FI77447C - Förfarande för framställning av nya bensoyl-fenyl-piperidinderivat. - Google Patents
Förfarande för framställning av nya bensoyl-fenyl-piperidinderivat. Download PDFInfo
- Publication number
- FI77447C FI77447C FI822215A FI822215A FI77447C FI 77447 C FI77447 C FI 77447C FI 822215 A FI822215 A FI 822215A FI 822215 A FI822215 A FI 822215A FI 77447 C FI77447 C FI 77447C
- Authority
- FI
- Finland
- Prior art keywords
- group
- formula
- phenyl
- process according
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (5)
1. Förfarande för framställning av nya terapeutiskt nyttiga, i synnerhet som immunostimulerande och immu-noadjuvanta substanser användbara derivat av bensoyl-fenyl-piperidiner, vilka är utvalda bland en grupp av 5 2-piperidinobensofenoner, som representeras av den allmänna formeln R3^ I / ,R 20. vilken R^, och R^, identiska eller olika, represente-rar var en väteatom, en hydroxidgrupp, en CF^-grupp, en halogen, en lägre alkylgrupp eller en lägre alkoxigrupp,
25. R^ och Rg, identiska eller olika, representerar var en väteatom, en lägre alkylgrupp, en OH-grupp, en fenylgrupp eller en bensylgrupp, varvid ätminstone en av de nämnda radikalerna R^, R2, R^, R5 och Rg är annan än väte,
30. R4 representerar en N02-grupp eller en NH2~grupp, samt derivatens syra-additionsalter, varvid förfaran-det är kännetecknad därav, att II i9 77447 (i) en 2-halogeno-5-nitrobensofenon änligt den bifo-gade formeln II fi Λ p x 10 ... i vilken R^, R£ och R^ ar bestamt sasom ovan, varvid X representerar en halogenatom (företrädesvis Cl och F) , bringas att reagera med en möjligtvis substitue- rad piperidin med formeln 15 /-VR5 H-N > (ΠΙ) \_ 1 vilken Rc och R<- ar bestamt sasom ovan, for att er-d 0 halla nitroförening enligt den bifogade formeln I . ' A (ii) och, om nödvändigt, den erhällna föreningen I bringas till reduktionsreaktion för att omsättanitro- gruppen till en aminogrupp för att erhälla aminoföre- ningen enligt formeln I, i vilken R. = NH_. 35 4 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8112745A FR2508445A1 (fr) | 1981-06-29 | 1981-06-29 | Nouveaux derives de benzoyl-phenyl-piperidine, leur procede de preparation et leur application, notamment en therapeutique |
| FR8112745 | 1981-06-29 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI822215A0 FI822215A0 (fi) | 1982-06-21 |
| FI822215L FI822215L (fi) | 1982-12-30 |
| FI77447B FI77447B (fi) | 1988-11-30 |
| FI77447C true FI77447C (sv) | 1989-03-10 |
Family
ID=9259970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI822215A FI77447C (sv) | 1981-06-29 | 1982-06-21 | Förfarande för framställning av nya bensoyl-fenyl-piperidinderivat. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US4528294A (sv) |
| EP (1) | EP0069012B1 (sv) |
| JP (1) | JPS588061A (sv) |
| KR (1) | KR880001298B1 (sv) |
| AR (1) | AR230048A1 (sv) |
| AT (1) | ATE9795T1 (sv) |
| AU (1) | AU550320B2 (sv) |
| CA (1) | CA1187501A (sv) |
| CS (1) | CS235542B2 (sv) |
| DD (1) | DD202557A5 (sv) |
| DE (1) | DE3260949D1 (sv) |
| DK (1) | DK152668C (sv) |
| ES (1) | ES8304936A1 (sv) |
| FI (1) | FI77447C (sv) |
| FR (1) | FR2508445A1 (sv) |
| GR (1) | GR76401B (sv) |
| HU (1) | HU189150B (sv) |
