FI91037C - Bioliimat solujen ja kudosten kiinnittämiseen - Google Patents
Bioliimat solujen ja kudosten kiinnittämiseen Download PDFInfo
- Publication number
- FI91037C FI91037C FI871728A FI871728A FI91037C FI 91037 C FI91037 C FI 91037C FI 871728 A FI871728 A FI 871728A FI 871728 A FI871728 A FI 871728A FI 91037 C FI91037 C FI 91037C
- Authority
- FI
- Finland
- Prior art keywords
- substrate
- cells
- bioadhesive
- coated
- protein
- Prior art date
Links
- 108010027529 Bio-glue Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims description 112
- 102000004169 proteins and genes Human genes 0.000 claims description 109
- 239000000227 bioadhesive Substances 0.000 claims description 101
- 239000000758 substrate Substances 0.000 claims description 89
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 84
- 235000013824 polyphenols Nutrition 0.000 claims description 84
- 239000000203 mixture Substances 0.000 claims description 62
- 238000009472 formulation Methods 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 36
- 239000000463 material Substances 0.000 claims description 17
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 238000000338 in vitro Methods 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 13
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 13
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000011521 glass Substances 0.000 claims description 12
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 claims description 11
- 229960004502 levodopa Drugs 0.000 claims description 11
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000002609 medium Substances 0.000 claims description 10
- 230000001464 adherent effect Effects 0.000 claims description 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 8
- -1 polytetrafluoroethylene Polymers 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 238000004113 cell culture Methods 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 230000001413 cellular effect Effects 0.000 claims description 4
- 150000002739 metals Chemical class 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000003104 tissue culture media Substances 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 3
- 230000007102 metabolic function Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 235000015097 nutrients Nutrition 0.000 claims description 3
- 239000012679 serum free medium Substances 0.000 claims description 3
- YAVWDJDEOLOYQO-UHFFFAOYSA-N OOOOOOOOOO Chemical compound OOOOOOOOOO YAVWDJDEOLOYQO-UHFFFAOYSA-N 0.000 claims description 2
- 239000003206 sterilizing agent Substances 0.000 claims 6
- WCRFXRIWBFRZBR-GGVZMXCHSA-N Thr-Tyr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 WCRFXRIWBFRZBR-GGVZMXCHSA-N 0.000 claims 3
- 239000007853 buffer solution Substances 0.000 claims 2
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 claims 1
- 238000012606 in vitro cell culture Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 149
- 235000018102 proteins Nutrition 0.000 description 99
- 239000004033 plastic Substances 0.000 description 44
- 229920003023 plastic Polymers 0.000 description 44
- 210000001519 tissue Anatomy 0.000 description 43
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 36
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 14
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 13
- 108010067306 Fibronectins Proteins 0.000 description 13
- 102000016359 Fibronectins Human genes 0.000 description 13
- 102000008186 Collagen Human genes 0.000 description 12
- 108010035532 Collagen Proteins 0.000 description 12
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 12
- 229920001436 collagen Polymers 0.000 description 12
- 239000012091 fetal bovine serum Substances 0.000 description 12
- 229920000669 heparin Polymers 0.000 description 12
- 229960002897 heparin Drugs 0.000 description 12
- 230000002792 vascular Effects 0.000 description 12
- 229940098773 bovine serum albumin Drugs 0.000 description 11
- 230000012010 growth Effects 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 239000004809 Teflon Substances 0.000 description 8
