FI78480C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-(bicyklis heterocyklyl)-4-piperidinaminderivat. - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-(bicyklis heterocyklyl)-4-piperidinaminderivat. Download PDF

Info

Publication number
FI78480C
FI78480C FI832521A FI832521A FI78480C FI 78480 C FI78480 C FI 78480C FI 832521 A FI832521 A FI 832521A FI 832521 A FI832521 A FI 832521A FI 78480 C FI78480 C FI 78480C
Authority
FI
Finland
Prior art keywords
formula
parts
compound
het
radical
Prior art date
Application number
FI832521A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI832521L (fi
FI78480B (fi
FI832521A0 (fi
Inventor
Frans Eduard Janssens
Joseph Leo Ghislanus Torremans
Offenwert Theophilus There Van
Josef Francis Hens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI832521A0 publication Critical patent/FI832521A0/fi
Publication of FI832521L publication Critical patent/FI832521L/fi
Application granted granted Critical
Publication of FI78480B publication Critical patent/FI78480B/fi
Publication of FI78480C publication Critical patent/FI78480C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FI832521A 1982-07-12 1983-07-11 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-(bicyklis heterocyklyl)-4-piperidinaminderivat. FI78480C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39762682A 1982-07-12 1982-07-12
US39762682 1982-07-12
US06/487,774 US4556660A (en) 1982-07-12 1983-04-22 N-(Bicyclic heterocyclyl)-4-piperidinamines
US48777483 1983-04-22

Publications (4)

Publication Number Publication Date
FI832521A0 FI832521A0 (fi) 1983-07-11
FI832521L FI832521L (fi) 1984-01-13
FI78480B FI78480B (fi) 1989-04-28
FI78480C true FI78480C (fi) 1989-08-10

Family

ID=27015931

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832521A FI78480C (fi) 1982-07-12 1983-07-11 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-(bicyklis heterocyklyl)-4-piperidinaminderivat.

Country Status (22)

Country Link
US (1) US4556660A (enExample)
EP (1) EP0099139B1 (enExample)
KR (1) KR870001510B1 (enExample)
AU (1) AU563363B2 (enExample)
BG (1) BG40655A3 (enExample)
CA (1) CA1266267A (enExample)
DE (1) DE3369784D1 (enExample)
DK (1) DK318583A (enExample)
ES (1) ES8602768A1 (enExample)
FI (1) FI78480C (enExample)
GR (1) GR81366B (enExample)
HU (1) HU203550B (enExample)
IE (1) IE56077B1 (enExample)
IL (1) IL69198A (enExample)
MA (1) MA19845A1 (enExample)
NO (1) NO160850C (enExample)
NZ (1) NZ204759A (enExample)
PH (1) PH22009A (enExample)
PT (1) PT77012B (enExample)
RO (1) RO87533A (enExample)
SU (1) SU1297728A3 (enExample)
ZW (1) ZW15583A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806649A (en) * 1983-08-22 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. 3-(piperidinyl)- and 3- (pyrrolidinyl)-1H-indazoles
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
US4839374A (en) * 1984-01-09 1989-06-13 Janssen Pharmaceutica, N.V. 4-((Bicyclic heterocyclyl)-methyl and -hetero)-piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
US5258380A (en) * 1985-06-24 1993-11-02 Janssen Pharmaceutica N.V. (4-piperidinylmethyl and -hetero)purines
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
FR2587029B1 (fr) * 1985-09-11 1987-10-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
ES2052544T3 (es) * 1986-02-03 1994-07-16 Janssen Pharmaceutica Nv Composiciones anti-histaminicas que contienen n-heterociclil-4-piperidinaminas.
US4943580A (en) * 1987-03-09 1990-07-24 Janssen Pharmaceutica N.V. Anti-histaminic benzimidazole, imidazopyridine and purine derivatives
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
US5151424A (en) * 1987-07-01 1992-09-29 Janssen Pharmaceutica N.V. Pharmacologically active (Bicyclic heterocyclyl)methyl and -hetero) substituted hexahydro-1H-azepines and pyrrolidines
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5272150A (en) * 1989-04-07 1993-12-21 Janssen Pharmaceutica N.V. Hydroxyalkylfuranyl derivatives
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
IT1229231B (it) * 1989-05-08 1991-07-26 Dompe Farmaceutici Spa Aminoimidazopiridine farmacologicamente attive
JP3023794B2 (ja) * 1989-05-17 2000-03-21 日本バイエルアグロケム株式会社 殺虫性ニトロ置換ヘテロ環式化合物
KR100190299B1 (ko) * 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
US5217980A (en) * 1990-07-19 1993-06-08 Janssen Pharmaceutica N.V. Oxazolyl and piperidinyl substituted benimidazolyl compounds
DE4037426A1 (de) * 1990-11-24 1992-05-27 Kali Chemie Pharma Gmbh Piperidinoalkylbenzoxazin- und -thiazin-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW401300B (en) * 1992-12-25 2000-08-11 Senju Pharma Co Antiallergic composition for ophthalmic or nasal use
KR100238346B1 (ko) * 1993-04-07 2000-03-02 오쓰까 아끼히꼬 피페리딘 유도체를 유효성분으로 하는 말초혈관확장제
BR9508178A (pt) * 1994-06-29 1997-11-18 Smithkline Beecham Corp Antagonistas de receptor de vitronectina
FI971334L (fi) * 1994-08-03 1997-04-01 Asta Medica Ag Indoli-, indatsoli-, pyridopyrroli- ja pyridopyratsolijohdannaiset, joilla on antiastmaattinen, antiallerginen, anti-inflammatorinen ja immunomoduloiva vaikutus
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US5817823A (en) * 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles
BR0011997A (pt) * 1999-06-28 2002-03-05 Janssen Pharmaceutica Nv Inibidores da replicação do vìrus sincicial respiratório
PT1196408E (pt) 1999-06-28 2005-01-31 Janssen Pharmaceutica Nv Inibidores da replicacao do virus sincicial respiratorio
TR200103806T2 (tr) 1999-06-28 2002-06-21 Janssen Pharmaceutica N. V. Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.
AR033517A1 (es) 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
MXPA03011722A (es) 2001-07-02 2004-03-19 Aztrazeneca Ab Derivados de piperidina utiles como moduladores de actividad de quimiocina.
GB0120461D0 (en) 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0300957D0 (sv) 2003-04-01 2003-04-01 Astrazeneca Ab Chemical compounds
MY142783A (en) 2003-12-18 2010-12-31 Tibotec Pharm Ltd 5-or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
ATE501135T1 (de) 2003-12-18 2011-03-15 Tibotec Pharm Ltd Piperidinamino-benzimidazol-derivate al respiratorisches syncytialvirus replikation inhibitoren
MY142362A (en) 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
JP2009501793A (ja) 2005-07-21 2009-01-22 アストラゼネカ・アクチエボラーグ 新規ピペリジン誘導体
CN117430548A (zh) * 2023-09-15 2024-01-23 浙江博崤生物制药有限公司 一种urat1抑制剂中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR71865B (enExample) * 1978-03-20 1983-07-07 Ciba Geigy
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines

