FI91259B - Förfarande för framställning av nya terapeutiskt användbara 1,2,3-triazolo/4,5-f/kinoxalinderivat - Google Patents

Förfarande för framställning av nya terapeutiskt användbara 1,2,3-triazolo/4,5-f/kinoxalinderivat Download PDF

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Publication number
FI91259B
FI91259B FI893170A FI893170A FI91259B FI 91259 B FI91259 B FI 91259B FI 893170 A FI893170 A FI 893170A FI 893170 A FI893170 A FI 893170A FI 91259 B FI91259 B FI 91259B
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FI
Finland
Prior art keywords
triazolo
compound
acid
formula
dihydroxy
Prior art date
Application number
FI893170A
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English (en)
Finnish (fi)
Other versions
FI91259C (sv
FI893170A0 (sv
FI893170A (sv
Inventor
Poul Jacobsen
Flemming Elmelund Nielsen
Tage Honore
Joergen Drejer
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Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI893170A0 publication Critical patent/FI893170A0/sv
Publication of FI893170A publication Critical patent/FI893170A/sv
Priority to FI931893A priority Critical patent/FI93840C/sv
Priority to FI931892A priority patent/FI93841C/sv
Priority to FI931891A priority patent/FI93838C/sv
Priority to FI931894A priority patent/FI93839C/sv
Application granted granted Critical
Publication of FI91259B publication Critical patent/FI91259B/sv
Publication of FI91259C publication Critical patent/FI91259C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
    • C07D517/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Luminescent Compositions (AREA)

Claims (3)

1. Förfarande för framställning av nya teapeutiskt användbara 1,2,3-triazolo[4,5-f]kinoxalinderivat med for-5 me In ÄcT 10 där R2 är väte, N02, NH2 eller CN och -X-Y-Z- är -N=N-NR3-eller -NR3-N=N-, varvid R3 är väte eller metyl, k ä n n e-t e c k n a t därav, att en förening med formeln 15 Y — z X\ | di) 20 där -X-Y-Z- och R2 betecknar samma som ovan, omsätts med oxalsyra eller ett reaktivt derivat därav, varefter, om sä önskas, a) en förening med formeln 25 N OH 30 där -X-Y-Z- betecknar samma som ovan, nitreras, varvid erhälls en förening med formeln I, där R2 är nitro, eller b) en förening med formeln 91259 Υ-Σ Ογ«γ°« 5 νο^^^ν'^'οη (ν) där -Χ-Υ-Ζ- betecknar samma som ovan, reduceras, varvid erhälls en förening med formeln I, där R2 är amino, eller c) en förening med formeln 10 2xr ™ 15 där -X-Y-Z- betecknar samma som ovan, omsätts med kalium-tetracyannickelat, varvid erhälls en förening med formeln I, R2 är CN.
2. Förfarande enligt patentkravet 1, k ä n n e -20 tecknat därav, att man framställer 7,8-dihydroxi- l-metyl-4-nitro-lH-l,2,3-triazolo[4, 5-f]kinoxalin.
3. Förfarande enligt patentkravet 1, känne-tecknat därav, att man framställer 7,8-dihydroxi-3-metyl-4-nitro-3H-l,2,3-triazolo[4,5-f]kinoxalin.
FI893170A 1988-06-28 1989-06-28 Förfarande för framställning av nya terapeutiskt användbara 1,2,3-triazolo/4,5-f/kinoxalinderivat FI91259C (sv)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FI931893A FI93840C (sv) 1988-06-28 1993-04-27 Förfarande för framställning av nya terapeutiskt användbara 7,8-dihydroxi-1,2,5-oxa-, tia- och selendiazolo/3,4-f/kinoxalinderivat
FI931892A FI93841C (sv) 1988-06-28 1993-04-27 Förfarande för framställning av nya terapeutiskt användbara tiazolo/5,4-f/- och tieno/3,2-f/kinoxalinderivat
FI931891A FI93838C (sv) 1988-06-28 1993-04-27 Förfarande för framställning av nya terapeutiskt användbara 7,8-dihydroksi-1H-imidazo- och pyrazolo/3,4-f/kinoxalinderivat
FI931894A FI93839C (sv) 1988-06-28 1993-04-27 Förfarande för framställning av nya terapeutiskt användbara 2,3-dihydroxi-pyrazino/2,3-f/kinoxalin- och pyrazino/2,3-g//1,5/bensodiazepindervat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK356788 1988-06-28
DK356788A DK160941C (da) 1988-06-28 1988-06-28 Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar

Publications (4)

Publication Number Publication Date
FI893170A0 FI893170A0 (sv) 1989-06-28
FI893170A FI893170A (sv) 1989-12-29
FI91259B true FI91259B (sv) 1994-02-28
FI91259C FI91259C (sv) 1994-06-10

Family

ID=8124358

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893170A FI91259C (sv) 1988-06-28 1989-06-28 Förfarande för framställning av nya terapeutiskt användbara 1,2,3-triazolo/4,5-f/kinoxalinderivat