| IE (1) | IE53189B1 (sv) |
| IL (2) | IL66123A (sv) |
| NO (1) | NO160136C (sv) |
| OA (1) | OA07133A (sv) |
| PH (1) | PH17368A (sv) |
| PT (1) | PT75135B (sv) |
| SU (1) | SU1147251A3 (sv) |
| YU (1) | YU43799B (sv) |
| ZA (1) | ZA824536B (sv) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL82573A0 (en) * | 1986-05-30 | 1987-11-30 | Sori Soc Rech Ind | Preparation of benzoylphenyl-piperidine derivatives |
| FR2620027A1 (fr) * | 1987-09-09 | 1989-03-10 | Fournier Innovation Synergie | Nouvelle utilisation de la (5-amino-2-(4-methyl-1-piperidinyl)phenyl)-(4-chlorophenyl)-methanone |
| AU4971600A (en) | 1999-05-21 | 2000-12-12 | Eli Lilly And Company | Immunopotentiator agents |
| US6794544B2 (en) * | 2000-03-10 | 2004-09-21 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3202655A (en) * | 1962-04-27 | 1965-08-24 | Yvon G Perron | 6-[alpha-substituted-alpha-(2-or 3-heterocyclic) acetamido] penicillanic acid and nontoxic salts thereof |
| FR1375300A (fr) * | 1962-11-13 | 1964-10-16 | Hoffmann La Roche | Dérivés de benzophénone et leur préparation |
| BE637329A (sv) * | 1962-11-13 | |||
| FR1403939A (fr) * | 1963-06-07 | 1965-06-25 | Hoffmann La Roche | Procédé pour la préparation de dérivés de benzodiazépine |
| US3668199A (en) * | 1966-06-13 | 1972-06-06 | Upjohn Co | 1,3-aminoalcohols |
| FR1526708A (fr) * | 1966-06-13 | 1968-05-24 | Upjohn Co | 1.3-amino-alcools, leurs intermédiaires et dérivés et leur procédé de préparation |
| FR1530393A (fr) * | 1966-07-11 | 1968-06-21 | Hoffmann La Roche | Procédé pour la préparation de dérivés de pipéridine |
| IE34545B1 (en) * | 1969-10-01 | 1975-06-11 | Continental Pharma | Amino-alcohols,their salts and process for preparing the same |
| HU167949B (sv) * | 1973-07-26 | 1976-01-28 | ||
| HU167950B (sv) * | 1973-07-26 | 1976-01-28 | ||
| US4064121A (en) * | 1973-07-26 | 1977-12-20 | Richter Gedeon Vegyeszeti Gyar Rt. | Substituted nitrobenzophenone derivatives and a process for the preparation thereof |
| US4021563A (en) * | 1975-02-06 | 1977-05-03 | Sven Eric Harry Hernestam | Method of treating cardiac arrhythmia with γ-piperidino-butyrophenones |
| IE49998B1 (en) * | 1979-08-06 | 1986-01-22 | Merrell Dow Pharma | 4-(naphthalenyloxy)piperidine derivatives |
-
1981
- 1981-06-29 FR FR8112745A patent/FR2508445A1/fr active Granted
-
1982
- 1982-06-21 GR GR68497A patent/GR76401B/el unknown
- 1982-06-21 FI FI822215A patent/FI77447C/sv not_active IP Right Cessation
- 1982-06-22 IE IE1475/82A patent/IE53189B1/en not_active IP Right Cessation
- 1982-06-23 DE DE8282401154T patent/DE3260949D1/de not_active Expired
- 1982-06-23 AT AT82401154T patent/ATE9795T1/de active
- 1982-06-23 EP EP82401154A patent/EP0069012B1/fr not_active Expired
- 1982-06-24 IL IL66123A patent/IL66123A/xx unknown
- 1982-06-24 US US06/391,915 patent/US4528294A/en not_active Expired - Fee Related
- 1982-06-25 ZA ZA824536A patent/ZA824536B/xx unknown
- 1982-06-28 SU SU823456997A patent/SU1147251A3/ru active
- 1982-06-28 NO NO822185A patent/NO160136C/no unknown
- 1982-06-28 DK DK289382A patent/DK152668C/da not_active IP Right Cessation
- 1982-06-28 HU HU822088A patent/HU189150B/hu not_active IP Right Cessation
