FI94253B - Förfarande för framställning av 3-cefemderivat - Google Patents

Förfarande för framställning av 3-cefemderivat

Info

Publication number
FI94253B
FI94253B FI881904A FI881904A FI94253B FI 94253 B FI94253 B FI 94253B FI 881904 A FI881904 A FI 881904A FI 881904 A FI881904 A FI 881904A FI 94253 B FI94253 B FI 94253B
Authority
FI
Finland
Prior art keywords
cephem
derivatives
carbocyclic
conjugated
alkenyl
Prior art date
Application number
FI881904A
Other languages
English (en)
Finnish (fi)
Other versions
FI881904A0 (sv
FI881904A (sv
FI94253C (sv
Inventor
Stephen Richard Baker
Vittorio Farina
Jr Chester Sapino
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/019,395 priority Critical patent/US4847373A/en
Priority to US07/019,396 priority patent/US4870168A/en
Priority to IE117988A priority patent/IE64885B1/en
Priority to AU14758/88A priority patent/AU602395B2/en
Priority to FI881872A priority patent/FI91760C/sv
Publication of FI881904A0 publication Critical patent/FI881904A0/sv
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to ZA882880A priority patent/ZA882880B/xx
Priority to FI881904A priority patent/FI94253C/sv
Priority to HU882083A priority patent/HU207521B/hu
Priority to CS882885A priority patent/CS272234B2/cs
Priority to PT87367A priority patent/PT87367B/pt
Priority to EP88107887A priority patent/EP0342252A1/en
Priority to CA000564614A priority patent/CA1338644C/en
Priority to AU16515/88A priority patent/AU617669B2/en
Priority to CN88102961A priority patent/CN1035181C/zh
Priority to JP63130057A priority patent/JP2650716B2/ja
Priority to ES88108505T priority patent/ES2060619T3/es
Priority to EP88108505A priority patent/EP0343277B1/en
Priority to DE3851749T priority patent/DE3851749T2/de
Priority to AT88108505T priority patent/ATE112571T1/de
Priority to JP63134270A priority patent/JP2706090B2/ja
Priority to DD88327653A priority patent/DD280533A5/de
Priority to DD88316493A priority patent/DD270712A5/de
Publication of FI881904A publication Critical patent/FI881904A/sv
Publication of FI94253B publication Critical patent/FI94253B/sv
Application granted granted Critical
Publication of FI94253C publication Critical patent/FI94253C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
FI881904A 1987-02-26 1988-04-22 Förfarande för framställning av 3-cefemderivat FI94253C (sv)

Priority Applications (22)

