FI68807B - Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat - Google Patents

Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat Download PDF

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Publication number
FI68807B
FI68807B FI803399A FI803399A FI68807B FI 68807 B FI68807 B FI 68807B FI 803399 A FI803399 A FI 803399A FI 803399 A FI803399 A FI 803399A FI 68807 B FI68807 B FI 68807B
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FI
Finland
Prior art keywords
trans
formula
tetrahydro
hydrogen
acid
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FI803399A
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English (en)
Finnish (fi)
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FI803399L (fi
FI68807C (fi
Inventor
Willard Mckowan Welch
Charles Armon Harbert
Billie Kenneth Koe
Allen Richard Kraska
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Pfizer
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (3)

1. Förfarande för framställning av nya, som depression s läkemedel användbara trans-4-fenyl-1,2,3,4-tetrahydro-5 1-naftalenaminderivat, vilka är trans-isomera baser med formeIn I, _ PlR2 - Wl Y X väri R.| är väte eller en normal alkyl med 1-3 kolatomer, R2 15 är en normal alkyl med 1-3 kolatomer, X och Y är vardera väte, fluor, klor, brom, trifluormetyl eller en alkoxi med 1-3 kolatomer, varvid ätminstone nägondera av X och Y är annat än väte, och W är väte, klor eller en alkoxi med 1-3 kolatomer, samt för framställning av deras farmaceutiskt 20 godtagbara syraadditionssalter, kännetecknat därav, att a) en förening med formeln II 25 (II) Y^^ X 30 väri X och Y anger väte, fluor, klor, brom eller trifluormetyl sä, att ätminstone den ena av X och Y anger annat än väte, och W anger samma som ovan, kondenseras i närvaro av en syrakatalysator med en amin med formeln
35 HNR1R2 44 68807 väri R.j och R2 anger sanana som ovan, för erhällande av, dä R1 är väte, en förening med formeln III (iii) Y X eller, da R^ är en normal alkyl, en förening med formeln IV 10 iPlR2 W--|l (IV) Y X och den erhällna föreningen med formeln III eller IV redu-ceras för erhällande av en blandning av cis- och trans-iso-mera baser med formeln I; eller 20 b) en förening med formeln V X (V) 25 ill väri R^, R2, X, Y och W anger samma som i formel I, hyde-ras för erhällande av en blandning av cis- och trans-iso-30 mera baser med formeln I; en (IS)(IR)-racemisk trans-isomer bas med formeln I, eller ett farmaceutiskt godtagbart syraadditionssalt därav, se-paras frän blandningen som erhällits i skede a) eller ske-de b);
FI803399A 1979-11-01 1980-10-30 Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat FI68807C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9023779A 1979-11-01 1979-11-01
US9023779 1979-11-01
US06/184,447 US4556676A (en) 1979-11-01 1980-09-05 Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US18444780 1980-09-05

Publications (3)

Publication Number Publication Date
FI803399L FI803399L (fi) 1981-05-02
FI68807B true FI68807B (fi) 1985-07-31
FI68807C FI68807C (fi) 1985-11-11

Family

ID=26782055

Family Applications (1)

Application Number Title Priority Date Filing Date
FI803399A FI68807C (fi) 1979-11-01 1980-10-30 Foerfarande foer framstaellning av nya som depressionslaekemedel anvaendbara trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenaminderivat

Country Status (18)

