US4948882A
(en)
*
|
1983-02-22 |
1990-08-14 |
Syngene, Inc. |
Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
|
EP0638807B1
(en)
*
|
1987-09-21 |
2002-07-17 |
Gen-Probe Incorporated |
Protection assay
|
US5141813A
(en)
*
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
US5451463A
(en)
*
|
1989-08-28 |
1995-09-19 |
Clontech Laboratories, Inc. |
Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
|
IL99069A
(en)
*
|
1990-08-09 |
1998-08-16 |
Genta Inc |
Methyphosphonate oligonucleotides associated with psoralen
|
NZ239250A
(en)
*
|
1990-08-09 |
1993-12-23 |
Genta Inc |
Chirally pure non-nucleotide reagents for use in preparing
|
US5512667A
(en)
*
|
1990-08-28 |
1996-04-30 |
Reed; Michael W. |
Trifunctional intermediates for preparing 3'-tailed oligonucleotides
|
GB9021625D0
(en)
*
|
1990-10-04 |
1990-11-21 |
Ici Plc |
Synthesis of oligonucleotides
|
US6093538A
(en)
*
|
1992-05-06 |
2000-07-25 |
Gen-Probe Incorporated |
Nucleic acid probes to ureaplasma
|
WO1993022461A1
(en)
*
|
1992-05-06 |
1993-11-11 |
Gen-Probe Incorporated |
Nucleic acid sequence amplification method, composition and kit
|
JPH09502092A
(ja)
|
1993-09-02 |
1997-03-04 |
リボザイム・ファーマシューティカルズ・インコーポレイテッド |
非ヌクレオチドを含有する酵素性核酸
|
US5886177A
(en)
*
|
1994-01-11 |
1999-03-23 |
Isis Pharmaceuticals, Inc. |
Phosphate linked oligomers
|
US6448373B1
(en)
|
1994-01-11 |
2002-09-10 |
Isis Pharmaceuticals, Inc. |
Phosphate linked oligomers formed of monomeric diols and processes for preparing same
|
US5514551A
(en)
*
|
1994-10-14 |
1996-05-07 |
Gen-Probe Incorporated |
Compositions for the detection of Chlamydia trachomatis
|
DE69535240T2
(de)
*
|
1994-10-28 |
2007-06-06 |
Gen-Probe Inc., San Diego |
Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
|
US5622827A
(en)
*
|
1995-02-07 |
1997-04-22 |
Gen-Probe Incorporated |
Amplification primers and nucleic acid probes targeted to coccidioides immitis nucleic acid
|
US5731148A
(en)
*
|
1995-06-07 |
1998-03-24 |
Gen-Probe Incorporated |
Adduct protection assay
|
US5739311A
(en)
*
|
1995-06-07 |
1998-04-14 |
Gen-Probe Incorporated |
Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
|
US5652126A
(en)
*
|
1995-06-07 |
1997-07-29 |
Gen-Probe Incorporated |
Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
|
US5756352A
(en)
*
|
1995-06-07 |
1998-05-26 |
Gen-Probe Incorporated |
Thiocationic lipid-nucleic acid conjugates
|
US5739271A
(en)
*
|
1995-06-07 |
1998-04-14 |
Gen-Probe Incorporated |
Thiocationic lipids
|
US5747252A
(en)
|
1995-06-07 |
1998-05-05 |
Gen-Probe Incorporated |
Nucleic acid probes and amplification oligonucleotides for Neisseria species
|
US5759519A
(en)
*
|
1995-06-07 |
1998-06-02 |
Gen-Probe Incorporated |
Method for the intracellular delivery of biomolecules using thiocationic lipids
|
US5851548A
(en)
*
|
1995-06-07 |
1998-12-22 |
Gen-Probe Incorporated |
Liposomes containing cationic lipids and vitamin D
|
US5916777A
(en)
*
|
1995-06-07 |
1999-06-29 |
Gen-Probe Incorporated |
Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
|
US5879885A
(en)
*
|
1995-06-07 |
1999-03-09 |
Gen-Probe Incorporated |
Compositions for detecting and quantifying biological samples
|
US5932450A
(en)
*
|
1995-06-07 |
1999-08-03 |
Gen-Probe Incorporated |
Enzymatic synthesis of oligonucleotides using digestible templates
|
US5711964A
(en)
*
|
1995-06-07 |
1998-01-27 |
United States Of America |
Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D
|
DE19534122A1
(de)
*
|
1995-09-14 |
1997-03-20 |
Behringwerke Ag |
Homogener Gensondentest mit einem gegen das Label gerichteten Rezeptor
|
US7034009B2
(en)
|
1995-10-26 |
2006-04-25 |
Sirna Therapeutics, Inc. |
Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
|
CA2237891C
(en)
|
1995-11-15 |
2013-07-30 |
Gen-Probe Incorporated |
Nucleic acid probes complementary to human papillomavirus nucleic acid and related methods and kits
|
AU710996B2
(en)
|
1996-05-22 |