- 1982-06-28 PT PT75135A patent/PT75135B/pt not_active IP Right Cessation
- 1982-06-28 AR AR289803A patent/AR230048A1/es active
- 1982-06-28 ES ES513565A patent/ES8304936A1/es not_active Expired
- 1982-06-29 KR KR8202891A patent/KR880001298B1/ko not_active IP Right Cessation
- 1982-06-29 YU YU1415/82A patent/YU43799B/xx unknown
- 1982-06-29 CA CA000406296A patent/CA1187501A/en not_active Expired
- 1982-06-29 AU AU85429/82A patent/AU550320B2/en not_active Ceased
- 1982-06-29 DD DD82241202A patent/DD202557A5/de not_active IP Right Cessation
- 1982-06-29 OA OA57724A patent/OA07133A/xx unknown
- 1982-06-29 PH PH27508A patent/PH17368A/en unknown
- 1982-06-29 JP JP57110936A patent/JPS588061A/ja active Granted
- 1982-06-29 CS CS824905A patent/CS235542B2/cs unknown
-
1985
- 1985-09-04 IL IL8576287A patent/IL76287A0/xx not_active IP Right Cessation
-
1986
- 1986-05-30 US US06/868,443 patent/US4680402A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0399569B1 (en) | Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient | |
| BG62023B2 (bg) | Тетрахидробензтиазоли,метод за получаването и приложението им като междинни продукти или като лекарствени средства | |
| PT1543002E (pt) | Preparação de intermediários 1h-imidazo ( 4,5-c )quinolin-4-aminas via 1h- imidazo (4,5-c ) quinolina-4-ftalimida | |
| FI100530B (sv) | Förfarande för framställning av substituerade diaminoftalimider och de ras analoger | |
| JPH02138238A (ja) | ベンジリデン−およびシンナミリデン−マロンニトリル誘導体およびその製法 | |
| JPS5915911B2 (ja) | インドリン化合物の製造法 | |
| JPH0369910B2 (sv) | ||
| FI77447C (sv) | Förfarande för framställning av nya bensoyl-fenyl-piperidinderivat. | |
| IE46484B1 (en) | Pyridinyl aminoalkyl ehers useful for treating cardiac arrhythmias | |
| FI71936C (sv) | Förfarande för framställning av neuroleptiskt aktiva 2-substituerade-8 -fluor-5-(4-fluorfenyl)-2,3,4,4a5,9b-hexahydro-4a,9b-trans-1H-pyrido/4 ,3-b/indolderivat. | |
| PL125663B1 (en) | Process for preparing novel derivatives of n-(trimethoxybenzyl)-piperazine | |
| US2830008A (en) | Amines | |
| JPH01193264A (ja) | 精神分裂病の治療に有効な１−（（５−（（４−置換−１−ピペラジニル）メチル）−ピロール−２−イル又はフラン−２−イル）メチル−２−ピペリジノン類 | |
| CA1094070A (en) | 1-phenyl-piperazine derivatives | |
| FI86637B (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tiazolo/3,2a/ pyrimidinderivat. | |
| FI74004C (sv) | Förfarande för framställning av terapeutiskt användbara piperazinylpyr ido/2,3-b/- och -/3,4-b/ pyrazinderivat | |
| US5071849A (en) | Dihydropyrimidothiazine derivatives | |
| EP0089426B1 (en) | 2-amino-6-biphenylacetic acids | |
| JPS63154663A (ja) | ３，５−ジ−タ−シヤリ−ブチル−４−ヒドロキシケイ皮酸アミド誘導体 | |
| AU714805B2 (en) | New bisimide compounds, process for preparing them and pharmaceutical compositions containing them | |
| FI85702C (sv) | Förfarande för framställning av tert.-butyl-ergolinderivat | |
| US3185705A (en) | 2-phenyl-5, 5-di-esters and di-amides of 2-pyrroline and the corresponding pyrrolidines | |
| DE2514084A1 (de) | Neue indolverbindungen | |
| JPH01221364A (ja) | Ｈｉｖ逆転写酵素阻害剤および抗腫瘍剤 | |
| US3632604A (en) | 2-substituted-4-phenyl and substituted phenyl-1-pyrrolines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: FOURNIER INNOVATION ET SYNERGIE |