FI931298A0 - Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi - Google Patents

Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi

Info

Publication number
FI931298A0
FI931298A0 FI931298A FI931298A FI931298A0 FI 931298 A0 FI931298 A0 FI 931298A0 FI 931298 A FI931298 A FI 931298A FI 931298 A FI931298 A FI 931298A FI 931298 A0 FI931298 A0 FI 931298A0
Authority
FI
Finland
Prior art keywords
threo
propionates
phenylthio
methoxyphenyl
hydroxy
Prior art date
Application number
FI931298A
Other languages
English (en)
Swedish (sv)
Other versions
FI93741B (fi
FI93741C (fi
FI931298A (fi
Inventor
Liisa Kanerva
Oskari Sundholm
Martti Hytoenen
Pekka Kairisalo
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of FI931298A0 publication Critical patent/FI931298A0/fi
Priority to FI931298A priority Critical patent/FI93741C/fi
Priority to HU9400762A priority patent/HU216797B/hu
Priority to IL109041A priority patent/IL109041A/en
Priority to US08/215,529 priority patent/US5514589A/en
Priority to EP94104620A priority patent/EP0617130A3/en
Priority to CA002119670A priority patent/CA2119670A1/en
Priority to JP6054169A priority patent/JP2612671B2/ja
Publication of FI931298A publication Critical patent/FI931298A/fi
Publication of FI93741B publication Critical patent/FI93741B/fi
Application granted granted Critical
Publication of FI93741C publication Critical patent/FI93741C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI931298A 1993-03-24 1993-03-24 Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi FI93741C (fi)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FI931298A FI93741C (fi) 1993-03-24 1993-03-24 Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi
HU9400762A HU216797B (hu) 1993-03-24 1994-03-12 Eljárás a (2S, 3S)-treo-2-hidroxi-3-(4-metoxi-fenil)-3-(fenil-tio)- és (2R, 3R)-treo-2-alkanoil-oxi-3-(4-metoxi-fenil)-3-(fenil-tio)-propionát-származékok előállítására
IL109041A IL109041A (en) 1993-03-24 1994-03-18 Method for the production of S3, S2 (thio-alkyl-2-hydroxy-3-) 4-methoxyphenyl (-3-phenylthiopropionates and) R3, R2 (-thrio-alkyl
US08/215,529 US5514589A (en) 1993-03-24 1994-03-22 Chiral resolution of an intermediate in diltiazem synthesis using lipase PS immobilized with sucrose
EP94104620A EP0617130A3 (en) 1993-03-24 1994-03-23 Method for solving racemic mixtures.
CA002119670A CA2119670A1 (en) 1993-03-24 1994-03-23 Chiral resolution of an intermediate in diltiazem synthesis using lipase
JP6054169A JP2612671B2 (ja) 1993-03-24 1994-03-24 光学活性なプロピオン酸エステルの製造法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI931298A FI93741C (fi) 1993-03-24 1993-03-24 Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi
FI931298 1993-03-24

Publications (4)

Publication Number Publication Date
FI931298A0 true FI931298A0 (fi) 1993-03-24
FI931298A FI931298A (fi) 1994-09-25
FI93741B FI93741B (fi) 1995-02-15
FI93741C FI93741C (fi) 1995-05-26

Family

ID=8537616

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931298A FI93741C (fi) 1993-03-24 1993-03-24 Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi

Country Status (7)

Country Link
US (1) US5514589A (fi)
EP (1) EP0617130A3 (fi)
JP (1) JP2612671B2 (fi)
CA (1) CA2119670A1 (fi)
FI (1) FI93741C (fi)
HU (1) HU216797B (fi)
IL (1) IL109041A (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97725C (fi) * 1995-02-17 1997-02-10 Orion Yhtymae Oy Menetelmä diltiatseemin valmistamiseksi
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
JPS6032775A (ja) * 1983-07-30 1985-02-19 Daikin Ind Ltd 含フッ素ベンゾジアゼピン類
US4908469A (en) * 1988-05-18 1990-03-13 Marion Laboratories, Inc. 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines
EP0342904A3 (en) * 1988-05-18 1991-01-30 MARION LABORATORIES, INC. (a Delaware corporation) 2-hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionic acid, 8'-phenylmenthyl ester, especially for diltiazem
IT1226300B (it) * 1988-07-26 1990-12-27 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem.
JPH02190195A (ja) * 1989-01-19 1990-07-26 Rikagaku Kenkyusho 光学活性プロピオン酸エステル類化合物の製法
IT1232306B (it) * 1989-07-27 1992-01-28 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione del diltiazem
US5210030A (en) * 1990-06-25 1993-05-11 Merck & Co., Inc. Process for selectively acylating immunomycin
FR2672600B1 (fr) * 1991-02-08 1994-10-14 Synthelabo Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

Also Published As

Publication number Publication date
FI93741B (fi) 1995-02-15
HUT70752A (en) 1995-10-30
HU9400762D0 (en) 1994-06-28
CA2119670A1 (en) 1994-09-25
FI93741C (fi) 1995-05-26
IL109041A0 (en) 1994-08-26
US5514589A (en) 1996-05-07
EP0617130A2 (en) 1994-09-28
HU216797B (hu) 1999-08-30
IL109041A (en) 1998-02-08
FI931298A (fi) 1994-09-25
JPH07303495A (ja) 1995-11-21
EP0617130A3 (en) 1995-03-08
JP2612671B2 (ja) 1997-05-21

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