FI68839C - Foerfarande foer framstaellning av en ny terapeutiskt anvaendbar-6-(d-alfa-(4-etyl-2,3-dioxo-1-piperazinokarboxiamido)-alfa-(3,4-dihydroxifenyl)acetamido)penicillansyra - Google Patents
Foerfarande foer framstaellning av en ny terapeutiskt anvaendbar-6-(d-alfa-(4-etyl-2,3-dioxo-1-piperazinokarboxiamido)-alfa-(3,4-dihydroxifenyl)acetamido)penicillansyra Download PDFInfo
- Publication number
- FI68839C FI68839C FI793169A FI793169A FI68839C FI 68839 C FI68839 C FI 68839C FI 793169 A FI793169 A FI 793169A FI 793169 A FI793169 A FI 793169A FI 68839 C FI68839 C FI 68839C
- Authority
- FI
- Finland
- Prior art keywords
- acid
- therapeutic
- ethyl
- dioxo
- dihydroxyphenyl
- Prior art date
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- 239000002253 acid Substances 0.000 title claims description 18
- 230000001225 therapeutic effect Effects 0.000 title description 4
- 150000003839 salts Chemical class 0.000 claims description 17
- -1 3,4-dihydroxyphenyl Chemical group 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 claims description 8
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 229910014033 C-OH Inorganic materials 0.000 claims description 2
- 229910014570 C—OH Inorganic materials 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 36
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- 239000000203 mixture Substances 0.000 description 18
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- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 3
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- 229940125758 compound 15 Drugs 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940092559 enterobacter aerogenes Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95190078A | 1978-10-16 | 1978-10-16 | |
| US95190078 | 1978-10-16 | ||
| US05/967,338 US4206116A (en) | 1978-10-16 | 1978-12-07 | Novel penicillins |
| US96733878 | 1978-12-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI793169A7 FI793169A7 (fi) | 1980-04-17 |
| FI68839B FI68839B (fi) | 1985-07-31 |
| FI68839C true FI68839C (fi) | 1985-11-11 |
Family
ID=27130320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI793169A FI68839C (fi) | 1978-10-16 | 1979-10-11 | Foerfarande foer framstaellning av en ny terapeutiskt anvaendbar-6-(d-alfa-(4-etyl-2,3-dioxo-1-piperazinokarboxiamido)-alfa-(3,4-dihydroxifenyl)acetamido)penicillansyra |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4206116A (de) |
| AT (1) | AT366385B (de) |
| AU (1) | AU533598B2 (de) |
| CA (1) | CA1132540A (de) |
| CH (1) | CH644383A5 (de) |
| DE (1) | DE2941717A1 (de) |
| DK (1) | DK435279A (de) |
| ES (1) | ES8101076A1 (de) |
| FI (1) | FI68839C (de) |
| FR (1) | FR2439202A1 (de) |
| GB (1) | GB2043627B (de) |
| GR (1) | GR72291B (de) |
| IE (1) | IE49083B1 (de) |
| IT (1) | IT1206996B (de) |
| LU (1) | LU81795A1 (de) |
| NL (1) | NL7907577A (de) |
| SE (2) | SE445456B (de) |
| YU (3) | YU41888B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3215085A1 (de) * | 1982-04-22 | 1983-10-27 | Bayer Ag, 5090 Leverkusen | Ss-lactam-antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE3372208D1 (en) * | 1982-04-29 | 1987-07-30 | Beecham Group Plc | Beta-lactam antibiotics |