1999-10-07 |
Gen-Probe Incorporated |
Compositions and methods for the detection of mycobacterium kansasii
|
US6025133A
(en)
*
|
1996-12-30 |
2000-02-15 |
Gen-Probe Incorporated |
Promoter-sequestered oligonucleoside and method of use
|
US6251666B1
(en)
|
1997-03-31 |
2001-06-26 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid catalysts comprising L-nucleotide analogs
|
US6548657B1
(en)
|
1997-06-09 |
2003-04-15 |
Ribozyme Pharmaceuticals, Inc. |
Method for screening nucleic acid catalysts
|
US6280936B1
(en)
|
1997-06-09 |
2001-08-28 |
Ribozyme Pharmaceuticals, Inc. |
Method for screening nucleic acid catalysts
|
DE19741738A1
(de)
|
1997-09-22 |
1999-03-25 |
Hoechst Ag |
Linker-Nucleosid, seine Herstellung und Verwendung
|
US6656731B1
(en)
|
1997-09-22 |
2003-12-02 |
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Nucleic acid catalysts with endonuclease activity
|
CA2304813A1
(en)
*
|
1997-09-22 |
1999-04-08 |
Fritz Eckstein |
Nucleic acid catalysts with endonuclease activity
|
DE19741715A1
(de)
|
1997-09-22 |
1999-03-25 |
Hoechst Ag |
Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
|
DE19815901A1
(de)
|
1998-04-08 |
1999-10-14 |
Aventis Res & Tech Gmbh & Co |
Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden
|
AU3751299A
(en)
|
1998-04-20 |
1999-11-08 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
US6831171B2
(en)
|
2000-02-08 |
2004-12-14 |
Yale University |
Nucleic acid catalysts with endonuclease activity
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
US20070026394A1
(en)
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
EP1572067A4
(en)
|
2001-05-18 |
2009-05-13 |
Sirna Therapeutics Inc |
CONJUGATES AND COMPOSITIONS FOR CELL DELIVERY
|
US9994853B2
(en)
|
2001-05-18 |
2018-06-12 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
US7109165B2
(en)
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
CN100334228C
(zh)
|
2001-06-21 |
2007-08-29 |
戴纳瓦克斯技术公司 |
嵌合免疫调制化合物及其使用方法
|
US7785610B2
(en)
|
2001-06-21 |
2010-08-31 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same—III
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
CN1688716A
(zh)
|
2002-06-28 |
2005-10-26 |
罗斯塔英法美蒂克斯有限责任公司 |
评估微阵列质量的方法
|
CN100471486C
(zh)
|
2002-08-12 |
2009-03-25 |
戴纳伐克斯技术股份有限公司 |
免疫调节组合物,其制备方法和使用方法
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US7560231B2
(en)
|
2002-12-20 |
2009-07-14 |
Roche Molecular Systems, Inc. |
Mannitol and glucitol derivatives
|
EP1625140A4
(en)
|
2002-12-23 |
2008-06-18 |
Dynavax Tech Corp |
BRANCHED IMMUNOMODULAR COMPOUNDS AND METHOD OF USE THEREOF
|
CA2463719A1
(en)
|
2003-04-05 |
2004-10-05 |
F. Hoffmann-La Roche Ag |
Nucleotide analogs with six membered rings
|
EP3222294A1
(en)
|
2003-04-30 |
2017-09-27 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
CA2557532A1
(en)
|
2004-04-23 |
2005-11-10 |
Angela M. Christiano |
Inhibition of hairless protein mrna
|
US20060040882A1
(en)
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
US10508277B2
(en)
|
2004-05-24 |
2019-12-17 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
CA2578775C
(en)
|
2004-09-01 |
2016-05-03 |
Dynavax Technologies Corporation |
Methods and compositions for inhibition of innate immune responses and autoimmunity
|
EP1700922B1
(en)
|
2005-03-10 |
2016-08-24 |
Roche Diagnostics GmbH |
3-Substituted 5-Nitroindole derivatives and labeled oligonucleotide probes containing them
|
US8252756B2
(en)
|
2005-06-14 |
2012-08-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
JP4713514B2
(ja)
*
|
2006-02-20 |
2011-06-29 |
エフ.ホフマン−ラ ロシュ アーゲー |
改善された標識試薬
|
WO2007127439A2
(en)
|
2006-04-28 |
2007-11-08 |
Children's Hospital Medical Center |
Compositions comprising fusogenic proteins or polypeptides derived from prosaposin for application in transmembrane drug delivery systems
|
MX2009008470A
(es)
|
2007-02-09 |
2009-11-26 |
Univ Northwestern |
Particulas para detectar objetivos intracelulares.
