FI873162A0 - Foerfarande foer framstaellning av proteiner med faktor viii aktivitet med mikrobiala vaerdceller; expressionsvektorer, vaerdceller och antikroppar. - Google Patents

Foerfarande foer framstaellning av proteiner med faktor viii aktivitet med mikrobiala vaerdceller; expressionsvektorer, vaerdceller och antikroppar.

Info

Publication number
FI873162A0
FI873162A0 FI873162A FI873162A FI873162A0 FI 873162 A0 FI873162 A0 FI 873162A0 FI 873162 A FI873162 A FI 873162A FI 873162 A FI873162 A FI 873162A FI 873162 A0 FI873162 A0 FI 873162A0
Authority
FI
Finland
Prior art keywords
vaerdceller
expressionsvektorer
antikroppar
och
proteins
Prior art date
Application number
FI873162A
Other languages
English (en)
Other versions
FI873162A (fi
Inventor
Ooyen Albert Johannes Jose Van
Peter Michael Andreoli
Mourik Jan Aart Van
Hans Pannekoek
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868617594A external-priority patent/GB8617594D0/en
Priority claimed from GB868630699A external-priority patent/GB8630699D0/en
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of FI873162A0 publication Critical patent/FI873162A0/fi
Publication of FI873162A publication Critical patent/FI873162A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
FI873162A 1986-07-18 1987-07-17 Foerfarande foer framstaellning av proteiner med faktor viii aktivitet med mikrobiala vaerdceller; expressionsvektorer, vaerdceller och antikroppar. FI873162A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868617594A GB8617594D0 (en) 1986-07-18 1986-07-18 Preparation of biologically active proteins
GB868630699A GB8630699D0 (en) 1986-12-23 1986-12-23 Preparation of biologically active proteins

Publications (2)

Publication Number Publication Date
FI873162A0 true FI873162A0 (fi) 1987-07-17
FI873162A FI873162A (fi) 1988-01-19

Family

ID=26291059

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873162A FI873162A (fi) 1986-07-18 1987-07-17 Foerfarande foer framstaellning av proteiner med faktor viii aktivitet med mikrobiala vaerdceller; expressionsvektorer, vaerdceller och antikroppar.

Country Status (9)

Country Link
EP (1) EP0253455A1 (fi)
JP (1) JPS63313587A (fi)
AU (1) AU620315B2 (fi)
DK (1) DK374087A (fi)
FI (1) FI873162A (fi)
IL (1) IL83192A (fi)
NO (1) NO872932L (fi)
NZ (1) NZ221119A (fi)
PT (1) PT85349B (fi)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US5543145A (en) * 1984-09-17 1996-08-06 Baxter International, Inc. Pharmaceutical composition and method for the suppression of factor VIII inhibitor production
WO1986006096A1 (en) * 1985-04-11 1986-10-23 The Children's Medical Center Corporation Von willebrand factor
US5278066A (en) * 1985-08-09 1994-01-11 Gist-Brocades Nv Molecular cloning and expression of gene encoding lipolytic enzyme
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
FR2613379B2 (fr) * 1987-04-03 1990-04-06 Transgene Sa Procede de preparation de fragments du facteur viii a partir de cellules de mammiferes
IL84168A0 (en) * 1986-10-15 1988-03-31 Rorer Int Overseas Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same
US5830735A (en) * 1987-03-06 1998-11-03 Gist-Brocades Nv Method for producing lipolytic enzymes using transformed Pseudomonas
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
AU627150B2 (en) * 1987-06-12 1992-08-20 Immuno Ag Novel proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US5171844A (en) * 1987-06-12 1992-12-15 Gist-Brocades N.W. Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US6346513B1 (en) 1987-06-12 2002-02-12 Baxter Trading Gmbh Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
EP0294910B1 (en) * 1987-06-12 1996-09-11 Immuno Ag Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
FR2619314B1 (fr) * 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
GB2214508A (en) * 1988-01-27 1989-09-06 Bayer Ag Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences.
DK0410498T3 (da) * 1989-06-29 1999-03-22 Genencor Int Mutante mikrobielle alfa-amylaser med øget termisk, syre og/eller alkalisk stabilitet
CA2067158A1 (en) * 1989-09-14 1991-03-15 R. Alan Hardwick Method and useful apparatus for preparing pharmaceutical compositions
FR2657884B1 (fr) 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5661008A (en) * 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
SE468050C (sv) * 1991-03-15 1998-02-11 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
GB9907461D0 (en) 1999-03-31 1999-05-26 King S College London Neurite regeneration
CA2276091A1 (en) * 1996-12-27 1998-07-09 Mochida Pharmaceutical Co., Ltd. Cell membrane-directed drugs
US8372620B2 (en) 1998-12-23 2013-02-12 Dupont Nutrition Biosciences Aps Bacterial xylanases
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
SK288130B6 (sk) 2000-09-21 2013-10-02 Basf Aktiengesellschaft Xylanase polypeptide, a polynucleotide, a vector, a host cell, method of polypeptide production, method of use of polypeptide
ES2301579T3 (es) 2000-12-07 2008-07-01 Dsm Ip Assets B.V. Prolil endoproteasa a partir de aspergillus niger.
AU2002219709B2 (en) 2000-12-07 2007-06-14 Dsm Ip Assets B.V. Method for the prevention or reduction of haze in beverages
GB0116453D0 (en) 2001-07-05 2001-08-29 Imp College Innovations Ltd Method
US7220718B2 (en) 2001-08-03 2007-05-22 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Oral treatment of hemophilia
BR0311655A (pt) 2002-06-07 2005-03-15 Dsm Ip Assets Bv Método melhorado para a prevenção ou redução de turbidez em bebidas
TWI328612B (en) 2002-07-25 2010-08-11 Dsm Ip Assets Bv Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
GB0403864D0 (en) 2004-02-20 2004-03-24 Ucl Ventures Modulator
EP1707634A1 (en) 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
AU2006316397B2 (en) 2005-11-28 2013-03-28 Dsm Ip Assets B.V. Enzyme preparations yielding a clean taste
GB0600406D0 (en) 2006-01-10 2006-02-15 Univ Bath Crystal
BRPI0807768A2 (pt) 2007-02-20 2014-06-24 Dsm Ip Assests Bv Nova sialidase.
WO2008113799A1 (en) 2007-03-22 2008-09-25 Dsm Ip Assets B.V. Novel lysyl oxidases
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins
WO2011101339A2 (en) 2010-02-18 2011-08-25 Dsm Ip Assets B.V. Fermentation broth and filtration filter cake and uses thereof
WO2012007445A1 (en) 2010-07-13 2012-01-19 Dsm Ip Assets B.V. Mutarotase in crystallization
WO2012007446A1 (en) 2010-07-13 2012-01-19 Dsm Ip Assets B.V. Use of a mutarotase in the production of dried powders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0826078B2 (ja) * 1984-01-12 1996-03-13 カイロン コーポレイション フアクタ−ｖ▲ｉｉｉ▼ｃ組成物
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta

Also Published As

Publication number Publication date
PT85349B (pt) 1990-04-30
DK374087D0 (da) 1987-07-17
AU7575487A (en) 1988-01-21
PT85349A (en) 1987-08-01
AU620315B2 (en) 1992-02-20
FI873162A (fi) 1988-01-19
NO872932D0 (no) 1987-07-14
JPS63313587A (ja) 1988-12-21
NO872932L (no) 1988-01-19
IL83192A (en) 1992-11-15
EP0253455A1 (en) 1988-01-20
NZ221119A (en) 1990-08-28
DK374087A (da) 1988-01-19
IL83192A0 (en) 1987-12-31

Similar Documents

Publication Publication Date Title
FI873162A (fi) Foerfarande foer framstaellning av proteiner med faktor viii aktivitet med mikrobiala vaerdceller; expressionsvektorer, vaerdceller och antikroppar.
NO874530D0 (no) Fremgangsmaate for fremstilling av nor-statin- eller nor-cyklostatin-polypeptider.
FI875202A0 (fi) Steroider med en spiranring i 17-staellning, foerfarande foer framstaellning av dessa och anvaendning av dessa.
NO894786L (no) Fremgangsmaate for fremstilling av propenonoksimetere.
FI913476A0 (fi) Konjugatvacciner innehaollande immunogent protein, peptider av hiv-typ och anjoniska grupper.
FI872841A0 (fi) Nya kromoforfoereningar, solskyddskompositioner och foerfarande foer hindrande av solbraenna.
FI863993A0 (fi) Foerfarande foer maetning av egenskaper hos formbara material, saerskilt plastiska och reologiska egenskaper.
NO895160D0 (no) Mikrobiell fremgangsmaate for fremstilling av immunhemmende antibiotika.
FI874055A0 (fi) Protein med antikoagulanta och antimetastatiska egenskaper.
FI884036A0 (fi) Rekombinerade eukariotceller, vilka producerar interleukin-2, foerfarande och och vektorer foer deras framstaellning och foerfarande foer framstaellning av interleukin-2.
FI873243A0 (fi) Nya 1,4-benzodiazepiner, deras framstaellning och anvaendning.
FI893142A0 (fi) Nya aromoljor av minttyp, foerfarande foer framstaellning av desamma, och kompositioner innehaollande desamma.
FI904676A0 (fi) Anordning foer loesgoerande av manteln i en haeftapparat.
NO893794D0 (no) Fremgangsmaate for fremstilling av forbedret hydrolysert protein.
FI891257A (fi) Foerfarande och anordning foer framstaellning av marinbyggnadskonstruktioner, saosom bropelare, bryggor och liknande.
FI885174A0 (fi) Foerfarande och anordning foer sammanfogning av profilstycken.
NO911252D0 (no) Benzoksazinderivater, fremgangsmaate for fremstilling derav, samt anvendelse av derivatene.
FI880933A0 (fi) Foerfarande och anordning foer framstaellning av kombinationsblockstycken, saerskilt byggnadsblock foersedda med vaermeisolerande mellanskikt.
DE59004618D1 (de) Verfahren zur Herstellung von 2-Alkylthio-1,3,4-thiadiazolen.
DE68910012T4 (de) Herstellung von nichtporzellanartigen, keramischen Artikeln.
FI906324A0 (fi) Anordning och foerfarande foer foerkromning av artiklar.
FI873791A0 (fi) Anordning och foerfarande foer framstaellning av en kopparbaserad legering.
FI860533A0 (fi) Saett och anordning foer bearbetning av vaeggstockar i en byggnad.
NO158915C (no) Fremgangsmaate for konservering av fiskeraastoff.
NO893795L (no) Fremgangsmaate for fremstilling av forbedret hydrolysert protein.

Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: GIST-BROCADES N.V.