FI77692B - Medel foer paovisning av esterolytiska och/eller proteolytiska enzymer och anvaendningen av detta. - Google Patents
Medel foer paovisning av esterolytiska och/eller proteolytiska enzymer och anvaendningen av detta. Download PDFInfo
- Publication number
- FI77692B FI77692B FI811418A FI811418A FI77692B FI 77692 B FI77692 B FI 77692B FI 811418 A FI811418 A FI 811418A FI 811418 A FI811418 A FI 811418A FI 77692 B FI77692 B FI 77692B
- Authority
- FI
- Finland
- Prior art keywords
- group
- hydrogen
- lower alkyl
- residue
- morpholino
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/30—Naphthol derivatives, e.g. alpha-naphthyl-esters, i.e. alpha-NE, beta-naphthyl-esters, i.e. beta-NE
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/50—Indoles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/70—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases the product, e.g. phenol, naphthol being diazotised in situ, e.g. with Fast Red
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Claims (3)
1. Medel för pavisning av esterolytiska och/eller pro- teolytiska enzymer i urea, vilket medel bestär av en bärare med uppsugningsförmäga, ett filmskikt, en pulverblandning, ett lyofilisat, en lösning eller reagenstablett innehallande en lämplig esteras- och/eller proteaspävisningsprincip, en buf-fert samt eventuellt andra allmänt använda tillsatsämnen, kännetecknat av att som esteras- och/eller proteaspavis-ningsprincip tillföres en kombination av ett diazoniumsalt och II „ 77692 33 en ester, varvid som diazoniumsalt tillsätts en förening med allmänna forraeIn I R R R MV - <-> R—(. )- N = N X (I) VM R R 4 5 i vilken forme1 R^ är en lägre alkyl-, lägre alkoxi-, N-morfolinogrupp, halogen eller väte, R^ är en lägre alkoxi-, aryloxi-, lägre alkylmerkapto-, alkylamino-, dialkylamino-, hydroxi-, N-morfolino-, N-tiomor- folino-, N-pyrrolidino, eventuellt N'-alkylerad N-piper- atsino-, N-piperidino-, fenylamino-, eventuellt med en lägre alkylrest substituerad fenylgrupp, halogen eller väte, R , R och R , som kan vara likadana eller olika, be-2 4 5 tecknar antingen en lägre alkoxigrupp eller väte, och X är en stabiliserande anion ur gruppen tetrafluoroborat, tetraklorsinkat och vätesulfat, och som ester används en förening med allmänna formeln II R ' Jv. o - A - B r2 \f (n) R3#X|^X#/; 4 i vilken formel R R ', R och R som kan vara likadana eller olika, 12 3 4 betecknar en väte- eller halogenatom, lägre alkyl- eller lägre alkoxigrupp, X' är en eventuellt med en lägre alkyl-, bensyl- eller ben-soylrest N-substituerad iminogrupp, A är en naturlig alfa-aminosyrarest, företrädesvis alanylrest, 34 7 7 6 9 2 B är en i peptidkemi sedvanlig kväveskyddgrupp, företrädesvis sulfonyl- eller oxikarbonylgrupp, eller en förening med den allmänna formeln III O - A - B R ” JL (III) 1 xl r2m R " 3 i vilken formel R ", R ", R " och R " som kan vara likadana eller olika, 12 3 4 är väte, en lägre alkyl-, lägre alkoxi- eller lägre dialkyl-aminogrupp, varvid tvä bredvid varandra varande substituenter aven kan bilda en konjugerad bensenring, och A är en L-alanylgrupp och B är en tosylgrupp förbunden tili alanylgruppens kväveatom.