|
HUE040417T2
(hu)
|
2007-05-04 |
2019-03-28 |
Marina Biotech Inc |
Aminosavlipidek és alkalmazásuk
|
DK2826863T3
(en)
|
2007-05-30 |
2017-12-04 |
Univ Northwestern |
NUCLEIC ACID FUNCTIONALIZED NANOPARTICLES FOR THERAPEUTIC APPLICATIONS
|
EP2209896B1
(en)
|
2007-10-26 |
2017-03-01 |
Dynavax Technologies Corporation |
Methods and compositions for inhibition of immune responses and autoimmunity
|
WO2009155100A1
(en)
|
2008-05-30 |
2009-12-23 |
Yale University |
Targeted oligonucleotide compositions for modifying gene expression
|
AU2009305639B2
(en)
|
2008-10-16 |
2016-06-23 |
Marina Biotech, Inc. |
Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics
|
CA2744207C
(en)
|
2008-11-24 |
2019-05-28 |
Northwestern University |
Polyvalent rna-nanoparticle compositions
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
DK2459743T3
(da)
|
2009-07-30 |
2017-11-06 |
Hoffmann La Roche |
Sæt af oligonukleotidprober såvel som fremgangsmåder og anvendelser relateret dertil
|
WO2011019679A1
(en)
|
2009-08-11 |
2011-02-17 |
Allergan, Inc. |
Ccr2 inhibitors for treating conditions of the eye
|
CA2781519A1
(en)
|
2009-09-16 |
2011-03-24 |
Genentech, Inc. |
Coiled coil and/or tether containing protein complexes and uses thereof
|
US8350038B2
(en)
|
2009-10-20 |
2013-01-08 |
Roche Diagnostics Operations, Inc. |
Fluorescence quencher molecules
|
CA2779099C
(en)
|
2009-10-30 |
2021-08-10 |
Northwestern University |
Templated nanoconjugates
|
AU2010328104B2
(en)
|
2009-12-09 |
2014-10-30 |
Nitto Denko Corporation |
Modulation of hsp47 expression
|
AU2011215753B2
(en)
|
2010-02-11 |
2015-09-03 |
Bruker Spatial Biology, Inc. |
Compositions and methods for the detection of small RNAs
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
WO2011120023A1
(en)
|
2010-03-26 |
2011-09-29 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting survivin gene expression uses thereof
|
WO2011133584A2
(en)
|
2010-04-19 |
2011-10-27 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting hras gene expression and uses thereof
|
EP2563922A1
(en)
|
2010-04-26 |
2013-03-06 |
Marina Biotech, Inc. |
Nucleic acid compounds with conformationally restricted monomers and uses thereof
|
WO2011139842A2
(en)
|
2010-04-28 |
2011-11-10 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof
|
US8940310B2
(en)
|
2010-06-16 |
2015-01-27 |
Dynavax Technologies Corporation |
Methods of treatment using TLR7 and/or TLR9 inhibitors
|
DK2632472T3
(en)
|
2010-10-29 |
2018-03-19 |
Sirna Therapeutics Inc |
RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
WO2012085113A1
(en)
|
2010-12-23 |
2012-06-28 |
Roche Diagnostics Gmbh |
Binding agent
|
CN103384825B
(zh)
|
2010-12-23 |
2017-05-24 |
霍夫曼-拉罗奇有限公司 |
通过二价结合剂检测经翻译后修饰的多肽
|
CA2828002A1
(en)
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treating lung disease and injury
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
CA2863253A1
(en)
|
2011-09-07 |
2013-03-14 |
Marina Biotech, Inc. |
Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