Country Status (18)

Country Link
US (5) US4977155A (sv)
EP (1) EP0348872B1 (sv)
JP (1) JPH0248578A (sv)
KR (1) KR910000735A (sv)
AT (1) ATE95181T1 (sv)
AU (1) AU619863B2 (sv)
CA (1) CA1326670C (sv)
DE (1) DE68909513T2 (sv)
DK (1) DK160941C (sv)
ES (1) ES2059636T3 (sv)
FI (1) FI91259C (sv)
IE (1) IE64289B1 (sv)
IL (1) IL90733A (sv)
NO (1) NO169390C (sv)
NZ (1) NZ229730A (sv)
PH (1) PH27565A (sv)
PT (1) PT91010B (sv)
ZA (1) ZA894903B (sv)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK716188D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
US5153195A (en) * 1988-12-22 1992-10-06 Novo Nordisk A/S Quinoxaline compounds and their preparation and use
PT99864B (pt) 1990-12-21 1999-06-30 Schering Ag Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
DK162491D0 (da) * 1991-09-20 1991-09-20 Novo Nordisk As Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
EP0647137B1 (en) * 1992-06-22 2008-08-13 The Regents Of The University Of California Glycine receptor antagonists and the use thereof
AU680632B2 (en) 1992-10-13 1997-08-07 Neurosearch A/S Quinoxalinedione derivatives as EAA antagonists
DE4310523A1 (de) * 1993-03-31 1994-10-06 Basf Ag Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen
US5631373A (en) * 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
US5576323A (en) * 1993-12-03 1996-11-19 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU688459B2 (en) * 1994-04-08 1998-03-12 Shionogi & Co., Ltd. Oxopyridinylquinoxaline derivative
US5476851A (en) * 1994-09-08 1995-12-19 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Pyrazolo[3,4-g]quinoxaline compounds which inhibit PDGF receptor protein tyrosine kinase
US5719153A (en) * 1995-08-15 1998-02-17 American Home Products Corporation 5H,8H-2-oxa-1,3,5,8-tetraaza-cyclopenta b!-naphthalene-6,7-diones
US5824662A (en) 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
IL128718A0 (en) 1996-09-27 2000-01-31 Guildford Pharmaceuticals Inc Naaldase compositions
BR9807083A (pt) 1997-01-23 2000-04-18 Smithkline Beckman Corp Antagonistas ao receptor de il-8
FR2760237B1 (fr) * 1997-02-28 1999-04-16 Rhone Poulenc Rorer Sa Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
US6288075B1 (en) 1998-02-26 2001-09-11 Rhone-Poulenc Rorer S.A. Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same
FR2766487B1 (fr) * 1997-07-28 1999-08-27 Rhone Poulenc Rorer Sa Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
US6262044B1 (en) 1998-03-12 2001-07-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPASES)
WO1999046267A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
JP2009286778A (ja) * 2008-04-30 2009-12-10 Sumitomo Chemical Co Ltd ｔｅｒｔ−ブチル３−アミノピペリジン−１−カルボキシレートの製造方法およびその中間体
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions
CN113549087A (zh) * 2020-04-26 2021-10-26 北京鼎材科技有限公司 一种化合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1246578A (en) * 1982-03-29 1988-12-13 John H. Musser 2-oxo-1,3-oxazolo[4,5]quinolines useful as anti-allergy agents
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse

Also Published As

Publication number Publication date
DK356788D0 (da) 1988-06-28
NO169390B (no) 1992-03-09
EP0348872B1 (en) 1993-09-29
IL90733A0 (en) 1990-01-18
US4977155A (en) 1990-12-11
IL90733A (en) 1994-02-27
FI91259C (sv) 1994-06-10
US5109001A (en) 1992-04-28
DK356788A (da) 1990-03-21
NO169390C (no) 1992-06-17
NZ229730A (en) 1991-07-26
US5075306A (en) 1991-12-24
IE892008L (en) 1989-12-28
JPH0248578A (ja) 1990-02-19
PT91010B (pt) 1995-01-31
KR910000735A (ko) 1991-01-30
DE68909513D1 (de) 1993-11-04
DK160941C (da) 1991-10-21
US5057516A (en) 1991-10-15
DK160941B (da) 1991-05-06
PT91010A (pt) 1989-12-29
CA1326670C (en) 1994-02-01
AU3707789A (en) 1990-01-04
US5079250A (en) 1992-01-07
NO892680L (no) 1989-12-29
DE68909513T2 (de) 1994-01-20
EP0348872A1 (en) 1990-01-03
AU619863B2 (en) 1992-02-06
PH27565A (en) 1993-08-18
FI893170A0 (sv) 1989-06-28
IE64289B1 (en) 1995-07-26
ATE95181T1 (de) 1993-10-15
NO892680D0 (no) 1989-06-27
ZA894903B (en) 1990-03-28
FI893170A (sv) 1989-12-29
ES2059636T3 (es) 1994-11-16

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MM Patent lapsed
MM Patent lapsed

Owner name: NOVO NORDISK A/S