FI68807B - Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat - Google Patents

Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat Download PDF

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Publication number
FI68807B
FI68807B FI803399A FI803399A FI68807B FI 68807 B FI68807 B FI 68807B FI 803399 A FI803399 A FI 803399A FI 803399 A FI803399 A FI 803399A FI 68807 B FI68807 B FI 68807B
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Finland
Prior art keywords
trans
formula
tetrahydro
hydrogen
acid
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FI803399A
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English (en)
Finnish (fi)
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FI68807C (fi
FI803399L (fi
Inventor
Willard Mckowan Welch
Charles Armon Harbert
Billie Kenneth Koe
Allen Richard Kraska
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Pfizer
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (3)

1. Förfarande för framställning av nya, som depression s läkemedel användbara trans-4-fenyl-1,2,3,4-tetrahydro-5 1-naftalenaminderivat, vilka är trans-isomera baser med formeIn I, _ PlR2 - Wl Y X väri R.| är väte eller en normal alkyl med 1-3 kolatomer, R2 15 är en normal alkyl med 1-3 kolatomer, X och Y är vardera väte, fluor, klor, brom, trifluormetyl eller en alkoxi med 1-3 kolatomer, varvid ätminstone nägondera av X och Y är annat än väte, och W är väte, klor eller en alkoxi med 1-3 kolatomer, samt för framställning av deras farmaceutiskt 20 godtagbara syraadditionssalter, kännetecknat därav, att a) en förening med formeln II 25 (II) Y^^ X 30 väri X och Y anger väte, fluor, klor, brom eller trifluormetyl sä, att ätminstone den ena av X och Y anger annat än väte, och W anger samma som ovan, kondenseras i närvaro av en syrakatalysator med en amin med formeln
35 HNR1R2 44 68807 väri R.j och R2 anger sanana som ovan, för erhällande av, dä R1 är väte, en förening med formeln III (iii) Y X eller, da R^ är en normal alkyl, en förening med formeln IV 10 iPlR2 W--|l (IV) Y X och den erhällna föreningen med formeln III eller IV redu-ceras för erhällande av en blandning av cis- och trans-iso-mera baser med formeln I; eller 20 b) en förening med formeln V X (V) 25 ill väri R^, R2, X, Y och W anger samma som i formel I, hyde-ras för erhällande av en blandning av cis- och trans-iso-30 mera baser med formeln I; en (IS)(IR)-racemisk trans-isomer bas med formeln I, eller ett farmaceutiskt godtagbart syraadditionssalt därav, se-paras frän blandningen som erhällits i skede a) eller ske-de b);
FI803399A 1979-11-01 1980-10-30 Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat FI68807C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9023779A 1979-11-01 1979-11-01
US9023779 1979-11-01
US18444780 1980-09-05
US06/184,447 US4556676A (en) 1979-11-01 1980-09-05 Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine

Publications (3)

Publication Number Publication Date
FI803399L FI803399L (fi) 1981-05-02
FI68807B true FI68807B (fi) 1985-07-31
FI68807C FI68807C (fi) 1985-11-11

Family

ID=26782055

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FI803399A FI68807C (fi) 1979-11-01 1980-10-30 Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat

Country Status (18)

Country Link
US (1) US4556676A (sv)
EP (1) EP0028901B1 (sv)
KR (1) KR840002021B1 (sv)
AR (2) AR225196A1 (sv)
AT (1) ATE2667T1 (sv)
AU (1) AU517842B2 (sv)
CA (1) CA1130816A (sv)
DE (1) DE3062226D1 (sv)
DK (1) DK149308C (sv)
ES (2) ES8201948A1 (sv)
FI (1) FI68807C (sv)
GR (1) GR70782B (sv)
IE (1) IE50396B1 (sv)
IL (1) IL61376A (sv)
NO (1) NO149102C (sv)
PH (1) PH15468A (sv)
PT (1) PT72005B (sv)
YU (2) YU41744B (sv)