- 229920006362 Teflon® Polymers 0.000 description 8
- 238000011084 recovery Methods 0.000 description 8
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 6
- 102000004142 Trypsin Human genes 0.000 description 6
- 108090000631 Trypsin Proteins 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 238000010186 staining Methods 0.000 description 6
- 239000012588 trypsin Substances 0.000 description 6
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 230000010261 cell growth Effects 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 210000002889 endothelial cell Anatomy 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000011081 inoculation Methods 0.000 description 5
- 102000013415 peroxidase activity proteins Human genes 0.000 description 5
- 108040007629 peroxidase activity proteins Proteins 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 241000283690 Bos taurus Species 0.000 description 4
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 239000012888 bovine serum Substances 0.000 description 4
- 230000035602 clotting Effects 0.000 description 4
- 229960000789 guanidine hydrochloride Drugs 0.000 description 4
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 4
- 239000005556 hormone Substances 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000002054 transplantation Methods 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000007547 Laminin Human genes 0.000 description 3
- 108010085895 Laminin Proteins 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- 230000021164 cell adhesion Effects 0.000 description 3
- 230000019522 cellular metabolic process Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000237536 Mytilus edulis Species 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 210000000399 corneal endothelial cell Anatomy 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 210000002555 descemet membrane Anatomy 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 239000008176 lyophilized powder Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 235000020638 mussel Nutrition 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 238000011027 product recovery Methods 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- BJBUEDPLEOHJGE-UHFFFAOYSA-N (2R,3S)-3-Hydroxy-2-pyrolidinecarboxylic acid Natural products OC1CCNC1C(O)=O BJBUEDPLEOHJGE-UHFFFAOYSA-N 0.000 description 1
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- WZIMSXIXZTUBSO-UHFFFAOYSA-N 2-[[bis(carboxymethyl)amino]methyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CN(CC(O)=O)CC(O)=O WZIMSXIXZTUBSO-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 244000131998 Eugenia edulis Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- JZKXXXDKRQWDET-QMMMGPOBSA-N L-m-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC(O)=C1 JZKXXXDKRQWDET-QMMMGPOBSA-N 0.000 description 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 1
- GHAZCVNUKKZTLG-UHFFFAOYSA-N N-ethyl-succinimide Natural products CCN1C(=O)CCC1=O GHAZCVNUKKZTLG-UHFFFAOYSA-N 0.000 description 1
- HDFGOPSGAURCEO-UHFFFAOYSA-N N-ethylmaleimide Chemical compound CCN1C(=O)C=CC1=O HDFGOPSGAURCEO-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108010076039 Polyproteins Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 159000000032 aromatic acids Chemical class 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002801 charged material Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 201000006845 reticulosarcoma Diseases 0.000 description 1
- 208000029922 reticulum cell sarcoma Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- BJBUEDPLEOHJGE-IMJSIDKUSA-N trans-3-hydroxy-L-proline Chemical compound O[C@H]1CC[NH2+][C@@H]1C([O-])=O BJBUEDPLEOHJGE-IMJSIDKUSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Botany (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85668786A | 1986-04-25 | 1986-04-25 | |
| US85668786 | 1986-04-25 | ||
| US07/034,801 US5108923A (en) | 1986-04-25 | 1987-04-03 | Bioadhesives for cell and tissue adhesion |
| US3480187 | 1987-04-03 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI871728A0 FI871728A0 (fi) | 1987-04-21 |
| FI871728A7 FI871728A7 (fi) | 1987-10-26 |
| FI91037B FI91037B (fi) | 1994-01-31 |
| FI91037C true FI91037C (fi) | 1994-05-10 |
Family
ID=26711386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI871728A FI91037C (fi) | 1986-04-25 | 1987-04-21 | Bioliimat solujen ja kudosten kiinnittämiseen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5108923A (de) |
| EP (1) | EP0243818B1 (de) |
| JP (1) | JPH0779695B2 (de) |
| AU (1) | AU597647B2 (de) |
| CA (1) | CA1328237C (de) |
| DE (1) | DE3783643T2 (de) |
| DK (1) | DK171996B1 (de) |
| FI (1) | FI91037C (de) |
| NO (1) | NO174675C (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202236A (en) * | 1984-09-13 | 1993-04-13 | Enzon Labs Inc. | Method of producing bioadhesive protein |
| US5049504A (en) * | 1986-11-24 | 1991-09-17 | Genex Corporation | Bioadhesive coding sequences |
| US5202256A (en) * | 1984-09-13 | 1993-04-13 | Enzon Labs, Inc. | Bioadhesive precursor protein expression vectors |
| AU592670B2 (en) * | 1986-08-15 | 1990-01-18 | Commonwealth Scientific And Industrial Research Organisation | Promoting cell adhesion and growth on a substrate |
| US5759774A (en) * | 1988-05-18 | 1998-06-02 | Cobe Laboratories, Inc. | Method of detecting circulating antibody types using dried or lyophilized cells |
| US5122470A (en) * | 1988-07-05 | 1992-06-16 | Banes Albert J | Floating cell culture device and method |
| EP0350714B1 (de) * | 1988-07-13 | 1994-03-09 | Collaborative Biomedical Products Inc. | Gewebe-Immobilisierungs- und Zellkultursystem und Verfahren zum Anbringen biologisch wirksamer Teile an einem Substrat |
| US5192663A (en) * | 1988-11-04 | 1993-03-09 | Immucor, Inc. | Article having an organic dye and a monolayer of dried mammalian cells and a method for utilizing the article |
| US5030560A (en) * | 1988-11-04 | 1991-07-09 | Immucor, Inc. | Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same |
| US5574134A (en) * | 1989-07-11 | 1996-11-12 | University Of Delaware | Polypeptide monomers, linearly extended and/or crosslinked forms thereof, and applications thereof |
| NZ237832A (en) * | 1990-04-17 | 1994-05-26 | Curative Tech Inc | Coating a prosthetic surface with mammalian cells |
| US5197973A (en) * | 1990-12-14 | 1993-03-30 | Creative Biomolecules, Inc. | Synthetic bioadhesive |
| GB9211176D0 (en) * | 1992-05-27 | 1992-07-08 | Central Blood Lab Authority | Assay |
| US5310669A (en) * | 1992-06-22 | 1994-05-10 | The Trustees Of Dartmouth College | Fullerene coated surfaces and uses thereof |
| US5817470A (en) * | 1995-03-10 | 1998-10-06 | Sociedad Biotecnologica Collico Limitada | Immobilization of antigens to solid support by the mussel adhesive polyphenolic protein and the method for use therein |
| US5955353A (en) * | 1997-05-22 | 1999-09-21 | Excorp Medical, Inc. | Hollow fiber bioreactor with an extrafilament flow plug |
| US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
| US20020022588A1 (en) * | 1998-06-23 | 2002-02-21 | James Wilkie | Methods and compositions for sealing tissue leaks |
| US6214054B1 (en) * | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
| WO2002034764A1 (en) * | 1998-09-28 | 2002-05-02 | Bio Polymer Products Of Sweden Ab | A process of producing polyphenolic adhesive proteins and proteins produced in accordance with the process |
| US7618937B2 (en) * | 2001-07-20 | 2009-11-17 | Northwestern University | Peptidomimetic polymers for antifouling surfaces |
| US7858679B2 (en) * | 2001-07-20 | 2010-12-28 | Northwestern University | Polymeric compositions and related methods of use |
| US8815793B2 (en) * | 2001-07-20 | 2014-08-26 | Northwestern University | Polymeric compositions and related methods of use |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| US20080171012A1 (en) * | 2007-01-11 | 2008-07-17 | Phillip Messersmith | Fouling Resistant Coatings and Methods of Making Same |
| US8911831B2 (en) * | 2002-07-19 | 2014-12-16 | Northwestern University | Surface independent, surface-modifying, multifunctional coatings and applications thereof |