2. Medel enligt patentkravet 1, kännetecknat av att som tillsattshjälpmedlen används andra sedvanliga hjälpmedlen.
3. Användning av ett medel för pävisning av esterolytiska och/eller proteolytiska enzymer i urea, vilket medel bestär av en bärare med uppsugningsförmäga, ett filmskikt, en pulver-blandning, ett lyofilisat, en lösning eller reagenstablett in-nehällande en lämplig esteras- och/eller proteaspävisnings-princip, en buffert samt eventuellt andra allmänt använda tillsatsämnen, varvid medlet tillsätts tili urean som skall undersökas och den uppkommande färgbildningen värderas vi-suellt eller fotometriskt, kännetecknad av att som esteras-och/eller proteaspävisningsprincip tillföres en kombination av ett diazoniumsalt och en ester, varvid som diazoniumsalt tillsätts en förening med den allmänna formeln I II 35 7 7 6 9 2 R R V=V (+>- - I-» X (I, R R 4 5 i vilken formel R^ är en lägre alkyl-, lägre alkoxi-, N-morfolinogrupp, halogen eller väte, R är en lägre alkoxi-, aryloxi-, lägre alkylmerkapto-, al- kylamino-, dialkylamino-, hydroxi-, N-morfolino-, N-tiomorfo- lino-, N-pyrrolidino, eventuellt N'-alkylerad N-piperatsino-, N-piperidino-, fenylamino-, eventuellt med en lägre alkylrest substituerad fenylgrupp, halogen eller väte, R , R och R , som kan vara likadana eller olika, betecknar 2 4 5 antingen en lägre alkoxigrupp eller väte, och X är en stabiliserande anion ur gruppen tetrafluoroborat, tetraklorsinkat och vätesulfat, och som ester används en förening med den allmänna formeln II R ' R ' O - A - B 2 ί (II) r ' 4 i vilken formel R ', R ', R och R ', som kan vara likadana eller olika, 12 3 4 betecknar en väte- eller halogenatom, lägre alkyl- eller lägre alkoxigrupp, X' är en eventuellt med en lägre alkyl-, bensyl- eller ben-soylrest N-substituerad iminogrupp, A är en naturlig alfa-aminosyrarest, företrädesvis alanylrest, B är en i peptidkemi sedvanlig kväveskyddgrupp, företrädesvis sulfonyl- eller oxikarbonylgrupp, eller en förening med den allmänna formeln III
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3017721 | 1980-05-09 | ||
| DE19803017721 DE3017721A1 (de) | 1980-05-09 | 1980-05-09 | Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI811418L FI811418L (fi) | 1981-11-10 |
| FI77692B true FI77692B (fi) | 1988-12-30 |
| FI77692C FI77692C (sv) | 1989-04-10 |
Family
ID=6101946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI811418A FI77692C (sv) | 1980-05-09 | 1981-05-08 | Medel för påvisning av esterolytiska och/eller proteolytiska enzymer o ch användningen av detta. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US4551428A (sv) |
| EP (1) | EP0039880B2 (sv) |
| JP (2) | JPS578798A (sv) |
| AR (1) | AR228452A1 (sv) |
| AT (1) | ATE3993T1 (sv) |
| AU (1) | AU523744B2 (sv) |
| BR (1) | BR8102876A (sv) |
| CA (1) | CA1186201A (sv) |
| CS (1) | CS223999B2 (sv) |
| DD (1) | DD158559A5 (sv) |
| DE (2) | DE3017721A1 (sv) |
| DK (1) | DK169974B1 (sv) |
| ES (1) | ES8202792A1 (sv) |
| FI (1) | FI77692C (sv) |
| HK (1) | HK82586A (sv) |
| HU (1) | HU187334B (sv) |
| MY (1) | MY8600605A (sv) |
| PL (1) | PL131123B1 (sv) |
| PT (1) | PT73005B (sv) |
| SG (1) | SG38786G (sv) |
| SU (1) | SU1466663A3 (sv) |
| UA (1) | UA6035A1 (sv) |
| YU (2) | YU117781A (sv) |
| ZA (1) | ZA812961B (sv) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3017721A1 (de) * | 1980-05-09 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate |
| US4499185A (en) * | 1982-05-17 | 1985-02-12 | Miles Laboratories, Inc. | Test for esterase activity in a liquid sample |
| DE3309544A1 (de) * | 1983-03-17 | 1984-09-20 | Macherey-Nagel & Co Chemikalienhandel, 5160 Düren | Teststreifen zum nachweis von leukozyten im harn |
| DE3329394A1 (de) * | 1983-08-13 | 1985-02-28 | Bayer Ag, 5090 Leverkusen | Chromogene und fluorogene carbonsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur bestimmung von hydrolasen |
| EP0146348B1 (en) * | 1983-12-14 | 1991-07-31 | The Upjohn Company | Substituted naphthalenes, indoles, benzofurans and benzothiophenes as lipoxygenase inhibitors |
| DE3413078A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| DE3413077A1 (de) * | 1984-04-06 | 1985-10-17 | Miles Laboratories, Inc., Elkhart, Ind. | Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| DE3413119A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| US4637979A (en) * | 1984-04-06 | 1987-01-20 | Miles Laboratories, Inc. | Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent |
| DE3413118A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| US4657855A (en) * | 1984-04-06 | 1987-04-14 | Miles Laboratories, Inc. | Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample |
| DE3413120A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| DE3446714A1 (de) * | 1984-12-21 | 1986-06-26 | Boehringer Mannheim Gmbh | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
| US4777267A (en) * | 1986-02-07 | 1988-10-11 | Kanebo Ltd. | 1,3-dioxol-2-one derivatives |
| US4677075A (en) * | 1986-05-05 | 1987-06-30 | Louderback Allan Lee | Urobilinogen control |
| DE3813503A1 (de) * | 1988-04-22 | 1989-11-02 | Boehringer Mannheim Gmbh | Traegergebundenes mehrkomponentiges nachweissystem zur kolorimetrischen bestimmung esterolytisch oder/und proteolytisch aktiver inhaltsstoffe von koerperfluessigkeiten |
| US5084324A (en) * | 1989-08-25 | 1992-01-28 | W. R. Grace & Co.-Conn. | Micro-bubble laminate with perforated substrate |
| US4950354A (en) * | 1989-08-25 | 1990-08-21 | W. R. Grace & Co.-Conn. | Method of making a micro-bubble laminate |
| JPH0465584U (sv) * | 1990-10-12 | 1992-06-08 | ||
| EP0661280A1 (en) * | 1993-12-29 | 1995-07-05 | Kyoto Daiichi Kagaku Co., Ltd. | Novel amino acid ester and reagent composition for detecting leucocytes or elastase in body liquid |
| CA2161574A1 (en) | 1994-11-15 | 1996-05-16 | James Noffsinger | Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid |
| US6528652B1 (en) * | 1999-01-21 | 2003-03-04 | Chronimed | Composition and device for detecting leukocytes in urine |
| US6348324B1 (en) | 1999-01-21 | 2002-02-19 | Hypoguard America Limited | Composition and device for detecting leukocytes in urine |
| US6203496B1 (en) * | 1999-08-12 | 2001-03-20 | Michael R. Gael | Apparatus with reagents for detection of medical conditions |
| IL140993A0 (en) | 2000-05-15 | 2002-02-10 | Bayer Ag | Trypsin substrate and diagnostic device, and method of using same |
| US6955921B2 (en) | 2001-04-30 | 2005-10-18 | Bayer Corporation | Trypsin substrate and diagnostic device, and method of using same |
| US6709868B2 (en) * | 2002-05-20 | 2004-03-23 | Portascience Inc. | Method and apparatus for measuring white blood cell count |
| US7727206B2 (en) * | 2005-12-27 | 2010-06-01 | Gorres Geoffrey H | Device for monitoring a patient for a urinary tract infection |
| EP3848708A1 (en) * | 2020-01-13 | 2021-07-14 | Roche Diagnostics GmbH | Reagent formulation for leukocyte test strip |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1128371A (en) * | 1965-10-04 | 1968-09-25 | Miles Lab | Diagnostic composition |
| US3585001A (en) * | 1969-02-17 | 1971-06-15 | Miles Lab | Stabilized test device and process for detecting couplable compounds |
| US3715325A (en) * | 1970-10-02 | 1973-02-06 | Miles Lab | Insoluble polymeric diazonium salt chromogen |
| US3905872A (en) * | 1973-12-14 | 1975-09-16 | American Cyanamid Co | Alkaline phosphatase test material |
| DE2531539A1 (de) * | 1975-07-15 | 1977-01-20 | Riedel De Haen Ag | Indikatorsubstanz zum nachweis von kuppelnden fluessigkeits-inhaltsstoffen, diese enthaltende diagnostische mittel und verfahren zu deren herstellung |
| DE2836644A1 (de) * | 1978-08-22 | 1980-03-06 | Boehringer Mannheim Gmbh | Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten und dafuer geeignete chromogene |
| DE2854987A1 (de) * | 1978-12-20 | 1980-06-26 | Boehringer Mannheim Gmbh | Diagnostische mittel zum nachweis proteolytischer enzyme und dafuer geeignete chromogene |
| DE2905531A1 (de) * | 1979-02-14 | 1981-01-08 | Boehringer Mannheim Gmbh | Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten |
| DE2936543A1 (de) * | 1979-09-10 | 1981-04-09 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen |
| DE3017721A1 (de) * | 1980-05-09 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate |
-
1980
- 1980-05-09 DE DE19803017721 patent/DE3017721A1/de not_active Withdrawn
-
1981
- 1981-05-04 AR AR285192A patent/AR228452A1/es active
- 1981-05-04 CS CS813290A patent/CS223999B2/cs unknown
- 1981-05-05 ZA ZA00812961A patent/ZA812961B/xx unknown
- 1981-05-05 EP EP81103385A patent/EP0039880B2/de not_active Expired
- 1981-05-05 US US06/260,616 patent/US4551428A/en not_active Expired - Lifetime
- 1981-05-05 DE DE8181103385T patent/DE3160522D1/de not_active Expired
- 1981-05-05 CA CA000376871A patent/CA1186201A/en not_active Expired
- 1981-05-05 AT AT81103385T patent/ATE3993T1/de not_active IP Right Cessation
- 1981-05-06 PL PL1981231002A patent/PL131123B1/pl unknown
- 1981-05-07 AU AU70239/81A patent/AU523744B2/en not_active Expired
- 1981-05-08 SU SU813278845A patent/SU1466663A3/ru active
- 1981-05-08 FI FI811418A patent/FI77692C/sv not_active IP Right Cessation
- 1981-05-08 HU HU811244A patent/HU187334B/hu unknown
- 1981-05-08 DK DK204881A patent/DK169974B1/da not_active IP Right Cessation
- 1981-05-08 DD DD81229847A patent/DD158559A5/de not_active IP Right Cessation
- 1981-05-08 PT PT73005A patent/PT73005B/pt unknown
- 1981-05-08 YU YU01177/81A patent/YU117781A/xx unknown
- 1981-05-08 JP JP6927981A patent/JPS578798A/ja active Granted
- 1981-05-08 BR BR8102876A patent/BR8102876A/pt unknown
- 1981-05-08 ES ES502034A patent/ES8202792A1/es not_active Expired
- 1981-05-08 UA UA3278845A patent/UA6035A1/uk unknown
-
1983
- 1983-05-19 YU YU112483A patent/YU45887B/sh unknown
-
1984
- 1984-05-04 US US06/606,984 patent/US4749648A/en not_active Expired - Lifetime
-
1985
- 1985-10-11 JP JP60225022A patent/JPS61199800A/ja active Granted
-
1986
- 1986-04-30 SG SG387/86A patent/SG38786G/en unknown
- 1986-10-30 HK HK825/86A patent/HK82586A/xx not_active IP Right Cessation
- 1986-12-30 MY MY605/86A patent/MY8600605A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: BOEHRINGER MANNHEIM GMBH |