Application Number Priority Date Filing Date Title
US07/019,395 US4847373A (en) 1987-02-26 1987-02-26 Production of 3-allyl- and 3-butenyl-3-cephems
US07/019,396 US4870168A (en) 1987-02-26 1987-02-26 3-Unsaturated alkyl cephems from 3-triflyl cephems
IE117988A IE64885B1 (en) 1987-02-26 1988-04-19 A process for the production of 3-hydrocarbyl-3-cephems
AU14758/88A AU602395B2 (en) 1987-02-26 1988-04-19 3-unsaturated alkyl cephems from 3-triflyl cephems
FI881872A FI91760C (sv) 1987-02-26 1988-04-21 Förfarande för framställning av terapeutiskt användbara 7-substituerade acetamido-3-alkenyl-3-cefemderivat
ZA882880A ZA882880B (sv) 1987-02-26 1988-04-22
FI881904A FI94253C (sv) 1987-02-26 1988-04-22 Förfarande för framställning av 3-cefemderivat
HU882083A HU207521B (en) 1987-02-26 1988-04-25 Process for producing 3-substituted 3-cepheme-derivatives
CS882885A CS272234B2 (en) 1987-02-26 1988-04-28 Method of 3-hydrocarbyl-3-cephaem derivative production
PT87367A PT87367B (pt) 1987-02-26 1988-04-29 Processo para a preparacao de derivados de alquil-cefem insaturados em posicao 3 a partir de novos compostos intermedios derivados de 3-triflil-cefem
EP88107887A EP0342252A1 (en) 1987-02-26 1988-05-17 3-allyl- and 3-butenyl-3-cephems and a process for the production thereof
CA000564614A CA1338644C (en) 1987-02-26 1988-05-18 Production of 3-allyl- and 3-butenyl-3-cephems
AU16515/88A AU617669B2 (en) 1987-02-26 1988-05-20 Production of 3-allyl- and 3-butenyl-3-cephems
CN88102961A CN1035181C (zh) 1987-02-26 1988-05-20 从3－三氟甲磺酰氧基头孢烯制备3－不饱和烃基头孢烯的方法
JP63130057A JP2650716B2 (ja) 1987-02-26 1988-05-27 ３−アリル及び３−ブテニル−３−セフェムの製造
ES88108505T ES2060619T3 (es) 1987-02-26 1988-05-27 Un procedimiento para la produccion de 3-hidrocarbil-3-cefems.
EP88108505A EP0343277B1 (en) 1987-02-26 1988-05-27 A process for the production of 3-hydrocarbyl-3-cephems
DE3851749T DE3851749T2 (de) 1987-02-26 1988-05-27 Verfahren zur Herstellung von 3-hydrocarbyl-3-cephemverbindungen.
AT88108505T ATE112571T1 (de) 1987-02-26 1988-05-27 Verfahren zur herstellung von 3-hydrocarbyl-3- cephemverbindungen.
JP63134270A JP2706090B2 (ja) 1987-02-26 1988-05-31 ３−トリフリルセフェムからの３−不飽和アルキルセフェム
DD88327653A DD280533A5 (de) 1987-02-26 1988-06-07 Verfahren zur herstellung von 3-trifluormethan-sulfonyloxy-3-cephem-zwischenverbindungen
DD88316493A DD270712A5 (de) 1987-02-26 1988-06-07 Verfahren zur herstellung von (hydrocarbyl)-3-cephem-derivaten

Applications Claiming Priority (32)

Application Number Priority Date Filing Date Title
US07/019,396 US4870168A (en) 1987-02-26 1987-02-26 3-Unsaturated alkyl cephems from 3-triflyl cephems
US1939587 1987-02-26
US1939687 1987-02-26
US07/019,395 US4847373A (en) 1987-02-26 1987-02-26 Production of 3-allyl- and 3-butenyl-3-cephems
AU14758/88A AU602395B2 (en) 1987-02-26 1988-04-19 3-unsaturated alkyl cephems from 3-triflyl cephems
AU1475888 1988-04-19
IE117988A IE64885B1 (en) 1987-02-26 1988-04-19 A process for the production of 3-hydrocarbyl-3-cephems
IE117988 1988-04-19
FI881872 1988-04-21
FI881872A FI91760C (sv) 1987-02-26 1988-04-21 Förfarande för framställning av terapeutiskt användbara 7-substituerade acetamido-3-alkenyl-3-cefemderivat
FI881904A FI94253C (sv) 1987-02-26 1988-04-22 Förfarande för framställning av 3-cefemderivat
FI881904 1988-04-22
HU208388 1988-04-25
HU882083A HU207521B (en) 1987-02-26 1988-04-25 Process for producing 3-substituted 3-cepheme-derivatives
CS288588 1988-04-28
CS882885A CS272234B2 (en) 1987-02-26 1988-04-28 Method of 3-hydrocarbyl-3-cephaem derivative production
PT8736788 1988-04-29
PT87367A PT87367B (pt) 1987-02-26 1988-04-29 Processo para a preparacao de derivados de alquil-cefem insaturados em posicao 3 a partir de novos compostos intermedios derivados de 3-triflil-cefem
CA000564614A CA1338644C (en) 1987-02-26 1988-05-18 Production of 3-allyl- and 3-butenyl-3-cephems
CA564614 1988-05-18
CN88102961A CN1035181C (zh) 1987-02-26 1988-05-20 从3－三氟甲磺酰氧基头孢烯制备3－不饱和烃基头孢烯的方法
CN88102961 1988-05-20
JP13005788 1988-05-27
EP88108505A EP0343277B1 (en) 1987-02-26 1988-05-27 A process for the production of 3-hydrocarbyl-3-cephems
EP88108505 1988-05-27
JP63130057A JP2650716B2 (ja) 1987-02-26 1988-05-27 ３−アリル及び３−ブテニル−３−セフェムの製造
JP63134270A JP2706090B2 (ja) 1987-02-26 1988-05-31 ３−トリフリルセフェムからの３−不飽和アルキルセフェム
JP13427088 1988-05-31
DD88327653A DD280533A5 (de) 1987-02-26 1988-06-07 Verfahren zur herstellung von 3-trifluormethan-sulfonyloxy-3-cephem-zwischenverbindungen
DD88316493A DD270712A5 (de) 1987-02-26 1988-06-07 Verfahren zur herstellung von (hydrocarbyl)-3-cephem-derivaten
DD31649388 1988-06-07
DD32765388 1988-06-07

