FI78617C - Roentgenkontrastmedel. - Google Patents
Roentgenkontrastmedel. Download PDFInfo
- Publication number
- FI78617C FI78617C FI840534A FI840534A FI78617C FI 78617 C FI78617 C FI 78617C FI 840534 A FI840534 A FI 840534A FI 840534 A FI840534 A FI 840534A FI 78617 C FI78617 C FI 78617C
- Authority
- FI
- Finland
- Prior art keywords
- ether
- ethers
- emulsion
- perfluoro
- bromobutyl
- Prior art date
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 67
- 239000002872 contrast media Substances 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000006185 dispersion Substances 0.000 claims description 6
- 229920005557 bromobutyl Polymers 0.000 claims description 4
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 3
- 239000002270 dispersing agent Substances 0.000 claims 1
- 238000009877 rendering Methods 0.000 claims 1
- 239000000839 emulsion Substances 0.000 description 23
- 150000002170 ethers Chemical class 0.000 description 22
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 8
- -1 perfluoro compounds Chemical class 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- DWRDSKIXIBSDIR-UHFFFAOYSA-N CC(C)OC(C(C(C(F)(F)F)(F)F)(F)F)(F)Br Chemical compound CC(C)OC(C(C(C(F)(F)F)(F)F)(F)F)(F)Br DWRDSKIXIBSDIR-UHFFFAOYSA-N 0.000 description 7
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 5
- 231100000252 nontoxic Toxicity 0.000 description 5
- 230000003000 nontoxic effect Effects 0.000 description 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000003633 blood substitute Substances 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical class FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 3
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229950011087 perflunafene Drugs 0.000 description 3
- UWEYRJFJVCLAGH-IJWZVTFUSA-N perfluorodecalin Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)[C@@]2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[C@@]21F UWEYRJFJVCLAGH-IJWZVTFUSA-N 0.000 description 3
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000002583 angiography Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- WTWWXOGTJWMJHI-UHFFFAOYSA-N perflubron Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br WTWWXOGTJWMJHI-UHFFFAOYSA-N 0.000 description 2
- 229960001217 perflubron Drugs 0.000 description 2
- 229920001993 poloxamer 188 Polymers 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- AEBYJSOWHQYRPK-UHFFFAOYSA-N 1,1'-biphenyl;sodium Chemical group [Na].C1=CC=CC=C1C1=CC=CC=C1 AEBYJSOWHQYRPK-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- AGDZOPGOYAVKSH-UHFFFAOYSA-N CC(C)OC(C(C(C(F)(F)F)(F)F)(F)F)(F)I Chemical compound CC(C)OC(C(C(C(F)(F)F)(F)F)(F)F)(F)I AGDZOPGOYAVKSH-UHFFFAOYSA-N 0.000 description 1
- UTJGIZAXXHYCSF-UHFFFAOYSA-N CC(C)OC(C(F)(F)F)(F)Br Chemical class CC(C)OC(C(F)(F)F)(F)Br UTJGIZAXXHYCSF-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 229930184489 Iodoether Natural products 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001649 bromium compounds Chemical class 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000009606 cholecystography Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000008344 egg yolk phospholipid Substances 0.000 description 1
- 229940068998 egg yolk phospholipid Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000003944 halohydrins Chemical class 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002497 iodine compounds Chemical class 0.000 description 1
- VSHDHKDWBUMJIJ-UHFFFAOYSA-N iodo hypoiodite Chemical compound IOI VSHDHKDWBUMJIJ-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000002587 lymphangiography Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- RVZRBWKZFJCCIB-UHFFFAOYSA-N perfluorotributylamine Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)N(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F RVZRBWKZFJCCIB-UHFFFAOYSA-N 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003822 preparative gas chromatography Methods 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 210000002254 renal artery Anatomy 0.000 description 1
- 210000002796 renal vein Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000007487 urography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/04—Saturated ethers
