FI873364A - Foerfarande foer framstaellning av ett sytotoxiskt laekemedel. - Google Patents

Foerfarande foer framstaellning av ett sytotoxiskt laekemedel. Download PDF

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Publication number
FI873364A
FI873364A FI873364A FI873364A FI873364A FI 873364 A FI873364 A FI 873364A FI 873364 A FI873364 A FI 873364A FI 873364 A FI873364 A FI 873364A FI 873364 A FI873364 A FI 873364A
Authority
FI
Finland
Prior art keywords
sytotoxiskt
ett
foerfarande foer
foer framstaellning
pct
Prior art date
Application number
FI873364A
Other languages
English (en)
Finnish (fi)
Other versions
FI873364A0 (fi
Inventor
Hansjoerg Eibl
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Publication of FI873364A0 publication Critical patent/FI873364A0/fi
Publication of FI873364A publication Critical patent/FI873364A/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
FI873364A 1985-12-04 1987-08-03 Foerfarande foer framstaellning av ett sytotoxiskt laekemedel. FI873364A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3542893 1985-12-04
DE3606631 1986-02-28
PCT/EP1986/000706 WO1987003478A2 (fr) 1985-12-04 1986-12-04 Medicaments

Publications (2)

Publication Number Publication Date
FI873364A0 FI873364A0 (fi) 1987-08-03
FI873364A true FI873364A (fi) 1987-08-03

Family

ID=25838509

Family Applications (2)

Application Number Title Priority Date Filing Date
FI873364A FI873364A (fi) 1985-12-04 1987-08-03 Foerfarande foer framstaellning av ett sytotoxiskt laekemedel.
FI873363A FI873363A0 (fi) 1985-12-04 1987-08-03 Foerfarande foer framstaellning av laekemedel med antitumoeraktivitet.

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI873363A FI873363A0 (fi) 1985-12-04 1987-08-03 Foerfarande foer framstaellning av laekemedel med antitumoeraktivitet.

Country Status (15)

Country Link
US (2) US4837023A (no)
EP (4) EP0230575A3 (no)
JP (2) JPH0637393B2 (no)
AT (2) ATE75608T1 (no)
CA (2) CA1338627C (no)
DE (4) DE3679908D1 (no)
DK (2) DK172954B1 (no)
ES (2) ES2038215T3 (no)
FI (2) FI873364A (no)
GR (2) GR3002487T3 (no)
HU (2) HU203201B (no)
IE (2) IE59778B1 (no)
NO (2) NO174877C (no)
PT (2) PT83872B (no)
WO (2) WO1987003478A2 (no)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916884A (en) * 1985-12-04 1999-06-29 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing a mixture of phosphorus compounds and alkylglycerols
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
DK0412941T3 (da) * 1989-08-10 1996-06-24 Sandoz Ag Phospholipider til behandling af dissemineret sklerose
US5182271A (en) * 1989-08-10 1993-01-26 Sandoz Ltd. Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis
EP0916343A1 (de) * 1989-09-27 1999-05-19 ASTA Medica Aktiengesellschaft Verwendung von Alkylphosphorsäure-Verbindungen zur Bekämpfung von Psoriasis-Erkrankungen
US5290769A (en) * 1989-09-27 1994-03-01 Asta Pharma Aktiengesellschaft Use of hexadecylphosphocholine for the treatment of psoriasis
DE4111105A1 (de) * 1991-04-05 1992-10-08 Max Planck Gesellschaft Neue erucyl-, brassidyl- und nervonylderivate
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
US5506217A (en) * 1991-04-25 1996-04-09 The University Of British Columbia Phosphonates as anti-cancer agents
ATE158295T1 (de) * 1991-07-04 1997-10-15 Asta Medica Ag Verfahren zur herstellung von alkylphosphocholinen und reinherstellung derselben
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
US6254879B1 (en) 1991-09-27 2001-07-03 Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. Methods of treating protozoal diseases
DE4132344A1 (de) * 1991-09-27 1993-04-01 Max Planck Gesellschaft Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
DE4235911A1 (de) * 1992-10-23 1994-04-28 Asta Medica Ag Stabilisierte Hexadecylphosphocholinlösungen in Glycerinalkylethern
DE69431596T4 (de) * 1993-06-10 2003-10-30 University Of North Carolina At Chapel Hill, Chapel Hill (phospho)lipide zum bekämpfen einer hepatitis b-infektion
WO1995007089A1 (en) 1993-09-09 1995-03-16 Imutec Corporation Immunomodulating compositions from bile
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
DE69535758D1 (de) * 1994-08-29 2008-07-03 Univ Wake Forest Lipid-analoge zur behandlung von viralen infektionen
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
WO1996024598A1 (en) * 1995-02-10 1996-08-15 The University Of British Columbia [4-hexadecyl-3-methoxy-butyl] phosphonic acid and its protein conjugates useful as anti-cancer agents
CN1182368A (zh) 1995-03-16 1998-05-20 伊姆特克药物公司 来源于胆汁的治疗免疫系统紊乱的免疫调节组合物
KR100499190B1 (ko) * 1996-03-29 2006-04-17 교와 핫꼬 고교 가부시끼가이샤 육모제
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US6121245A (en) * 1997-01-29 2000-09-19 Firshein; Richard N. Method of treating cancer using alkylglycerols in conjunction with chemotherapy
SE9701912D0 (sv) * 1997-05-22 1997-05-22 Interhealth Ab Pharmaceutical composition and use thereof
US7582678B2 (en) * 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
NZ505648A (en) * 1998-01-22 2002-10-25 Zentaris Ag Hexadecylphosphocholine (HPC) and a flow controlling agent and/or a lubricant and a filler in a daily dosage of 10-250 mg
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
IL137672A0 (en) 2000-08-03 2001-10-31 Dpharm Ltd Derivatives of branched-chain lipophilic molecules and uses thereof
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
CN1486289A (zh) * 2001-05-29 2004-03-31 皇家菲利浦电子有限公司 金属-陶瓷的结合
IL160080A0 (en) * 2001-08-31 2004-06-20 Thomson Licensing Sa Sequence counter for an audio visual stream
WO2003090757A1 (en) * 2002-04-26 2003-11-06 Rudolf Perl Pharmaceutical compositions of phospholipid derivatives
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
EP1962862B1 (en) 2005-12-19 2013-09-04 Æterna Zentaris GmbH Alkyl phospholipid derivatives with reduced cytotoxicity and uses therof
US8637688B2 (en) * 2006-12-20 2014-01-28 Julia Diederichs Topical dosage form comprising tri-substituted glycerol compounds
JP2011057647A (ja) * 2009-09-14 2011-03-24 Adeka Corp 化粧料
BR112013033309B1 (pt) 2011-06-24 2022-07-05 Gri Bio, Inc Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i
CN102491994B (zh) * 2011-12-07 2014-10-15 宁波九胜创新医药科技有限公司 一种胆碱磷酸烷基酯的制备方法
CA3007970A1 (en) * 2014-12-09 2016-06-16 Gri Bio, Inc. Prevention and treatment of inflammatory conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds

