FI93112B - Förfarande för framställning av nya kinolyloxazol-2-oner, vilka är användbara såsom inhibitorer mot proteinkinas C - Google Patents

Förfarande för framställning av nya kinolyloxazol-2-oner, vilka är användbara såsom inhibitorer mot proteinkinas C Download PDF

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Publication number
FI93112B
FI93112B FI894459A FI894459A FI93112B FI 93112 B FI93112 B FI 93112B FI 894459 A FI894459 A FI 894459A FI 894459 A FI894459 A FI 894459A FI 93112 B FI93112 B FI 93112B
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FI
Finland
Prior art keywords
compound
compounds
formula
grams
solution
Prior art date
Application number
FI894459A
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English (en)
Finnish (fi)
Other versions
FI93112C (sv
FI894459A0 (sv
FI894459A (sv
Inventor
Winton Dennis Jones
Richard Cyrus Dage
George Philip Claxton
Hsien Chang Cheng
Phillip James Robinson
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Merrell Dow Pharma
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Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI894459A0 publication Critical patent/FI894459A0/sv
Publication of FI894459A publication Critical patent/FI894459A/sv
Application granted granted Critical
Publication of FI93112B publication Critical patent/FI93112B/sv
Publication of FI93112C publication Critical patent/FI93112C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Claims (2)

1. Förfarande för framställning av terapeutiskt aktiva kinolyloxazol-2-onderivat med formeln (I) °vH o 10 (I) väri R är väte eller C^-Ce-alkyl och R2 är en 2-, 3- eller 4-kinolylgrupp, och farmaceutiskt godtagbara salter därav, kännetecknat därav, att man upphettar en före-ning med formeln 0=C-CHR NH-C-1- imidazolyl 10 O väri R är som ovan definierats, för bildande av en före-*· ning med formeln I.
2. Förfarande enligt patentkrav 1, k ä n n e -15 tecknat därav, att man framställer en förening väri R2 är 4-kinolyl och R är propyl. « · I · i»
FI894459A 1988-10-24 1989-09-20 Förfarande för framställning av nya kinolyloxazol-2-oner, vilka är användbara såsom inhibitorer mot proteinkinas C FI93112C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26143588 1988-10-24
US07/261,435 US4886811A (en) 1988-10-24 1988-10-24 Qunolyloxazole-2-ones useful as proteinkinase C inhibitors

Publications (4)

Publication Number Publication Date
FI894459A0 FI894459A0 (sv) 1989-09-20
FI894459A FI894459A (sv) 1990-04-25
FI93112B true FI93112B (sv) 1994-11-15
FI93112C FI93112C (sv) 1995-02-27

Family

ID=22993289

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894459A FI93112C (sv) 1988-10-24 1989-09-20 Förfarande för framställning av nya kinolyloxazol-2-oner, vilka är användbara såsom inhibitorer mot proteinkinas C

Country Status (21)