| US20080085554A1 (en) * | 2004-02-13 | 2008-04-10 | Norio Nakatsuji | Culture Medium for Culturing Feeder Cells for Embryonic Stem Cells Culture and the Prepared Feeder Cells |
| DE102004031258A1 (de) * | 2004-06-29 | 2006-02-09 | Jennissen, Herbert P., Prof. Dr. | Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen |
| US7732539B2 (en) * | 2006-02-16 | 2010-06-08 | National Science Foundation | Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives |
| US8652833B2 (en) * | 2006-04-28 | 2014-02-18 | Kuraray Co., Ltd. | Cell culture container and method of producing the same |
| WO2008091386A2 (en) * | 2006-08-04 | 2008-07-31 | Northwestern University | Biomimetic modular adhesive complex: material, methods and applications therefore |
| WO2008019352A1 (en) | 2006-08-04 | 2008-02-14 | Nerites Corporation | Biomimetic compounds and synthetic methods therefor |
| CN103933612B (zh) * | 2006-10-27 | 2016-06-22 | 爱德华兹生命科学公司 | 用于外科植入的生物组织 |
| US8673286B2 (en) | 2007-04-09 | 2014-03-18 | Northwestern University | DOPA-functionalized, branched, poly(aklylene oxide) adhesives |
| US8383092B2 (en) * | 2007-02-16 | 2013-02-26 | Knc Ner Acquisition Sub, Inc. | Bioadhesive constructs |
| US9101691B2 (en) * | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
| US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| US20110130465A1 (en) * | 2009-12-01 | 2011-06-02 | Nerites Corporation | Coatings for prevention of biofilms |
| EP3636293A1 (de) | 2010-03-23 | 2020-04-15 | Edwards Lifesciences Corporation | Verfahren zur bearbeitung eines scheibenförmigen bioprothese-gewebes |
| US8906601B2 (en) | 2010-06-17 | 2014-12-09 | Edwardss Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
| CA2794135C (en) | 2010-06-17 | 2018-01-02 | Edwards Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
| WO2012064821A2 (en) | 2010-11-09 | 2012-05-18 | Knc Ner Acquisition Sub, Inc. | Adhesive compounds and methods use for hernia repair |
| US9351829B2 (en) | 2010-11-17 | 2016-05-31 | Edwards Lifesciences Corporation | Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability |
| US10238771B2 (en) | 2012-11-08 | 2019-03-26 | Edwards Lifesciences Corporation | Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system |
| JPWO2014098182A1 (ja) * | 2012-12-19 | 2017-01-12 | 国立大学法人 東京医科歯科大学 | 心筋毒性検査および心筋細胞評価のための方法および装置 |
| WO2015009431A1 (en) * | 2013-07-19 | 2015-01-22 | Rarecyte, Inc. | Solution and method for adhering suspension components to a substrate |
| US10101247B2 (en) * | 2013-07-19 | 2018-10-16 | Rarecyte, Inc. | Solution and method for adhering suspension components to a substrate |
| US10101248B1 (en) * | 2015-12-02 | 2018-10-16 | Rarecyte, Inc. | Solution and method for adhering suspension components to a substrate |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910819A (en) * | 1974-02-19 | 1975-10-07 | California Inst Of Techn | Treatment of surfaces to stimulate biological cell adhesion and growth |
| DE2603319C3 (de) * | 1976-01-29 | 1979-08-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Fixierung von biologisch aktiven Proteinen an Trägern |
| FR2447275A1 (fr) * | 1979-01-25 | 1980-08-22 | Charbonnages Ste Chimique | Materiaux stratifies a base de resine phenolique et procede pour leur preparation |
| US4266032A (en) * | 1979-08-10 | 1981-05-05 | Monsanto Company | Method of culturing microcarrier supported cells |
| US4501815A (en) * | 1979-10-29 | 1985-02-26 | Albert Einstein College Of Medicine Of Yeshiva University | Article for culturing differentiated cells |
| US4352887A (en) * | 1979-10-29 | 1982-10-05 | Albert Einstein College Of Medicine Of Yeshiva University | Method and article for culturing differentiated cells |
| US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
| JPS5928472A (ja) * | 1982-08-09 | 1984-02-15 | Koken:Kk | 細胞培養用基質およびこの基質を用いた細胞培養・分離法 |
| ZA839115B (en) * | 1982-12-14 | 1984-07-25 | Cpc International Inc | Continuous enzymatic process for producing maltose from starch and starch hydrolysates |
| US4496397A (en) * | 1984-03-07 | 1985-01-29 | University Of Connecticut | Process for purifying and stabilizing catechol-containing proteins and materials obtained thereby |
