FI87734B - Immunologisk motverkan foer tumoerer och virus - Google Patents
Immunologisk motverkan foer tumoerer och virus Download PDFInfo
- Publication number
- FI87734B FI87734B FI852683A FI852683A FI87734B FI 87734 B FI87734 B FI 87734B FI 852683 A FI852683 A FI 852683A FI 852683 A FI852683 A FI 852683A FI 87734 B FI87734 B FI 87734B
- Authority
- FI
- Finland
- Prior art keywords
- antibody
- idiotypic
- antibodies
- mab
- serum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Claims (4)
1. Förfarande för framställning av terapeu-tiskt användbara antiidiotypa antikroppar, vilka är 5 avsedda att framkalla immunologisk moteffekt mot fasta tumörer eller rabiesvirus, kännetecknat därav, att vid förfarandet (a) antiidiotypa antikroppar framställs med hjälp av odödlig B-lymfocyt, eller (b) antikroppar mot en fast tumör eller rabiesvirus ges ät 10 en heterolog värd och de önskade antiidiotypa antikrop-parna isoleras och renas frän värdens serum; varvid de antiidiotypa antikropparna identifierar en epitop, som är parotopen för en antikropp mot en fast tumör eller rabiesvirus. 15
2. Förfarande enligt patentkrav 1, kän netecknat därav, att de antiidiotypa antikropparna är monoklonala.
3. Förfarande enligt patentkrav 1, kännetecknat därav, att de antiidiotypa antikrop- 20 parna är polyklonala.
4. Förfarande enligt patentkrav 1, kännetecknat därav, att den odödliga B-lymfocyt, som skall användas, är en hybridom.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI894503A FI894503A (fi) | 1983-11-07 | 1989-09-22 | Immunologisk motverkan foer tumoerer och virus foer diagnostisk anvaendning. |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54950583A | 1983-11-07 | 1983-11-07 | |
US06/549,506 US4731237A (en) | 1983-11-07 | 1983-11-07 | Immune response to virus induced by anti-idiotype antibodies |
US54950583 | 1983-11-07 | ||
US54950683 | 1983-11-07 | ||
EP8400334 | 1984-11-05 | ||
PCT/EP1984/000334 WO1985002121A1 (en) | 1983-11-07 | 1984-11-05 | Immune response to tumors and viruses induced by anti-idiotype antibodies |
Publications (4)
Publication Number | Publication Date |
---|---|
FI852683A0 FI852683A0 (fi) | 1985-07-05 |
FI852683L FI852683L (fi) | 1985-07-05 |
FI87734B true FI87734B (fi) | 1992-11-13 |
FI87734C FI87734C (sv) | 1993-02-25 |
Family
ID=27069155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI852683A FI87734C (sv) | 1983-11-07 | 1985-07-05 | Immunologisk motverkan för tumörer och virus |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP0141783B2 (sv) |
JP (1) | JP2633807B2 (sv) |
KR (1) | KR910001127B1 (sv) |
AT (1) | ATE45285T1 (sv) |
AU (1) | AU596070B2 (sv) |
DE (1) | DE3479289D1 (sv) |
DK (2) | DK162056C (sv) |
ES (1) | ES8900226A1 (sv) |
FI (1) | FI87734C (sv) |
HU (1) | HU194497B (sv) |
IL (1) | IL73428A (sv) |
MY (1) | MY100952A (sv) |
NZ (1) | NZ210106A (sv) |
PT (1) | PT79455A (sv) |
WO (1) | WO1985002121A1 (sv) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59116230A (ja) * | 1982-11-29 | 1984-07-05 | ベイロ−・カレツジ・オヴ・メデイスン | ウイルス性感染因子に対する免疫応答を生起する抗−イデイオタイプ抗体 |
