 A FI 950485A FI 950485 L FI950485 L FI 950485L
Authority
FI
Finland
Prior art keywords
angiotensin
receptor antagonists
prodrug forms
imidazolecarboxylic
acids
Prior art date
Application number
FI950485A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950485A7 (fi
FI950485A0 (fi
Inventor
Robert John Ardecky
Carol Lee Ensinger
James Russell Pruitt
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of FI950485A7 publication Critical patent/FI950485A7/fi
Publication of FI950485A0 publication Critical patent/FI950485A0/fi
Publication of FI950485L publication Critical patent/FI950485L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI950485A 1992-08-06 1993-08-02 Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina FI950485L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
PCT/US1993/007103 WO1994003435A1 (en) 1992-08-06 1993-08-02 Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists

Publications (3)

Publication Number Publication Date
FI950485A7 FI950485A7 (fi) 1995-02-03
FI950485A0 FI950485A0 (fi) 1995-02-03
FI950485L true FI950485L (fi) 1995-02-03

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950485A FI950485L (fi) 1992-08-06 1993-08-02 Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina

Country Status (18)

Country Link
US (1) US5310929A (member.php)
EP (1) EP0654027A1 (member.php)
JP (1) JP2892838B2 (member.php)
CN (1) CN1090275A (member.php)
AU (1) AU688735B2 (member.php)
BR (1) BR9306911A (member.php)
CA (1) CA2141692C (member.php)
FI (1) FI950485L (member.php)
HU (1) HU9500349D0 (member.php)
IL (1) IL106553A0 (member.php)
MX (1) MX9304787A (member.php)
NO (1) NO950404D0 (member.php)
PL (1) PL307309A1 (member.php)
SG (1) SG47108A1 (member.php)
SK (1) SK13195A3 (member.php)
TW (1) TW239131B (member.php)
WO (1) WO1994003435A1 (member.php)
ZA (1) ZA935693B (member.php)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
NO304429B1 (no) * 1992-12-17 1998-12-14 Sankyo Co Bifenylderivater, farmas°ytisk preparat og deres anvendelse for fremstilling av et medikament for behandling av hypertensjon og hjertesykdom
DE69533045T2 (de) * 1994-03-16 2005-01-27 Sankyo Co., Ltd. Okulares Hypotonikum
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
DE69507887T2 (de) * 1994-09-20 1999-06-17 Wakunaga Seiyaku K.K., Osaka Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
ATE372987T1 (de) 2001-05-31 2007-09-15 Vicore Pharma Ab Trizyklische verbindungen, nützlich als angiotensin ii agonisten
US7019148B2 (en) * 2003-01-16 2006-03-28 Teva Pharmaceutical Industries, Ltd. Synthesis of irbesartan
KR20060129393A (ko) 2004-01-20 2006-12-15 아이치 프레펙츄러 ＨＬＡ－Ａ2402-제한 Ｅｐ－ＣＡＭ 특이적 ＣＴＬ에인식되는 에피토프/펩티드 및 그 용도
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
US20060074117A1 (en) * 2004-09-02 2006-04-06 Lilach Hedvati Purification of olmesartan medoxomil
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
CA2604190A1 (en) * 2005-04-20 2006-11-02 Merck & Co., Inc. Angiotensin ii receptor antagonists
WO2008027385A2 (en) * 2006-08-29 2008-03-06 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole
US8076492B2 (en) * 2006-10-09 2011-12-13 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
AU2006351517B8 (en) * 2006-12-06 2012-01-19 Shenzhen Salubris Pharmaceuticals Co., Ltd. The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
WO2011084848A2 (en) 2010-01-07 2011-07-14 Alkermes, Inc. Prodrugs of heteraromatic compounds
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN104610232B (zh) * 2013-11-01 2019-09-20 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
CN114514032A (zh) 2019-08-02 2022-05-17 兰提欧派普有限公司 用于治疗癌症的血管紧张素2型(at2)受体激动剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
WO1991000281A2 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
JP2550442B2 (ja) * 1989-06-30 1996-11-06 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 置換イミダゾール
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
EP0573218B1 (en) * 1992-06-02 2001-03-07 Sankyo Company Limited 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use

Also Published As

Publication number Publication date
BR9306911A (pt) 1998-12-08
MX9304787A (es) 1995-01-31
IL106553A0 (en) 1993-12-08
CA2141692C (en) 2006-05-30
ZA935693B (en) 1995-02-06
PL307309A1 (en) 1995-05-15
JPH08500103A (ja) 1996-01-09
SG47108A1 (en) 1998-03-20
CA2141692A1 (en) 1994-02-17
US5310929A (en) 1994-05-10
NO950404D0 (no) 1995-02-03
FI950485A7 (fi) 1995-02-03
EP0654027A1 (en) 1995-05-24
WO1994003435A1 (en) 1994-02-17
FI950485A0 (fi) 1995-02-03
TW239131B (member.php) 1995-01-21
JP2892838B2 (ja) 1999-05-17
SK13195A3 (en) 1995-07-11
HU9500349D0 (en) 1995-03-28
AU688735B2 (en) 1998-03-19
CN1090275A (zh) 1994-08-03
AU4790393A (en) 1994-03-03

Similar Documents

Publication Publication Date Title
FI950485L (fi) Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina
FI932517A0 (fi) Antagonister av angiotensin II
FI903331A7 (fi) Angiotensiini-II-antagonisteina käyttökelpoisia substituoituja kinatsolinoneja
FI932518A7 (fi) Angiotensiinin II antagonistit
FI933810L (fi) Reseptorantagonister av exiterbara aminosyror
KR950700304A (ko) 5ht4-수용체 길항질로서 축합 인돌 유도체(condensed indole derivatives as 5ht4-receptor antagonists)
DK0569013T3 (da) Quinolinforbindelser som angiotensin II antagonister
NO972016L (no) Indolyl neuropeptid Y reseptorantagonister
FI944394A7 (fi) Kinuklidiinijohdannaisia P-aineen antagonisteina
KR100345626B1 (ko) 안지오텐신ii길항물질로서의치환된인돌및아자인돌
FI950089A7 (fi) Dioksosyklobuteenijohdannaiset angiotensiini-II-antagonisteina
EP0574787A3 (en) Benzimidazole derivatives as angiotensin ii antagonists
ID16742A (id) Antagonis reseptor endotelin
FI960516L (fi) Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
FI942282L (fi) Tetratsolyylifenyyliboorihappovälituotteita AII-reseptoriantagonistien synteesiä varten
FI943941L (fi) CCK-reseptoriantagonisteina käyttökelpoiset bentsodiatsepiinijohdannaiset
FI943807L (fi) Pyratsolopyrimidiinijohdannaisia angiotensiini II:n reseptoreiden vastavaikuttajina
FI951798L (fi) Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
LV10448A (lv) Piperazinilkamparsulfoniloksitocina antagonista aizvietotie amidu atvasinajumi
DE69513832D1 (de) Exzitatorische aminosäure-rezeptor-antagonisten
FI943359L (fi) Atsasykliset-heterosykliset yhdisteet angiotensiini II reseptoriantagonisteina
EP0591891A3 (en) Benzimidazole derivatives as angiotensin ii antagonists
FI943513L (fi) Kolekystokiniiniantagonisteina käyttökelpoisia 3-fenyyliureidoatsepin-2-oneja ja -bentsatsepin-2-oneja
DK68092D0 (da) Hoved til gulvskraber
ITMI921145A0 (it) Procedimento per la produzione di marmette di cemento migliorato

Legal Events

Date Code Title Description
FD Application lapsed