FI863121A - Indenanaloger av mevalonolaktoner och deras derivater. - Google Patents

Indenanaloger av mevalonolaktoner och deras derivater. Download PDF

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Publication number
FI863121A
FI863121A FI863121A FI863121A FI863121A FI 863121 A FI863121 A FI 863121A FI 863121 A FI863121 A FI 863121A FI 863121 A FI863121 A FI 863121A FI 863121 A FI863121 A FI 863121A
Authority
FI
Finland
Prior art keywords
6alkyl
hydrogen
3alkyl
benzyloxy
phenoxy
Prior art date
Application number
FI863121A
Other languages
English (en)
Finnish (fi)
Other versions
FI863121A0 (fi
Inventor
Faizulla G Kathawala
Sompong Wattanasin
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of FI863121A publication Critical patent/FI863121A/fi
Publication of FI863121A0 publication Critical patent/FI863121A0/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/57—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
FI863121A 1984-12-04 1986-07-30 Indenanaloger av mevalonolaktoner och deras derivater. FI863121A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67791784A 1984-12-04 1984-12-04
PCT/EP1985/000653 WO1986003488A1 (fr) 1984-12-04 1985-11-29 Analogues indenes de mevalonolactones et leurs derives

Publications (2)

Publication Number Publication Date
FI863121A true FI863121A (fi) 1986-07-30
FI863121A0 FI863121A0 (fi) 1986-07-30

Family

ID=24720627

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863121A FI863121A0 (fi) 1984-12-04 1986-07-30 Indenanaloger av mevalonolaktoner och deras derivater.

Country Status (19)

Country Link
EP (1) EP0216785B1 (fr)
JP (1) JPS62501009A (fr)
KR (1) KR910003427B1 (fr)
AT (1) ATE60571T1 (fr)
AU (1) AU599580B2 (fr)
DE (1) DE3581638D1 (fr)
DK (1) DK369086D0 (fr)
ES (1) ES8800888A1 (fr)
FI (1) FI863121A0 (fr)
GR (1) GR852895B (fr)
HU (1) HU198005B (fr)
IL (1) IL77199A (fr)
MY (1) MY100972A (fr)
NZ (1) NZ214402A (fr)
PH (1) PH24502A (fr)
PL (1) PL147645B1 (fr)
PT (1) PT81603B (fr)
WO (1) WO1986003488A1 (fr)
ZA (1) ZA859303B (fr)

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US4751235A (en) * 1986-12-23 1988-06-14 Sandoz Pharm. Corp. Anti-atherosclerotic indolizine derivatives
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US4904691A (en) * 1987-12-21 1990-02-27 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
US4876280A (en) * 1988-03-10 1989-10-24 Sandoz Pharm. Corp. Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
EP0363934B1 (fr) * 1988-10-13 1993-12-29 Sandoz Ag Procédé pour la préparation des acides hept-6-énoiques et heptanoiques substitués sur la position 7 et dérivés
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
US5025017A (en) * 1989-09-28 1991-06-18 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
US5189180A (en) * 1989-09-28 1993-02-23 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
JPH03173882A (ja) * 1989-09-29 1991-07-29 Tanabe Seiyaku Co Ltd クロメン又はチオクロメン誘導体、その製法及びその合成中間体
WO1992019239A1 (fr) * 1991-05-01 1992-11-12 University Of New Mexico Traitement d'etats cellulaires aberrants a l'aide de biomodulateurs
WO1992019240A1 (fr) * 1991-05-01 1992-11-12 University Of New Mexico Traitement d'aberrations cellulaires avec des biomodulateurs
US5256692A (en) * 1992-01-07 1993-10-26 E. R. Squibb & Sons, Inc. Sulfur-containing HMG-COA reductase inhibitors
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
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Also Published As

Publication number Publication date
PH24502A (en) 1990-07-18
PT81603A (en) 1986-01-01
AU5230686A (en) 1986-07-01
JPS62501009A (ja) 1987-04-23
NZ214402A (en) 1989-01-27
DE3581638D1 (de) 1991-03-07
PL256608A1 (en) 1988-01-07
IL77199A (en) 1990-02-09
AU599580B2 (en) 1990-07-26
DK369086A (da) 1986-08-01
ATE60571T1 (de) 1991-02-15
KR910003427B1 (ko) 1991-05-31
EP0216785B1 (fr) 1991-01-30
HU198005B (en) 1989-07-28
DK369086D0 (da) 1986-08-01
EP0216785A1 (fr) 1987-04-08
WO1986003488A1 (fr) 1986-06-19
GR852895B (fr) 1986-04-01
MY100972A (en) 1991-06-15
ES8800888A1 (es) 1987-12-01
ZA859303B (en) 1987-07-29
PL147645B1 (en) 1989-07-31
HUT40398A (en) 1986-12-28
ES549546A0 (es) 1987-12-01
PT81603B (pt) 1988-04-21
KR870700063A (ko) 1987-02-28
FI863121A0 (fi) 1986-07-30

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