FI906464A7 - Menetelmä (1R,5S,6S)-2-((6,7-dihydro-5H-pyratsolo(1,2-a)(1,2,4)triatsolium-6-yl))tio-6-((R)-1-hydroksietyyli)-1-metyylikarbapeneemi-3-karboksylaatin valmistamiseksi ja menetelmässä käytetyt lähtöaineet - Google Patents

Menetelmä (1R,5S,6S)-2-((6,7-dihydro-5H-pyratsolo(1,2-a)(1,2,4)triatsolium-6-yl))tio-6-((R)-1-hydroksietyyli)-1-metyylikarbapeneemi-3-karboksylaatin valmistamiseksi ja menetelmässä käytetyt lähtöaineet Download PDF

Info

Publication number
FI906464A7
FI906464A7 FI906464A FI906464A FI906464A7 FI 906464 A7 FI906464 A7 FI 906464A7 FI 906464 A FI906464 A FI 906464A FI 906464 A FI906464 A FI 906464A FI 906464 A7 FI906464 A7 FI 906464A7
Authority
FI
Finland
Prior art keywords
methylcarbapenem
triazolium
pyrazolo
thio
dihydro
Prior art date
Application number
FI906464A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI906464L (fi
FI906464A0 (fi
Inventor
Takao Abe
Yunosuke Nagase
Satoshi Tamai
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of FI906464A0 publication Critical patent/FI906464A0/fi
Publication of FI906464L publication Critical patent/FI906464L/fi
Publication of FI906464A7 publication Critical patent/FI906464A7/fi
Priority to FI933245A priority Critical patent/FI93962C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI906464A 1990-10-12 1990-12-31 Menetelmä (1R,5S,6S)-2-((6,7-dihydro-5H-pyratsolo(1,2-a)(1,2,4)triatsolium-6-yl))tio-6-((R)-1-hydroksietyyli)-1-metyylikarbapeneemi-3-karboksylaatin valmistamiseksi ja menetelmässä käytetyt lähtöaineet FI906464A7 (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI933245A FI93962C (fi) 1990-10-12 1993-07-16 6,7-dihydro-6-merkapto-5H-pyratsolo/1,2-a//1,2,4/triatsolium-välituotteet ja menetelmä niiden valmistamiseksi

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27242790 1990-10-12
JP27242890 1990-10-12
JP27242690 1990-10-12

Publications (3)

Publication Number Publication Date
FI906464A0 FI906464A0 (fi) 1990-12-31
FI906464L FI906464L (fi) 1992-04-13
FI906464A7 true FI906464A7 (fi) 1992-04-13

Family

ID=27335996

Family Applications (1)

Application Number Title Priority Date Filing Date
FI906464A FI906464A7 (fi) 1990-10-12 1990-12-31 Menetelmä (1R,5S,6S)-2-((6,7-dihydro-5H-pyratsolo(1,2-a)(1,2,4)triatsolium-6-yl))tio-6-((R)-1-hydroksietyyli)-1-metyylikarbapeneemi-3-karboksylaatin valmistamiseksi ja menetelmässä käytetyt lähtöaineet

Country Status (13)

Country Link
EP (1) EP0480100B1 (enExample)
KR (1) KR970011387B1 (enExample)
AT (1) ATE144260T1 (enExample)
AU (1) AU627970B2 (enExample)
CA (1) CA2033479C (enExample)
DE (1) DE69028920T2 (enExample)
DK (1) DK0480100T3 (enExample)
ES (1) ES2093010T3 (enExample)
FI (1) FI906464A7 (enExample)
GR (1) GR3021807T3 (enExample)
IL (1) IL96843A (enExample)
NO (1) NO176102C (enExample)
TW (1) TW239142B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0776574A (ja) * 1993-09-06 1995-03-20 Wako Pure Chem Ind Ltd ジスルフィド化合物の製造法
CN101768174B (zh) * 2009-01-07 2012-08-08 四川科伦药业股份有限公司 一种比阿培南的制备方法
CN103497207B (zh) * 2011-01-29 2015-09-30 正大天晴药业集团股份有限公司 比阿培南b型结晶
CN102731534B (zh) * 2011-04-13 2016-02-03 石药集团中奇制药技术（石家庄）有限公司 一种比阿培南的制备方法
CN102268025A (zh) * 2011-07-15 2011-12-07 海南美兰史克制药有限公司 一种比阿培南化合物及其制法
CN103965220A (zh) * 2013-02-01 2014-08-06 上海医药工业研究院 一种制备高纯度比阿培南的方法
CN103570750A (zh) * 2013-11-15 2014-02-12 安徽悦康凯悦制药有限公司 一种比阿培南的制备工艺
CN105481883A (zh) * 2015-10-26 2016-04-13 山东鲁抗生物制造有限公司 一种高纯度比阿培南的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds

Also Published As

Publication number Publication date
IL96843A0 (en) 1991-09-16
EP0480100A3 (en) 1992-10-21
NO905625L (no) 1992-04-13
ES2093010T3 (es) 1996-12-16
GR3021807T3 (en) 1997-02-28
ATE144260T1 (de) 1996-11-15
CA2033479C (en) 2001-01-23
CA2033479A1 (en) 1992-04-13
NO176102C (no) 1995-02-01
FI906464L (fi) 1992-04-13
IL96843A (en) 1995-07-31
DK0480100T3 (da) 1996-11-18
DE69028920D1 (de) 1996-11-21
TW239142B (enExample) 1995-01-21
DE69028920T2 (de) 1997-02-13
NO176102B (no) 1994-10-24
AU6862891A (en) 1992-06-11
KR920008039A (ko) 1992-05-27
KR970011387B1 (ko) 1997-07-10
NO905625D0 (no) 1990-12-28
AU627970B2 (en) 1992-09-03
EP0480100B1 (en) 1996-10-16
EP0480100A2 (en) 1992-04-15
FI906464A0 (fi) 1990-12-31

Similar Documents

Publication Publication Date Title
FI104170B1 (fi) Menetelmä terapeuttisesti käyttökelpoisten 3-amidopyratsolijohdannaisten valmistamiseksi
AU7122291A (en) 3-arylcarbonyl-1h-indoles useful as therapeutic agents
FI921952A7 (fi) Menetelmä lääkeaineina käyttökelpoisten dialkyleenipiperidinoyhdisteiden ja niiden enantiomeerien valmistamiseksi
CA2083179A1 (en) Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
NO960909D0 (no) Fremgangsmåte for fremstilling av zeolitt Y med öket mellomporevolum
FI903215A7 (fi) Heteroaryyliamino- ja heteroaryylioksipyridiiniamiineja ja niihin liittyviä yhdisteitä, menetelmä niiden valmistamiseksi sekä niiden käyttö lääkkeinä
FI940810L (fi) Substituoidut bentseenisulfonyylivirtsa-aineet ja -tiovirtsa-aineet, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
PT82435A (en) Process for the preparation of intermediate compounds used in the synthesis of carbapenem antibiotics
FI906464A7 (fi) Menetelmä (1R,5S,6S)-2-((6,7-dihydro-5H-pyratsolo(1,2-a)(1,2,4)triatsolium-6-yl))tio-6-((R)-1-hydroksietyyli)-1-metyylikarbapeneemi-3-karboksylaatin valmistamiseksi ja menetelmässä käytetyt lähtöaineet
DE3466525D1 (en) Stabilised formulation suitable for use in pyrolytic glass coating process
FI933065A7 (fi) Menetelmä atsabisyklo(2.2.2)oktaani-3-imiinien valmistamiseksi ja menetelmässä käytetyt välituotteet
AU1022195A (en) Cytokine antibody for the treatment of sepsis
AU8044691A (en) Substituted benzanilides and related benzylamides and their use as herbicides
IE800945L (en) Pyrido pyrimidines
AU8457591A (en) Process for the preparation of carbapenem compounds
ZA892869B (en) 5-fluoromethyl-1,2,4-triazolo(1,5-a)-pyrimidine-2-sulfonamides,process for their preparation and composition for their use as herbicides
AU2253088A (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
ZA9114B (en) Process for preparing(1r,5s,6s)-2-((6,7-dihydro-5h-pyrazolo(1,2-a)(1,2,4)triazolium-6-yl))thio-6-((r)-1-hydroxyethyl)-1-methyl-carbapenem-3-carboxylate and starting materials thereof
FI942888A7 (fi) Menetelmä pyranyylisyaaniguanidiinijohdanaisten valmistuksessa käyttökelpoisten välituotteiden valmistamiseksi
AU3687389A (en) 5-fluoromethyl-1,2,4-triazolo(1,5-a)-pyrimidine-2- sulfonamides, process for their preparation and compositions for their use as herbicides
FI915025A7 (fi) 8-atsabisyklo(3,2,1)oktyylialkyylitiatsolidinoneja, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineina
AU4434593A (en) Process for the preparation of imidazopyridines
FI914874A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten C-3-ditioasetaalisubstituoitujen karbapeneemiyhdisteiden valmistamiseksi
AU8931591A (en) Pyridyl-pyrimidin-derivates, process for producing the same, agents containing the same and their use as fungicides
BR9105405A (pt) Derivados de cefalosporina,preparado farmaceutico,processo para a preparacao de compostos e uso

Legal Events

Date Code Title Description
FD Application lapsed
FD Application lapsed

Owner name: LEDERLE (JAPAN), LTD.