FI80276C - Mot denaturering skyddade vattenloesningar av proteiner, foerfarande foer deras framstaellning och deras anvaendning. - Google Patents

Mot denaturering skyddade vattenloesningar av proteiner, foerfarande foer deras framstaellning och deras anvaendning. Download PDF

Info

Publication number
FI80276C
FI80276C FI842798A FI842798A FI80276C FI 80276 C FI80276 C FI 80276C FI 842798 A FI842798 A FI 842798A FI 842798 A FI842798 A FI 842798A FI 80276 C FI80276 C FI 80276C
Authority
FI
Finland
Prior art keywords
proteins
protein
solution
formula
aqueous solution
Prior art date
Application number
FI842798A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI842798A7 (fi
FI842798A0 (fi
FI80276B (fi
Inventor
Horst Thurow
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI842798A0 publication Critical patent/FI842798A0/fi
Publication of FI842798A7 publication Critical patent/FI842798A7/fi
Application granted granted Critical
Publication of FI80276B publication Critical patent/FI80276B/fi
Publication of FI80276C publication Critical patent/FI80276C/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41Porphyrin- or corrin-ring-containing peptides
    • A61K38/42Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
FI842798A 1983-07-13 1984-07-11 Mot denaturering skyddade vattenloesningar av proteiner, foerfarande foer deras framstaellning och deras anvaendning. FI80276C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3325223 1983-07-13
DE19833325223 DE3325223A1 (de) 1983-07-13 1983-07-13 Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung

Publications (4)

Publication Number Publication Date
FI842798A0 FI842798A0 (fi) 1984-07-11
FI842798A7 FI842798A7 (fi) 1985-01-14
FI80276B FI80276B (fi) 1990-01-31
FI80276C true FI80276C (fi) 1990-05-10

Family

ID=6203842

Family Applications (1)

Application Number Title Priority Date Filing Date
FI842798A FI80276C (fi) 1983-07-13 1984-07-11 Mot denaturering skyddade vattenloesningar av proteiner, foerfarande foer deras framstaellning och deras anvaendning.

Country Status (15)

Country Link
US (1) US4637834A (OSRAM)
EP (1) EP0131864B1 (OSRAM)
JP (1) JPS6038398A (OSRAM)
KR (1) KR920002934B1 (OSRAM)
AT (1) ATE56876T1 (OSRAM)
AU (1) AU579106B2 (OSRAM)
DE (2) DE3325223A1 (OSRAM)
DK (1) DK168030B1 (OSRAM)
ES (2) ES8600319A1 (OSRAM)
FI (1) FI80276C (OSRAM)
GR (1) GR81504B (OSRAM)
IE (1) IE57694B1 (OSRAM)
IL (1) IL72389A (OSRAM)
PT (1) PT78892A (OSRAM)
ZA (1) ZA845384B (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0018609B1 (de) * 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
JPS61277633A (ja) * 1985-05-31 1986-12-08 Toray Ind Inc インタ−フエロン組成物
US5183746A (en) * 1986-10-27 1993-02-02 Schering Aktiengesellschaft Formulation processes for pharmaceutical compositions of recombinant β-
US4956274A (en) * 1987-04-06 1990-09-11 Microgenics Corporation Reagent stabilization in enzyme-donor and acceptor assay
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
US5981485A (en) * 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
AU4278393A (en) * 1992-04-07 1993-11-08 Mallinckrodt Veterinary, Inc. Lyophilized somatotropin formulations
IL106524A (en) * 1992-07-31 2000-08-31 Genentech Inc Human growth hormone aqueous formulation
US6790439B1 (en) 1995-06-07 2004-09-14 Zymogenetics, Inc. Thrombopoietin compositions
DK1602667T3 (da) 1995-06-07 2007-07-23 Novartis Vaccines & Diagnostic Vandig formulering omfattende TFPI og solubiliseringsmidler
MX9602398A (es) * 1995-06-23 1997-02-28 Kimberly Clark Co Material polimerico modificado teniendo humectabilidad mejorada.
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
BR0013162A (pt) * 1999-07-12 2002-05-28 Grandis Biotech Gmbh Formulações de hormÈnio de crescimento
US20060165733A1 (en) * 2002-07-09 2006-07-27 Michael Betz Liquid formulations with high concentration of hunan growth hormone (hgh) comprising phenol
EP1654283B1 (en) * 2003-08-13 2011-07-13 Novartis Vaccines and Diagnostics, Inc. Improved method of purifying tfpi and tfpi analogs
MXPA06011029A (es) 2004-04-07 2007-01-25 Ares Trading Sa Formulacion liquida de hormona del crecimiento.
EP1847830A1 (en) * 2006-04-20 2007-10-24 TF Instruments, Inc. Determining optimal concentrations of protective additives for biomolecules
WO2024133849A1 (en) * 2022-12-22 2024-06-27 The Protein Brewery B.V. Ovalbumin fermentation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439355A (en) * 1976-12-02 1984-03-27 Colgate-Palmolive Company Elastic detergent product of improved foaming power after use
EP0018609B1 (de) * 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DE2917535C2 (de) * 1979-04-30 1986-10-30 Hoechst Ag, 6230 Frankfurt Gegen Denaturierung beständige Insulinlösungen
JPS58501125A (ja) * 1981-07-17 1983-07-14 ノルデイスク・インスリンラボラトリウム 安定な水性治療性インシユリン製剤及びその製造方法

Also Published As

Publication number Publication date
ES534195A0 (es) 1985-10-01
ZA845384B (en) 1985-02-27
ES8600319A1 (es) 1985-10-01
EP0131864A2 (de) 1985-01-23
JPH0582397B2 (OSRAM) 1993-11-18
IE57694B1 (en) 1993-03-10
DK168030B1 (da) 1994-01-24
GR81504B (OSRAM) 1984-12-11
ES535482A0 (es) 1986-09-01
IL72389A (en) 1988-11-30
DE3325223A1 (de) 1985-01-24
FI842798A7 (fi) 1985-01-14
EP0131864B1 (de) 1990-09-26
KR850000971A (ko) 1985-03-14
DK342684D0 (da) 1984-07-12
KR920002934B1 (ko) 1992-04-10
EP0131864A3 (en) 1987-08-26
ATE56876T1 (de) 1990-10-15
PT78892A (de) 1984-08-01
FI842798A0 (fi) 1984-07-11
AU579106B2 (en) 1988-11-17
DE3483287D1 (de) 1990-10-31
FI80276B (fi) 1990-01-31
ES8609361A1 (es) 1986-09-01
IL72389A0 (en) 1984-11-30
US4637834A (en) 1987-01-20
AU3053784A (en) 1985-01-17
DK342684A (da) 1985-01-14
JPS6038398A (ja) 1985-02-27
IE841796L (en) 1985-01-13

Similar Documents

Publication Publication Date Title
FI80276C (fi) Mot denaturering skyddade vattenloesningar av proteiner, foerfarande foer deras framstaellning och deras anvaendning.
US4783441A (en) Aqueous protein solutions stable to denaturation
US4885164A (en) Aqueous protein solutions stable to denaturation
FI80595C (fi) Foerfarande foer framstaellning av en vattenhaltig insulinloesning som aer fysikaliskt stabiliserad mot graensytepolymerisation.
JP6894493B2 (ja) 遊離チオール部分を有するタンパク質の安定化された組成物
CA1330301C (en) Stabilised human protein preparations
CN1130223C (zh) 包含生长激素,氨基酸和非离子去污剂的药物配方
Costantino et al. Aggregation of a lyophilized pharmaceutical protein, recombinant human albumin: effect of moisture and stabilization by excipients
EP1308170B1 (en) Dried blood factor composition comprising trehalose
KR100231398B1 (ko) 응고인자 viii 활성을 지닌 안정화된 액제
KR0184027B1 (ko) 재구성된 지방단백질의 제조방법
WO2000051629A1 (en) Preparations stabilized over long time
JP2007045841A (ja) ヒト成長ホルモン水性製剤
EP0787497A2 (en) Pharmaceutical preparation containing human growth hormone
CN1264569C (zh) 无蛋白制剂
CN1089249C (zh) 生物适合的生长激素溶液
CA1293941C (en) Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product
KR900004799B1 (ko) 안정한 감마 인터페론 제제 및 이의 제조방법
Akers et al. Peptides and proteins as parenteral solutions
KR880002037B1 (ko) 인터페론 조성물 및 이의 제조방법
EP3849519B1 (en) A composition comprising a protein and a polyalkoxy fatty acyl surfactant
CZ302750B6 (cs) Farmaceutická kompozice a ampulka na bázi erythropoietinu a zpusob inhibování mikrobiálního rustu v roztoku obsahujícím tuto látku
JPH0118920B2 (OSRAM)
WO2016046101A1 (en) Stable, benzyl alcohol-free aqueous solution formulations containing alpha-type interferon
WO2004045645A2 (en) A bacteriophage preparation of enhanced stability by application of a block copolymer of ethylene oxide and propylene oxide

Legal Events

Date Code Title Description
MA Patent expired

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH