FI942345A7 - Menetelmä proliiniboronaattiesterin valmistamiseksi - Google Patents

Menetelmä proliiniboronaattiesterin valmistamiseksi Download PDF

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Publication number
FI942345A7
FI942345A7 FI942345A FI942345A FI942345A7 FI 942345 A7 FI942345 A7 FI 942345A7 FI 942345 A FI942345 A FI 942345A FI 942345 A FI942345 A FI 942345A FI 942345 A7 FI942345 A7 FI 942345A7
Authority
FI
Finland
Prior art keywords
boronate ester
proline boronate
preparing
preparing proline
ester
Prior art date
Application number
FI942345A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942345A0 (fi
Inventor
Roger Snow
Terence A Kelly
Julian Adams
Simon Coutts
Clark Perry
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of FI942345A0 publication Critical patent/FI942345A0/fi
Publication of FI942345A7 publication Critical patent/FI942345A7/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI942345A 1991-11-22 1994-05-20 Menetelmä proliiniboronaattiesterin valmistamiseksi FI942345A7 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79614891A 1991-11-22 1991-11-22
US93619892A 1992-08-26 1992-08-26
PCT/US1992/009845 WO1993010127A1 (en) 1991-11-22 1992-11-19 Method for making a prolineboronate ester

Publications (2)

Publication Number Publication Date
FI942345A0 FI942345A0 (fi) 1994-05-20
FI942345A7 true FI942345A7 (fi) 1994-05-20

Family

ID=27121696

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942345A FI942345A7 (fi) 1991-11-22 1994-05-20 Menetelmä proliiniboronaattiesterin valmistamiseksi

Country Status (17)

Country Link
EP (1) EP0641347A1 (enrdf_load_html_response)
JP (1) JPH07501078A (enrdf_load_html_response)
CN (1) CN1073946A (enrdf_load_html_response)
AU (1) AU661362B2 (enrdf_load_html_response)
CA (1) CA2123128A1 (enrdf_load_html_response)
CZ (1) CZ124494A3 (enrdf_load_html_response)
FI (1) FI942345A7 (enrdf_load_html_response)
HU (1) HUT67937A (enrdf_load_html_response)
IL (1) IL103817A0 (enrdf_load_html_response)
MX (1) MX9206628A (enrdf_load_html_response)
NO (1) NO941905L (enrdf_load_html_response)
NZ (1) NZ245207A (enrdf_load_html_response)
PT (1) PT101079A (enrdf_load_html_response)
SI (1) SI9200332A (enrdf_load_html_response)
SK (1) SK59294A3 (enrdf_load_html_response)
TW (1) TW232697B (enrdf_load_html_response)
WO (1) WO1993010127A1 (enrdf_load_html_response)

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US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5965532A (en) * 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6258597B1 (en) 1997-09-29 2001-07-10 Point Therapeutics, Inc. Stimulation of hematopoietic cells in vitro
BR9910251A (pt) 1998-05-04 2001-01-02 Point Therapeutics Inc Estimulação hematopoiética
CA2334155C (en) 1998-06-05 2005-04-19 Point Therapeutics, Inc. Cyclic boroproline compounds
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
JP2003523396A (ja) * 2000-02-25 2003-08-05 ノボ ノルディスク アクティーゼルスカブ ベータ細胞変性の抑制
WO2003063903A2 (en) * 2002-02-01 2003-08-07 Probiodrug Ag Modulation of t lymphocytes using dp iv inhibitors
US7576121B2 (en) 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7317109B2 (en) 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
SG134333A1 (en) 2003-11-12 2007-08-29 Phenomix Corp Heterocyclic boronic acid compounds
US7767828B2 (en) 2003-11-12 2010-08-03 Phenomix Corporation Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
KR20130105741A (ko) 2003-11-17 2013-09-25 노파르티스 아게 디펩티딜 펩티다제 ⅳ 억제제의 용도
SI3366283T1 (sl) 2004-01-20 2021-12-31 Novartis Ag Formulacija za neposredno stiskanje in postopek
PA8631101A1 (es) 2004-04-27 2006-09-08 Wyeth Corp Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
US7399869B2 (en) 2005-05-19 2008-07-15 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
US7825139B2 (en) 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN1331835C (zh) * 2005-10-18 2007-08-15 武汉大学 光活性β-羟基酮的制备方法
CN101379069A (zh) * 2005-12-19 2009-03-04 塔夫茨大学信托人 软蛋白酶抑制剂及其前软形式
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
TWI409458B (zh) 2006-04-11 2013-09-21 Arena Pharm Inc 使用gpr119受體鑑定可用於增加個體骨質量之化合物之方法
EP2146210A1 (en) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
FI2318419T4 (fi) * 2008-06-17 2025-01-29 Takeda Pharmaceuticals Co Boronaattiesteriyhdisteitä ja niiden farmaseuttisia koostumuksia
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
CA2795513A1 (en) 2010-04-06 2011-10-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US10894787B2 (en) 2010-09-22 2021-01-19 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
US20140018371A1 (en) 2011-04-01 2014-01-16 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140038889A1 (en) 2011-04-22 2014-02-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140051714A1 (en) 2011-04-22 2014-02-20 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US9523687B2 (en) 2014-02-28 2016-12-20 Institut Pasteur Levels of CXCL 10/IP-10 forms and soluble CD26/DPPIV activity as early predictive biomarkers for HIV/SIV associated mucosal inflammation and progression towards AIDS
SG11201609259VA (en) 2014-05-20 2016-12-29 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
CN107683135A (zh) 2015-03-09 2018-02-09 因特克林医疗有限公司 用于治疗非酒精性脂肪肝疾病和/或脂肪营养不良的方法
WO2018162722A1 (en) 2017-03-09 2018-09-13 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Dpp-4 inhibitors for use in treating bone fractures
WO2018187350A1 (en) 2017-04-03 2018-10-11 Coherus Biosciences Inc. PPARγ AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY
CN108047257B (zh) * 2017-12-17 2020-03-13 沧州普瑞东方科技有限公司 一种手性n-boc-吡咯烷-2-硼酸的制备工艺
ES2929196T3 (es) * 2018-02-20 2022-11-25 Otsuka Pharma Co Ltd Método de producción de 4-boronofenilalanina
CN110452258B (zh) * 2019-09-03 2021-01-01 上海馨远医药科技有限公司 一种二肽缬氨酸硼脯氨酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
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US4935493A (en) * 1987-10-06 1990-06-19 E. I. Du Pont De Nemours And Company Protease inhibitors
WO1991016339A1 (en) * 1990-04-14 1991-10-31 New England Medical Center Hospitals, Inc. Inhibitors of dipeptidyl-aminopeptidase type iv
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry

Also Published As

Publication number Publication date
PT101079A (pt) 1994-02-28
FI942345A0 (fi) 1994-05-20
HUT67937A (en) 1995-05-29
SI9200332A (en) 1993-06-30
JPH07501078A (ja) 1995-02-02
MX9206628A (es) 1993-05-01
NZ245207A (en) 1994-07-26
WO1993010127A1 (en) 1993-05-27
CA2123128A1 (en) 1993-05-27
TW232697B (enrdf_load_html_response) 1994-10-21
HU9401350D0 (en) 1994-08-29
CN1073946A (zh) 1993-07-07
SK59294A3 (en) 1995-02-08
IL103817A0 (en) 1993-04-04
CZ124494A3 (en) 1995-07-12
NO941905L (no) 1994-07-14
EP0641347A1 (en) 1995-03-08
NO941905D0 (no) 1994-05-20
AU3136893A (en) 1993-06-15
AU661362B2 (en) 1995-07-20

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