FI950485A7 - Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina - Google Patents
Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina Download PDFInfo
- Publication number
- FI950485A7 FI950485A7 FI950485A FI950485A FI950485A7 FI 950485 A7 FI950485 A7 FI 950485A7 FI 950485 A FI950485 A FI 950485A FI 950485 A FI950485 A FI 950485A FI 950485 A7 FI950485 A7 FI 950485A7
- Authority
- FI
- Finland
- Prior art keywords
- angiotensin
- receptor antagonists
- prodrug forms
- imidazolecarboxylic
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/926,795 US5310929A (en) | 1992-08-06 | 1992-08-06 | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
| PCT/US1993/007103 WO1994003435A1 (en) | 1992-08-06 | 1993-08-02 | Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI950485A0 FI950485A0 (fi) | 1995-02-03 |
| FI950485L FI950485L (fi) | 1995-02-03 |
| FI950485A7 true FI950485A7 (fi) | 1995-02-03 |
Family
ID=25453732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI950485A FI950485A7 (fi) | 1992-08-06 | 1993-08-02 | Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5310929A (show.php) |
| EP (1) | EP0654027A1 (show.php) |
| JP (1) | JP2892838B2 (show.php) |
| CN (1) | CN1090275A (show.php) |
| AU (1) | AU688735B2 (show.php) |
| BR (1) | BR9306911A (show.php) |
| CA (1) | CA2141692C (show.php) |
| FI (1) | FI950485A7 (show.php) |
| HU (1) | HU9500349D0 (show.php) |
| IL (1) | IL106553A0 (show.php) |
| MX (1) | MX9304787A (show.php) |
| NO (1) | NO950404D0 (show.php) |
| PL (1) | PL307309A1 (show.php) |
| SG (1) | SG47108A1 (show.php) |
| SK (1) | SK13195A3 (show.php) |
| TW (1) | TW239131B (show.php) |
| WO (1) | WO1994003435A1 (show.php) |
| ZA (1) | ZA935693B (show.php) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| RU2109736C1 (ru) * | 1992-12-17 | 1998-04-27 | Санкио Компани Лимитед | Производные бифенила и способ их получения |
| ES2163501T3 (es) * | 1994-03-16 | 2002-02-01 | Sankyo Co | Agente para la disminucion de la tension ocular. |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5510495A (en) * | 1994-09-19 | 1996-04-23 | The Du Pont Merck Pharmaceutical Company | Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis |
| WO1996009301A1 (en) * | 1994-09-20 | 1996-03-28 | Wakunaga Seiyaku Kabushiki Kaisha | Process for producing n-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same |
| IT1292437B1 (it) | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
| IT1295405B1 (it) | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| ES2154191B1 (es) * | 1998-11-24 | 2001-10-16 | Ferrer Int | Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. |
| GR20000100281A (el) * | 2000-08-17 | 2002-05-24 | Ιωαννης Ματσουκας | Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων |
| ES2295339T3 (es) | 2001-05-31 | 2008-04-16 | Vicore Pharma Ab | Compuestos tricilicos utiles como agonistas de la angiotensina ii. |
| EP1509517B1 (en) * | 2003-01-16 | 2008-06-11 | Teva Pharmaceutical Industries Ltd. | Novel synthesis of irbesartan |
| WO2005068632A1 (ja) | 2004-01-20 | 2005-07-28 | Aichi Prefecture | ＨＬＡ−Ａ２４０２拘束性Ｅｐ−ＣＡＭ特異的ＣＴＬが認識するエピトープ・ペプチド及びその用途 |
| US7157584B2 (en) * | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
| JP4437141B2 (ja) * | 2004-09-02 | 2010-03-24 | テバ ファーマシューティカル インダストリーズ リミティド | オルメサルタンメドキソミルの精製法 |
| CA2604190A1 (en) * | 2005-04-20 | 2006-11-02 | Merck & Co., Inc. | Angiotensin ii receptor antagonists |
