FI884461A - Menetelmä trans-1,1,2-trifenyylibut-1-eenijohdannaisten valmistamiseksi - Google Patents
Menetelmä trans-1,1,2-trifenyylibut-1-eenijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI884461A FI884461A FI884461A FI884461A FI884461A FI 884461 A FI884461 A FI 884461A FI 884461 A FI884461 A FI 884461A FI 884461 A FI884461 A FI 884461A FI 884461 A FI884461 A FI 884461A
- Authority
- FI
- Finland
- Prior art keywords
- triphenyl
- trans
- ene
- derivatives
- preparation
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873736682 DE3736682A1 (de) | 1987-10-29 | 1987-10-29 | Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten |
| DE3736682 | 1987-10-29 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI884461A0 FI884461A0 (fi) | 1988-09-28 |
| FI884461A true FI884461A (fi) | 1989-04-30 |
| FI94625B FI94625B (fi) | 1995-06-30 |
| FI94625C FI94625C (fi) | 1995-10-10 |
Family
ID=6339363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI884461A FI94625C (fi) | 1987-10-29 | 1988-09-28 | Menetelmä trans-1,1,2-trifenyylibut-1-eenijohdannaisten valmistamiseksi |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4960937A (fi) |
| EP (1) | EP0313799B1 (fi) |
| AT (1) | ATE85605T1 (fi) |
| DE (2) | DE3736682A1 (fi) |
| DK (1) | DK170300B1 (fi) |
| ES (1) | ES2038263T3 (fi) |
| FI (1) | FI94625C (fi) |
| GR (1) | GR3007027T3 (fi) |
| HU (1) | HU202824B (fi) |
| NO (1) | NO169120C (fi) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0169186B1 (ko) * | 1993-10-25 | 1999-03-20 | 고바야시 유끼오 | 트리페닐에틸렌 화합물의 z이성체 산부가염의 제조방법 |
| DE69409835T2 (de) * | 1994-01-03 | 1998-10-01 | Klinge Co Chem Pharm Fab | Verfahren zur herstellung von e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'hydroxyphenyl)-2-phenyl-1-buten |
| US5681835A (en) * | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| HUP9900951A3 (en) | 1996-01-20 | 2000-02-28 | Bradford University Bradford | Process for producing tamoxifen and analogues thereof |
| GB9715479D0 (en) * | 1997-07-23 | 1997-10-01 | Univ Bradford | Tamoxifen and analogues thereof |
| HUP0002852A3 (en) | 1997-08-15 | 2001-11-28 | Univ Durham | A method of preventing or treating estrogen-dependent diseases and disorders using triphenil-ethylene derivatives |
| CN114133334A (zh) * | 2021-11-09 | 2022-03-04 | 北京京丰制药(山东)有限公司 | 枸橼酸他莫昔芬的工业化制备工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637389A (fi) * | 1962-09-13 | |||
| GB1013907A (en) * | 1962-09-13 | 1965-12-22 | Ici Ltd | Alkene derivatives |
| DE3046719C2 (de) * | 1980-12-11 | 1983-02-17 | Klinge Pharma GmbH, 8000 München | 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
| EP0127128B1 (en) * | 1983-05-24 | 1987-02-25 | Bristol-Myers Company | Process for the conversion of the e isomer of 1,2-diphenyl-1-(4-(2-dimethylaminoethoxy)-phenyl)-1-butene to tamoxifen hcl |
| EP0168175B1 (en) * | 1984-06-12 | 1987-11-19 | National Research Development Corporation | Preparation of tamoxifen |
| CN1013859B (zh) * | 1986-11-21 | 1991-09-11 | 中国人民解放军防化研究院第四所 | 枸橼酸三苯氧胺合成方法的改进 |
-
1987
- 1987-10-29 DE DE19873736682 patent/DE3736682A1/de not_active Withdrawn
-
1988
- 1988-09-19 EP EP88115306A patent/EP0313799B1/de not_active Expired - Lifetime
- 1988-09-19 ES ES198888115306T patent/ES2038263T3/es not_active Expired - Lifetime
- 1988-09-19 AT AT88115306T patent/ATE85605T1/de not_active IP Right Cessation
- 1988-09-19 DE DE8888115306T patent/DE3878394D1/de not_active Expired - Fee Related
- 1988-09-28 FI FI884461A patent/FI94625C/fi not_active IP Right Cessation
- 1988-10-27 NO NO884800A patent/NO169120C/no not_active IP Right Cessation
- 1988-10-27 US US07/263,209 patent/US4960937A/en not_active Expired - Fee Related
- 1988-10-28 HU HU885630A patent/HU202824B/hu not_active IP Right Cessation
- 1988-10-28 DK DK604288A patent/DK170300B1/da not_active IP Right Cessation
-
1993
- 1993-02-11 GR GR920402546T patent/GR3007027T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK604288D0 (da) | 1988-10-28 |
| HUT51592A (en) | 1990-05-28 |
| DE3878394D1 (de) | 1993-03-25 |
| EP0313799A3 (en) | 1990-05-30 |
| ATE85605T1 (de) | 1993-02-15 |
| NO884800D0 (no) | 1988-10-27 |
| EP0313799A2 (de) | 1989-05-03 |
| ES2038263T3 (es) | 1993-07-16 |
| FI94625C (fi) | 1995-10-10 |
| FI884461A0 (fi) | 1988-09-28 |
| DK170300B1 (da) | 1995-07-31 |
| NO169120C (no) | 1992-05-13 |
| HU202824B (en) | 1991-04-29 |
| NO169120B (no) | 1992-02-03 |
| DK604288A (da) | 1989-04-30 |
| US4960937A (en) | 1990-10-02 |
| GR3007027T3 (fi) | 1993-07-30 |
| EP0313799B1 (de) | 1993-02-10 |
| FI94625B (fi) | 1995-06-30 |
| DE3736682A1 (de) | 1989-05-11 |
| NO884800L (no) | 1989-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: KLINGE PHARMA GMBH |