| DE3479731D1 (en) * | 1983-07-07 | 1989-10-19 | Beecham Group Plc | Substituted phenylglycine derivatives of beta-lactam antibiotics |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1450764A (en) * | 1972-09-14 | 1976-09-29 | Beecham Group Ltd | Penicillins |
| US4110327A (en) * | 1974-05-09 | 1978-08-29 | Toyama Chemical Co., Ltd. | 2,3 Diketo-piperazinocarbonylamino alkanoic acids and derivatives |
| US4087424A (en) * | 1974-05-09 | 1978-05-02 | Toyama Chemical Co., Ltd. | Novel penicillins and cephalosporins and process for producing the same |
-
1978
- 1978-12-07 US US05/967,338 patent/US4206116A/en not_active Expired - Lifetime
-
1979
- 1979-10-02 CA CA336,802A patent/CA1132540A/en not_active Expired
- 1979-10-04 GR GR60185A patent/GR72291B/el unknown
- 1979-10-05 AU AU51499/79A patent/AU533598B2/en not_active Ceased
- 1979-10-08 YU YU2437/79A patent/YU41888B/xx unknown
- 1979-10-09 GB GB7934995A patent/GB2043627B/en not_active Expired
- 1979-10-11 FI FI793169A patent/FI68839C/fi not_active IP Right Cessation
- 1979-10-11 FR FR7925346A patent/FR2439202A1/fr active Granted
- 1979-10-12 NL NL7907577A patent/NL7907577A/nl not_active Application Discontinuation
- 1979-10-15 SE SE7908528A patent/SE445456B/sv unknown
- 1979-10-15 DE DE19792941717 patent/DE2941717A1/de not_active Withdrawn
- 1979-10-15 IE IE1952/79A patent/IE49083B1/en unknown
- 1979-10-15 IT IT7950565A patent/IT1206996B/it active
- 1979-10-15 CH CH927379A patent/CH644383A5/fr not_active IP Right Cessation
- 1979-10-15 DK DK435279A patent/DK435279A/da not_active Application Discontinuation
- 1979-10-16 AT AT0673579A patent/AT366385B/de active
- 1979-10-16 ES ES485079A patent/ES8101076A1/es not_active Expired
- 1979-10-16 LU LU81795A patent/LU81795A1/fr unknown
-
1982
- 1982-10-04 YU YU2227/82A patent/YU42051B/xx unknown
- 1982-10-04 YU YU02226/82A patent/YU222682A/xx unknown
-
1984
- 1984-09-11 SE SE8404556A patent/SE8404556L/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA673579A (de) | 1981-08-15 |
| IT1206996B (it) | 1989-05-17 |
| FR2439202A1 (fr) | 1980-05-16 |
| GB2043627B (en) | 1982-10-06 |
| YU222682A (en) | 1983-04-30 |
| AU533598B2 (en) | 1983-12-01 |
| SE8404556D0 (sv) | 1984-09-11 |
| SE8404556L (sv) | 1984-09-11 |
| YU41888B (en) | 1988-02-29 |
| CA1132540A (en) | 1982-09-28 |
| GR72291B (de) | 1983-10-17 |
| IE791952L (en) | 1980-04-16 |
| IE49083B1 (en) | 1985-07-24 |
| CH644383A5 (fr) | 1984-07-31 |
| ES485079A0 (es) | 1980-12-01 |
| FI793169A7 (fi) | 1980-04-17 |
| FI68839B (fi) | 1985-07-31 |
| YU222782A (en) | 1983-04-30 |
| YU42051B (en) | 1988-04-30 |
| AT366385B (de) | 1982-04-13 |
| SE445456B (sv) | 1986-06-23 |
| DK435279A (da) | 1980-04-17 |
| FR2439202B1 (de) | 1983-02-11 |
| DE2941717A1 (de) | 1980-04-24 |
| YU243779A (en) | 1983-01-21 |
| US4206116A (en) | 1980-06-03 |
| AU5149979A (en) | 1980-04-24 |
| IT7950565A0 (it) | 1979-10-15 |
| GB2043627A (en) | 1980-10-08 |
| LU81795A1 (fr) | 1980-05-07 |
| NL7907577A (nl) | 1980-04-18 |
| ES8101076A1 (es) | 1980-12-01 |
| SE7908528L (sv) | 1980-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed | ||
| MM | Patent lapsed |
Owner name: BRISTOL-MYERS CO |