FI913909A0 - Stabilisering av t-PA pro - Google Patents
Stabilisering av t-PA proInfo
- Publication number
- FI913909A0 FI913909A0 FI913909A FI913909A FI913909A0 FI 913909 A0 FI913909 A0 FI 913909A0 FI 913909 A FI913909 A FI 913909A FI 913909 A FI913909 A FI 913909A FI 913909 A0 FI913909 A0 FI 913909A0
- Authority
- FI
- Finland
- Prior art keywords
- stabilization
- pro
- compound
- disclosed
- enzymatic activity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3942143A DE3942143A1 (de) | 1989-12-20 | 1989-12-20 | T-pa pro stabilisierung |
DE3942143 | 1989-12-20 | ||
EP9002251 | 1990-12-19 | ||
PCT/EP1990/002251 WO1991008766A1 (de) | 1989-12-20 | 1990-12-19 | t-PA pro STABILISIERUNG |
Publications (3)
Publication Number | Publication Date |
---|---|
FI913909A0 true FI913909A0 (sv) | 1991-08-19 |
FI96000B FI96000B (sv) | 1996-01-15 |
FI96000C FI96000C (sv) | 1996-04-25 |
Family
ID=6395926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI913909A FI96000C (sv) | 1989-12-20 | 1991-08-19 | Stabilisering av t-PA pro |
Country Status (13)
Country | Link |
---|---|
US (1) | US5352453A (sv) |
EP (1) | EP0458939B1 (sv) |
JP (1) | JPH0657661B2 (sv) |
KR (1) | KR920700684A (sv) |
AT (1) | ATE103178T1 (sv) |
AU (1) | AU633684B2 (sv) |
CA (1) | CA2046929C (sv) |
DE (2) | DE3942143A1 (sv) |
FI (1) | FI96000C (sv) |
HU (2) | HU208637B (sv) |
LV (1) | LV10199B (sv) |
NO (1) | NO305583B1 (sv) |
WO (1) | WO1991008766A1 (sv) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3942141A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | K2p pro-stabilisierung |
JPH06506459A (ja) * | 1991-04-16 | 1994-07-21 | ロシュ ダイアグノスティックス ゲーエムベーハー | プラスミノーゲン活性化剤を含有する多重ボーラス投与用医薬パッケージユニット |
DE69322268T2 (de) * | 1992-04-30 | 1999-08-05 | Cor Therapeutics Inc | Stabile zusammensetzung von polypeptiden |
US6001480A (en) * | 1993-06-11 | 1999-12-14 | Zexel Corporation | Amorphous hard carbon film and mechanical parts coated therewith |
DE4405426A1 (de) * | 1994-02-21 | 1995-08-24 | Boehringer Mannheim Gmbh | Pharmazeutisches Präparat enthaltend Plasminogenaktivator (t-PA) oder dessen Derivate |
US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
DE3584902D1 (de) * | 1984-02-29 | 1992-01-30 | Asahi Chemical Ind | Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren. |
ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
DE3687255T2 (de) * | 1985-09-10 | 1993-05-06 | Eisai Co Ltd | Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. |
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
JPH0678241B2 (ja) * | 1986-04-02 | 1994-10-05 | エーザイ株式会社 | tPA医薬組成物 |
DE3718889A1 (de) * | 1987-06-05 | 1988-12-22 | Behringwerke Ag | Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin |
WO1990001333A1 (en) * | 1988-08-02 | 1990-02-22 | Invitron Corporation | METHOD FOR PREPARING tPA COMPOSITIONS |
US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
DE3942141A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | K2p pro-stabilisierung |
JPH0813750B2 (ja) * | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
-
1989
- 1989-12-20 DE DE3942143A patent/DE3942143A1/de not_active Withdrawn
-
1990
- 1990-12-19 AT AT91901285T patent/ATE103178T1/de not_active IP Right Cessation
- 1990-12-19 EP EP91901285A patent/EP0458939B1/de not_active Expired - Lifetime
- 1990-12-19 CA CA002046929A patent/CA2046929C/en not_active Expired - Lifetime
- 1990-12-19 WO PCT/EP1990/002251 patent/WO1991008766A1/de active IP Right Grant
- 1990-12-19 DE DE91901285T patent/DE59005128D1/de not_active Expired - Lifetime
- 1990-12-19 AU AU70375/91A patent/AU633684B2/en not_active Ceased
- 1990-12-19 JP JP3501677A patent/JPH0657661B2/ja not_active Expired - Lifetime
- 1990-12-19 HU HU912742A patent/HU208637B/hu unknown
- 1990-12-19 HU HU912742A patent/HUT59610A/hu unknown
- 1990-12-19 KR KR1019910700935A patent/KR920700684A/ko not_active Application Discontinuation
-
1991
- 1991-08-06 US US07/741,483 patent/US5352453A/en not_active Expired - Lifetime
- 1991-08-09 NO NO913118A patent/NO305583B1/no not_active IP Right Cessation
- 1991-08-19 FI FI913909A patent/FI96000C/sv active
-
1993
- 1993-06-02 LV LVP-93-463A patent/LV10199B/lv unknown
Also Published As
Publication number | Publication date |
---|---|
NO913118D0 (no) | 1991-08-09 |
KR920700684A (ko) | 1992-08-10 |
EP0458939A1 (de) | 1991-12-04 |
FI96000C (sv) | 1996-04-25 |
NO305583B1 (no) | 1999-06-28 |
LV10199A (lv) | 1994-10-20 |
ATE103178T1 (de) | 1994-04-15 |
AU7037591A (en) | 1991-07-18 |
HU912742D0 (en) | 1992-01-28 |
DE59005128D1 (de) | 1994-04-28 |
JPH03505465A (ja) | 1991-11-28 |
WO1991008766A1 (de) | 1991-06-27 |
NO913118L (no) | 1991-08-09 |
AU633684B2 (en) | 1993-02-04 |
EP0458939B1 (de) | 1994-03-23 |
DE3942143A1 (de) | 1991-06-27 |
LV10199B (en) | 1995-04-20 |
HUT59610A (en) | 1992-06-29 |
HU208637B (en) | 1993-12-28 |
CA2046929A1 (en) | 1991-06-21 |
US5352453A (en) | 1994-10-04 |
CA2046929C (en) | 1997-01-14 |
FI96000B (sv) | 1996-01-15 |
JPH0657661B2 (ja) | 1994-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application |