FI90075B - Foerfarande foer framstaellning av ett terapeutiskt aktivt 1,3,5-tritianderivat substituerat i position 2 - Google Patents
Foerfarande foer framstaellning av ett terapeutiskt aktivt 1,3,5-tritianderivat substituerat i position 2 Download PDFInfo
- Publication number
- FI90075B FI90075B FI873116A FI873116A FI90075B FI 90075 B FI90075 B FI 90075B FI 873116 A FI873116 A FI 873116A FI 873116 A FI873116 A FI 873116A FI 90075 B FI90075 B FI 90075B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- phenyl
- general formula
- tritian
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D341/00—Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (3)
1. Förfarande för framställning av ett terapeutiskt aktivt 1,3,5-tritianderivat substituerat i position 2 och 5 med den allmänna formeln Cs>t^r4
10 R' R" i vilken R' är H och R" är OH eller R' och R" tillsammans bildar en tilläggsbindning,
15 R3 är fenyl, sora eventuellt är substituerad med en eller tvä substituenter, som är brom, klor, fluor, C^-alkyl, C1_5-alkoxi, morfolino, trifluormetyl, cyklohexyl, fenyl, bromfenyl, fenylmetyl, dimetylamino, imidazolyl, fenyltio, fenylsulfinyl, nitro, cyklohexyloxi, etyloxi- 20 karbonylpropyloxi och/eller fenoxi, vars fenyldel eventuellt är substituerad med fluor, klor, metyl eller meto-xi, och R4 är C^-alkyl, metoximetyl, trifluormetyl eller fenyl, som eventuellt är substituerad med en eller tvä . 25 substituenter, som är brom, fluor, klor, trifluormetyl och/eller C^-alkyl, förutsatt, att R3 och R4 inte samti-digt betyder osubstituerad fenyl, kännetecknat därav, att a) en bas tilläts päverka en förening med formeln 30 /-S s y un \_s 35. ett vattenfritt inert lösningsmedel, och därefter bringas det erhällna saltet med formeln 39 /-s s y— m w 5 i vilken M är en alkalimetallkatjon, att reagera med en förening med den allmänna formeln R3CR4 (III) 10 0 i vilken R3 och R4 är ovan definierade, och om sä önskas, behandlas den erhällna föreningen med formeln Ia, i vilken R' är H och R" är hydroxyl, med en syra, varvid erhällas 15 en förening med formeln Ia, i vilken R' och R" tillsammans bildar en tilläggsbindning, eller b) för framställning av en förening med formeln Ia, i vilken R' och R" tillsammans bildar en tilläggsbindning, en bas tilläts päverka en förening med den allmänna for-20 meln S\ / x (IV)
25 S i vilken X är en trimetylsilyl-, trifenylsilyl-, dialkyl-fosforyl-, tributylstannyl- eller klortrifenylfosfonium-grupp, i ett vattenfritt inert lösninsgmedel, och det er-30 hälinä saltet med formeln ; - C x: 40 ')nP75 i vilken M är en alkalimetallkatjon, bringas att reagera med en förening med den allmänna formeIn R3CR4 (III) 5 0 i vilken R3 och R4 är ovan definierade.
2. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att tritianderivatet 2-[l-(4-fenoxi-10 fenyl)propan-1-yliden]-1,3,5-tritian framställs.
3. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att tritianderivatet 2-(4,4'-di-fluorbentshydryliden)-1,3,5-tritian framställs.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16616786 | 1986-07-15 | ||
| JP16616786 | 1986-07-15 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI873116A0 FI873116A0 (fi) | 1987-07-14 |
| FI873116A FI873116A (fi) | 1988-01-16 |
| FI90075B true FI90075B (fi) | 1993-09-15 |
| FI90075C FI90075C (sv) | 1993-12-27 |
Family
ID=15826315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI873116A FI90075C (sv) | 1986-07-15 | 1987-07-14 | Förfarande för framställning av ett terapeutiskt aktivt 1,3,5-tritiand erivat substituerat i position 2 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US4816475A (sv) |
| EP (1) | EP0253370B1 (sv) |
| JP (1) | JPS63146870A (sv) |
| KR (1) | KR950003499B1 (sv) |
| AU (1) | AU596434B2 (sv) |
| CA (1) | CA1296728C (sv) |
| DE (1) | DE3788163T2 (sv) |
| DK (1) | DK365087A (sv) |
| FI (1) | FI90075C (sv) |
| HU (1) | HUT46904A (sv) |
| IE (1) | IE60984B1 (sv) |
| IL (1) | IL83171A (sv) |
| NO (1) | NO173389C (sv) |
| NZ (1) | NZ221032A (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8728235D0 (en) * | 1987-12-02 | 1988-01-06 | Sandoz Ltd | Novel azole compounds |
| US5149844A (en) * | 1989-10-20 | 1992-09-22 | Air Products And Chemicals, Inc. | Heterocyclic diorganotin catalysts for use in polyurethane systems |
| BR112013001237A2 (pt) | 2010-07-19 | 2016-05-17 | Syngenta Participations Ag | compostos de isoxazola, isoatiazola, furano e tiofeno como microbicidas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3492313A (en) * | 1967-01-16 | 1970-01-27 | Pfizer & Co C | Novel derivatives of 1,3,5-trithiane |
| US3525751A (en) * | 1967-03-27 | 1970-08-25 | Syntex Corp | Hormonal diphenyl methylol and benzhydrylidene derivatives |
| US3792043A (en) * | 1971-12-02 | 1974-02-12 | Squibb & Sons Inc | Process for converting compounds containing a cyclic sulfur group to aldehydes or ketones |
| JPS5748980A (en) * | 1980-09-05 | 1982-03-20 | Mitsubishi Chem Ind Ltd | Cyclopropanecarboxylic ester |
| ZA821644B (en) * | 1981-03-25 | 1983-01-26 | Expansia Sa | Borane complexes |
-
1987
- 1987-07-10 NO NO872885A patent/NO173389C/no unknown
- 1987-07-10 NZ NZ221032A patent/NZ221032A/xx unknown
- 1987-07-13 IL IL83171A patent/IL83171A/xx not_active IP Right Cessation
- 1987-07-14 HU HU873210A patent/HUT46904A/hu unknown
- 1987-07-14 FI FI873116A patent/FI90075C/sv not_active IP Right Cessation
- 1987-07-14 DE DE87110180T patent/DE3788163T2/de not_active Expired - Fee Related
- 1987-07-14 DK DK365087A patent/DK365087A/da not_active Application Discontinuation
- 1987-07-14 US US07/073,449 patent/US4816475A/en not_active Expired - Fee Related
- 1987-07-14 JP JP62175640A patent/JPS63146870A/ja active Pending
- 1987-07-14 EP EP87110180A patent/EP0253370B1/en not_active Expired - Lifetime
- 1987-07-14 IE IE190287A patent/IE60984B1/en not_active IP Right Cessation
- 1987-07-14 CA CA000542009A patent/CA1296728C/en not_active Expired - Fee Related
- 1987-07-15 KR KR1019870007666A patent/KR950003499B1/ko active IP Right Grant
- 1987-07-15 AU AU75680/87A patent/AU596434B2/en not_active Ceased
-
1988
- 1988-10-17 US US07/258,667 patent/US5045562A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR950003499B1 (ko) | 1995-04-13 |
| NO872885D0 (no) | 1987-07-10 |
| US5045562A (en) | 1991-09-03 |
| DE3788163T2 (de) | 1994-03-10 |
| FI873116A (fi) | 1988-01-16 |
| FI90075C (sv) | 1993-12-27 |
| NO173389B (no) | 1993-08-30 |
| NO872885L (no) | 1988-01-18 |
| DK365087A (da) | 1988-01-16 |
| DK365087D0 (da) | 1987-07-14 |
| IE60984B1 (en) | 1994-09-07 |
| IL83171A0 (en) | 1987-12-31 |
| CA1296728C (en) | 1992-03-03 |
| HUT46904A (en) | 1988-12-28 |
| FI873116A0 (fi) | 1987-07-14 |
| NO173389C (no) | 1993-12-08 |
| US4816475A (en) | 1989-03-28 |
| EP0253370A1 (en) | 1988-01-20 |
| IE871902L (en) | 1988-01-15 |
| KR880001629A (ko) | 1988-04-25 |
| AU7568087A (en) | 1988-01-21 |
| EP0253370B1 (en) | 1993-11-18 |
| DE3788163D1 (de) | 1993-12-23 |
| AU596434B2 (en) | 1990-05-03 |
| IL83171A (en) | 1992-07-15 |
| JPS63146870A (ja) | 1988-06-18 |
| NZ221032A (en) | 1990-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: NIHON NOHYAKU CO., LTD. |
|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: NIHON NOHYAKU CO., LTD. |