FI941986A7 - Antifungaaliset tri-substituoidut tetrahydrofuraanit - Google Patents
Antifungaaliset tri-substituoidut tetrahydrofuraanit Download PDFInfo
- Publication number
- FI941986A7 FI941986A7 FI941986A FI941986A FI941986A7 FI 941986 A7 FI941986 A7 FI 941986A7 FI 941986 A FI941986 A FI 941986A FI 941986 A FI941986 A FI 941986A FI 941986 A7 FI941986 A7 FI 941986A7
- Authority
- FI
- Finland
- Prior art keywords
- antifungal
- tri
- substituted tetrahydrofurans
- tetrahydrofurans
- substituted
- Prior art date
Links
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- -1 tri-substituted tetrahydrofurans Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78535791A | 1991-10-30 | 1991-10-30 | |
| US90726292A | 1992-07-01 | 1992-07-01 | |
| PCT/US1992/008981 WO1993009114A1 (en) | 1991-10-30 | 1992-10-28 | Tri-substituted tetrahydrofuran antifungals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI941986A0 FI941986A0 (fi) | 1994-04-29 |
| FI941986A7 true FI941986A7 (fi) | 1994-04-29 |
Family
ID=27120397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI941986A FI941986A7 (fi) | 1991-10-30 | 1994-04-29 | Antifungaaliset tri-substituoidut tetrahydrofuraanit |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP0539938A1 (enExample) |
| JP (1) | JP3210017B2 (enExample) |
| CN (1) | CN1037267C (enExample) |
| AT (1) | ATE198888T1 (enExample) |
| AU (1) | AU665218B2 (enExample) |
| CA (1) | CA2122270C (enExample) |
| CZ (1) | CZ102794A3 (enExample) |
| DE (1) | DE69231661T2 (enExample) |
| ES (1) | ES2153364T3 (enExample) |
| FI (1) | FI941986A7 (enExample) |
| HR (1) | HRP921145A2 (enExample) |
| HU (1) | HUT70742A (enExample) |
| IL (1) | IL103558A0 (enExample) |
| MX (1) | MX9206222A (enExample) |
| MY (1) | MY109529A (enExample) |
| NO (1) | NO941589L (enExample) |
| NZ (1) | NZ244910A (enExample) |
| SG (1) | SG42920A1 (enExample) |
| SI (1) | SI9200285A (enExample) |
| SK (1) | SK48894A3 (enExample) |
| WO (1) | WO1993009114A1 (enExample) |
| YU (1) | YU94792A (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5349099A (en) * | 1993-12-13 | 1994-09-20 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| HU225062B1 (en) * | 1993-12-21 | 2006-05-29 | Schering Corp | Tetrahydrofuran derivatives with antifungal- effect, pharmaceutical compositions containing them and process for their preparation |
| US5703236A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| US5714490A (en) * | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| US5693626A (en) * | 1993-12-21 | 1997-12-02 | Schering Corporation | Tetrahydrofuran antifungals |
| US5661151A (en) * | 1993-12-21 | 1997-08-26 | Schering Corporation | Tetrahydrofuran antifungals |
| US5703079A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| US5710154A (en) * | 1993-12-21 | 1998-01-20 | Schering Corporation | Tetrahydrofuran antifungals |
| KR100352147B1 (ko) * | 1994-01-24 | 2002-11-11 | 얀센 파마슈티카 엔.브이. | 수용성아졸항진균제 |
| WO1995028374A1 (en) * | 1994-04-19 | 1995-10-26 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for producing triazole derivative |
| US5442093A (en) * | 1994-05-09 | 1995-08-15 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5486625A (en) * | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| EP0725146A4 (en) * | 1994-07-18 | 1998-12-23 | Daicel Chem | METHOD FOR PRODUCING OPTICALLY ACTIVE TRIAZOLE COMPOUNDS AND METHOD FOR RAZEMIZING OPTICALLY ACTIVE TRIAZOLE COMPOUNDS |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| US5616777A (en) * | 1995-04-19 | 1997-04-01 | Schering Corporation | Chiral hydrazine derivatives |
