FI950485A7 - Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina - Google Patents

Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina Download PDF

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Publication number
FI950485A7
FI950485A7 FI950485A FI950485A FI950485A7 FI 950485 A7 FI950485 A7 FI 950485A7 FI 950485 A FI950485 A FI 950485A FI 950485 A FI950485 A FI 950485A FI 950485 A7 FI950485 A7 FI 950485A7
Authority
FI
Finland
Prior art keywords
angiotensin
receptor antagonists
prodrug forms
imidazolecarboxylic
acids
Prior art date
Application number
FI950485A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950485L (fi
FI950485A0 (fi
Inventor
Robert John Ardecky
Carol Lee Ensinger
James Russell Pruitt
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of FI950485L publication Critical patent/FI950485L/fi
Publication of FI950485A0 publication Critical patent/FI950485A0/fi
Publication of FI950485A7 publication Critical patent/FI950485A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI950485A 1992-08-06 1993-08-02 Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina FI950485A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
PCT/US1993/007103 WO1994003435A1 (en) 1992-08-06 1993-08-02 Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists

Publications (3)

Publication Number Publication Date
FI950485L FI950485L (fi) 1995-02-03
FI950485A0 FI950485A0 (fi) 1995-02-03
FI950485A7 true FI950485A7 (fi) 1995-02-03

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950485A FI950485A7 (fi) 1992-08-06 1993-08-02 Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptor in antagonisteina

Country Status (18)

Country Link
US (1) US5310929A (cg-RX-API-DMAC7.html)
EP (1) EP0654027A1 (cg-RX-API-DMAC7.html)
JP (1) JP2892838B2 (cg-RX-API-DMAC7.html)
CN (1) CN1090275A (cg-RX-API-DMAC7.html)
AU (1) AU688735B2 (cg-RX-API-DMAC7.html)
BR (1) BR9306911A (cg-RX-API-DMAC7.html)
CA (1) CA2141692C (cg-RX-API-DMAC7.html)
FI (1) FI950485A7 (cg-RX-API-DMAC7.html)
HU (1) HU9500349D0 (cg-RX-API-DMAC7.html)
IL (1) IL106553A0 (cg-RX-API-DMAC7.html)
MX (1) MX9304787A (cg-RX-API-DMAC7.html)
NO (1) NO950404D0 (cg-RX-API-DMAC7.html)
PL (1) PL307309A1 (cg-RX-API-DMAC7.html)
SG (1) SG47108A1 (cg-RX-API-DMAC7.html)
SK (1) SK13195A3 (cg-RX-API-DMAC7.html)
TW (1) TW239131B (cg-RX-API-DMAC7.html)
WO (1) WO1994003435A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA935693B (cg-RX-API-DMAC7.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
CA2111662C (en) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease
DE69533045T2 (de) * 1994-03-16 2005-01-27 Sankyo Co., Ltd. Okulares Hypotonikum
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
ATE176784T1 (de) * 1994-09-20 1999-03-15 Wakunaga Seiyaku Kk Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) * 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
DK1395566T3 (da) 2001-05-31 2008-01-07 Vicore Pharma Ab Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister
SI1509517T1 (sl) * 2003-01-16 2008-10-31 Teva Pharma Nova sinteza irbesartana
JP4779067B2 (ja) 2004-01-20 2011-09-21 愛知県 ＨＬＡ−Ａ２４０２拘束性Ｅｐ−ＣＡＭ特異的ＣＴＬが認識するエピトープ・ペプチド及びその用途
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
JP4437141B2 (ja) * 2004-09-02 2010-03-24 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの精製法
CA2604190A1 (en) * 2005-04-20 2006-11-02 Merck & Co., Inc. Angiotensin ii receptor antagonists
US20080103312A1 (en) * 2006-08-29 2008-05-01 Kansal Vinod K Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole
EP2074116A2 (en) * 2006-10-09 2009-07-01 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
ATE525371T1 (de) * 2006-12-06 2011-10-15 Shanghai Allist Pharmaceutical Inc Salze von imidazol-5-carbonsäure-derivaten, herstellungsverfahren und verwendung davon
EP2521545B1 (en) * 2010-01-07 2019-11-27 Alkermes Pharma Ireland Limited Prodrugs of heteroaromatic compounds
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN104610232B (zh) * 2013-11-01 2019-09-20 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
JP2022542437A (ja) 2019-08-02 2022-10-03 ランティオペプ ベスローテン ヴェンノーツハップ 癌の処置に用いるアンジオテンシン２型（ａｔ２）受容体アゴニスト

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
FI916130A7 (fi) * 1989-06-30 1991-12-27 Du Pont Aryylisubstituoituja imidatsoleja
DK0479903T3 (da) * 1989-06-30 1996-03-18 Du Pont Substituerede imidazoler og deres anvendelse som angiotensin II hæmmere
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
EP0573218B1 (en) * 1992-06-02 2001-03-07 Sankyo Company Limited 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use

Also Published As

Publication number Publication date
SG47108A1 (en) 1998-03-20
US5310929A (en) 1994-05-10
JP2892838B2 (ja) 1999-05-17
MX9304787A (es) 1995-01-31
SK13195A3 (en) 1995-07-11
CA2141692A1 (en) 1994-02-17
BR9306911A (pt) 1998-12-08
CA2141692C (en) 2006-05-30
AU4790393A (en) 1994-03-03
JPH08500103A (ja) 1996-01-09
ZA935693B (en) 1995-02-06
FI950485L (fi) 1995-02-03
PL307309A1 (en) 1995-05-15
IL106553A0 (en) 1993-12-08
CN1090275A (zh) 1994-08-03
AU688735B2 (en) 1998-03-19
HU9500349D0 (en) 1995-03-28
FI950485A0 (fi) 1995-02-03
TW239131B (cg-RX-API-DMAC7.html) 1995-01-21
WO1994003435A1 (en) 1994-02-17
EP0654027A1 (en) 1995-05-24
NO950404D0 (no) 1995-02-03

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