FI83877C - Förfarande för framställning av en ny terapeutiskt användbar 7-(3-klor isoxazol-5-yl)-acetamido-3-(1-metyl-1H-1,2,3,4-tetrazol-5-yl)-tiometyl -cef-3-em-4-karboxylsyra - Google Patents
Förfarande för framställning av en ny terapeutiskt användbar 7-(3-klor isoxazol-5-yl)-acetamido-3-(1-metyl-1H-1,2,3,4-tetrazol-5-yl)-tiometyl -cef-3-em-4-karboxylsyra Download PDFInfo
- Publication number
- FI83877C FI83877C FI862965A FI862965A FI83877C FI 83877 C FI83877 C FI 83877C FI 862965 A FI862965 A FI 862965A FI 862965 A FI862965 A FI 862965A FI 83877 C FI83877 C FI 83877C
- Authority
- FI
- Finland
- Prior art keywords
- methyl
- tetrazol
- acetamido
- formula
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
1. Förfarande för framställning av en ny terapeutiskt användbar 7-(3-klorisoxazol-5-yl)-acetamido-3-(1-metyl-lH- l,2,3,4-tetrazol-5-yl)-tiometyl-cef-3-em-4-karboxylsyra med formeln I C1V“\ \ /“ CH2_C0 N N—-N 0 ) ° fOOH \N/ , . in3 och farmaceutiskt lämpliga sait därav, känneteck-n a t av att a) man omsätter en 3-klorisoxazolättiksyra med formel II ‘M. cf \ / 2 (li) No eller ett reaktivt derivat därav med en 7-amino-3-(1-metyl-1H-1,2,3,4-tetrazol-5-yl)tlometyl-cef-3-em-4-karboxylsyra med formeln III S hoWi—n—n / ) COOH I ^111^ ch3 och isolerar den sälunda erhällna 7-(3-klorisoxazol-5-yl)-acetamido-3-(1-metyl-lH-l,2,3,4-tetrazol-5-yl)tiometyl-cef- 3-em-4-karboxylsyran med formeln I frän reaktionsblandningen i7 83877 pä i och för sig känt sätt och, om sä önskas, överför den-samma tili ett farmakologiskt lämpligt sait därav medelst i och för sig kända metoder och isolerar saltet frän reak-tionsblandingen pä i och för sig känt sätt, eller b) man omsätter 1-metyl-lH-l,2,3,4-tetrazol-5-yl-tiol med formeln IV O n' , , , (IV) CH3 med 7-(3-klorisoxazol-5-yl)acetamido-cefalosporinsyra och isolerar den sälunda erhällna 7-( 3-klorisoxazol-5-yl)acet-amido-3-(1-metyl-lH-l,2,3,4-tetrazol-5-yl)tiometyl-cef-3-em-4-karboxylsyran pä i och för sig känt sätt och, om sä önskas, överför densamma tili ett farmakologiskt lämpligt sait därav medelst i och för sig kända metoder och isolerar saltet frän reaktionsblandningen pä i och för sig känt sätt.
