FI80450B - Foerfarande foer framstaellning av n-/2-//5-/(dimetylamino)metyl/-2-furanylmetyl/-tio/etyl/-n'metyl-2- nitro-1,1-etendiamin. - Google Patents

Foerfarande foer framstaellning av n-/2-//5-/(dimetylamino)metyl/-2-furanylmetyl/-tio/etyl/-n'metyl-2- nitro-1,1-etendiamin. Download PDF

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Publication number
FI80450B
FI80450B FI810039A FI810039A FI80450B FI 80450 B FI80450 B FI 80450B FI 810039 A FI810039 A FI 810039A FI 810039 A FI810039 A FI 810039A FI 80450 B FI80450 B FI 80450B
Authority
FI
Finland
Prior art keywords
methyl
formula
dimethylamino
nitro
iii
Prior art date
Application number
FI810039A
Other languages
English (en)
Finnish (fi)
Other versions
FI810039L (fi
FI80450C (sv
Inventor
John Watson Clitherow
John Bradshaw
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI810039L publication Critical patent/FI810039L/fi
Priority to FI894014A priority Critical patent/FI84059C/sv
Application granted granted Critical
Publication of FI80450B publication Critical patent/FI80450B/fi
Publication of FI80450C publication Critical patent/FI80450C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/12—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (4)

1. Förfarande för framställning av N-[2-[[5-[(dimetylamino)-metyl]-2-furanylmetyl]-tio]etyl]-N'-metyl-2-nitro-l,1-eten-diamin enligt den allmänna formeln (I) /\ /\ »HN02 Me2NCH2 O CH2SCH2CH2NHCNHMe (I) kännetecknat därav, att en tiol enligt formeln (II) Me2NCH2 N0 CH2SH (II) omsätts med ett alkyleringsmedel enligt formeln (III) CH2 ^ chno2 1 ^ » N-CNHMe (III) CH2
2. Förfarandet enligt patentkravet 1, kännetecknat därav, att tiolen enligt formeln (II) bildas in situ ur syra-additionssalt.
3. N-metyl-a-(nitromety1 en)-1-atsiridin-metanamin, med formeln (III) CH2 _ CHN02
1. H I N-CNHMe (III) CH2
FI810039A 1980-01-08 1981-01-08 Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/-tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin FI80450C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI894014A FI84059C (sv) 1980-01-08 1989-08-28 Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8000580 1980-01-08
GB8000581 1980-01-08
GB8000580 1980-01-08
GB8000581 1980-01-08
GB8039336 1980-12-08
GB8039336 1980-12-08

Publications (3)

Publication Number Publication Date
FI810039L FI810039L (fi) 1981-07-09
FI80450B true FI80450B (fi) 1990-02-28
FI80450C FI80450C (sv) 1990-06-11

Family

ID=27260837

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810039A FI80450C (sv) 1980-01-08 1981-01-08 Förfarande för framställning av N-/2-//5-/(dimetylamino)metyl/-2-furan ylmetyl/-tio/etyl/-N'-metyl-2-nitro-1,1-etendiamin

Country Status (14)

Country Link
JP (1) JPH02167259A (sv)
AR (1) AR225940A1 (sv)
AT (1) AT376966B (sv)
CH (1) CH650257A5 (sv)
DE (1) DE3100364A1 (sv)
DK (1) DK157865C (sv)
ES (1) ES498389A0 (sv)
FI (1) FI80450C (sv)
FR (1) FR2473044A1 (sv)
HU (1) HU182272B (sv)
NL (1) NL8100068A (sv)
PT (1) PT72320B (sv)
SE (2) SE449747B (sv)
YU (1) YU42372B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
YU42819B (en) * 1982-11-22 1988-12-31 Lek Tovarna Farmacevtskih Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
IL56265A (en) 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor
NO784350L (no) * 1977-12-30 1979-07-03 Crc Ricerca Chim Fremgangsmaate til alkylering av 4(5)-merkaptometyl-imidazoler med aziridinderivater
ZA792608B (en) * 1978-05-30 1980-06-25 Smith Kline French Lab Nitro compounds
NO811501L (no) * 1980-05-13 1981-11-16 Crc Ricerca Chim Fremgangsmaate ved fremstilling av etendiaminderivater, samt mellomprodukter for disse

Also Published As

Publication number Publication date
CH650257A5 (fr) 1985-07-15
SE8502780L (sv) 1985-06-05
JPH0346465B2 (sv) 1991-07-16
SE449747B (sv) 1987-05-18
FI810039L (fi) 1981-07-09
PT72320B (en) 1982-07-23
SE8502780D0 (sv) 1985-06-05
YU42372B (en) 1988-08-31
DE3100364A1 (de) 1981-11-19
FI80450C (sv) 1990-06-11
FR2473044A1 (fr) 1981-07-10
NL8100068A (nl) 1981-08-03
SE8100074L (sv) 1981-07-09
AT376966B (de) 1985-01-25
DE3100364C2 (sv) 1989-12-28
SE460604B (sv) 1989-10-30
DK157865B (da) 1990-02-26
DK157865C (da) 1990-07-30
AR225940A1 (es) 1982-05-14
ES8200673A1 (es) 1981-11-16
HU182272B (en) 1983-12-28
JPH02167259A (ja) 1990-06-27
PT72320A (en) 1981-02-01
ATA3781A (de) 1984-06-15
DK7181A (da) 1981-07-09
YU2781A (en) 1983-06-30
FR2473044B1 (sv) 1984-04-13
ES498389A0 (es) 1981-11-16

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Owner name: GLAXO GROUP LIMITED