FI803397L - Nya klor- och alkoxisubstituerade 2,4-diaminokinazoliner - Google Patents

Nya klor- och alkoxisubstituerade 2,4-diaminokinazoliner

Info

Publication number
FI803397L
FI803397L FI803397A FI803397A FI803397L FI 803397 L FI803397 L FI 803397L FI 803397 A FI803397 A FI 803397A FI 803397 A FI803397 A FI 803397A FI 803397 L FI803397 L FI 803397L
Authority
FI
Finland
Prior art keywords
chloroch
diaminoquinazoline
nya
alcoxy
substitutes
Prior art date
Application number
FI803397A
Other languages
English (en)
Other versions
FI77455B (fi
FI77455C (fi
Inventor
Hans-Jurgen Ernst Hess
Jasjit Singh Bindra
Praful Keshav Shah
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI803397L publication Critical patent/FI803397L/fi
Publication of FI77455B publication Critical patent/FI77455B/fi
Application granted granted Critical
Publication of FI77455C publication Critical patent/FI77455C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI803397A 1979-11-01 1980-10-30 Foerfarande foer framstaellning av antihypertensiva 2,4-diaminokinazolinfoereningar. FI77455C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9031379A 1979-11-01 1979-11-01
US9031379 1979-11-01
US12683880 1980-03-03
US06/126,838 US4287341A (en) 1979-11-01 1980-03-03 Alkoxy-substituted-6-chloro-quinazoline-2,4-diones

Publications (3)

Publication Number Publication Date
FI803397L true FI803397L (fi) 1981-05-02
FI77455B FI77455B (fi) 1988-11-30
FI77455C FI77455C (fi) 1989-03-10

Family

ID=26782146

Family Applications (1)

Application Number Title Priority Date Filing Date
FI803397A FI77455C (fi) 1979-11-01 1980-10-30 Foerfarande foer framstaellning av antihypertensiva 2,4-diaminokinazolinfoereningar.

Country Status (15)