Also Published As

Publication number Publication date
AU563363B2 (en) 1987-07-09
ES524029A0 (es) 1985-11-16
DE3369784D1 (en) 1987-03-19
IL69198A0 (en) 1983-11-30
SU1297728A3 (ru) 1987-03-15
EP0099139B1 (en) 1987-02-11
EP0099139A2 (en) 1984-01-25
HU203550B (en) 1991-08-28
ZW15583A1 (en) 1984-01-30
PT77012B (en) 1986-02-26
NZ204759A (en) 1985-12-13
IE56077B1 (en) 1991-04-10
IE831613L (en) 1984-01-12
NO832524L (no) 1984-01-13
RO87533A (ro) 1985-10-31
IL69198A (en) 1987-01-30
DK318583D0 (da) 1983-07-11
KR840005446A (ko) 1984-11-12
CA1266267A (en) 1990-02-27
PT77012A (en) 1983-08-01
NO160850B (no) 1989-02-27
GR81366B (enExample) 1984-12-11
FI832521L (fi) 1984-01-13
RO87533B (ro) 1985-10-01
NO160850C (no) 1989-06-07
FI78480B (fi) 1989-04-28
DK318583A (da) 1984-01-13
BG40655A3 (en) 1987-01-15
MA19845A1 (fr) 1984-04-01
ES8602768A1 (es) 1985-11-16
EP0099139A3 (en) 1984-02-22
US4556660A (en) 1985-12-03
FI832521A0 (fi) 1983-07-11
AU1672883A (en) 1985-01-17
KR870001510B1 (ko) 1987-08-20
PH22009A (en) 1988-05-02

Similar Documents

Publication Publication Date Title
FI78480C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-(bicyklis heterocyklyl)-4-piperidinaminderivat.
FI83867B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-/(tvaorngheterocyklyl)-metyl- och -hetero/ piperidiner.
FI83781C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara bicykliska kondenserade n-(4-piperidinyl)-2 -imidazolaminderivat.
US5041448A (en) (4-piperidinylmethyl and -hetero) purines
CA1257258A (en) Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
US5258380A (en) (4-piperidinylmethyl and -hetero)purines
EP0145037B1 (en) N-(bicyclic heterocyclyl)-4-piperidinamines
JP2009542604A (ja) ４−ヘテロシクロアルキルピリミジン、それらの調製方法及び医薬としての使用
DE69130255T2 (de) Oxadolderivate
FI94526B (fi) Menetelmä terapeuttisesti käyttökelpoisten bentsimidatsol-2-yyli- ja imidatso/4,5-b/pyridin-2-yyli-amino- ja -metyyli-1-piperidinyylietyylijohdannaisten valmistamiseksi
JPH05508638A (ja) 新規な置換チアゾリル及び置換ピリジニル誘導体
CA3145821A1 (en) Heterocyclic compounds as kinase inhibitors
KR880000044B1 (ko) N-(비사이클 헤테로사이클릴)-4-피페리딘아민의 제조 방법
EP2259681A1 (en) Dual pharmacophores-pde4-muscarinic antagonistics
WO2006078775A1 (en) Imidazole and benzimidazole derivatives useful as histamine h3 antagonists
US4943580A (en) Anti-histaminic benzimidazole, imidazopyridine and purine derivatives
USRE33833E (en) Novel N-(bicyclic heterocyclyl)-4-piperidinamines
US4760074A (en) Novel-N-(bicyclic heterocyclyl)-4-piperidinamines
JPS5921680A (ja) 新規なｎ−（二環式複素環）−４−ピペリジナミン類、その製法およびそれを含む薬学的組成物
US4820822A (en) Novel N-(bicyclic heterocyclyl)-4-piperidinamines
KR880000489B1 (ko) N-(비사이클 헤테로사이클릴)-4-피페리딘 아민의 제조방법
CA1330081C (en) Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
PL144514B1 (en) Method of obtaining novel derivatives of n-/4-piperidinolo/-2-imidazoloamine

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: JANSSEN PHARMACEUTICA N.V.