FI79836B - Foerfarande foer framstaellning av en farmaceutiskt aktiv n,n-di-n-propyl-4-hydroxi-3-metansulfonamidofenetylamin - Google Patents
Foerfarande foer framstaellning av en farmaceutiskt aktiv n,n-di-n-propyl-4-hydroxi-3-metansulfonamidofenetylamin Download PDFInfo
- Publication number
- FI79836B FI79836B FI844818A FI844818A FI79836B FI 79836 B FI79836 B FI 79836B FI 844818 A FI844818 A FI 844818A FI 844818 A FI844818 A FI 844818A FI 79836 B FI79836 B FI 79836B
- Authority
- FI
- Finland
- Prior art keywords
- propyl
- ether
- compound
- acid
- methanesulfonamidophenethylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (5)
1. Förfarande för framställning av en farmaceutiskt aktiv N,N-di-n-propyl-4-hydroxi-3-metansulfonamidofenetylamin eller ett farmaceutiskt acceptabelt sait därav, k ä n -netecknat av att en förening med formeln CH2CH2N(n-C3H-7 )2 Λ NHS02CH3 OR väri R är en möjligen substituerad Ci_6-alkyl, omsättes med ett eter-avspaltande medel och den erhällna produkten överföres möjligen tili ett farmaceutiskt acceptabelt sait pä i och för sig känt sätt.
2. Förfarande enligt patentkravet 1, känne-tecknatav att R är metyl och att man som eter-avspaltande medel använder bortribromid i metylenklorid.
3. Förfarande enligt patentkravet 1, känne- t e c k n a t av att R är bensyl och att man som eter-avspaltande medel använder katalytisk hydrering med en ädelmetallkatalysator.
4. Förfarande enligt patentkravet 1, k ä n netecknat av att den erhällna N,N-di-n-propyl-4-hydro-xi-3-metansulfonamidofenetylaminen omsättes med ett övers-kott av saltsyra för bildande av klorvätesaltet.
5. Förfarande enligt patentkravet 1, känne-tecknat av att den erhällna N,N-di-n-propyl-4-hydro-xi-3-metansulfonamidofenetylaminen omsättes med ett övers-kott av metansulfonsyra för bildande av metansulfonatsaltet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55915183 | 1983-12-07 | ||
| US06/559,151 US4507320A (en) | 1983-12-07 | 1983-12-07 | Dopaminergic agonist N,N-di-n-propyl-4-hydroxy-3-methanesulfonamidophenethylamine |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI844818A0 FI844818A0 (fi) | 1984-12-05 |
| FI844818L FI844818L (fi) | 1985-06-08 |
| FI79836B true FI79836B (fi) | 1989-11-30 |
| FI79836C FI79836C (sv) | 1990-03-12 |
Family
ID=24232466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI844818A FI79836C (sv) | 1983-12-07 | 1984-12-05 | Förfarande för framställning av en farmaceutiskt aktiv N,N-di-n-propyl -4-hydroxi-3-metansulfonamidofenetylamin |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4507320A (sv) |
| EP (1) | EP0147114B1 (sv) |
| JP (1) | JPS60139664A (sv) |
| KR (1) | KR850004586A (sv) |
| AR (1) | AR240555A1 (sv) |
| AT (1) | ATE26702T1 (sv) |
| AU (1) | AU565667B2 (sv) |
| CA (1) | CA1212959A (sv) |
| DE (1) | DE3463265D1 (sv) |
| DK (1) | DK550384A (sv) |
| EG (1) | EG16694A (sv) |
| ES (2) | ES8604497A1 (sv) |
| FI (1) | FI79836C (sv) |
| GR (1) | GR81145B (sv) |
| HU (1) | HU193722B (sv) |
| IL (1) | IL73471A (sv) |
| NO (1) | NO159998C (sv) |
| NZ (1) | NZ210053A (sv) |
| PH (1) | PH21807A (sv) |
| PT (1) | PT79618B (sv) |
| ZA (1) | ZA849459B (sv) |
| ZW (1) | ZW18784A1 (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155268A (en) * | 1984-05-04 | 1992-10-13 | The Upjohn Company | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides |
| US4629730A (en) * | 1985-04-11 | 1986-12-16 | Syntex (U.S.A.) Inc. | Method for treating intraocular hypertension |
| ES8606847A1 (es) * | 1984-11-08 | 1986-05-16 | Syntex Inc | Procedimiento para la preparacion de derivados de dialquila-mino-etilanilina antihipertensos |
| US4642378A (en) * | 1985-04-11 | 1987-02-10 | Syntex (U.S.A.) Inc. | Arylalkyl amines useful for lowering intraocular pressure |
| US4847269A (en) * | 1985-04-11 | 1989-07-11 | Syntex (U.S.A.) Inc. | Method for treating intraocular hypertension |
| US4752621A (en) * | 1985-04-11 | 1988-06-21 | Syntex (U.S.A.) Inc. | Arylalkyl amines useful for lowering intraocular pressure |
| US5405997A (en) * | 1989-07-25 | 1995-04-11 | The Upjohn Company | Antiarrhythmic methanesulfonamides |
| JP3312629B2 (ja) * | 1991-01-23 | 2002-08-12 | 日産化学工業株式会社 | アニリン誘導体及び製法 |