| US4585585A (en) * | 1984-03-07 | 1986-04-29 | University Of Connecticut Research & Development Corporation | Decapeptides produced from bioadhesive polyphenolic proteins |
| US4553974A (en) * | 1984-08-14 | 1985-11-19 | Mayo Foundation | Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor |
-
1987
- 1987-04-03 US US07/034,801 patent/US5108923A/en not_active Expired - Lifetime
- 1987-04-16 DE DE8787105672T patent/DE3783643T2/de not_active Expired - Fee Related
- 1987-04-16 EP EP87105672A patent/EP0243818B1/de not_active Expired - Lifetime
- 1987-04-21 FI FI871728A patent/FI91037C/fi not_active IP Right Cessation
- 1987-04-22 CA CA000535245A patent/CA1328237C/en not_active Expired - Fee Related
- 1987-04-22 DK DK205287A patent/DK171996B1/da not_active IP Right Cessation
- 1987-04-22 NO NO871665A patent/NO174675C/no unknown
- 1987-04-23 AU AU71885/87A patent/AU597647B2/en not_active Ceased
- 1987-04-25 JP JP62102971A patent/JPH0779695B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU597647B2 (en) | 1990-06-07 |
| JPH0779695B2 (ja) | 1995-08-30 |
| DE3783643T2 (de) | 1993-05-13 |
| AU7188587A (en) | 1987-10-29 |
| NO174675B (no) | 1994-03-07 |
| DK205287D0 (da) | 1987-04-22 |
| FI871728A7 (fi) | 1987-10-26 |
| DE3783643D1 (de) | 1993-03-04 |
| EP0243818B1 (de) | 1993-01-20 |
| NO871665D0 (no) | 1987-04-22 |
| FI871728A0 (fi) | 1987-04-21 |
| DK205287A (da) | 1987-10-26 |
| CA1328237C (en) | 1994-04-05 |
| EP0243818A3 (en) | 1989-03-08 |
| NO871665L (no) | 1987-10-26 |
| DK171996B1 (da) | 1997-09-08 |
| FI91037B (fi) | 1994-01-31 |
| EP0243818A2 (de) | 1987-11-04 |
| NO174675C (no) | 1994-06-22 |
| JPS6339583A (ja) | 1988-02-20 |
| US5108923A (en) | 1992-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI91037B (fi) | Bioliimat solujen ja kudosten kiinnittämiseen | |
| US7815686B2 (en) | Vascularization enhanced graft constructs | |
| US5643561A (en) | Coating composition for culturing animal cells and method for culturing of the cells in serum-free condition | |
| WO2002014480A9 (en) | Decellularized tissue engineered constructs and tissues | |
| US5932207A (en) | Complex active ingredient for the production of biological parts, especially organs for living organisms: method for the production of the same and its use | |
| Sipehia et al. | Enhanced attachment and growth of human endothelial cells derived from umbilical veins on ammonia plasma modified surfaces of PTFE and ePTFE synthetic vascular graft biomaterials | |
| EP0905231B1 (de) | Verfahren zur Verbesserung der Stabilität und/oder Haltbarkeit von verschiedenen Substraten | |
| DE4438015A1 (de) | Epithelzellenhaltiges Biomaterial und dessen Verwendung als Transplantat | |
| JPH09511673A (ja) | 上皮細胞を含む生物材料及び移植片としてのその利用 | |
| Costăchel et al. | Tumor cell suspension culture on non adhesive substratum | |
| EP0350887A2 (de) | Serum-freies Medium und Verfahren zur Züchtung von Säugetierzellen | |
| EP0350714B1 (de) | Gewebe-Immobilisierungs- und Zellkultursystem und Verfahren zum Anbringen biologisch wirksamer Teile an einem Substrat | |
| CN110201233B (zh) | 一种制备心肌补片的方法及其应用 | |
| TW419367B (en) | A biomedical material for improving the adhesive and proliferating ability of tissue cell and a artificial vessel | |
| KR0156685B1 (ko) | 3차원 배양물을 이용한 약물의 효과를 테스트하는 방법 | |
| WO2001032850A1 (en) | Surface treatment with polypeptides to improve fibroblast adhesion to hyaluronan | |
| JPH07135961A (ja) | 血管内皮細胞培養用基材及びその製造方法 | |
| KR870001417B1 (ko) | Pta-210 세포주를 이용한 인간 성장호르몬의 생산방법 | |
| CN113509401A (zh) | 一种干细胞因子的抗衰修复配方及其制备方法 | |
| EP4671361A1 (de) | Zelldesignermolekül zur verleihung von proteinadhäsionseigenschaften an zellen | |
| CN117844749A (zh) | 一种人造细胞外基质及其在细胞培养中的应用 | |
| CN114381428A (zh) | 作用于注射皮下或损伤组织部位的细胞培养基 | |
| KR0156571B1 (ko) | 3차원 세포 및 조직 배양계 | |
| CN1391607A (zh) | 用多肽化表面处理法改进成纤维素对透明质酸之黏附性 | |
| JPS62107783A (ja) | 新規細胞株 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: COLLABORATIVE BIOMEDICAL PRODUCTS, INC. |
|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: COLLABORATIVE BIOMEDICAL PRODUCTS, INC. |