|
ES2856091T3
(es)
|
2011-09-14 |
2021-09-27 |
Univ Northwestern |
Nanoconjugados capaces de atravesar la barrera hematoencefálica
|
EP3511426B1
(en)
|
2012-02-01 |
2022-08-17 |
Gen-Probe Incorporated |
Asymmetric hairpin target capture oligomers
|
KR20140127854A
(ko)
|
2012-02-10 |
2014-11-04 |
제넨테크, 인크. |
단일-쇄 항체 및 다른 이종다량체
|
RU2639287C2
(ru)
|
2012-06-27 |
2017-12-20 |
Ф. Хоффманн-Ля Рош Аг |
Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
|
ES2930185T3
(es)
|
2012-06-27 |
2022-12-07 |
Univ Princeton |
Inteínas divididas, conjugados y usos de las mismas
|
WO2014001325A1
(en)
|
2012-06-27 |
2014-01-03 |
F. Hoffmann-La Roche Ag |
Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
|
WO2014043291A1
(en)
|
2012-09-12 |
2014-03-20 |
Quark Pharmaceuticals, Inc. |
Double-stranded nucleic acid compounds
|
US9228184B2
(en)
|
2012-09-29 |
2016-01-05 |
Dynavax Technologies Corporation |
Human toll-like receptor inhibitors and methods of use thereof
|
EP3508198A1
(en)
|
2014-06-04 |
2019-07-10 |
Exicure, Inc. |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
WO2016022866A1
(en)
|
2014-08-07 |
2016-02-11 |
Agilent Technologies, Inc. |
Cis-blocked guide rna
|
AU2015349680A1
(en)
|
2014-11-21 |
2017-06-08 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
WO2016087416A1
(en)
|
2014-12-03 |
2016-06-09 |
F. Hoffmann-La Roche Ag |
Multispecific antibodies
|
US10264976B2
(en)
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
EP3816287A1
(en)
|
2015-12-13 |
2021-05-05 |
Nitto Denko Corporation |
Sirna structures for high activity and reduced off target
|
US11364304B2
(en)
|
2016-08-25 |
2022-06-21 |
Northwestern University |
Crosslinked micellar spherical nucleic acids
|
EP4365289A3
(en)
|
2018-11-16 |
2024-07-10 |
Nitto Denko Corporation |
Rna interference delivery formulation and methods for malignant tumors
|
WO2023092102A1
(en)
|
2021-11-19 |
2023-05-25 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting angiopoietin-like 3 (angptl-3) and methods of use thereof
|
WO2023220561A1
(en)
|
2022-05-09 |
2023-11-16 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting 17-beta hydroxysteroiddehydrogenase 13 (hsd17b13) and methods of use thereof
|
US20240052348A1
(en)
|
2022-08-05 |
2024-02-15 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting angiotensinogen (agt) and methods of use thereof
|
US20240175026A1
(en)
|
2022-10-14 |
2024-05-30 |
Sanegene Bio Usa Inc. |
Small interfering rna targeting c3 and uses thereof
|
EP4444357A1
(en)
*
|
2022-12-19 |
2024-10-16 |
Arnatar Therapeutics, Inc |
Arnatar compounds and methods for enhanced cellular uptake
|
WO2024137590A2
(en)
|
2022-12-19 |
2024-06-27 |
Sanegene Bio Usa Inc. |
Small interfering rna targeting cfb and uses thereof
|
WO2024175111A2
(en)
|
2023-02-24 |
2024-08-29 |
Suzhou Sanegene Bio Inc. |
Small interfering rna targeting hbv and uses thereof
|
US20240309380A1
(en)
|
2023-03-03 |
2024-09-19 |
Sanegene Bio Usa Inc. |
Small interfering rna targeting apoc3 and uses thereof
|