Publications (4)

Publication Number Publication Date
FI881904A0 FI881904A0 (sv) 1988-04-22
FI881904A FI881904A (sv) 1989-10-23
FI94253B true FI94253B (sv) 1995-04-28
FI94253C FI94253C (sv) 1995-08-10

Family

ID=39688793

Family Applications (2)

Application Number Title Priority Date Filing Date
FI881872A FI91760C (sv) 1987-02-26 1988-04-21 Förfarande för framställning av terapeutiskt användbara 7-substituerade acetamido-3-alkenyl-3-cefemderivat
FI881904A FI94253C (sv) 1987-02-26 1988-04-22 Förfarande för framställning av 3-cefemderivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI881872A FI91760C (sv) 1987-02-26 1988-04-21 Förfarande för framställning av terapeutiskt användbara 7-substituerade acetamido-3-alkenyl-3-cefemderivat

Country Status (16)

Country Link
US (2) US4847373A (sv)
EP (2) EP0342252A1 (sv)
JP (2) JP2650716B2 (sv)
CN (1) CN1035181C (sv)
AT (1) ATE112571T1 (sv)
AU (2) AU602395B2 (sv)
CA (1) CA1338644C (sv)
CS (1) CS272234B2 (sv)
DD (2) DD280533A5 (sv)
DE (1) DE3851749T2 (sv)
ES (1) ES2060619T3 (sv)
FI (2) FI91760C (sv)
HU (1) HU207521B (sv)
IE (1) IE64885B1 (sv)
PT (1) PT87367B (sv)
ZA (1) ZA882880B (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
GB8821797D0 (en) * 1988-09-16 1988-10-19 Beecham Group Plc Novel compounds
US5245027A (en) * 1989-11-21 1993-09-14 Bristol-Myers Squibb Company 3-fluorosulfonyloxyceph-3-em compounds
US5043439A (en) * 1990-03-08 1991-08-27 Bristol-Myers Squibb Company Process for production of cephalosporins
DE4030706A1 (de) * 1990-09-28 1992-04-02 Bayer Ag Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5106842A (en) * 1990-10-22 1992-04-21 Bristol-Myers Squibb Co. Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof
DE4037841A1 (de) * 1990-11-28 1992-06-04 Bayer Ag Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AT396106B (de) * 1991-03-08 1993-06-25 Biochemie Gmbh Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
DE69232048T2 (de) 1992-02-05 2002-07-04 Biochemie Gesellschaft M.B.H., Kundl Verfahren zur reinigung eines 3-cephem-4-carboxyl säure derivates
JP3224279B2 (ja) * 1992-07-27 2001-10-29 大塚化学株式会社 セフエム化合物の製造法
CN1149874A (zh) * 1994-04-01 1997-05-14 迈克罗赛药品公司 头孢菌素类抗菌素
US5698547A (en) * 1994-04-01 1997-12-16 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
MY127641A (en) * 1995-10-12 2006-12-29 Essential Therapeutics Inc Cephalosporin antibiotics
US6025352A (en) * 1997-09-29 2000-02-15 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US6030965A (en) * 1997-09-30 2000-02-29 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
JP4535530B2 (ja) * 1999-09-20 2010-09-01 大塚化学株式会社 ３−スルホニルオキシ−３−セフェム化合物の製造方法
TW500724B (en) 1999-10-05 2002-09-01 Pharmacia & Amp Upjohn Company Oxazinoquinolones useful for the treatment of viral infections
US6821969B2 (en) * 2001-02-13 2004-11-23 Pharmacia & Upjohn Company Thioxazinoquinolones as antiviral agents
US20050080255A1 (en) * 2001-12-13 2005-04-14 Yatendra Kumar Crystalline cefdinir potassium dihydrate
EP1848724A2 (en) * 2005-10-31 2007-10-31 Teva Pharmaceutical Industries Ltd Process for the preparation of cefdinir
WO2007053722A2 (en) * 2005-10-31 2007-05-10 Teva Pharmaceutical Industries Ltd. Crystalline form of cefdinir cesium salt
US8883772B2 (en) * 2007-10-09 2014-11-11 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
DK2968352T3 (da) 2013-03-12 2019-01-02 Gladius Pharmaceuticals Corp Derivatiserede 3-styryl-cephalosporiner

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
US3959324A (en) * 1972-04-26 1976-05-25 The Procter & Gamble Company Alkyltin cyclopropylcarbinylsulfonate
GB1377624A (en) * 1972-07-07 1974-12-18 Glaxo Lab Ltd Cephalosporin compounds
JPS543087A (en) * 1977-06-03 1979-01-11 Fujisawa Pharmaceut Co Ltd Preparation of cephalosporin compound
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
JPS5758689A (en) * 1980-09-25 1982-04-08 Toyama Chem Co Ltd Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
ZA832226B (en) * 1982-03-31 1984-02-29 Beecham Group Plc Penicillins,a process for the preparation and compositions containing them
US4609730A (en) * 1982-11-22 1986-09-02 Fujisawa Pharmaceutical Co., Ltd. 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
FR2580652B1 (fr) * 1985-04-22 1989-01-06 Bristol Myers Co Acide 7-amino-3-propenylcephalosporanique et ses esters
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4619925A (en) * 1985-11-08 1986-10-28 Bristol-Myers Company 3-Propenyl cephalosporin derivatives
US4727070A (en) * 1985-11-25 1988-02-23 Bristol-Myers Company 3-Propenzl cephalosporin isomer separation process and derivative

Also Published As

Publication number Publication date
US4870168A (en) 1989-09-26
IE64885B1 (en) 1995-09-20
ATE112571T1 (de) 1994-10-15
FI881872A (sv) 1989-10-22
AU1475888A (en) 1989-10-26
EP0342252A1 (en) 1989-11-23
HU207521B (en) 1993-04-28
DD270712A5 (de) 1989-08-09
AU617669B2 (en) 1991-12-05
CS272234B2 (en) 1991-01-15
DD280533A5 (de) 1990-07-11
FI91760C (sv) 1994-08-10
AU1651588A (en) 1989-11-23
HUT49885A (en) 1989-11-28
US4847373A (en) 1989-07-11
ZA882880B (sv) 1988-10-27
JP2650716B2 (ja) 1997-09-03
JP2706090B2 (ja) 1998-01-28
FI881872A0 (sv) 1988-04-21
CN1037709A (zh) 1989-12-06
AU602395B2 (en) 1990-10-11
PT87367A (pt) 1989-11-10
JPH01313483A (ja) 1989-12-18
CA1338644C (en) 1996-10-15
EP0343277A1 (en) 1989-11-29
FI91760B (sv) 1994-04-29
CS288588A2 (en) 1990-03-14
ES2060619T3 (es) 1994-12-01
FI881904A0 (sv) 1988-04-22
FI881904A (sv) 1989-10-23
CN1035181C (zh) 1997-06-18
DE3851749T2 (de) 1995-02-09
FI94253C (sv) 1995-08-10
EP0343277B1 (en) 1994-10-05
PT87367B (pt) 1994-04-29
JPH01313482A (ja) 1989-12-18
DE3851749D1 (de) 1994-11-10

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