Country Link
US (1) US4556676A (sv)
EP (1) EP0028901B1 (sv)
KR (1) KR840002021B1 (sv)
AR (2) AR225196A1 (sv)
AT (1) ATE2667T1 (sv)
AU (1) AU517842B2 (sv)
CA (1) CA1130816A (sv)
DE (1) DE3062226D1 (sv)
DK (1) DK149308C (sv)
ES (2) ES8201948A1 (sv)
FI (1) FI68807C (sv)
GR (1) GR70782B (sv)
IE (1) IE50396B1 (sv)
IL (1) IL61376A (sv)
NO (1) NO149102C (sv)
PH (1) PH15468A (sv)
PT (1) PT72005B (sv)
YU (2) YU41744B (sv)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
US4866208A (en) * 1981-12-21 1989-09-12 The Dow Chemical Company Meta-phenylene diamine derivatives
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
US4839104A (en) * 1987-06-11 1989-06-13 Pfizer, Inc. Process for preparing sertraline intermediates
FR2623802B1 (fr) * 1987-11-26 1990-05-04 Lucien Laboratoires Derives d'amino-4 trifluoromethyl-1 tetralines. leur preparation et leur application en therapeutique
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
FR2665443B1 (fr) * 1990-08-03 1992-11-06 Lucien Laboratoires Derives d'amino-4-methyl-1-tetralines, leur preparation et leur application en therapeutique.
US5082970A (en) * 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
GB9114948D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5196607A (en) * 1992-02-14 1993-03-23 Pfizer Inc. Process for preparing ketone enantiomer
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5466880A (en) * 1992-09-15 1995-11-14 Pfizer Inc. Process for preparing ketone enantiomer
EP0697894A4 (en) * 1993-03-31 1996-05-01 Univ Pennsylvania DOPAMINE D-3 AND SEROTONIN (5-HT 1A) RECEPTOR LIGANDS AND IMAGING AGENTS
CA2176500C (en) * 1993-11-30 1999-09-28 George J. Quallich Process for preparing a chiral tetralone
US6455736B1 (en) 1994-12-16 2002-09-24 Uop Llc Process for preparation of pharmaceutically desired sertraline and sertraline analogs
US6410794B1 (en) 1994-12-16 2002-06-25 Uop Llc Process for preparation of pharmaceutically desired chiral tetralone from tetralones
HU222341B1 (hu) * 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
IN182588B (sv) 1998-05-12 1999-05-08 Sun Pharmaceutical Ind Ltd
IN187170B (sv) 2000-01-04 2002-02-23 Sun Pharmaceutical Ind Ltd
DE10006411C2 (de) * 2000-02-14 2002-03-07 Huf Huelsbeck & Fuerst Gmbh Elektronischer Zündanlaßschalter für Kraftfahrzeuge und Reserveschlüssel zur Betätigung desselben
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
US6482440B2 (en) 2000-09-21 2002-11-19 Phase 2 Discovery, Inc. Long acting antidepressant microparticles
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
US8134029B2 (en) 2002-09-16 2012-03-13 Sunovion Pharmaceuticals Inc. Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
DK1542961T3 (da) * 2002-09-16 2013-11-04 Sepracor Inc Trans-4-(3,4-dichlorphenyl)-1,2,3,4-tetrahydro-1-napthalenamin til anvendelse til behandling af cns-forstyrrelser
WO2004024130A2 (en) * 2002-09-16 2004-03-25 Sepracor, Inc. TREATMENT OF CNS DISORDERS WITH trans 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
US20060014838A1 (en) * 2004-07-14 2006-01-19 Sudhakar Valluri Process for converting trans-sertraline to cis-sertraline
MX2008000250A (es) 2005-07-06 2008-03-19 Sepracor Inc Combinaciones de eszopiclona y trans-4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-n-metil-1-naftalenamina o trans 4-(3,4-diclorofenil)-1, 2,3,4-tetrahidro-1-naftalenamina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y
CN101421228B (zh) * 2006-03-31 2014-05-21 塞普拉柯公司 手性酰胺和胺的制备
KR20090015089A (ko) * 2006-05-31 2009-02-11 세프라코 아이엔시. 트랜스 4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로-1-나프탈렌아민 및 그의 포름아미드에 의한 통증장애 치료방법
WO2007146796A2 (en) * 2006-06-13 2007-12-21 Ramot At Tel-Aviv University Ltd. Antiproliferative compounds, compositions and methods of use
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
US20100081713A1 (en) * 2008-03-19 2010-04-01 CombinatoRx, (Singapore) Pte. Ltd. Compositions and methods for treating viral infections
WO2015175523A1 (en) * 2014-05-13 2015-11-19 Sunovion Pharmaceuticals Inc. Dosage of dasotraline and method for treatment of adhd
CA2948829A1 (en) * 2014-05-13 2015-11-19 Sunovion Pharmaceuticals Inc. Methods and compositions of dasotraline for treatment of adhd
WO2016046669A2 (en) * 2014-09-27 2016-03-31 Mohan M Alapati Compositions and methods for the treatment of depression and neurological diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB793853A (en) * 1954-09-15 1958-04-23 Schering Ag Manufacture of new 3-amino-indanes
DE1098511B (de) * 1959-11-21 1961-02-02 Schering Ag Verfahren zur Abtrennung von analgetisch wirksamen d-1-Phenyl-3-dimethylaminoindan
US3704323A (en) * 1969-12-23 1972-11-28 Squibb & Sons Inc Indane derivatives
GB1420472A (en) * 1972-09-27 1976-01-07 Pfizer Aminophenyltetralin compounds
US4029731A (en) * 1974-11-06 1977-06-14 Pfizer Inc. Aminophenyltetralin compounds
US4045488A (en) * 1974-11-06 1977-08-30 Pfizer Inc. Aminophenyltetralin compounds

Also Published As

Publication number Publication date
ES496441A0 (es) 1982-01-16
ES8207120A1 (es) 1982-09-01
ES506893A0 (es) 1982-09-01
PT72005B (en) 1981-08-31
AU6389880A (en) 1981-05-07
NO149102C (no) 1984-02-15
AR229106A1 (es) 1983-06-15
PT72005A (en) 1980-11-01
DK149308B (da) 1986-04-28
CA1130816A (en) 1982-08-31
IE802260L (en) 1981-05-01
DK149308C (da) 1986-12-08
FI803399L (fi) 1981-05-02
DK462480A (da) 1981-05-02
KR840002021B1 (ko) 1984-11-05
AU517842B2 (en) 1981-08-27
ES8201948A1 (es) 1982-01-16
IL61376A0 (en) 1980-12-31
ATE2667T1 (de) 1983-03-15
IL61376A (en) 1983-10-31
EP0028901B1 (en) 1983-03-02
PH15468A (en) 1983-01-24
IE50396B1 (en) 1986-04-16
AR225196A1 (es) 1982-02-26
DE3062226D1 (en) 1983-04-07
NO149102B (no) 1983-11-07
KR830004201A (ko) 1983-07-06
YU42066B (en) 1988-04-30
YU277480A (en) 1983-09-30
YU3383A (en) 1983-09-30
FI68807C (fi) 1985-11-11
GR70782B (sv) 1983-03-23
EP0028901A1 (en) 1981-05-20
YU41744B (en) 1987-12-31
US4556676A (en) 1985-12-03
NO803259L (no) 1981-05-04

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