DE3486404T2 (de) * | 1983-04-27 | 1996-02-01 | President And Fellows Of Harvard College, Cambridge, Mass. | Verfahren und produkte zur feststellung von menschlichem t-zellen-leukämie-virus. |
WO1986000991A1 (en) * | 1984-07-24 | 1986-02-13 | Commonwealth Serum Laboratories Commission | Method for determining mimotopes |
WO1986006487A1 (en) * | 1985-04-22 | 1986-11-06 | Commonwealth Serum Laboratories Commission | Method for determining mimotopes |
NZ215865A (en) * | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
SE8601645D0 (sv) * | 1986-04-11 | 1986-04-11 | Ulf R Nilsson | Immunologiskt forfarande |
WO1988006040A1 (en) * | 1987-02-20 | 1988-08-25 | Imclone Systems, Inc. | Monoclonal antibodies in vaccine formulations |
AU662539B2 (en) * | 1987-03-16 | 1995-09-07 | Roland Keith Mcgready | Anti-paratopic antibody as an immunogen |
WO1988007058A1 (en) * | 1987-03-16 | 1988-09-22 | Biosolutions Pty. Ltd. | Anti-paratopic antibody as an immunogen |
EP0286405A3 (en) * | 1987-04-08 | 1989-08-09 | Synbiotics Corporation | Method for the early selection of anti-idiotype-antibody internal images |
US5217869A (en) * | 1987-10-13 | 1993-06-08 | Terrapin Technologies, Inc. | Method to produce immunodiagnostic reagents |
HUT55143A (en) * | 1987-10-13 | 1991-04-29 | Terrapin Diagnostics Inc | Method for obtaining immunodiagnostic reagents |
US5227159A (en) * | 1989-01-31 | 1993-07-13 | Miller Richard A | Anti-idiotype antibodies reactive with shared idiotopes expressed by B cell lymphomas and autoantibodies |
US5493009A (en) * | 1989-11-14 | 1996-02-20 | New York Medical College | Antiidiotypic monoclonal antibodies MK2-23 anti-melanomal antibody 763.74 |
EP0438803B1 (en) * | 1990-01-26 | 1997-03-12 | Immunomedics, Inc. | Vaccines against cancer and infectious diseases |
US5969109A (en) * | 1990-02-28 | 1999-10-19 | Bona; Constantin | Chimeric antibodies comprising antigen binding sites and B and T cell epitopes |
EP0672253A4 (en) * | 1992-01-29 | 1995-12-06 | Sci Clone Inc | MONOCLONAL ANTIBODIES AGAINST CARCINOMA ASSOCIATED ANTI-SKI, METHOD FOR THEIR PRODUCTION AND THEIR USE. |
DK1225226T3 (da) * | 1992-03-13 | 2008-04-14 | Biomerieux Bv | Peptider og nucleinsyresekvenser beslægtet med Epstein-Barr-virus |
US6008327A (en) | 1992-03-13 | 1999-12-28 | Akzo Nobel, N.V. | Peptides and nucleic acid sequences related to the Epstein Barr virus |
EP0640131B1 (en) * | 1992-03-17 | 1999-04-21 | Novartis AG | Genetically engineered antibodies |
EP0672068A4 (en) * | 1992-09-25 | 1997-02-26 | Commw Scient Ind Res Org | TARGET MOLECULES BINDING POLYPEPTIDES. |
DE69530107T2 (de) | 1994-12-28 | 2003-10-16 | University Of Kentucky, Lexington | Monoklonaler anti-idiotypischer antikörper 3h1 aus maus |
US6949244B1 (en) | 1995-12-20 | 2005-09-27 | The Board Of Trustees Of The University Of Kentucky | Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof |
ATE208403T1 (de) * | 1995-05-26 | 2001-11-15 | Merck Patent Gmbh | Antiidiotypische antikörper die eine immunantwort gegen den rezeptor für epidermalen wachstumsfaktor induzieren |
GB9908533D0 (en) | 1999-04-14 | 1999-06-09 | Novartis Ag | Organic compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4285955A (en) * | 1978-10-31 | 1981-08-25 | Bayer Aktiengesellschaft | 1,4-Dihydropyridinecarboxylic acids |
JPS59116230A (ja) * | 1982-11-29 | 1984-07-05 | ベイロ−・カレツジ・オヴ・メデイスン | ウイルス性感染因子に対する免疫応答を生起する抗−イデイオタイプ抗体 |
US4692416A (en) * | 1982-12-03 | 1987-09-08 | Yeshiva University | Monoclonal antibodies reactive with shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus |
-
1984
- 1984-10-25 EP EP84810516A patent/EP0141783B2/en not_active Expired - Lifetime
- 1984-10-25 DE DE8484810516T patent/DE3479289D1/de not_active Expired
- 1984-10-25 AT AT84810516T patent/ATE45285T1/de not_active IP Right Cessation
- 1984-10-25 EP EP88102108A patent/EP0291636A1/en not_active Withdrawn
- 1984-11-05 AU AU36143/84A patent/AU596070B2/en not_active Expired
- 1984-11-05 KR KR1019850700115A patent/KR910001127B1/ko not_active IP Right Cessation
- 1984-11-05 HU HU8579A patent/HU194497B/hu not_active IP Right Cessation
- 1984-11-05 IL IL73428A patent/IL73428A/xx not_active IP Right Cessation
- 1984-11-05 NZ NZ210106A patent/NZ210106A/xx unknown
- 1984-11-05 WO PCT/EP1984/000334 patent/WO1985002121A1/en active IP Right Grant
- 1984-11-05 PT PT79455A patent/PT79455A/pt unknown
- 1984-11-07 ES ES537459A patent/ES8900226A1/es not_active Expired
-
1985
- 1985-07-05 DK DK310285A patent/DK162056C/da not_active IP Right Cessation
- 1985-07-05 FI FI852683A patent/FI87734C/sv active IP Right Grant
-
1987
- 1987-09-28 MY MYPI87001996A patent/MY100952A/en unknown
-
1991
- 1991-01-16 DK DK007891A patent/DK162605B/da not_active Application Discontinuation
-
1994
- 1994-05-31 JP JP6118065A patent/JP2633807B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2633807B2 (ja) | 1997-07-23 |
AU596070B2 (en) | 1990-04-26 |
ES8900226A1 (es) | 1989-04-16 |
DK310285A (da) | 1985-07-05 |
DK7891D0 (da) | 1991-01-16 |
EP0141783A2 (en) | 1985-05-15 |
FI852683A0 (fi) | 1985-07-05 |
MY100952A (en) | 1991-06-15 |
DK162056B (da) | 1991-09-09 |
FI87734C (sv) | 1993-02-25 |
EP0141783B2 (en) | 1993-06-16 |
ES537459A0 (es) | 1989-04-16 |
HUT38841A (en) | 1986-07-28 |
IL73428A0 (en) | 1985-02-28 |
EP0291636A1 (en) | 1988-11-23 |
FI852683L (fi) | 1985-07-05 |
IL73428A (en) | 1991-04-15 |
DE3479289D1 (en) | 1989-09-14 |
WO1985002121A1 (en) | 1985-05-23 |
AU3614384A (en) | 1985-06-03 |
NZ210106A (en) | 1990-05-28 |
EP0141783A3 (en) | 1985-07-03 |
KR910001127B1 (ko) | 1991-02-25 |
ATE45285T1 (de) | 1989-08-15 |
DK310285D0 (da) | 1985-07-05 |
DK7891A (da) | 1991-01-16 |
PT79455A (en) | 1984-12-01 |
JPH07194390A (ja) | 1995-08-01 |
DK162605B (da) | 1991-11-18 |
DK162056C (da) | 1992-02-17 |
EP0141783B1 (en) | 1989-08-09 |
KR850700111A (ko) | 1985-10-25 |
HU194497B (en) | 1988-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: SANDOZ AG Owner name: THE WISTAR INSTITUTE |