FI89485B - Foerfarande foer metylering av xantiner - Google Patents

Foerfarande foer metylering av xantiner Download PDF

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Publication number
FI89485B
FI89485B FI885708A FI885708A FI89485B FI 89485 B FI89485 B FI 89485B FI 885708 A FI885708 A FI 885708A FI 885708 A FI885708 A FI 885708A FI 89485 B FI89485 B FI 89485B
Authority
FI
Finland
Prior art keywords
dimethyl carbonate
reaction
methylation
methanol
process according
Prior art date
Application number
FI885708A
Other languages
English (en)
Finnish (fi)
Other versions
FI885708A (fi
FI885708A0 (fi
FI89485C (sv
Inventor
Georg Hilgers
Jutta Kroeber
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of FI885708A0 publication Critical patent/FI885708A0/fi
Publication of FI885708A publication Critical patent/FI885708A/fi
Publication of FI89485B publication Critical patent/FI89485B/fi
Application granted granted Critical
Publication of FI89485C publication Critical patent/FI89485C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Machines For Manufacturing Corrugated Board In Mechanical Paper-Making Processes (AREA)
  • Incineration Of Waste (AREA)

Claims (7)

1. Förfarande för metylering av xantiner, känneteck-n a t därav, att dimetylkarbonat användes som mety1eringsrea-gens, varvid utgängsmaterialets mol förhäl1ande tili dimetyl-karbonatet är 1:3 - 1:50, reaktionsblandningens pH justeras med en vattenbuffert tili mellan 7,8 - 7,1 och reaktionen sker 100 - 250°C, under motsvarande förhöjt tryck.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att tili reaktionsblandningen sätts ett organiskt 1ösningsmedel med en sur väteatom, lämpligen metanol.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att xantin eller 3-metylxantin eller deras natrium-eller kalciumsalt metyleras tili teobromin, varvid dimetylkarbonat användes i ett mol förhil1ande utgängsmaterialet:dimetyl-karbonat = 1:3 - 1:50, företrädesvis 1:7 - 1:10, och reaktionen utföres i vatten eller en vattenbuffert (pH 7,8 - 7,1) vid 100 - 250°C, företrädesvis 170 - 200°, och under motsvarande förhöjt tryck.
4. Förfarande enligt patentkravet 1, kännetecknat därav, att xantin, 3-metylxantin eller teofyllin eller deras natrium- eller kalciumsalt metyleras koffein, varvid dimetylkarbonat användes i ett mol förhällande utgängsmaterialet:di -metylkarbonat = 1:3 - 1:50, företrädesvis 1:7 - 1:10, och reaktionen utföres 100 - 250°C, företrädesvis 170 - 200°C, och under motsvarande förhöjt tryck.
5. Förfarande enligt patentkravet 4, kännetecknat därav, att ett surt 1ösningsmedel tillsätts i reaktionsblandningen.
6. Förfarande enligt patentkravet 5, kännetecknat därav, att metanol tillsätts reaktionsblandningen. 13 89 4 0 5
7. Förfarande enligt patentkravet 6, kännetecknat därav, att metanol tillsätts i ett mol förhäl1ande dimetylkar-bonat:metanol frän = 3,3:1 - 2:1.
FI885708A 1987-12-10 1988-12-09 Förfarande för metylering av xantiner FI89485C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873741883 DE3741883A1 (de) 1987-12-10 1987-12-10 Verfahren zum methylieren von xanthinen
DE3741883 1987-12-10

Publications (4)

Publication Number Publication Date
FI885708A0 FI885708A0 (fi) 1988-12-09
FI885708A FI885708A (fi) 1989-06-11
FI89485B true FI89485B (fi) 1993-06-30
FI89485C FI89485C (sv) 1993-10-11

Family

ID=6342299

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885708A FI89485C (sv) 1987-12-10 1988-12-09 Förfarande för metylering av xantiner

Country Status (5)

Country Link
EP (1) EP0319854B1 (sv)
JP (1) JPH0645620B2 (sv)
AT (1) ATE102200T1 (sv)
DE (2) DE3741883A1 (sv)
FI (1) FI89485C (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225535B (sv) * 1992-11-10 1994-06-21 Hoechst Ag
GB9418499D0 (en) * 1994-09-14 1994-11-02 Ciba Geigy Ag Process for producing n-methylated organic pigments
CN103724348B (zh) * 2013-12-16 2016-04-27 吉林省舒兰合成药业股份有限公司 一种可可碱的制备方法
CN104892611B (zh) * 2015-05-19 2017-03-22 青岛科技大学 一种咖啡因的合成方法
CN112724143B (zh) * 2021-02-07 2022-04-15 河北工业大学 一种由3-甲基黄嘌呤甲基化制备可可碱的方法

Also Published As

Publication number Publication date
ATE102200T1 (de) 1994-03-15
JPH0645620B2 (ja) 1994-06-15
FI885708A (fi) 1989-06-11
FI885708A0 (fi) 1988-12-09
JPH01190686A (ja) 1989-07-31
DE3888113D1 (de) 1994-04-07
FI89485C (sv) 1993-10-11
EP0319854A2 (de) 1989-06-14
EP0319854A3 (de) 1991-03-27
EP0319854B1 (de) 1994-03-02
DE3741883A1 (de) 1989-06-22

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MM Patent lapsed
MM Patent lapsed

Owner name: BOEHRINGER INGELHEIM KG