FI79097C - Foerfarande foer framstaellning av farmaceutiskt aktiva 5-oxo-2-pyrrolidin-propansyra-derivat. - Google Patents
Foerfarande foer framstaellning av farmaceutiskt aktiva 5-oxo-2-pyrrolidin-propansyra-derivat. Download PDFInfo
- Publication number
- FI79097C FI79097C FI831794A FI831794A FI79097C FI 79097 C FI79097 C FI 79097C FI 831794 A FI831794 A FI 831794A FI 831794 A FI831794 A FI 831794A FI 79097 C FI79097 C FI 79097C
- Authority
- FI
- Finland
- Prior art keywords
- oxo
- acid
- preparation
- formula
- pyrrolidinepropanoic
- Prior art date
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- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- DAZXVJBJRMWXJP-UHFFFAOYSA-N n,n-dimethylethylamine Chemical compound CCN(C)C DAZXVJBJRMWXJP-UHFFFAOYSA-N 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000001477 organic nitrogen group Chemical group 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical compound OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- DRDCQJADRSJFFD-UHFFFAOYSA-N tris-hydroxymethyl-methyl-ammonium Chemical compound OC[N+](C)(CO)CO DRDCQJADRSJFFD-UHFFFAOYSA-N 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38166282A | 1982-05-24 | 1982-05-24 | |
| US38166282 | 1982-05-24 | ||
| US06/476,524 US4559358A (en) | 1982-05-24 | 1983-03-24 | 5-Oxo-2-pyrrolidinepropanoic acid and derivatives for reversing electroshock amnesia |
| US47652483 | 1983-03-24 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI831794A0 FI831794A0 (fi) | 1983-05-20 |
| FI831794L FI831794L (fi) | 1983-11-25 |
| FI79097B FI79097B (fi) | 1989-07-31 |
| FI79097C true FI79097C (fi) | 1989-11-10 |
Family
ID=27009474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI831794A FI79097C (fi) | 1982-05-24 | 1983-05-20 | Foerfarande foer framstaellning av farmaceutiskt aktiva 5-oxo-2-pyrrolidin-propansyra-derivat. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4559358A (es) |
| EP (1) | EP0095278B1 (es) |
| KR (1) | KR870000742B1 (es) |
| AU (1) | AU563605B2 (es) |
| CA (1) | CA1240329A (es) |
| DE (1) | DE3378577D1 (es) |
| DK (1) | DK228583A (es) |
| ES (1) | ES8407021A1 (es) |
| FI (1) | FI79097C (es) |
| GR (1) | GR79263B (es) |
| HU (1) | HU189688B (es) |
| IL (1) | IL68520A (es) |
| NO (1) | NO159588C (es) |
| NZ (1) | NZ204320A (es) |
| PH (1) | PH18562A (es) |
| PT (1) | PT76746B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677114A (en) * | 1985-11-22 | 1987-06-30 | Warner-Lambert Company | Pyrrolidone-2 derivatives and pharmaceutical compositions thereof |
| DE3718563A1 (de) * | 1987-06-03 | 1988-12-15 | Basf Ag | Verfahren zur herstellung von substituierten lactamen |
| AT391692B (de) * | 1989-04-24 | 1990-11-12 | Fleischhacker Wilhelm Dr | Enantiomerenreine, in position 1 alkylierte 5-oxo-2-pyrrolidinpropansaeuren und deren ester, deren herstellung und verwendung |
| WO1991006536A1 (en) * | 1989-10-25 | 1991-05-16 | The Regents Of The University Of California | Method of inhibiting the transport of l-glutamate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2496163A (en) * | 1948-03-30 | 1950-01-31 | Du Pont | Synthesis of a 2-substituted-5-oxopyrrolidine |
| US2948714A (en) * | 1954-02-19 | 1960-08-09 | Roussel Uclaf | New n-benzyl peptides and a process of making same |
| US4372966A (en) * | 1980-09-15 | 1983-02-08 | Warner-Lambert Company | Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator |
-
1983
- 1983-03-24 US US06/476,524 patent/US4559358A/en not_active Expired - Fee Related
- 1983-04-28 IL IL68520A patent/IL68520A/xx unknown
- 1983-05-10 DE DE8383302629T patent/DE3378577D1/de not_active Expired
- 1983-05-10 EP EP83302629A patent/EP0095278B1/en not_active Expired
- 1983-05-20 NO NO831794A patent/NO159588C/no unknown
- 1983-05-20 FI FI831794A patent/FI79097C/fi not_active IP Right Cessation
- 1983-05-20 AU AU14815/83A patent/AU563605B2/en not_active Ceased
- 1983-05-20 DK DK228583A patent/DK228583A/da not_active Application Discontinuation
- 1983-05-23 GR GR71428A patent/GR79263B/el unknown
- 1983-05-23 NZ NZ204320A patent/NZ204320A/en unknown
- 1983-05-23 ES ES522620A patent/ES8407021A1/es not_active Expired
- 1983-05-23 PT PT76746A patent/PT76746B/pt unknown
- 1983-05-23 KR KR1019830002256A patent/KR870000742B1/ko active
- 1983-05-23 PH PH28948A patent/PH18562A/en unknown
- 1983-05-23 HU HU831809A patent/HU189688B/hu not_active IP Right Cessation
- 1983-05-24 CA CA000428718A patent/CA1240329A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| KR840004721A (ko) | 1984-10-24 |
| AU1481583A (en) | 1983-12-01 |
| PT76746B (en) | 1985-12-27 |
| FI79097B (fi) | 1989-07-31 |
| FI831794L (fi) | 1983-11-25 |
| DK228583A (da) | 1983-11-25 |
| US4559358A (en) | 1985-12-17 |
| EP0095278B1 (en) | 1988-11-30 |
| PH18562A (en) | 1985-08-09 |
| NO159588B (no) | 1988-10-10 |
| KR870000742B1 (ko) | 1987-04-13 |
| EP0095278A3 (en) | 1985-05-02 |
| ES522620A0 (es) | 1984-09-01 |
| NZ204320A (en) | 1986-06-11 |
| IL68520A (en) | 1986-09-30 |
| GR79263B (es) | 1984-10-22 |
| NO831794L (no) | 1983-11-25 |
| DE3378577D1 (en) | 1989-01-05 |
| ES8407021A1 (es) | 1984-09-01 |
| CA1240329A (en) | 1988-08-09 |
| FI831794A0 (fi) | 1983-05-20 |
| EP0095278A2 (en) | 1983-11-30 |
| DK228583D0 (da) | 1983-05-20 |
| IL68520A0 (en) | 1983-07-31 |
| AU563605B2 (en) | 1987-07-16 |
| PT76746A (en) | 1983-06-01 |
| NO159588C (no) | 1989-01-18 |
| HU189688B (en) | 1986-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: WARNER-LAMBERT COMPANY |