Country Link
US (1) US4287341A (fi)
EP (1) EP0028473B1 (fi)
AR (1) AR227650A1 (fi)
AU (1) AU520344B2 (fi)
CA (1) CA1146546A (fi)
DE (1) DE3069944D1 (fi)
DK (1) DK153399C (fi)
ES (5) ES496442A0 (fi)
FI (1) FI77455C (fi)
GR (1) GR70728B (fi)
IE (1) IE50366B1 (fi)
IL (1) IL61375A (fi)
PH (3) PH17552A (fi)
PT (1) PT72007B (fi)
YU (1) YU41745B (fi)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607034A (en) * 1979-10-29 1986-08-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinazoline derivatives and pharmaceutical composition thereof
US4426382A (en) 1980-02-13 1984-01-17 Sankyo Company Limited 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
US4351832A (en) * 1980-04-18 1982-09-28 American Home Products Corporation 2-(Piperazinyl)-4-pyrimidinamines
FI70411C (fi) 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat
ES515338A0 (es) * 1981-09-09 1983-11-01 Orion Yhtymae Oy "metodo para la preparacion de piperidinilquinazolidinas substituidas".
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
CH651027A5 (de) * 1982-11-12 1985-08-30 Sandoz Ag Heterocyclische verbindungen, ihre herstellung und verwendung.
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
US4933460A (en) * 1983-08-22 1990-06-12 Hoechst-Roussel Pharmaceuticals Inc. Piperdine substituted phenyl hydrazones
US4634769A (en) * 1984-09-25 1987-01-06 Ortho Pharmaceutical Corporation Process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their salts
FR2582513B1 (fr) * 1985-05-28 1988-08-05 Synthelabo Compositions pharmaceutiques contenant de l'alfuzosine
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
US4668787A (en) * 1985-12-20 1987-05-26 Ortho Pharmaceutical Corporation 5,6-dialkoxy-4-imino-2(1H)quinazolinone derivatives
US4672116A (en) * 1985-12-20 1987-06-09 Ortho Pharmaceutical Corporation Substituted 5,6-dialkoxyquinazoline derivatives
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
EP0360936A1 (de) * 1988-09-29 1990-04-04 Siemens Aktiengesellschaft Österreich Verfahren zur Wandlung des Abtastsignals eines analogen Eingangssignals
EP0367888A1 (en) * 1988-11-08 1990-05-16 ISTITUTO LUSO FARMACO D'ITALIA S.p.A. 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity
GB8910722D0 (en) * 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
ES2074867T3 (es) * 1990-11-06 1995-09-16 Pfizer Derivados de quinazolina para potenciar la actividad antitumoral.
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
IL108630A0 (en) * 1993-02-18 1994-05-30 Fmc Corp Insecticidal substituted 2,4-diaminoquinazolines
DE4429978A1 (de) * 1994-08-24 1996-02-29 Bayer Ag Verfahren zur Herstellung von Chinazolin-2,4-dionen
US5747490A (en) * 1995-09-29 1998-05-05 Merck & Co., Inc. Alpha 1b adrenergic receptor antagonists
AU7692996A (en) * 1995-12-01 1997-06-27 Ciba-Geigy Ag Receptor antagonists
CA2173408C (en) * 1996-04-03 2001-09-04 K.S. Keshava Murthy Process for the manufacture of intermediates suitable to make doxazosin,terazosin, prazosin, tiodazosin and related antihypertensive medicines
IT1286302B1 (it) * 1996-04-10 1998-07-08 Rotta Research Lab Chinazoline-4-amino-2-(piperidino-1-il-4-sostituite) ad attivita' anti-ipertensiva, procedimento per la loro preparazione e loro uso
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
DZ3415A1 (fr) * 2000-08-31 2002-03-07 Chiron Corp Guanidinobenzamides comme mc4-r agonistes.
DE60216747T2 (de) * 2001-04-09 2007-10-04 Novartis Vaccines and Diagnostics, Inc., Emeryville Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten
EP1487474A4 (en) * 2002-02-25 2006-11-29 Chiron Corp INTRANASAL ADMINISTRATION OF MC4-R AGONISTS
US7034033B2 (en) * 2002-05-23 2006-04-25 Chiron Corporation Substituted quinazolinone compounds
EP1539754A4 (en) 2002-08-23 2009-02-25 Novartis Vaccines & Diagnostic BENZIMIDAZOLE QUINOLINONES AND USES THEREOF
ES2312843T3 (es) 2002-09-30 2009-03-01 Bayer Healthcare Ag Derivados de azolpirimidina condensados.
US6608200B1 (en) * 2002-10-07 2003-08-19 Council Of Scientific & Industrial Research Process for the preparation of N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine
JP2007501861A (ja) * 2003-05-23 2007-02-01 カイロン コーポレイション Ｍｃ４−ｒアゴニストとしてのグアニジノ置換キナゾリノン化合物
EP1692085A4 (en) 2003-11-07 2010-10-13 Novartis Vaccines & Diagnostic INHIBITION OF FGFR3 AND TREATMENT OF MULTIPLE MYELOMA
KR20060105785A (ko) * 2003-11-19 2006-10-11 카이론 코포레이션 감소된 생체축적을 갖는 퀴나졸리논 화합물
BRPI0518229A (pt) * 2004-10-27 2008-11-04 Daiichi Sankyo Co Ltd composto de benzeno tendo 2 ou mais substituintes
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
WO2012068096A2 (en) 2010-11-15 2012-05-24 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use
CN113105350B (zh) * 2021-04-06 2023-11-24 利尔化学股份有限公司 制备2-氨基-3-烷基-5-氯苯甲酸的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1117130B (de) * 1959-10-14 1961-11-16 Basf Ag Verfahren zur Herstellung von 2, 4-Dihydroxychinazolinen
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
DE2027645A1 (de) * 1970-06-05 1971-12-09 Byk Gulden Lomberg Chemische Fa bnk GmbH, 7750 Konstanz Piperazinylalkyl chinazolon (4) den vate, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel
GB1334633A (en) * 1972-04-07 1973-10-24 Parke Davis & Co Quinazoline compounds and methods for their production
JPS536156B2 (fi) * 1972-10-30 1978-03-04
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4001238A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company 1,3,4-oxadiazole amides
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
US4102885A (en) * 1977-06-20 1978-07-25 Bristol-Myers Company Process for preparing 2,4-dihaloquinazolines
US4098788A (en) * 1977-06-20 1978-07-04 Bristol-Myers Company Process for preparing quinazolines

Also Published As

Publication number Publication date
FI77455B (fi) 1988-11-30
ES8202334A1 (es) 1982-01-16
AU520344B2 (en) 1982-01-28
ES507041A0 (es) 1983-02-01
ES496442A0 (es) 1982-01-16
DK153399B (da) 1988-07-11
ES8400415A1 (es) 1983-10-16
PH17552A (en) 1984-09-20
US4287341A (en) 1981-09-01
DK153399C (da) 1988-12-19
IL61375A (en) 1986-09-30
IE802258L (en) 1981-05-01
PT72007B (en) 1981-08-31
AU6389680A (en) 1981-05-07
YU277580A (en) 1983-06-30
EP0028473A1 (en) 1981-05-13
GR70728B (fi) 1983-01-24
ES507042A0 (es) 1982-08-16
EP0028473B1 (en) 1985-01-09
PH18321A (en) 1985-05-29
PH20061A (en) 1986-09-18
DE3069944D1 (en) 1985-02-21
ES8206491A1 (es) 1982-08-16
IE50366B1 (en) 1986-04-02
DK462380A (da) 1981-05-02
ES516286A0 (es) 1983-10-16
YU41745B (en) 1987-12-31
PT72007A (en) 1980-11-01
CA1146546A (en) 1983-05-17
IL61375A0 (en) 1980-12-31
FI77455C (fi) 1989-03-10
AR227650A1 (es) 1982-11-30
ES507043A0 (es) 1982-10-01
ES8303360A1 (es) 1983-02-01
ES8207520A1 (es) 1982-10-01

Similar Documents

Publication Publication Date Title
FI803397L (fi) Nya klor- och alkoxisubstituerade 2,4-diaminokinazoliner
FI782607A (fi) Nya 3,4,5-trihydroxipiperidinderivat foerfarande foer deras framstaellning och deras anvaendning
NO803848L (no) Krystallinsk, 4,1`,6`-triklor-4,1`,6`-trideoksygalaktosukrose
FI791084A (fi) Nya n-heterocyklo-4-piperidinaminer
FI791754A (fi) Nya aminotiazoler
DK537780A (da) 1,8-naphthyridin-derivater
FI792567A (fi) Nya spiro-oxazolidinoner
FI802506A (fi) Anti-inflammatoriska 5-substituerade 2,3-diaryltiofener
DK3881A (da) Substituerede 9,10-anthracen-bishydrazoner
FI803579L (fi) Nya 6alfa 9alfa-difluor-16-metyl-prednisolon 17,21-diestrar
FI801618A (fi) Foerfarande foer framstaellning av nya penicillansyraderivat
FI800298A (fi) Foerfarande foer framstaellning av nya antracyklina derivater
SE8008339L (sv) 24,24-difluoro-1alfa,25-dihydroxikolekalciferol
FI803403L (fi) Nya pyridotienotriaziner
SE7907312L (sv) Nya 1,2-dioxialkylenbensenderivat
IT1151077B (it) 24,24-difluoro-25-idrossicolecalciferolo
FI803727L (fi) 2,3-indolidionderivat
FI791424A (fi) Substituerade 8-hydroxi-1-fenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar
SE7908480L (sv) Nya 2,6-diaminonebularinderivat
SE7909023L (sv) Nya azolylketaler
FI811421L (fi) Nya substituerade pyrazinyl-1,2,4-oxadiazoler och foerfarande foer deras framstaellning
FI781339A (fi) Nya 3,5-disubstituerade 1h-1,2,4-triazoler
FI791210A (fi) Nya benzodioxolderivat
FI782340A (fi) Nya dibenso(d,g)(1,3,6)dioxazocinderivat foerfarande foer deras framstaellning och laekemedelspreparat innehaollande dessa
FI801473A (fi) Framstaellningsfoerfarande foer 5-merkapto-1,2,3-triazoler

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: PFIZER INC.