| FR2724654B1 (fr) * | 1994-09-16 | 1997-12-12 | Roussel Uclaf | Nouveaux derives de l'acide gallique, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| US5874475A (en) * | 1995-12-21 | 1999-02-23 | Pharmacia & Upjohn Company | Antiarrhythmic (S)-enantiomers of methanesulfonamides |
| DE19842796A1 (de) * | 1998-09-18 | 2000-03-30 | Atochem Elf Deutschland | Radikalbildner und Phlegmatisierungsmittel enthaltende Zusammensetzungen, Verwendungen und Verfahren zur Herstellung solcher Zusammensetzungen |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR148F (sv) * | 1962-01-24 | |||
| US3701808A (en) * | 1967-12-21 | 1972-10-31 | Allen & Hanburys Ltd | Phenylethanolamines |
| US3574741A (en) * | 1969-04-14 | 1971-04-13 | Mead Johnson & Co | Sulfonamidophenalkylamines |
| US3758692A (en) * | 1969-04-14 | 1973-09-11 | Mead Johnson & Co | Ylamines sympathomimetic process and compositions employing sulfonamidophenalk |
| BE757005A (fr) * | 1969-10-02 | 1971-04-02 | Bristol Myers Co | Phenethanolamines substituees et procede pour leur preparation |
| US3801631A (en) * | 1972-02-16 | 1974-04-02 | Mead Johnson & Co | 2'-hydroxy-5'-(1-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl)meth-anesulfonanilide and its salts |
| US4219568A (en) * | 1978-03-01 | 1980-08-26 | University Patents, Inc. | Method of increasing renal blood flow with dopamine derivatives |
| US4404224A (en) * | 1981-12-02 | 1983-09-13 | American Cyanamid Company | Alkanesulfonanilide derivatives and pharmaceutically acceptable acid addition salts thereof for increasing the growth rate and/or improving the lean meat to fat ratio of warm blooded animals |
-
1983
- 1983-12-07 US US06/559,151 patent/US4507320A/en not_active Expired - Fee Related
-
1984
- 1984-10-31 CA CA000466693A patent/CA1212959A/en not_active Expired
- 1984-10-31 NZ NZ210053A patent/NZ210053A/en unknown
- 1984-11-09 IL IL73471A patent/IL73471A/xx unknown
- 1984-11-12 AU AU35324/84A patent/AU565667B2/en not_active Ceased
- 1984-11-19 ZW ZW187/84A patent/ZW18784A1/xx unknown
- 1984-11-20 DK DK550384A patent/DK550384A/da not_active Application Discontinuation
- 1984-11-26 PH PH31485A patent/PH21807A/en unknown
- 1984-12-03 GR GR81145A patent/GR81145B/el unknown
- 1984-12-04 EG EG742/84A patent/EG16694A/xx active
- 1984-12-05 ZA ZA849459A patent/ZA849459B/xx unknown
- 1984-12-05 FI FI844818A patent/FI79836C/sv not_active IP Right Cessation
- 1984-12-05 AR AR29883984A patent/AR240555A1/es active
- 1984-12-05 PT PT79618A patent/PT79618B/pt unknown
- 1984-12-06 ES ES538319A patent/ES8604497A1/es not_active Expired
- 1984-12-06 NO NO844895A patent/NO159998C/no unknown
- 1984-12-06 HU HU844540A patent/HU193722B/hu not_active IP Right Cessation
- 1984-12-06 JP JP59259025A patent/JPS60139664A/ja active Pending
- 1984-12-06 KR KR1019840007700A patent/KR850004586A/ko not_active Application Discontinuation
- 1984-12-07 AT AT84308533T patent/ATE26702T1/de not_active IP Right Cessation
- 1984-12-07 EP EP84308533A patent/EP0147114B1/en not_active Expired
- 1984-12-07 DE DE8484308533T patent/DE3463265D1/de not_active Expired
-
1985
- 1985-10-22 ES ES548109A patent/ES8606853A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO159998C (no) | 1989-03-01 |
| AR240555A1 (es) | 1990-05-31 |
| DK550384A (da) | 1985-06-08 |
| FI844818A0 (fi) | 1984-12-05 |
| HU193722B (en) | 1987-11-30 |
| PH21807A (en) | 1988-02-29 |
| NO159998B (no) | 1988-11-21 |
| EP0147114A1 (en) | 1985-07-03 |
| DK550384D0 (da) | 1984-11-20 |
| ATE26702T1 (de) | 1987-05-15 |
| US4507320A (en) | 1985-03-26 |
| NO844895L (no) | 1985-06-10 |
| AU565667B2 (en) | 1987-09-24 |
| NZ210053A (en) | 1987-06-30 |
| JPS60139664A (ja) | 1985-07-24 |
| HUT37744A (en) | 1986-02-28 |
| ZA849459B (en) | 1986-04-30 |
| KR850004586A (ko) | 1985-07-25 |
| FI844818L (fi) | 1985-06-08 |
| ES8606853A1 (es) | 1986-05-01 |
| FI79836C (sv) | 1990-03-12 |
| ES548109A0 (es) | 1986-05-01 |
| EG16694A (en) | 1988-09-30 |
| PT79618A (en) | 1985-01-01 |
| ZW18784A1 (en) | 1985-02-20 |
| GR81145B (en) | 1985-04-04 |
| DE3463265D1 (de) | 1987-05-27 |
| ES8604497A1 (es) | 1986-02-01 |
| ES538319A0 (es) | 1986-02-01 |
| EP0147114B1 (en) | 1987-04-22 |
| PT79618B (en) | 1986-11-18 |
| IL73471A0 (en) | 1985-02-28 |
| IL73471A (en) | 1987-12-20 |
| CA1212959A (en) | 1986-10-21 |
| AU3532484A (en) | 1985-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SMITHKLINE BECKMAN CORPORATION |