FI68246C - Analogifoerfarande foer framstaellning av nya cyklopeptider - Google Patents

Analogifoerfarande foer framstaellning av nya cyklopeptider Download PDF

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Publication number
FI68246C
FI68246C FI782907A FI782907A FI68246C FI 68246 C FI68246 C FI 68246C FI 782907 A FI782907 A FI 782907A FI 782907 A FI782907 A FI 782907A FI 68246 C FI68246 C FI 68246C
Authority
FI
Finland
Prior art keywords
phe
trp
thr
lys
boc
Prior art date
Application number
FI782907A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI782907A (fi
FI68246B (fi
Inventor
Hans Rink
Bruno Kamber
Peter Sieber
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI782907A publication Critical patent/FI782907A/fi
Application granted granted Critical
Publication of FI68246B publication Critical patent/FI68246B/fi
Publication of FI68246C publication Critical patent/FI68246C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI782907A 1977-09-28 1978-09-25 Analogifoerfarande foer framstaellning av nya cyklopeptider FI68246C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78191A LU78191A1 (de) 1977-09-28 1977-09-28 Verfahren zur herstellung von neuen cyclopeptiden
LU78191 1977-09-28

Publications (3)

Publication Number Publication Date
FI782907A FI782907A (fi) 1979-03-29
FI68246B FI68246B (fi) 1985-04-30
FI68246C true FI68246C (fi) 1985-08-12

Family

ID=19728716

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782907A FI68246C (fi) 1977-09-28 1978-09-25 Analogifoerfarande foer framstaellning av nya cyklopeptider

Country Status (18)

Country Link
US (1) US4238481A (fr)
EP (1) EP0001295B1 (fr)
JP (1) JPS5459293A (fr)
AT (1) AT370090B (fr)
AU (1) AU523050B2 (fr)
CA (1) CA1111841A (fr)
DD (1) DD140142A5 (fr)
DE (1) DE2861672D1 (fr)
DK (1) DK151034C (fr)
ES (1) ES473677A1 (fr)
FI (1) FI68246C (fr)
HU (1) HU184612B (fr)
IE (1) IE47380B1 (fr)
IL (1) IL55643A (fr)
LU (1) LU78191A1 (fr)
NO (1) NO148957C (fr)
NZ (1) NZ188517A (fr)
ZA (1) ZA785488B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328214A (en) * 1979-07-04 1982-05-04 Ciba-Geigy Corporation Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4369179A (en) * 1979-12-14 1983-01-18 Ciba-Geigy Corporation Acylpeptides
EP0031303A3 (fr) * 1979-12-21 1981-11-04 Ciba-Geigy Ag Cyclooctapeptides et leurs préparations pharmaceutiques, procédé pour leur préparation et leur application
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
EP0083305B1 (fr) * 1981-12-24 1985-07-10 Ciba-Geigy Ag Octapeptides cycliques, préparations pharmaceutiques les contenant et procédés de leur préparation et leur utilisation
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
CA2053250A1 (fr) * 1989-04-26 1990-10-27 David H. Coy Analogues lineaires de la somatostatine
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
DE69816808T2 (de) 1997-05-13 2004-04-15 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin agoniste zur reduzierung von körpergewicht
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP0981364B1 (fr) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Procede et compositions pour traiter l'hyperlipidemie
DE69822810T2 (de) * 1997-05-13 2005-02-03 Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. Somatostatin und somatostatin agoniste zur behandlung der insulinsunempfindlichkeit und syndrome x
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
TWI318214B (en) 2001-06-08 2009-12-11 Sod Conseils Rech Applic Somatosatin-dopamine chimeric analogs
EP1511761B1 (fr) * 2003-04-07 2006-08-02 Novetide Ltd. Procede relatif a l'elaboration de peptides cycliques
WO2004093807A2 (fr) 2003-04-22 2004-11-04 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Vecteurs de somatostatine
CA2726092A1 (fr) 2008-06-12 2009-12-17 Syntaxin Limited Suppression de cancers
US20110171191A1 (en) 2008-06-12 2011-07-14 Syntaxin Limited Suppression of neuroendocrine diseases
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
CA2822442C (fr) 2010-12-22 2021-03-16 The Salk Institute For Biological Studies Peptides cycliques antagonistes de la corticoliberine
JP6869720B2 (ja) 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド 併用療法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011182A (en) * 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
US4000259A (en) * 1975-06-16 1976-12-28 American Home Products Corporation Cyclic dodecapeptide analogs of somatostatin and intermediates
NL7607987A (nl) * 1975-08-08 1977-02-10 Merck & Co Inc Werkwijze voor het bereiden van peptiden.
US3988304A (en) * 1975-08-25 1976-10-26 American Home Products Corporation Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4133805A (en) * 1975-12-16 1979-01-09 American Home Products Corporation Cyclic undecapeptides related to somatostatin and intermediates therefor
US4054558A (en) * 1976-05-24 1977-10-18 American Home Products Corporation Cyclic dodecapeptide and intermediates therefor
DE2860734D1 (en) * 1977-06-08 1981-09-03 Merck & Co Inc Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
US4115554A (en) * 1977-08-29 1978-09-19 Merck & Co., Inc. Somatostatin analogs

Also Published As

Publication number Publication date
AU523050B2 (en) 1982-07-08
IE47380B1 (en) 1984-03-07
US4238481A (en) 1980-12-09
FI782907A (fi) 1979-03-29
DD140142A5 (de) 1980-02-13
HU184612B (en) 1984-09-28
AT370090B (de) 1983-02-25
NO148957B (no) 1983-10-10
JPS5459293A (en) 1979-05-12
DK151034C (da) 1988-02-22
IE781931L (en) 1979-03-28
ES473677A1 (es) 1980-05-16
DK151034B (da) 1987-10-12
EP0001295A2 (fr) 1979-04-04
EP0001295B1 (fr) 1982-03-17
EP0001295A3 (en) 1979-06-13
NO783268L (no) 1979-03-29
IL55643A0 (en) 1978-12-17
LU78191A1 (de) 1979-05-25
AU4022978A (en) 1980-04-03
JPS6218560B2 (fr) 1987-04-23
DE2861672D1 (en) 1982-04-15
IL55643A (en) 1981-12-31
NZ188517A (en) 1981-04-24
CA1111841A (fr) 1981-11-03
DK428478A (da) 1979-03-29
ATA698278A (de) 1982-07-15
NO148957C (no) 1984-01-18
ZA785488B (en) 1979-09-26
FI68246B (fi) 1985-04-30

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Owner name: CIBA-GEIGY AG