Also Published As

Publication number Publication date
WO1987003478A2 (fr) 1987-06-18
EP0225608A2 (de) 1987-06-16
JPH0637393B2 (ja) 1994-05-18
DK398587D0 (da) 1987-07-30
HUT44441A (en) 1988-03-28
DE3679908D1 (de) 1991-07-25
ATE64529T1 (de) 1991-07-15
DK398587A (da) 1987-07-30
NO873244D0 (no) 1987-08-03
EP0248047A1 (de) 1987-12-09
EP0230575A2 (de) 1987-08-05
ES2038215T3 (es) 1993-07-16
EP0248062A1 (de) 1987-12-09
EP0230575A3 (de) 1987-12-02
GR3002487T3 (en) 1992-12-30
DK172954B1 (da) 1999-10-18
CA1280369C (en) 1991-02-19
US5049552A (en) 1991-09-17
IE863177L (en) 1987-06-04
NO174877B (no) 1994-04-18
FI873364A0 (fi) 1987-08-03
PT83872A (de) 1987-01-01
EP0248047B1 (de) 1991-06-19
EP0225608A3 (de) 1987-10-28
FI873363A (fi) 1987-08-03
JPH0859677A (ja) 1996-03-05
ES2032755T3 (es) 1993-03-01
WO1987003478A3 (fr) 1987-09-24
US4837023A (en) 1989-06-06
ATE75608T1 (de) 1992-05-15
GR3005168T3 (no) 1993-05-24
HUT44431A (en) 1988-03-28
PT83872B (pt) 1989-01-17
DK393187A (da) 1987-07-28
NO174877C (no) 1994-07-27
WO1987003480A2 (en) 1987-06-18
NO175620B (no) 1994-08-01
HU208143B (en) 1993-08-30
PT83873A (de) 1987-01-01
CA1338627C (en) 1996-10-01
PT83873B (pt) 1989-01-17
WO1987003480A3 (fr) 1988-02-25
NO873243L (no) 1987-10-02
DE3641379A1 (de) 1987-09-03
NO873244L (no) 1987-10-01
JPS63501719A (ja) 1988-07-14
DE3641491A1 (de) 1987-09-17
HU203201B (en) 1991-06-28
NO175620C (no) 1994-11-09
NO873243D0 (no) 1987-08-03
IE863176L (en) 1987-06-04
IE59778B1 (en) 1994-04-06
FI873363A0 (fi) 1987-08-03
IE59777B1 (en) 1994-04-06
DK393187D0 (da) 1987-07-28
DE19375061I2 (de) 2008-11-20
EP0248062B1 (de) 1992-05-06
JP2857084B2 (ja) 1999-02-10

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Legal Events

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Owner name: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENS