DE69409835T2 - Verfahren zur herstellung von e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'hydroxyphenyl)-2-phenyl-1-buten - Google Patents

Verfahren zur herstellung von e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'hydroxyphenyl)-2-phenyl-1-buten

Info

Publication number
DE69409835T2
DE69409835T2 DE69409835T DE69409835T DE69409835T2 DE 69409835 T2 DE69409835 T2 DE 69409835T2 DE 69409835 T DE69409835 T DE 69409835T DE 69409835 T DE69409835 T DE 69409835T DE 69409835 T2 DE69409835 T2 DE 69409835T2
Authority
DE
Germany
Prior art keywords
phenyl
dimethylaminoethoxy
buten
hydroxyphenyl
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69409835T
Other languages
English (en)
Other versions
DE69409835D1 (de
Inventor
Helmut Grill
Axel Woschina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Application granted granted Critical
Publication of DE69409835D1 publication Critical patent/DE69409835D1/de
Publication of DE69409835T2 publication Critical patent/DE69409835T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69409835T 1994-01-03 1994-01-03 Verfahren zur herstellung von e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'hydroxyphenyl)-2-phenyl-1-buten Expired - Fee Related DE69409835T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP1994/000001 WO1995018786A1 (en) 1994-01-03 1994-01-03 Method for the production of e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl)-2-phenyl-1-butene
CN94194961A CN1142815A (zh) 1994-01-03 1994-01-03 E-1-[4'-(2-二甲氨基乙氧基)-苯基]-1-(3'羟苯基)-2-苯基-1-丁烯的制备方法

Publications (2)

Publication Number Publication Date
DE69409835D1 DE69409835D1 (de) 1998-05-28
DE69409835T2 true DE69409835T2 (de) 1998-10-01

Family

ID=37708199

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69409835T Expired - Fee Related DE69409835T2 (de) 1994-01-03 1994-01-03 Verfahren zur herstellung von e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'hydroxyphenyl)-2-phenyl-1-buten

Country Status (15)

Country Link
US (1) US5693863A (de)
EP (1) EP0738256B1 (de)
JP (1) JPH09507240A (de)
CN (1) CN1142815A (de)
AU (1) AU691113B2 (de)
CZ (1) CZ330994A3 (de)
DE (1) DE69409835T2 (de)
EE (1) EE03191B1 (de)
ES (1) ES2115207T3 (de)
FI (1) FI950011A (de)
IL (1) IL112166A0 (de)
NO (1) NO301003B1 (de)
PL (1) PL177916B1 (de)
RU (1) RU2124499C1 (de)
WO (1) WO1995018786A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601167D0 (en) * 1996-01-20 1996-03-20 Univ Bradford Tamoxifen and analogues thereof
EP0883587A1 (de) * 1996-01-20 1998-12-16 Bradford University Tamoxifen und analoge verbindungen
GB9715479D0 (en) * 1997-07-23 1997-10-01 Univ Bradford Tamoxifen and analogues thereof
JP4572407B2 (ja) * 2005-03-04 2010-11-04 学校法人東京理科大学 ドロロキシフェンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
EP0260066B1 (de) * 1986-09-11 1990-05-09 National Research Development Corporation Tamoxifenderivate
DE3736682A1 (de) * 1987-10-29 1989-05-11 Klinge Co Chem Pharm Fab Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten

Also Published As

Publication number Publication date
AU5815894A (en) 1995-08-01
NO945077D0 (no) 1994-12-29
EP0738256B1 (de) 1998-04-22
CZ330994A3 (en) 1995-07-12
WO1995018786A1 (en) 1995-07-13
ES2115207T3 (es) 1998-06-16
EE03191B1 (et) 1999-06-15
AU691113B2 (en) 1998-05-07
FI950011A0 (fi) 1995-01-02
JPH09507240A (ja) 1997-07-22
DE69409835D1 (de) 1998-05-28
US5693863A (en) 1997-12-02
FI950011A (fi) 1995-07-04
PL177916B1 (pl) 2000-01-31
CN1142815A (zh) 1997-02-12
PL306666A1 (en) 1995-07-10
NO301003B1 (no) 1997-09-01
NO945077L (no) 1995-07-04
EP0738256A1 (de) 1996-10-23
IL112166A0 (en) 1995-03-15
RU2124499C1 (ru) 1999-01-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee