FI87734B - Immunologisk motverkan foer tumoerer och virus - Google Patents

Immunologisk motverkan foer tumoerer och virus Download PDF

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Publication number
FI87734B
FI87734B FI852683A FI852683A FI87734B FI 87734 B FI87734 B FI 87734B FI 852683 A FI852683 A FI 852683A FI 852683 A FI852683 A FI 852683A FI 87734 B FI87734 B FI 87734B
Authority
FI
Finland
Prior art keywords
antibody
idiotypic
antibodies
mab
serum
Prior art date
Application number
FI852683A
Other languages
English (en)
Finnish (fi)
Other versions
FI852683A0 (fi
FI87734C (sv
FI852683L (fi
Inventor
Elaine Defreitas
Dorothee Herlyn
Hilary Koprowski
Kevin Reagan
Tadeusz Wiktor
Original Assignee
Wistar Inst
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27069155&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI87734(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/549,506 external-priority patent/US4731237A/en
Application filed by Wistar Inst, Sandoz Ag filed Critical Wistar Inst
Publication of FI852683A0 publication Critical patent/FI852683A0/fi
Publication of FI852683L publication Critical patent/FI852683L/fi
Priority to FI894503A priority Critical patent/FI894503A/fi
Application granted granted Critical
Publication of FI87734B publication Critical patent/FI87734B/fi
Publication of FI87734C publication Critical patent/FI87734C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Claims (4)

1. Förfarande för framställning av terapeu-tiskt användbara antiidiotypa antikroppar, vilka är 5 avsedda att framkalla immunologisk moteffekt mot fasta tumörer eller rabiesvirus, kännetecknat därav, att vid förfarandet (a) antiidiotypa antikroppar framställs med hjälp av odödlig B-lymfocyt, eller (b) antikroppar mot en fast tumör eller rabiesvirus ges ät 10 en heterolog värd och de önskade antiidiotypa antikrop-parna isoleras och renas frän värdens serum; varvid de antiidiotypa antikropparna identifierar en epitop, som är parotopen för en antikropp mot en fast tumör eller rabiesvirus. 15
2. Förfarande enligt patentkrav 1, kän netecknat därav, att de antiidiotypa antikropparna är monoklonala.
3. Förfarande enligt patentkrav 1, kännetecknat därav, att de antiidiotypa antikrop- 20 parna är polyklonala.
4. Förfarande enligt patentkrav 1, kännetecknat därav, att den odödliga B-lymfocyt, som skall användas, är en hybridom.
FI852683A 1983-11-07 1985-07-05 Immunologisk motverkan för tumörer och virus FI87734C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI894503A FI894503A (fi) 1983-11-07 1989-09-22 Immunologisk motverkan foer tumoerer och virus foer diagnostisk anvaendning.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US54950583A 1983-11-07 1983-11-07
US06/549,506 US4731237A (en) 1983-11-07 1983-11-07 Immune response to virus induced by anti-idiotype antibodies
US54950583 1983-11-07
US54950683 1983-11-07
EP8400334 1984-11-05
PCT/EP1984/000334 WO1985002121A1 (en) 1983-11-07 1984-11-05 Immune response to tumors and viruses induced by anti-idiotype antibodies

Publications (4)

Publication Number Publication Date
FI852683A0 FI852683A0 (fi) 1985-07-05
FI852683L FI852683L (fi) 1985-07-05
FI87734B true FI87734B (fi) 1992-11-13
FI87734C FI87734C (sv) 1993-02-25

Family

ID=27069155

Family Applications (1)

Application Number Title Priority Date Filing Date
FI852683A FI87734C (sv) 1983-11-07 1985-07-05 Immunologisk motverkan för tumörer och virus

Country Status (15)

Country Link
EP (2) EP0141783B2 (sv)
JP (1) JP2633807B2 (sv)
KR (1) KR910001127B1 (sv)
AT (1) ATE45285T1 (sv)
AU (1) AU596070B2 (sv)
DE (1) DE3479289D1 (sv)
DK (2) DK162056C (sv)
ES (1) ES8900226A1 (sv)
FI (1) FI87734C (sv)
HU (1) HU194497B (sv)
IL (1) IL73428A (sv)
MY (1) MY100952A (sv)
NZ (1) NZ210106A (sv)
PT (1) PT79455A (sv)
WO (1) WO1985002121A1 (sv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59116230A (ja) * 1982-11-29 1984-07-05 ベイロ−・カレツジ・オヴ・メデイスン ウイルス性感染因子に対する免疫応答を生起する抗−イデイオタイプ抗体
DE3486404T2 (de) * 1983-04-27 1996-02-01 President And Fellows Of Harvard College, Cambridge, Mass. Verfahren und produkte zur feststellung von menschlichem t-zellen-leukämie-virus.
WO1986000991A1 (en) * 1984-07-24 1986-02-13 Commonwealth Serum Laboratories Commission Method for determining mimotopes
WO1986006487A1 (en) * 1985-04-22 1986-11-06 Commonwealth Serum Laboratories Commission Method for determining mimotopes
NZ215865A (en) * 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
SE8601645D0 (sv) * 1986-04-11 1986-04-11 Ulf R Nilsson Immunologiskt forfarande
WO1988006040A1 (en) * 1987-02-20 1988-08-25 Imclone Systems, Inc. Monoclonal antibodies in vaccine formulations
AU662539B2 (en) * 1987-03-16 1995-09-07 Roland Keith Mcgready Anti-paratopic antibody as an immunogen
WO1988007058A1 (en) * 1987-03-16 1988-09-22 Biosolutions Pty. Ltd. Anti-paratopic antibody as an immunogen
EP0286405A3 (en) * 1987-04-08 1989-08-09 Synbiotics Corporation Method for the early selection of anti-idiotype-antibody internal images
US5217869A (en) * 1987-10-13 1993-06-08 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
HUT55143A (en) * 1987-10-13 1991-04-29 Terrapin Diagnostics Inc Method for obtaining immunodiagnostic reagents
US5227159A (en) * 1989-01-31 1993-07-13 Miller Richard A Anti-idiotype antibodies reactive with shared idiotopes expressed by B cell lymphomas and autoantibodies
US5493009A (en) * 1989-11-14 1996-02-20 New York Medical College Antiidiotypic monoclonal antibodies MK2-23 anti-melanomal antibody 763.74
EP0438803B1 (en) * 1990-01-26 1997-03-12 Immunomedics, Inc. Vaccines against cancer and infectious diseases
US5969109A (en) * 1990-02-28 1999-10-19 Bona; Constantin Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
EP0672253A4 (en) * 1992-01-29 1995-12-06 Sci Clone Inc MONOCLONAL ANTIBODIES AGAINST CARCINOMA ASSOCIATED ANTI-SKI, METHOD FOR THEIR PRODUCTION AND THEIR USE.
DK1225226T3 (da) * 1992-03-13 2008-04-14 Biomerieux Bv Peptider og nucleinsyresekvenser beslægtet med Epstein-Barr-virus
US6008327A (en) 1992-03-13 1999-12-28 Akzo Nobel, N.V. Peptides and nucleic acid sequences related to the Epstein Barr virus
EP0640131B1 (en) * 1992-03-17 1999-04-21 Novartis AG Genetically engineered antibodies
EP0672068A4 (en) * 1992-09-25 1997-02-26 Commw Scient Ind Res Org TARGET MOLECULES BINDING POLYPEPTIDES.
DE69530107T2 (de) 1994-12-28 2003-10-16 University Of Kentucky, Lexington Monoklonaler anti-idiotypischer antikörper 3h1 aus maus
US6949244B1 (en) 1995-12-20 2005-09-27 The Board Of Trustees Of The University Of Kentucky Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof
ATE208403T1 (de) * 1995-05-26 2001-11-15 Merck Patent Gmbh Antiidiotypische antikörper die eine immunantwort gegen den rezeptor für epidermalen wachstumsfaktor induzieren
GB9908533D0 (en) 1999-04-14 1999-06-09 Novartis Ag Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
JPS59116230A (ja) * 1982-11-29 1984-07-05 ベイロ−・カレツジ・オヴ・メデイスン ウイルス性感染因子に対する免疫応答を生起する抗−イデイオタイプ抗体
US4692416A (en) * 1982-12-03 1987-09-08 Yeshiva University Monoclonal antibodies reactive with shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus

Also Published As

Publication number Publication date
JP2633807B2 (ja) 1997-07-23
AU596070B2 (en) 1990-04-26
ES8900226A1 (es) 1989-04-16
DK310285A (da) 1985-07-05
DK7891D0 (da) 1991-01-16
EP0141783A2 (en) 1985-05-15
FI852683A0 (fi) 1985-07-05
MY100952A (en) 1991-06-15
DK162056B (da) 1991-09-09
FI87734C (sv) 1993-02-25
EP0141783B2 (en) 1993-06-16
ES537459A0 (es) 1989-04-16
HUT38841A (en) 1986-07-28
IL73428A0 (en) 1985-02-28
EP0291636A1 (en) 1988-11-23
FI852683L (fi) 1985-07-05
IL73428A (en) 1991-04-15
DE3479289D1 (en) 1989-09-14
WO1985002121A1 (en) 1985-05-23
AU3614384A (en) 1985-06-03
NZ210106A (en) 1990-05-28
EP0141783A3 (en) 1985-07-03
KR910001127B1 (ko) 1991-02-25
ATE45285T1 (de) 1989-08-15
DK310285D0 (da) 1985-07-05
DK7891A (da) 1991-01-16
PT79455A (en) 1984-12-01
JPH07194390A (ja) 1995-08-01
DK162605B (da) 1991-11-18
DK162056C (da) 1992-02-17
EP0141783B1 (en) 1989-08-09
KR850700111A (ko) 1985-10-25
HU194497B (en) 1988-02-29

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FG Patent granted

Owner name: SANDOZ AG

Owner name: THE WISTAR INSTITUTE