| CZ59497A3 (en) * | 1995-06-02 | 1997-08-13 | Schering Corp | Tetrahydrofuran derivative and pharmaceutical composition containing thereof |
| US5698557A (en) * | 1995-06-19 | 1997-12-16 | Schering Corporation | Hydroxy-substituted antifungals |
| ES2203707T3 (es) * | 1995-06-19 | 2004-04-16 | Schering Corporation | Antifungicos de tetrahidrofurano. |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5846971A (en) * | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| TW593312B (en) | 1997-07-11 | 2004-06-21 | Janssen Pharmaceutica Nv | 2,4,4-trisubstituted-1,3-dioxolane antifungals |
| NZ503662A (en) * | 1997-10-07 | 2002-10-25 | Schering Corp | Crystalline polymorph of (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]-methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one and its use as a fungicide |
| CN1628119A (zh) * | 2002-04-12 | 2005-06-15 | 兰贝克赛实验室有限公司 | 作为抗真菌剂的2,2,4－三取代的四氢呋喃衍生物 |
| CN102892762B (zh) | 2010-05-19 | 2016-04-20 | 桑多斯股份公司 | 制备泊沙康唑中间体 |
| MX2012013331A (es) | 2010-05-19 | 2013-02-01 | Sandoz Ag | Purificacion de posaconazol y de intermediarios de posaconazol. |
| BR112012029225B1 (pt) | 2010-05-19 | 2020-10-27 | Sandoz Ag | processo para a preparação de um composto quiral, composto quiral e uso de um composto quiral |
| BR112012029227B1 (pt) | 2010-05-19 | 2020-01-07 | Sandoz Ag | Processo para a preparação de um composto quiral, composto quiral e uso de um composto |
| CA2838051C (en) | 2011-06-16 | 2019-09-24 | Sandoz Ag | Process for the preparation of a chiral compound |
| CA2913634C (en) * | 2013-06-07 | 2022-08-09 | The California Institute For Biomedical Research | Small molecule inhibitors of fibrosis |
| CN106397417A (zh) * | 2016-08-30 | 2017-02-15 | 甘肃皓天化学科技有限公司 | 用于制备泊沙康唑的中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| DK354185A (da) | 1984-08-31 | 1986-03-01 | Hoffmann La Roche | 1,3-dioxolanderivater |
| NZ223799A (en) * | 1987-03-25 | 1989-12-21 | Janssen Pharmaceutica Nv | Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions |
| US5006513A (en) | 1987-11-09 | 1991-04-09 | Miles Inc. | Antimycotic compositions of nikkomycin compounds and azole antimycotica |
| EP0318214B1 (en) | 1987-11-20 | 1994-12-14 | Schering Corporation | Tri- and tetra-substituted-oxetanes and -tetrahydrofurans and intermediates thereof |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
| NZ233502A (en) * | 1989-06-09 | 1991-11-26 | Janssen Pharmaceutica Nv | 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US20040220100A1 (en) | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
-
1992
- 1992-10-27 IL IL103558A patent/IL103558A0/xx unknown
- 1992-10-28 CZ CZ941027A patent/CZ102794A3/cs unknown
- 1992-10-28 DE DE69231661T patent/DE69231661T2/de not_active Expired - Lifetime
- 1992-10-28 NZ NZ244910A patent/NZ244910A/en unknown
- 1992-10-28 HU HU9401256A patent/HUT70742A/hu unknown
- 1992-10-28 MX MX9206222A patent/MX9206222A/es unknown
- 1992-10-28 EP EP92118413A patent/EP0539938A1/en active Pending
- 1992-10-28 SK SK488-94A patent/SK48894A3/sk unknown
- 1992-10-28 SG SG1996000735A patent/SG42920A1/en unknown
- 1992-10-28 CA CA002122270A patent/CA2122270C/en not_active Expired - Lifetime