Country Link
US (1) US4886811A (sv)
EP (1) EP0365863B1 (sv)
JP (2) JP2879454B2 (sv)
KR (1) KR0162637B1 (sv)
CN (1) CN1025854C (sv)
AR (1) AR246733A1 (sv)
AT (1) ATE110074T1 (sv)
AU (1) AU613302B2 (sv)
CA (1) CA2000804C (sv)
DE (1) DE68917556T2 (sv)
DK (1) DK461389A (sv)
ES (1) ES2061863T3 (sv)
FI (1) FI93112C (sv)
HU (1) HUT58088A (sv)
IE (1) IE893011L (sv)
IL (1) IL91788A (sv)
NO (1) NO894210L (sv)
NZ (1) NZ230718A (sv)
PH (1) PH27450A (sv)
PT (1) PT91870B (sv)
ZA (1) ZA897259B (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
DE3907414A1 (de) * 1989-03-08 1990-09-13 Hoechst Ag Die anwendung inhalierter schleifendiuretika zur behandlung von allergen-induzierten nasalen reaktionen
US5190957A (en) * 1989-11-13 1993-03-02 Merrell Dow Pharmaceuticals Inc. Treatment of multi-drug resistant tumors with quinolyl-and isoquinolyloxazole-2-ones
PH27309A (en) * 1989-11-13 1993-05-28 Merrell Dow Pharma Prevention of glycoprotein enveloped virus infectivity by quinolyl-and isoquinolyloxazone-2-ones
ZA908936B (en) * 1989-11-13 1991-09-25 Merrell Dow Pharma Treatment of multi-drug resistant tumors with quinolyloxazole-2-ones
US5182293A (en) * 1989-11-13 1993-01-26 Merrell Dow Pharmaceuticals Inc. Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9929216D0 (en) * 1999-12-11 2000-02-02 Univ Bristol Isoquinoline and Quinoline Containing substances
WO2006130090A1 (en) * 2005-06-03 2006-12-07 Pronas Pharma Ab Use of a substance which inhibits endothelin type b and 5-hydroxytryptamine type 1b receptor upregulation in the treatment of ischemic disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3025215A (en) * 1959-07-29 1962-03-13 Monsanto Chemicals Bis (8-quinolyl carbonate) derivatives
US3857877A (en) * 1973-01-12 1974-12-31 Karamchand Premchand Private 8-hydroxy quinoline derivatives
US4565820A (en) * 1980-07-28 1986-01-21 Pfizer Inc. Hypoglycemic 5-pyrrolyl, indolyl and quinolyl substituted oxazolidine-2,4-diones and their use
GB8505492D0 (en) * 1985-03-04 1985-04-03 Roussel Lab Ltd Chemical compounds
US4738972A (en) * 1985-05-21 1988-04-19 Pfizer Inc. Hypoglycemic thiazolidinediones
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US4698353A (en) * 1985-11-13 1987-10-06 Merrell Dow Pharmaceuticals Inc. Cardiotonic heterocyclic oxazolones
US4670450A (en) * 1985-11-13 1987-06-02 Merrell Dow Pharmaceuticals Inc. Cardiotonic thiazolones
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
US4681940A (en) * 1985-11-19 1987-07-21 American Home Products Corporation 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles

Also Published As

Publication number Publication date
JPH02164878A (ja) 1990-06-25
JP2983970B2 (ja) 1999-11-29
ES2061863T3 (es) 1994-12-16
ATE110074T1 (de) 1994-09-15
JPH11152285A (ja) 1999-06-08
FI93112C (sv) 1995-02-27
DK461389D0 (da) 1989-09-19
DK461389A (da) 1990-04-25
HUT58088A (en) 1992-01-28
AU613302B2 (en) 1991-07-25
US4886811A (en) 1989-12-12
HU895410D0 (en) 1990-01-28
DE68917556T2 (de) 1994-12-15
NZ230718A (en) 1990-11-27
CA2000804C (en) 1999-04-06
EP0365863A3 (en) 1990-11-07
JP2879454B2 (ja) 1999-04-05
KR0162637B1 (ko) 1998-12-01
CN1042145A (zh) 1990-05-16
ZA897259B (en) 1990-07-25
EP0365863B1 (en) 1994-08-17
NO894210D0 (no) 1989-10-23
IL91788A (en) 1994-04-12
PT91870B (pt) 1995-05-31
IL91788A0 (en) 1990-06-10
CA2000804A1 (en) 1990-04-24
AR246733A1 (es) 1994-09-30
IE893011L (en) 1990-04-24
KR900006307A (ko) 1990-05-07
NO894210L (no) 1990-04-25
AU4249389A (en) 1990-04-26
CN1025854C (zh) 1994-09-07
EP0365863A2 (en) 1990-05-02
DE68917556D1 (de) 1994-09-22
FI894459A0 (sv) 1989-09-20
PH27450A (en) 1993-07-02
FI894459A (sv) 1990-04-25
PT91870A (pt) 1990-04-30

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Owner name: MERRELL DOW PHARMACEUTICALS INC.