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SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
US4866208A (en) * 1981-12-21 1989-09-12 The Dow Chemical Company Meta-phenylene diamine derivatives
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
US4839104A (en) * 1987-06-11 1989-06-13 Pfizer, Inc. Process for preparing sertraline intermediates
FR2623802B1 (fr) * 1987-11-26 1990-05-04 Lucien Laboratoires Derives d'amino-4 trifluoromethyl-1 tetralines. leur preparation et leur application en therapeutique
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
FR2665443B1 (fr) * 1990-08-03 1992-11-06 Lucien Laboratoires Derives d'amino-4-methyl-1-tetralines, leur preparation et leur application en therapeutique.
US5082970A (en) * 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
GB9114948D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5196607A (en) * 1992-02-14 1993-03-23 Pfizer Inc. Process for preparing ketone enantiomer
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5466880A (en) * 1992-09-15 1995-11-14 Pfizer Inc. Process for preparing ketone enantiomer
EP0697894A4 (en) * 1993-03-31 1996-05-01 Univ Pennsylvania DOPAMINE D-3 AND SEROTONIN (5-HT 1A) RECEPTOR LIGANDS AND IMAGING AGENTS
DK0724552T3 (da) * 1993-11-30 1997-12-22 Pfizer Fremgangsmåde til fremstilling af chiralt tetralon
US6410794B1 (en) 1994-12-16 2002-06-25 Uop Llc Process for preparation of pharmaceutically desired chiral tetralone from tetralones
US6455736B1 (en) 1994-12-16 2002-09-24 Uop Llc Process for preparation of pharmaceutically desired sertraline and sertraline analogs
HU222341B1 (hu) * 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
IN182588B (sv) 1998-05-12 1999-05-08 Sun Pharmaceutical Ind Ltd
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DE10006411C2 (de) * 2000-02-14 2002-03-07 Huf Huelsbeck & Fuerst Gmbh Elektronischer Zündanlaßschalter für Kraftfahrzeuge und Reserveschlüssel zur Betätigung desselben
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US8134029B2 (en) 2002-09-16 2012-03-13 Sunovion Pharmaceuticals Inc. Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
US20060014838A1 (en) * 2004-07-14 2006-01-19 Sudhakar Valluri Process for converting trans-sertraline to cis-sertraline
JP2009500425A (ja) 2005-07-06 2009-01-08 セプラコア インコーポレーテッド エスゾピクロン及びトランス4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロ−n−メチル−1−ナフタレンアミン又はトランス4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロ−1−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
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Also Published As

Publication number Publication date
AR225196A1 (es) 1982-02-26
ES8207120A1 (es) 1982-09-01
YU3383A (en) 1983-09-30
YU41744B (en) 1987-12-31
ES496441A0 (es) 1982-01-16
AU6389880A (en) 1981-05-07
DK149308B (da) 1986-04-28
FI68807C (fi) 1985-11-11
DK462480A (da) 1981-05-02
FI803399L (fi) 1981-05-02
EP0028901A1 (en) 1981-05-20
IE50396B1 (en) 1986-04-16
KR840002021B1 (ko) 1984-11-05
NO803259L (no) 1981-05-04
NO149102B (no) 1983-11-07
DK149308C (da) 1986-12-08
ATE2667T1 (de) 1983-03-15
EP0028901B1 (en) 1983-03-02
YU277480A (en) 1983-09-30
IL61376A0 (en) 1980-12-31
YU42066B (en) 1988-04-30
ES506893A0 (es) 1982-09-01
GR70782B (sv) 1983-03-23
US4556676A (en) 1985-12-03
AU517842B2 (en) 1981-08-27
NO149102C (no) 1984-02-15
CA1130816A (en) 1982-08-31
IL61376A (en) 1983-10-31
DE3062226D1 (en) 1983-04-07
AR229106A1 (es) 1983-06-15
PT72005A (en) 1980-11-01
PT72005B (en) 1981-08-31
IE802260L (en) 1981-05-01
PH15468A (en) 1983-01-24
ES8201948A1 (es) 1982-01-16
KR830004201A (ko) 1983-07-06

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