PT72007B - Process for preparing novel chloro- and alkoxy-substituted-2,4-diaminoquinazolines - Google Patents

Process for preparing novel chloro- and alkoxy-substituted-2,4-diaminoquinazolines

Info

Publication number
PT72007B
PT72007B PT72007A PT7200780A PT72007B PT 72007 B PT72007 B PT 72007B PT 72007 A PT72007 A PT 72007A PT 7200780 A PT7200780 A PT 7200780A PT 72007 B PT72007 B PT 72007B
Authority
PT
Portugal
Prior art keywords
diaminoquinazolines
alkoxy
substituted
preparing novel
novel chloro
Prior art date
Application number
PT72007A
Other languages
Portuguese (pt)
Other versions
PT72007A (en
Inventor
Hans-Jurgen Ernst Hess
Jasjit Singh Bindra
Praful Keshav Shah
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT72007A publication Critical patent/PT72007A/en
Publication of PT72007B publication Critical patent/PT72007B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
PT72007A 1979-11-01 1980-10-31 Process for preparing novel chloro- and alkoxy-substituted-2,4-diaminoquinazolines PT72007B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9031379A 1979-11-01 1979-11-01
US06/126,838 US4287341A (en) 1979-11-01 1980-03-03 Alkoxy-substituted-6-chloro-quinazoline-2,4-diones

Publications (2)

Publication Number Publication Date
PT72007A PT72007A (en) 1980-11-01
PT72007B true PT72007B (en) 1981-08-31

Family

ID=26782146

Family Applications (1)

Application Number Title Priority Date Filing Date
PT72007A PT72007B (en) 1979-11-01 1980-10-31 Process for preparing novel chloro- and alkoxy-substituted-2,4-diaminoquinazolines

Country Status (15)

Country Link
US (1) US4287341A (en)
EP (1) EP0028473B1 (en)
AR (1) AR227650A1 (en)
AU (1) AU520344B2 (en)
CA (1) CA1146546A (en)
DE (1) DE3069944D1 (en)
DK (1) DK153399C (en)
ES (5) ES8202334A1 (en)
FI (1) FI77455C (en)
GR (1) GR70728B (en)
IE (1) IE50366B1 (en)
IL (1) IL61375A (en)
PH (3) PH17552A (en)
PT (1) PT72007B (en)
YU (1) YU41745B (en)

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US4351832A (en) * 1980-04-18 1982-09-28 American Home Products Corporation 2-(Piperazinyl)-4-pyrimidinamines
FI70411C (en) 1980-12-29 1986-09-19 Pfizer FORM OF ANTHYPERTENSIVE 4-AMINO-6,7-DIMETOXY-2-PIPERAZINOQUINAZOLE DERIVATIVES
ES515338A0 (en) * 1981-09-09 1983-11-01 Orion Yhtymae Oy "METHOD FOR THE PREPARATION OF SUBSTITUTED PIPERIDINYLQUINAZOLIDINES".
GR79603B (en) * 1982-07-24 1984-10-31 Pfizer
CH651027A5 (en) * 1982-11-12 1985-08-30 Sandoz Ag HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE.
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
US4933460A (en) * 1983-08-22 1990-06-12 Hoechst-Roussel Pharmaceuticals Inc. Piperdine substituted phenyl hydrazones
US4634769A (en) * 1984-09-25 1987-01-06 Ortho Pharmaceutical Corporation Process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their salts
FR2582513B1 (en) * 1985-05-28 1988-08-05 Synthelabo PHARMACEUTICAL COMPOSITIONS CONTAINING ALFUZOSINE
AT384218B (en) * 1985-12-04 1987-10-12 Gerot Pharmazeutika METHOD FOR PRODUCING NEW CHINAZOLINE DERIVATIVES
US4668787A (en) * 1985-12-20 1987-05-26 Ortho Pharmaceutical Corporation 5,6-dialkoxy-4-imino-2(1H)quinazolinone derivatives
US4672116A (en) * 1985-12-20 1987-06-09 Ortho Pharmaceutical Corporation Substituted 5,6-dialkoxyquinazoline derivatives
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
EP0360936A1 (en) * 1988-09-29 1990-04-04 Siemens Aktiengesellschaft Österreich Method for the conversion of a sampled analog input signal
EP0367888A1 (en) * 1988-11-08 1990-05-16 ISTITUTO LUSO FARMACO D'ITALIA S.p.A. 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB8910722D0 (en) * 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
JPH05507290A (en) * 1990-11-06 1993-10-21 フアイザー・インコーポレイテツド Quinazoline derivatives for enhanced antitumor activity
PT100905A (en) * 1991-09-30 1994-02-28 Eisai Co Ltd BICYCLE HYGIENEOUS HETEROCYCLIC COMPOUNDS CONTAINING BENZENE, CYCLOHEXAN OR PYRIDINE AND PYRIMIDINE, PYRIDINE OR IMIDAZOLE SUBSTITUTES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
IL108630A0 (en) * 1993-02-18 1994-05-30 Fmc Corp Insecticidal substituted 2,4-diaminoquinazolines
DE4429978A1 (en) * 1994-08-24 1996-02-29 Bayer Ag Process for the preparation of quinazoline-2,4-diones
US5747490A (en) * 1995-09-29 1998-05-05 Merck & Co., Inc. Alpha 1b adrenergic receptor antagonists
AU7692996A (en) * 1995-12-01 1997-06-27 Ciba-Geigy Ag Receptor antagonists
CA2173408C (en) * 1996-04-03 2001-09-04 K.S. Keshava Murthy Process for the manufacture of intermediates suitable to make doxazosin,terazosin, prazosin, tiodazosin and related antihypertensive medicines
IT1286302B1 (en) * 1996-04-10 1998-07-08 Rotta Research Lab CHINAZOLINE-4-AMINO-2- (PIPERIDINO-1-IL-4-SUBSTITUTED) WITH ANTI-HYPERTENSIVE ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND USE
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
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EP1551834B1 (en) * 2002-05-23 2010-08-25 Novartis Vaccines and Diagnostics, Inc. Substituted quinazolinone compounds
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US6608200B1 (en) * 2002-10-07 2003-08-19 Council Of Scientific & Industrial Research Process for the preparation of N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine
JP2007501861A (en) * 2003-05-23 2007-02-01 カイロン コーポレイション Guanidino-substituted quinazolinone compounds as MC4-R agonists
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EP1806332A4 (en) * 2004-10-27 2010-03-31 Daiichi Sankyo Co Ltd Benzene compound having 2 or more substituents
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
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GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use
CN113105350B (en) * 2021-04-06 2023-11-24 利尔化学股份有限公司 Process for preparing 2-amino-3-alkyl-5-chlorobenzoic acid

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US4098788A (en) * 1977-06-20 1978-07-04 Bristol-Myers Company Process for preparing quinazolines

Also Published As

Publication number Publication date
AU520344B2 (en) 1982-01-28
US4287341A (en) 1981-09-01
YU277580A (en) 1983-06-30
FI803397L (en) 1981-05-02
IL61375A0 (en) 1980-12-31
DK462380A (en) 1981-05-02
ES496442A0 (en) 1982-01-16
PH20061A (en) 1986-09-18
EP0028473A1 (en) 1981-05-13
CA1146546A (en) 1983-05-17
ES8202334A1 (en) 1982-01-16
DK153399B (en) 1988-07-11
GR70728B (en) 1983-01-24
YU41745B (en) 1987-12-31
ES8400415A1 (en) 1983-10-16
FI77455C (en) 1989-03-10
PT72007A (en) 1980-11-01
ES507042A0 (en) 1982-08-16
PH17552A (en) 1984-09-20
AU6389680A (en) 1981-05-07
ES507041A0 (en) 1983-02-01
PH18321A (en) 1985-05-29
ES507043A0 (en) 1982-10-01
ES8303360A1 (en) 1983-02-01
ES8207520A1 (en) 1982-10-01
IL61375A (en) 1986-09-30
ES516286A0 (en) 1983-10-16
DK153399C (en) 1988-12-19
IE802258L (en) 1981-05-01
IE50366B1 (en) 1986-04-02
EP0028473B1 (en) 1985-01-09
AR227650A1 (en) 1982-11-30
DE3069944D1 (en) 1985-02-21
FI77455B (en) 1988-11-30
ES8206491A1 (en) 1982-08-16

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