FI950485A7 - Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina - Google Patents
Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina Download PDFInfo
- Publication number
- FI950485A7 FI950485A7 FI950485A FI950485A FI950485A7 FI 950485 A7 FI950485 A7 FI 950485A7 FI 950485 A FI950485 A FI 950485A FI 950485 A FI950485 A FI 950485A FI 950485 A7 FI950485 A7 FI 950485A7
- Authority
- FI
- Finland
- Prior art keywords
- angiotensin
- receptor antagonists
- prodrug forms
- imidazolecarboxylic
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/926,795 US5310929A (en) | 1992-08-06 | 1992-08-06 | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
| PCT/US1993/007103 WO1994003435A1 (en) | 1992-08-06 | 1993-08-02 | Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI950485L FI950485L (fi) | 1995-02-03 |
| FI950485A0 FI950485A0 (fi) | 1995-02-03 |
| FI950485A7 true FI950485A7 (fi) | 1995-02-03 |
Family
ID=25453732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI950485A FI950485A7 (fi) | 1992-08-06 | 1993-08-02 | Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5310929A (enExample) |
| EP (1) | EP0654027A1 (enExample) |
| JP (1) | JP2892838B2 (enExample) |
| CN (1) | CN1090275A (enExample) |
| AU (1) | AU688735B2 (enExample) |
| BR (1) | BR9306911A (enExample) |
| CA (1) | CA2141692C (enExample) |
| FI (1) | FI950485A7 (enExample) |
| HU (1) | HU9500349D0 (enExample) |
| IL (1) | IL106553A0 (enExample) |
| MX (1) | MX9304787A (enExample) |
| NO (1) | NO950404D0 (enExample) |
| PL (1) | PL307309A1 (enExample) |
| SG (1) | SG47108A1 (enExample) |
| SK (1) | SK13195A3 (enExample) |
| TW (1) | TW239131B (enExample) |
| WO (1) | WO1994003435A1 (enExample) |
| ZA (1) | ZA935693B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| HU219598B (hu) * | 1992-12-17 | 2001-05-28 | Sankyo Co. Ltd. | Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények |
| AU684916B2 (en) * | 1994-03-16 | 1998-01-08 | Sankyo Company Limited | Ocular tension depressant |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5510495A (en) * | 1994-09-19 | 1996-04-23 | The Du Pont Merck Pharmaceutical Company | Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis |
| ATE176784T1 (de) * | 1994-09-20 | 1999-03-15 | Wakunaga Seiyaku Kk | Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen |
| IT1292437B1 (it) * | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
| IT1295405B1 (it) * | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| ES2154191B1 (es) * | 1998-11-24 | 2001-10-16 | Ferrer Int | Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. |
| GR20000100281A (el) * | 2000-08-17 | 2002-05-24 | Ιωαννης Ματσουκας | Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων |
| DE60222409T2 (de) | 2001-05-31 | 2008-09-25 | Vicore Pharma Ab | Trizyklische verbindungen, nützlich als angiotensin ii agonisten |
| CN1759113A (zh) * | 2003-01-16 | 2006-04-12 | 特瓦制药工业有限公司 | 伊贝沙坦的新合成方法 |
| CN1910284B (zh) | 2004-01-20 | 2011-04-06 | 爱知县 | 由HLA-A2402-限制的Ep-CAM-特异的CTL识别的表位/肽及其应用 |
| US7157584B2 (en) * | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
| KR20090102883A (ko) * | 2004-09-02 | 2009-09-30 | 테바 파마슈티컬 인더스트리즈 리미티드 | 올메살탄 메독소밀의 정제 |
| CN101160126A (zh) * | 2005-04-20 | 2008-04-09 | 默克公司 | 血管紧张肽ⅱ受体拮抗剂 |
| JP2009515834A (ja) * | 2006-08-29 | 2009-04-16 | テバ ファーマシューティカル インダストリーズ リミティド | ５−フェニル−１−トリチル−１ｈ−テトラゾールの合成のための方法 |