2. Förfarande enligt patentkrav l, alternativ a), kännetecknat av att säsom reaktivt derivat av 3-klorisoxazolättiksyran med formel II används dess klorid eller pentaklorfenylester.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU272585 | 1985-07-16 | ||
HU852725A HU203243B (en) | 1985-07-16 | 1985-07-16 | Process for producing cefalosporin derivative |
Publications (4)
Publication Number | Publication Date |
---|---|
FI862965A0 FI862965A0 (fi) | 1986-07-16 |
FI862965A FI862965A (fi) | 1987-01-17 |
FI83877B FI83877B (fi) | 1991-05-31 |
FI83877C true FI83877C (sv) | 1991-09-10 |
Family
ID=10960853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI862965A FI83877C (sv) | 1985-07-16 | 1986-07-16 | Förfarande för framställning av en ny terapeutiskt användbar 7-(3-klor isoxazol-5-yl)-acetamido-3-(1-metyl-1H-1,2,3,4-tetrazol-5-yl)-tiometyl -cef-3-em-4-karboxylsyra |
Country Status (14)
Country | Link |
---|---|
JP (1) | JPS6222787A (sv) |
KR (1) | KR930007263B1 (sv) |
CN (1) | CN1012614B (sv) |
AT (1) | AT389877B (sv) |
BE (1) | BE905113A (sv) |
DE (1) | DE3623900A1 (sv) |
FI (1) | FI83877C (sv) |
FR (1) | FR2591598B1 (sv) |
GB (1) | GB2177696B (sv) |
GR (1) | GR861855B (sv) |
HU (1) | HU203243B (sv) |
IL (1) | IL79410A0 (sv) |
IT (1) | IT1196494B (sv) |
NL (1) | NL8601842A (sv) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2012729C (en) | 1989-04-07 | 1997-05-20 | Takashi Kuroda | Dulled stretched molding and process for producing the same |
JP2893286B2 (ja) * | 1990-05-17 | 1999-05-17 | グンゼ株式会社 | 熱収縮性発泡複合フィルム及びその製法 |
JP2515295Y2 (ja) * | 1993-06-30 | 1996-10-30 | 株式会社川崎製作所 | 管継手 |
KR100408343B1 (ko) * | 2001-11-01 | 2003-12-06 | 주식회사 이앤티 | 자돈의 항상성(Homeostasis)을 유지시킬 수 있는 사료 및그 제조방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2219775A1 (en) * | 1973-03-02 | 1974-09-27 | Gist Brocades Nv | Isoxazolylacetamido penicillanic and cephalosporanic acids - partic. active against Gram-positive bacteria |
JPS539787A (en) * | 1976-07-16 | 1978-01-28 | Yamanouchi Pharmaceut Co Ltd | Novel cephalosporin derivatives and their preparation |
-
1985
- 1985-07-16 HU HU852725A patent/HU203243B/hu unknown
-
1986
- 1986-07-15 BE BE0/216927A patent/BE905113A/fr not_active IP Right Cessation
- 1986-07-15 GB GB08617181A patent/GB2177696B/en not_active Expired
- 1986-07-15 JP JP61166540A patent/JPS6222787A/ja active Pending
- 1986-07-15 IT IT21135/86A patent/IT1196494B/it active
- 1986-07-15 NL NL8601842A patent/NL8601842A/nl not_active Application Discontinuation
- 1986-07-15 FR FR868610264A patent/FR2591598B1/fr not_active Expired - Lifetime
- 1986-07-15 DE DE3623900A patent/DE3623900A1/de not_active Ceased
- 1986-07-15 IL IL79410A patent/IL79410A0/xx not_active IP Right Cessation
- 1986-07-15 KR KR1019860005723A patent/KR930007263B1/ko not_active IP Right Cessation
- 1986-07-15 AT AT0192686A patent/AT389877B/de active
- 1986-07-16 FI FI862965A patent/FI83877C/sv not_active IP Right Cessation
- 1986-07-16 CN CN86104805A patent/CN1012614B/zh not_active Expired
- 1986-07-16 GR GR861855A patent/GR861855B/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI83877B (fi) | 1991-05-31 |
HUT48890A (en) | 1989-07-28 |
GR861855B (en) | 1986-11-18 |
GB2177696A (en) | 1987-01-28 |
IL79410A0 (en) | 1986-10-31 |
FI862965A0 (fi) | 1986-07-16 |
NL8601842A (nl) | 1987-02-16 |
HU203243B (en) | 1991-06-28 |
ATA192686A (de) | 1989-07-15 |
KR930007263B1 (ko) | 1993-08-04 |
FR2591598B1 (fr) | 1990-01-26 |
DE3623900A1 (de) | 1987-01-29 |
IT1196494B (it) | 1988-11-16 |
BE905113A (fr) | 1986-11-03 |
CN86104805A (zh) | 1987-02-18 |
GB8617181D0 (en) | 1986-08-20 |
IT8621135A0 (it) | 1986-07-15 |
AT389877B (de) | 1990-02-12 |
CN1012614B (zh) | 1991-05-15 |
JPS6222787A (ja) | 1987-01-30 |
KR870001219A (ko) | 1987-03-12 |
FR2591598A1 (fr) | 1987-06-19 |
FI862965A (fi) | 1987-01-17 |
GB2177696B (en) | 1989-01-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: BIOGAL GYOGYSZERGYAR RT. |