FI71148C - Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner - Google Patents

Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner Download PDF

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Publication number
FI71148C
FI71148C FI811504A FI811504A FI71148C FI 71148 C FI71148 C FI 71148C FI 811504 A FI811504 A FI 811504A FI 811504 A FI811504 A FI 811504A FI 71148 C FI71148 C FI 71148C
Authority
FI
Finland
Prior art keywords
quinoxalin
methyl
triazolo
mmol
ether
Prior art date
Application number
FI811504A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI811504L (fi
FI71148B (fi
Inventor
Bernard Loev
John T Suh
Bruce E Williams
Vassil St Georgiev
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of FI811504L publication Critical patent/FI811504L/fi
Application granted granted Critical
Publication of FI71148B publication Critical patent/FI71148B/fi
Publication of FI71148C publication Critical patent/FI71148C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI811504A 1980-05-19 1981-05-15 Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner FI71148C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/151,220 US4354027A (en) 1980-05-19 1980-05-19 Triazoloquinoxalin-4-ones
US15122080 1980-05-19

Publications (3)

Publication Number Publication Date
FI811504L FI811504L (fi) 1981-11-20
FI71148B FI71148B (fi) 1986-08-14
FI71148C true FI71148C (fi) 1986-11-24

Family

ID=22537818

Family Applications (1)

Application Number Title Priority Date Filing Date
FI811504A FI71148C (fi) 1980-05-19 1981-05-15 Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner

Country Status (12)

Country Link
US (1) US4354027A (fr)
EP (1) EP0040401B1 (fr)
JP (1) JPS5718681A (fr)
AU (1) AU538782B2 (fr)
CA (1) CA1176634A (fr)
DE (1) DE3162761D1 (fr)
DK (1) DK214981A (fr)
ES (1) ES502747A0 (fr)
FI (1) FI71148C (fr)
NO (1) NO811646L (fr)
NZ (1) NZ197101A (fr)
ZA (1) ZA813255B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141304A (en) * 1960-11-14 1964-07-21 Jefferson Chem Co Inc Soil stabilization by atactic polypropylene coating
US4507300A (en) * 1980-05-09 1985-03-26 Usv Pharmaceutical Corporation Pyridotriazolopyrazine-diones for treating allergy
US4400382A (en) * 1980-05-09 1983-08-23 Usv Pharmaceutical Corporation Thiazoloquinoxalin-1,4-diones for treating allergy
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
DK162491D0 (da) * 1991-09-20 1991-09-20 Novo Nordisk As Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
FR2696466B1 (fr) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK31093D0 (fr) * 1993-03-19 1993-03-19 Novo Nordisk As
FR2717812B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2717805B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant .
FR2717813B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant .
FR2717814B1 (fr) * 1994-03-28 1996-04-26 Rhone Poulenc Rorer Sa Dérivés de 1,2,4-triazolo(4,3-a)pyrazine-4-one, leur préparation et les médicaments les contenant.
JPH10506620A (ja) * 1994-09-16 1998-06-30 ノボ ノルディスク アクティーゼルスカブ 〔１，２，４〕トリアゾロ〔４，３−ａ〕キノキサリノン誘導体、それらの調製方法及び使用
ATE190616T1 (de) * 1994-09-16 2000-04-15 Novo Nordisk As (1,2,4)triazolo(4,3-a)chinoxylinonderivate, ihre darstellung und verwendung als antagonisten von ampa-rezeptoren
FR2726275B1 (fr) * 1994-11-02 1996-12-06 Rhone Poulenc Rorer Sa Spiro heterocycle-imidazo(1,2-a)indeno(1,2-e)pyrazine)-4'- ones, leur preparation et les medicaments les contenants
US5679680A (en) * 1995-02-16 1997-10-21 Warner-Lambert Company α-substituted hydrazides having calpain inhibitory activity
WO2008072779A1 (fr) * 2006-12-13 2008-06-19 Aska Pharmaceutical Co., Ltd. Dérivé de quinoxaline
AR107456A1 (es) * 2016-02-12 2018-05-02 Lilly Co Eli Inhibidor de pde1
JOP20170164A1 (ar) 2016-08-25 2019-01-30 Lilly Co Eli مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري
AR112457A1 (es) 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
AR112346A1 (es) 2017-08-10 2019-10-16 Lilly Co Eli Derivados de [1,2,4]triazolo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1301228A (fr) * 1971-03-04 1972-12-29 Ici Ltd
JPS50116498A (fr) * 1974-02-27 1975-09-11
US3979387A (en) * 1975-06-10 1976-09-07 Eli Lilly And Company 4,5-Dihydrotetrazolo(1,5-A)quinoxalines

Also Published As

Publication number Publication date
FI811504L (fi) 1981-11-20
EP0040401A1 (fr) 1981-11-25
US4354027A (en) 1982-10-12
AU538782B2 (en) 1984-08-30
AU7054481A (en) 1981-11-19
FI71148B (fi) 1986-08-14
ES8203375A1 (es) 1982-04-01
NO811646L (no) 1981-11-20
DE3162761D1 (en) 1984-04-26
ES502747A0 (es) 1982-04-01
JPS5718681A (en) 1982-01-30
DK214981A (da) 1981-11-20
ZA813255B (en) 1982-06-30
NZ197101A (en) 1984-03-16
CA1176634A (fr) 1984-10-23
EP0040401B1 (fr) 1984-03-21

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Owner name: USV PHARMACEUTICAL CORPORATION