| WO2008027385A2 (en) * | 2006-08-29 | 2008-03-06 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole |
| JP5269798B2 (ja) * | 2006-10-09 | 2013-08-21 | シプラ・リミテッド | トリチルオルメサルタンメドキソミルおよびオルメサルタンメドキソミルの製造方法 |
| ATE525371T1 (de) * | 2006-12-06 | 2011-10-15 | Shanghai Allist Pharmaceutical Inc | Salze von imidazol-5-carbonsäure-derivaten, herstellungsverfahren und verwendung davon |
| WO2011084848A2 (en) | 2010-01-07 | 2011-07-14 | Alkermes, Inc. | Prodrugs of heteraromatic compounds |
| EP2455388A1 (en) | 2010-11-23 | 2012-05-23 | LanthioPep B.V. | Novel angiotensin type 2 (AT2) receptor agonists and uses thereof. |
| CN109320501B (zh) * | 2013-11-01 | 2021-06-01 | 深圳信立泰药业股份有限公司 | 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物 |
| WO2021023698A1 (en) | 2019-08-02 | 2021-02-11 | Lanthiopep B.V | Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| FI916130A7 (fi) * | 1989-06-30 | 1991-12-27 | Du Pont | Aryylisubstituoituja imidatsoleja |
| RU2099330C1 (ru) * | 1989-06-30 | 1997-12-20 | Е.И.Дюпон Де Немур Энд Компани | Замещенные имидазолы или их фармацевтически приемлемые соли и фармацевтическая композиция |
| GB8927277D0 (en) * | 1989-12-01 | 1990-01-31 | Glaxo Group Ltd | Chemical compounds |
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5137902A (en) * | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
| DK0573218T3 (da) * | 1992-06-02 | 2001-06-18 | Sankyo Co | 4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse |
-
1992
- 1992-08-06 US US07/926,795 patent/US5310929A/en not_active Expired - Lifetime
-
1993
- 1993-08-02 CA CA002141692A patent/CA2141692C/en not_active Expired - Lifetime
- 1993-08-02 BR BR9306911A patent/BR9306911A/pt not_active Application Discontinuation
- 1993-08-02 SK SK131-95A patent/SK13195A3/sk unknown
- 1993-08-02 JP JP6505415A patent/JP2892838B2/ja not_active Expired - Lifetime
- 1993-08-02 WO PCT/US1993/007103 patent/WO1994003435A1/en not_active Ceased
- 1993-08-02 EP EP93918463A patent/EP0654027A1/en not_active Withdrawn
- 1993-08-02 FI FI950485A patent/FI950485A7/fi not_active Application Discontinuation
- 1993-08-02 AU AU47903/93A patent/AU688735B2/en not_active Ceased
- 1993-08-02 IL IL106553A patent/IL106553A0/xx unknown
- 1993-08-02 SG SG1996008109A patent/SG47108A1/en unknown
- 1993-08-02 PL PL93307309A patent/PL307309A1/xx unknown
- 1993-08-02 HU HU9500349A patent/HU9500349D0/hu unknown
- 1993-08-05 ZA ZA935693A patent/ZA935693B/xx unknown
- 1993-08-06 MX MX9304787A patent/MX9304787A/es unknown
- 1993-08-06 TW TW082106302A patent/TW239131B/zh active
- 1993-08-06 CN CN93117634A patent/CN1090275A/zh active Pending
-
1995
- 1995-02-03 NO NO950404A patent/NO950404D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9304787A (es) | 1995-01-31 |
| EP0654027A1 (en) | 1995-05-24 |
| FI950485A0 (fi) | 1995-02-03 |
| FI950485L (fi) | 1995-02-03 |
| CN1090275A (zh) | 1994-08-03 |
| TW239131B (show.php) | 1995-01-21 |
| ZA935693B (en) | 1995-02-06 |
| NO950404D0 (no) | 1995-02-03 |
| BR9306911A (pt) | 1998-12-08 |
| JPH08500103A (ja) | 1996-01-09 |
| JP2892838B2 (ja) | 1999-05-17 |
| HU9500349D0 (en) | 1995-03-28 |
| SK13195A3 (en) | 1995-07-11 |
| WO1994003435A1 (en) | 1994-02-17 |
| PL307309A1 (en) | 1995-05-15 |
| CA2141692A1 (en) | 1994-02-17 |
| CA2141692C (en) | 2006-05-30 |
| SG47108A1 (en) | 1998-03-20 |
| AU4790393A (en) | 1994-03-03 |
| US5310929A (en) | 1994-05-10 |
| IL106553A0 (en) | 1993-12-08 |
| AU688735B2 (en) | 1998-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |