NO882454D0 - Plasminogen-aktivator. - Google Patents

Plasminogen-aktivator.

Info

Publication number
NO882454D0
NO882454D0 NO882454A NO882454A NO882454D0 NO 882454 D0 NO882454 D0 NO 882454D0 NO 882454 A NO882454 A NO 882454A NO 882454 A NO882454 A NO 882454A NO 882454 D0 NO882454 D0 NO 882454D0
Authority
NO
Norway
Prior art keywords
analogs
plasminogen activator
domain
native
diluent
Prior art date
Application number
NO882454A
Other languages
English (en)
Other versions
NO882454L (no
NO179874C (no
NO179874B (no
Inventor
Eileen R Mulvihill
Patrick J O'hara
Bjoern A Nexoe
Shinji Yoshitake
Yasunori Ikeda
Suguru Suzuki
Akira Hashimoto
Teruaki Yuzuriha
Original Assignee
Zymogenetics Inc
Novo Industri As
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Novo Industri As, Eisai Co Ltd filed Critical Zymogenetics Inc
Publication of NO882454D0 publication Critical patent/NO882454D0/no
Publication of NO882454L publication Critical patent/NO882454L/no
Publication of NO179874B publication Critical patent/NO179874B/no
Publication of NO179874C publication Critical patent/NO179874C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Integrated Circuits (AREA)
NO882454A 1987-06-04 1988-06-03 Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekvens som koder for t-PA-analogen, samt ekspresjonsvektor omfattende DNA-sekvensen og vertcelle omfattende denne NO179874C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5806187A 1987-06-04 1987-06-04
US16284788A 1988-03-02 1988-03-02

Publications (4)

Publication Number Publication Date
NO882454D0 true NO882454D0 (no) 1988-06-03
NO882454L NO882454L (no) 1988-12-05
NO179874B NO179874B (no) 1996-09-23
NO179874C NO179874C (no) 1997-01-02

Family

ID=26737188

Family Applications (1)

Application Number Title Priority Date Filing Date
NO882454A NO179874C (no) 1987-06-04 1988-06-03 Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekvens som koder for t-PA-analogen, samt ekspresjonsvektor omfattende DNA-sekvensen og vertcelle omfattende denne

Country Status (14)

Country Link
US (1) US5403734A (no)
EP (1) EP0293936B1 (no)
JP (1) JPS6485079A (no)
KR (1) KR0135427B1 (no)
AT (1) ATE118815T1 (no)
AU (1) AU625752B2 (no)
CA (1) CA1341446C (no)
DE (1) DE3853100T2 (no)
DK (1) DK302388A (no)
ES (1) ES2069536T3 (no)
FI (1) FI101306B (no)
IE (1) IE67036B1 (no)
NO (1) NO179874C (no)
NZ (1) NZ224914A (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714372A (en) * 1985-04-22 1998-02-03 Genentech, Inc. Tissue plasminogen activator variants
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
ZA883958B (en) * 1987-06-04 1989-07-26 Zymogenetics Inc Mutant t-pa with ringle replacement
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5087572A (en) * 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
JPH0595786A (ja) * 1991-10-07 1993-04-20 Green Cross Corp:The 変異ヒトプロウロキナーゼ
DE69312493T2 (de) * 1992-06-03 1998-01-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
US9150844B2 (en) * 2010-08-05 2015-10-06 Neeraj Maheshwari Protein fusion constructs possessing thrombolytic and anticoagulant properties

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
WO1984001786A1 (en) * 1982-10-28 1984-05-10 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
PT82326B (pt) * 1985-04-04 1988-10-14 Beecham Group Plc Processo para a preparacao de activador de plasminogenio de tipo tissular fibrinoliticamente activo
DK175380B1 (da) * 1985-04-22 2004-09-20 Genentech Inc Mutant af human vævsplasminogenaktivator, DNA-sekvens som koder herfor, replicerbar udtrykkelsesvektor til at udtrykke denne DNA-sekvens, mikroorganisme transformeret med denne vektor, cellekulturer transformeret med denne....
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins
JP2983997B2 (ja) * 1987-01-30 1999-11-29 アメリカン・ホーム・プロダクツ・コーポレイション 脱―表皮細胞成長因子プラスミノーゲンアクチベーター

Also Published As

Publication number Publication date
KR0135427B1 (ko) 1998-04-23
EP0293936A3 (en) 1989-09-20
ES2069536T3 (es) 1995-05-16
ATE118815T1 (de) 1995-03-15
AU625752B2 (en) 1992-07-16
EP0293936B1 (en) 1995-02-22
JPS6485079A (en) 1989-03-30
EP0293936A2 (en) 1988-12-07
IE67036B1 (en) 1996-05-15
FI882627A (fi) 1988-12-05
NZ224914A (en) 1991-02-26
IE881680L (en) 1988-12-04
US5403734A (en) 1995-04-04
KR890000521A (ko) 1989-03-15
DK302388A (da) 1989-02-03
NO882454L (no) 1988-12-05
DE3853100T2 (de) 1995-08-03
CA1341446C (en) 2003-11-18
FI101306B1 (fi) 1998-05-29
NO179874C (no) 1997-01-02
NO179874B (no) 1996-09-23
DE3853100D1 (de) 1995-03-30
FI882627A0 (fi) 1988-06-03
JPH0448434B2 (no) 1992-08-06
DK302388D0 (da) 1988-06-03
FI101306B (fi) 1998-05-29
AU1743088A (en) 1988-12-08

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