FI71148C - Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner - Google Patents

Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner Download PDF

Info

Publication number
FI71148C
FI71148C FI811504A FI811504A FI71148C FI 71148 C FI71148 C FI 71148C FI 811504 A FI811504 A FI 811504A FI 811504 A FI811504 A FI 811504A FI 71148 C FI71148 C FI 71148C
Authority
FI
Finland
Prior art keywords
quinoxalin
methyl
triazolo
mmol
ether
Prior art date
Application number
FI811504A
Other languages
English (en)
Finnish (fi)
Other versions
FI71148B (fi
FI811504L (fi
Inventor
Bernard Loev
John T Suh
Bruce E Williams
Vassil St Georgiev
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of FI811504L publication Critical patent/FI811504L/fi
Application granted granted Critical
Publication of FI71148B publication Critical patent/FI71148B/fi
Publication of FI71148C publication Critical patent/FI71148C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Claims (4)

1. Förfarande för framställning av antihypertensiva 4H-1,2,4-triazolo(4,3-a)kinoxalin-4-oner med formeln I och 5 syraadditionssalter därav, _ Γ3 o ifr r R1 I 1 /—-N R4 väri
15 R^ är C1~C7-alkoxi, halogen eller trifluormetyl, och är C^-C^-alkyl, cykloalkyl, C2-C7-alkenyl eller fenyl, kännetecknat därav, att man underkastar motsva-rande 3-(21-acyldiazanyl)kinoxalinon med formeln
20 CH3 j (nCT° R, NHNHCOR. 25. q en ringtillslutningsreaktion, och eventuellt omvandlar de sä erhällna föreningarna tili syraadditionssalter därav. 30 2. Förfarande enligt patentkravet 1 för framställning av 8-metoxi-5-metyl-l-propyl-4H-l,2,4-triazolo(4,3-a)kinoxa-lin-4-on, kännetecknat därav, att man underkastar 6-metoxi-l-metyl-3-(21-buatanoyldiazanyl)-lH-kinoxalin- 2-on en ringtillslutningsreaktion. 35 3. Förfarande för framställning av 8-trifluormetyl- 5-metyl-l-propyl-4H-l,2,4-triazolo(4,3-a)kinoxalin-4-on,
FI811504A 1980-05-19 1981-05-15 Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner FI71148C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/151,220 US4354027A (en) 1980-05-19 1980-05-19 Triazoloquinoxalin-4-ones
US15122080 1980-05-19

Publications (3)

Publication Number Publication Date
FI811504L FI811504L (fi) 1981-11-20
FI71148B FI71148B (fi) 1986-08-14
FI71148C true FI71148C (fi) 1986-11-24

Family

ID=22537818

Family Applications (1)

Application Number Title Priority Date Filing Date
FI811504A FI71148C (fi) 1980-05-19 1981-05-15 Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner

Country Status (12)

Country Link
US (1) US4354027A (sv)
EP (1) EP0040401B1 (sv)
JP (1) JPS5718681A (sv)
AU (1) AU538782B2 (sv)
CA (1) CA1176634A (sv)
DE (1) DE3162761D1 (sv)
DK (1) DK214981A (sv)
ES (1) ES8203375A1 (sv)
FI (1) FI71148C (sv)
NO (1) NO811646L (sv)
NZ (1) NZ197101A (sv)
ZA (1) ZA813255B (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141304A (en) * 1960-11-14 1964-07-21 Jefferson Chem Co Inc Soil stabilization by atactic polypropylene coating
US4400382A (en) * 1980-05-09 1983-08-23 Usv Pharmaceutical Corporation Thiazoloquinoxalin-1,4-diones for treating allergy
US4507300A (en) * 1980-05-09 1985-03-26 Usv Pharmaceutical Corporation Pyridotriazolopyrazine-diones for treating allergy
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
DK162491D0 (da) * 1991-09-20 1991-09-20 Novo Nordisk As Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
FR2696466B1 (fr) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK31093D0 (sv) * 1993-03-19 1993-03-19 Novo Nordisk As
FR2717812B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2717813B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant .
FR2717805B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant .
FR2717814B1 (fr) * 1994-03-28 1996-04-26 Rhone Poulenc Rorer Sa Dérivés de 1,2,4-triazolo(4,3-a)pyrazine-4-one, leur préparation et les médicaments les contenant.
ATE190616T1 (de) * 1994-09-16 2000-04-15 Novo Nordisk As (1,2,4)triazolo(4,3-a)chinoxylinonderivate, ihre darstellung und verwendung als antagonisten von ampa-rezeptoren
CA2200056A1 (en) * 1994-09-16 1996-03-21 Novo Nordisk A/S [1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use
FR2726275B1 (fr) * 1994-11-02 1996-12-06 Rhone Poulenc Rorer Sa Spiro heterocycle-imidazo(1,2-a)indeno(1,2-e)pyrazine)-4'- ones, leur preparation et les medicaments les contenants
US5679680A (en) * 1995-02-16 1997-10-21 Warner-Lambert Company α-substituted hydrazides having calpain inhibitory activity
ES2536906T3 (es) * 2006-12-13 2015-05-29 Aska Pharmaceutical Co., Ltd. Derivado de quinoxalina
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑
JOP20170164A1 (ar) 2016-08-25 2019-01-30 Lilly Co Eli مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري
AR112457A1 (es) 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
AR112346A1 (es) * 2017-08-10 2019-10-16 Lilly Co Eli Derivados de [1,2,4]triazolo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1301228A (sv) * 1971-03-04 1972-12-29 Ici Ltd
JPS50116498A (sv) * 1974-02-27 1975-09-11
US3979387A (en) * 1975-06-10 1976-09-07 Eli Lilly And Company 4,5-Dihydrotetrazolo(1,5-A)quinoxalines

Also Published As

Publication number Publication date
DK214981A (da) 1981-11-20
ZA813255B (en) 1982-06-30
DE3162761D1 (en) 1984-04-26
ES502747A0 (es) 1982-04-01
CA1176634A (en) 1984-10-23
FI71148B (fi) 1986-08-14
ES8203375A1 (es) 1982-04-01
AU538782B2 (en) 1984-08-30
US4354027A (en) 1982-10-12
FI811504L (fi) 1981-11-20
EP0040401A1 (en) 1981-11-25
AU7054481A (en) 1981-11-19
NZ197101A (en) 1984-03-16
NO811646L (no) 1981-11-20
EP0040401B1 (en) 1984-03-21
JPS5718681A (en) 1982-01-30

Similar Documents

Publication Publication Date Title
FI71148C (fi) Foerfarande foer framstaellning av nya antihypertensiva 4h-1,2,4-triazolo(4,3-a)kinoxalin-4-oner
CA1101430A (en) Derivatives of 4-amino 5-alkylsulphonyl ortho- anisamides, methods of preparing them
EP0129128B1 (de) 2-Pyrimidinyl-l-piperazin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0100200B1 (en) 2-substituted 4-amino-6,7-dimethoxyquinolines
US5162318A (en) Benzimidazolinone derivatives
US20070287840A1 (en) Process for Preparing Telmisartan
EP1802628A1 (en) Crystalline forms and process for preparing spiro-hydantoin compounds
AU745051B2 (en) Benzothiadiazoles and derivatives
FR2717812A1 (fr) Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
KR870001362B1 (ko) 테트라하이드로 이미다조퀴나졸리논 유도체의 제조방법
CA1092108A (en) Oxadiazolopyrimidine derivatives
EP0198235B1 (en) Imidazole derivatives having antimycotic and antibacterial activities, a process for the preparation thereof and pharmaceutical compositions containing them
CA1100511A (en) 3,5-disubstituted-1h-1,2,4-triazole derivatives
WO1993021171A1 (fr) Application de derives d'acide 2h-1,2,4-benzothiadiazine-1,1-dioxyde-3-carboxylique a la preparation de medicaments antagonistes des recepteurs nmda/ampa, ainsi que produits nouveaux, leur preparation et les medicaments les contenant
JPH02115160A (ja) チオホルムアミジン
US4221798A (en) Hypotensive 2-heterocycloamino-imidazolines
US4438121A (en) Isoquinoline amidoxime derivatives
KR930003611B1 (ko) 퀴놀론 카복실산 유도체의 제조방법
FR2648135A1 (fr) Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique
EP0278265B1 (en) 1- [(4-Morpholinyl) alkyl] -1H-indoles useful as analgesics and preparation thereof
EP0305298A2 (fr) Nouvelles imidazo benzodiazépines et leurs sels d'addition avec les acides, leur procédé et les intermédiaires de préparation, leur application comme médicaments et les compositions les renfermant
DE3519735A1 (de) Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0369334A2 (en) 1-Aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodiazepine-2-ones, a process for their preparation and their use as medicaments
JP3145364B2 (ja) 新規化合物及び該化合物を含有する医薬組成物
JPH049791B2 (sv)

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: USV PHARMACEUTICAL CORPORATION