| KR101458369B1 (ko) * | 2006-10-09 | 2014-11-05 | 씨아이피엘에이 엘티디. | 트리틸 올메사탄 메독소밀 및 올메사탄 메독소밀의 제조방법 |
| EP2103610B1 (en) * | 2006-12-06 | 2011-09-21 | Shanghai Allist Pharmaceutical., Inc. | Salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof |
| EP2521545B1 (en) | 2010-01-07 | 2019-11-27 | Alkermes Pharma Ireland Limited | Prodrugs of heteroaromatic compounds |
| EP2455388A1 (en) | 2010-11-23 | 2012-05-23 | LanthioPep B.V. | Novel angiotensin type 2 (AT2) receptor agonists and uses thereof. |
| CN104610232B (zh) * | 2013-11-01 | 2019-09-20 | 深圳信立泰药业股份有限公司 | 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物 |
| JP2022542437A (ja) | 2019-08-02 | 2022-10-03 | ランティオペプ ベスローテン ヴェンノーツハップ | 癌の処置に用いるアンジオテンシン２型（ａｔ２）受容体アゴニスト |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| KR950009860B1 (ko) * | 1989-06-30 | 1995-08-29 | 이. 아이. 듀퐁 드 네모아 앤드 캄파니 | 융합된 환 아릴 치환된 이미다졸과 약제학적으로 허용되는 이의 염, 이들의 제조방법 및 이들을 함유하는 약제학적 조성물 |
| KR0163595B1 (ko) * | 1989-06-30 | 1998-12-01 | 미리암디, 메코너헤이 | 치환된 이미다졸 |
| GB8927277D0 (en) * | 1989-12-01 | 1990-01-31 | Glaxo Group Ltd | Chemical compounds |
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5137902A (en) * | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
| ES2155827T3 (es) * | 1992-06-02 | 2001-06-01 | Sankyo Co | 4-carboxiimidazoles como antagonistas de la angiotensina ii y su uso terapeutico. |
-
1992
- 1992-08-06 US US07/926,795 patent/US5310929A/en not_active Expired - Lifetime
-
1993
- 1993-08-02 SG SG1996008109A patent/SG47108A1/en unknown
- 1993-08-02 SK SK131-95A patent/SK13195A3/sk unknown
- 1993-08-02 IL IL106553A patent/IL106553A0/xx unknown
- 1993-08-02 CA CA002141692A patent/CA2141692C/en not_active Expired - Lifetime
- 1993-08-02 AU AU47903/93A patent/AU688735B2/en not_active Ceased
- 1993-08-02 HU HU9500349A patent/HU9500349D0/hu unknown
- 1993-08-02 JP JP6505415A patent/JP2892838B2/ja not_active Expired - Lifetime
- 1993-08-02 BR BR9306911A patent/BR9306911A/pt not_active Application Discontinuation
- 1993-08-02 FI FI950485A patent/FI950485A7/fi not_active Application Discontinuation
- 1993-08-02 EP EP93918463A patent/EP0654027A1/en not_active Withdrawn
- 1993-08-02 PL PL93307309A patent/PL307309A1/xx unknown
- 1993-08-02 WO PCT/US1993/007103 patent/WO1994003435A1/en not_active Ceased
- 1993-08-05 ZA ZA935693A patent/ZA935693B/xx unknown
- 1993-08-06 TW TW082106302A patent/TW239131B/zh active
- 1993-08-06 CN CN93117634A patent/CN1090275A/zh active Pending
- 1993-08-06 MX MX9304787A patent/MX9304787A/es unknown
-
1995
- 1995-02-03 NO NO950404A patent/NO950404D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1090275A (zh) | 1994-08-03 |
| HU9500349D0 (en) | 1995-03-28 |
| FI950485L (fi) | 1995-02-03 |
| AU4790393A (en) | 1994-03-03 |
| PL307309A1 (en) | 1995-05-15 |
| BR9306911A (pt) | 1998-12-08 |
| FI950485A0 (fi) | 1995-02-03 |
| NO950404D0 (no) | 1995-02-03 |
| JP2892838B2 (ja) | 1999-05-17 |
| WO1994003435A1 (en) | 1994-02-17 |
| TW239131B (enExample) | 1995-01-21 |
| SG47108A1 (en) | 1998-03-20 |
| AU688735B2 (en) | 1998-03-19 |
| EP0654027A1 (en) | 1995-05-24 |
| US5310929A (en) | 1994-05-10 |
| MX9304787A (es) | 1995-01-31 |
| IL106553A0 (en) | 1993-12-08 |
| CA2141692C (en) | 2006-05-30 |
| JPH08500103A (ja) | 1996-01-09 |
| ZA935693B (en) | 1995-02-06 |
| SK13195A3 (en) | 1995-07-11 |
| CA2141692A1 (en) | 1994-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |