FI69631C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 17beta-amino-16alfa-hydroxisteroider av androstan- och estranserier samt av enantiomerer och racemat och farmaceutisktgodtagbara syraadditionssalter av dessa - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 17beta-amino-16alfa-hydroxisteroider av androstan- och estranserier samt av enantiomerer och racemat och farmaceutisktgodtagbara syraadditionssalter av dessa Download PDF

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Publication number
FI69631C
FI69631C FI810255A FI810255A FI69631C FI 69631 C FI69631 C FI 69631C FI 810255 A FI810255 A FI 810255A FI 810255 A FI810255 A FI 810255A FI 69631 C FI69631 C FI 69631C
Authority
FI
Finland
Prior art keywords
amino
group
diol
hydroxy
acyloxy
Prior art date
Application number
FI810255A
Other languages
English (en)
Finnish (fi)
Other versions
FI69631B (fi
FI810255L (fi
Inventor
Thomas Sleigh
David Samuel Savage
Filippus Johannes Zeelen
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of FI810255L publication Critical patent/FI810255L/fi
Application granted granted Critical
Publication of FI69631B publication Critical patent/FI69631B/fi
Publication of FI69631C publication Critical patent/FI69631C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0052—Nitrogen only at position 16(17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI810255A 1980-01-30 1981-01-29 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 17beta-amino-16alfa-hydroxisteroider av androstan- och estranserier samt av enantiomerer och racemat och farmaceutisktgodtagbara syraadditionssalter av dessa FI69631C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8003053 1980-01-30
GB8003053 1980-01-30

Publications (3)

Publication Number Publication Date
FI810255L FI810255L (fi) 1981-07-31
FI69631B FI69631B (fi) 1985-11-29
FI69631C true FI69631C (fi) 1986-03-10

Family

ID=10510984

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810255A FI69631C (fi) 1980-01-30 1981-01-29 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 17beta-amino-16alfa-hydroxisteroider av androstan- och estranserier samt av enantiomerer och racemat och farmaceutisktgodtagbara syraadditionssalter av dessa

Country Status (13)

Country Link
EP (1) EP0033561B1 (es)
JP (1) JPS56120699A (es)
AT (1) ATE3298T1 (es)
AU (1) AU542419B2 (es)
CA (1) CA1167837A (es)
DE (1) DE3160232D1 (es)
DK (1) DK163997C (es)
ES (1) ES8300788A1 (es)
FI (1) FI69631C (es)
GR (1) GR73137B (es)
HU (1) HU185441B (es)
IE (1) IE51100B1 (es)
ZA (1) ZA81348B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917930A1 (de) * 1999-04-15 2000-10-19 Schering Ag Ent-Steroide als selektiv wirksame Estrogene
JP2004518637A (ja) 2000-11-03 2004-06-24 ワシントン・ユニバーシティ 細胞保護活性を有する修飾されたヒドロキシ置換芳香族構造体
JPWO2005026190A1 (ja) * 2003-09-10 2010-02-25 学校法人日本大学 アミノ化環状化合物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL104598C (es) * 1959-07-23
GB1439605A (en) * 1972-07-14 1976-06-16 Akzo Nv 2beta-hydroxy-3-alpha-amino-steroids and derivatives thereof and the processes for their preparation
GB2030569A (en) * 1978-10-03 1980-04-10 Akzo Nv Amino hydroxy steroids and derivatives thereof

Also Published As

Publication number Publication date
DK39981A (da) 1981-07-31
ES498942A0 (es) 1982-11-16
ES8300788A1 (es) 1982-11-16
ATE3298T1 (de) 1983-05-15
ZA81348B (en) 1982-02-24
AU542419B2 (en) 1985-02-21
AU6664981A (en) 1981-08-06
HU185441B (en) 1985-02-28
EP0033561A1 (en) 1981-08-12
GR73137B (es) 1984-02-07
FI69631B (fi) 1985-11-29
JPH0115518B2 (es) 1989-03-17
DE3160232D1 (en) 1983-06-16
CA1167837A (en) 1984-05-22
FI810255L (fi) 1981-07-31
JPS56120699A (en) 1981-09-22
DK163997C (da) 1992-09-21
IE51100B1 (en) 1986-10-01
EP0033561B1 (en) 1983-05-11
IE810107L (en) 1981-07-30
DK163997B (da) 1992-04-27

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Legal Events

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MM Patent lapsed
MM Patent lapsed

Owner name: AKZO N.V.