- C07C43/12—Saturated ethers containing halogen
- C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47034383A | 1983-02-28 | 1983-02-28 | |
| US47034383 | 1983-02-28 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI840534A0 FI840534A0 (fi) | 1984-02-09 |
| FI840534L FI840534L (fi) | 1984-08-29 |
| FI78617B FI78617B (fi) | 1989-05-31 |
| FI78617C true FI78617C (fi) | 1989-09-11 |
Family
ID=23867226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI840534A FI78617C (fi) | 1983-02-28 | 1984-02-09 | Roentgenkontrastmedel. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0120583B1 (OSRAM) |
| JP (1) | JPS59216827A (OSRAM) |
| BE (1) | BE899028A (OSRAM) |
| CA (1) | CA1226521A (OSRAM) |
| CH (1) | CH664492A5 (OSRAM) |
| DE (1) | DE3406834C2 (OSRAM) |
| DK (1) | DK107284A (OSRAM) |
| FI (1) | FI78617C (OSRAM) |
| FR (1) | FR2541580A1 (OSRAM) |
| GB (1) | GB2135578B (OSRAM) |
| IL (1) | IL71026A (OSRAM) |
| IT (1) | IT1173287B (OSRAM) |
| NL (1) | NL8400542A (OSRAM) |
| NO (1) | NO161602C (OSRAM) |
| SE (1) | SE466187B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213536B (it) * | 1986-11-14 | 1989-12-20 | Ausimont Spa | 2-bromo,1',2',-dicloro-perfluoro dietil-etere e procedimento per lasua preparazione. |
| GB9624612D0 (en) * | 1996-11-26 | 1997-01-15 | Nycomed Imaging As | Process |
| RU2497801C1 (ru) * | 2012-07-18 | 2013-11-10 | Закрытое акционерное общество научно-производственное Объединение "ПиМ-Инвест" (ЗАО НПО "Пим-Инвест") | Окса- и полиоксаперфторалкилбромиды и способ их получения |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3453333A (en) * | 1965-10-01 | 1969-07-01 | Allied Chem | Fluorinated ethers |
| US3470256A (en) * | 1965-12-13 | 1969-09-30 | Allied Chem | Fluorinated ethers |
| US3547861A (en) * | 1968-04-12 | 1970-12-15 | Allied Chem | Novel fluorinated acrylates and polyacrylates |
| US3975512A (en) * | 1970-12-21 | 1976-08-17 | University Of Illinois Foundation | Non-toxic brominated perfluorocarbons radiopaque agents |
| US3778381A (en) * | 1972-04-24 | 1973-12-11 | Allied Chem | Fluorocarbon microemulsions |
-
1984
- 1984-02-09 FI FI840534A patent/FI78617C/fi not_active IP Right Cessation
- 1984-02-16 GB GB08404123A patent/GB2135578B/en not_active Expired
- 1984-02-16 EP EP84301009A patent/EP0120583B1/en not_active Expired
- 1984-02-16 IT IT19658/84A patent/IT1173287B/it active
- 1984-02-16 NO NO840590A patent/NO161602C/no unknown
- 1984-02-21 IL IL71026A patent/IL71026A/xx unknown
- 1984-02-21 NL NL8400542A patent/NL8400542A/nl not_active Application Discontinuation
- 1984-02-24 FR FR8402827A patent/FR2541580A1/fr not_active Withdrawn
- 1984-02-24 DE DE3406834A patent/DE3406834C2/de not_active Expired - Fee Related
- 1984-02-24 SE SE8401030A patent/SE466187B/sv not_active IP Right Cessation
- 1984-02-27 CA CA000448339A patent/CA1226521A/en not_active Expired
- 1984-02-27 CH CH941/84A patent/CH664492A5/de not_active IP Right Cessation
- 1984-02-27 DK DK107284A patent/DK107284A/da not_active Application Discontinuation
- 1984-02-27 JP JP59034487A patent/JPS59216827A/ja active Granted
- 1984-02-28 BE BE0/212468A patent/BE899028A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO161602C (no) | 1989-09-06 |
| NL8400542A (nl) | 1984-09-17 |
| CH664492A5 (de) | 1988-03-15 |
| FI840534L (fi) | 1984-08-29 |
| IT1173287B (it) | 1987-06-18 |
| DK107284A (da) | 1984-08-29 |
| IL71026A0 (en) | 1984-05-31 |
| SE8401030L (sv) | 1984-08-29 |
| JPH0468290B2 (OSRAM) | 1992-11-02 |
| FI840534A0 (fi) | 1984-02-09 |
| DE3406834C2 (de) | 1997-06-12 |
| EP0120583B1 (en) | 1987-08-12 |
| BE899028A (fr) | 1984-08-28 |
| FR2541580A1 (fr) | 1984-08-31 |
| FI78617B (fi) | 1989-05-31 |
| DE3406834A1 (de) | 1984-08-30 |
| NO161602B (no) | 1989-05-29 |
| EP0120583A1 (en) | 1984-10-03 |
| IL71026A (en) | 1987-09-16 |
| CA1226521A (en) | 1987-09-08 |
| DK107284D0 (da) | 1984-02-27 |
| SE8401030D0 (sv) | 1984-02-24 |
| GB8404123D0 (en) | 1984-03-21 |
| GB2135578A (en) | 1984-09-05 |
| SE466187B (sv) | 1992-01-13 |
| GB2135578B (en) | 1987-04-08 |
| JPS59216827A (ja) | 1984-12-06 |
| NO840590L (no) | 1984-08-29 |
| IT8419658A0 (it) | 1984-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: AFFINITY BIOTECH, INC. Owner name: CHILDREN S HOSPITAL MEDICAL CENTER |