- 1992-10-28 ES ES92923060T patent/ES2153364T3/es not_active Expired - Lifetime
- 1992-10-28 WO PCT/US1992/008981 patent/WO1993009114A1/en not_active Ceased
- 1992-10-28 AT AT92923060T patent/ATE198888T1/de active
- 1992-10-28 AU AU29169/92A patent/AU665218B2/en not_active Ceased
- 1992-10-28 EP EP92923060A patent/EP0610377B1/en not_active Expired - Lifetime
- 1992-10-28 MY MYPI92001943A patent/MY109529A/en unknown
- 1992-10-28 JP JP50846493A patent/JP3210017B2/ja not_active Expired - Fee Related
- 1992-10-29 HR HR921145A patent/HRP921145A2/hr not_active Application Discontinuation
- 1992-10-29 CN CN92113399A patent/CN1037267C/zh not_active Expired - Fee Related
- 1992-10-29 SI SI19929200285A patent/SI9200285A/sl unknown
- 1992-10-29 YU YU94792A patent/YU94792A/sh unknown
-
1994
- 1994-04-29 NO NO941589A patent/NO941589L/no unknown
- 1994-04-29 FI FI941986A patent/FI941986A7/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2916992A (en) | 1993-06-07 |
| HU9401256D0 (en) | 1994-08-29 |
| FI941986A0 (fi) | 1994-04-29 |
| NO941589L (enExample) | 1994-06-23 |
| MY109529A (en) | 1997-02-28 |
| CA2122270C (en) | 2006-05-23 |
| SG42920A1 (en) | 1997-10-17 |
| NO941589D0 (enExample) | 1994-04-29 |
| WO1993009114A1 (en) | 1993-05-13 |
| JPH07500605A (ja) | 1995-01-19 |
| NZ244910A (en) | 1996-01-26 |
| EP0539938A1 (en) | 1993-05-05 |
| EP0610377A1 (en) | 1994-08-17 |
| SK48894A3 (en) | 1995-02-08 |
| AU665218B2 (en) | 1995-12-21 |
| EP0610377B1 (en) | 2001-01-24 |
| MX9206222A (es) | 1993-04-01 |
| YU94792A (sh) | 1995-12-04 |
| CN1073944A (zh) | 1993-07-07 |
| IL103558A0 (en) | 1993-03-15 |
| ES2153364T3 (es) | 2001-03-01 |
| ATE198888T1 (de) | 2001-02-15 |
| HRP921145A2 (en) | 1994-08-31 |
| CZ102794A3 (en) | 1995-03-15 |
| CA2122270A1 (en) | 1993-05-13 |
| JP3210017B2 (ja) | 2001-09-17 |
| SI9200285A (en) | 1993-06-30 |
| HUT70742A (en) | 1995-10-30 |
| DE69231661D1 (de) | 2001-03-01 |
| CN1037267C (zh) | 1998-02-04 |
| DE69231661T2 (de) | 2001-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI941986A7 (fi) | Antifungaaliset tri-substituoidut tetrahydrofuraanit | |
| FI962577L (fi) | Antifungaaliset tetrahydrofuraanit | |
| DE69217997D1 (de) | Pyrazolcarboxamilide als fungizide | |
| FI935134A7 (fi) | Substituoidut 3-aminokinuklidiinit | |
| FI925100A7 (fi) | Substituoituja bifenyylipyridoneja | |
| FI933655L (fi) | Reducerad polydextros | |
| FI935880A7 (fi) | Immobiliserade lewis-syrakatalysatorer | |
| DE69232341D1 (de) | Bewegungskompensationsvorrichtung | |
| KR920018690U (ko) | 전동안테나 장치 | |
| FI941644L (fi) | Sieniä vastustavat triatsoliyhdisteet | |
| DE69223533D1 (de) | Kodierer | |
| FI934441A0 (fi) | Antifungal mikroorganism | |
| FI933062L (fi) | Vedklyv | |
| NO924745D0 (no) | Benzofuraner | |
| ITMN910019V0 (it) | Tappo antiprofanazione | |
| ITMI911812A0 (it) | Benzofenoni ad azione antifungina | |
| NO921942L (no) | Benzofuranderivater | |
| TR25953A (tr) | SüBSTITüE EDILMIS 2-ARILPIROLLER | |
| DE4294912T1 (de) | Balkonanordnung | |
| KR930006731U (ko) | 스팡글 띠 | |
| FI940934A7 (fi) | Vaahdonestokoostumus | |
| TR26694A (tr) | SüBSTITüE EDILMIS 4-HETARIL-PIRAZOLINLER | |
| ITTO920010A1 (it) | Incannatoio | |
| NO934382D0 (no) | Suppressor T-celle - hybridoma | |
| FI920903A7 (fi) | Stroemdetektor enligt kompensationsprincipen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |