FI67544B - Foerfarande foer framstaellning av farmakologiskt vaerdefullt imidazolinderivat - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefullt imidazolinderivat Download PDF

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Publication number
FI67544B
FI67544B FI820262A FI820262A FI67544B FI 67544 B FI67544 B FI 67544B FI 820262 A FI820262 A FI 820262A FI 820262 A FI820262 A FI 820262A FI 67544 B FI67544 B FI 67544B
Authority
FI
Finland
Prior art keywords
formula
compound
alkyl
compounds
methyl
Prior art date
Application number
FI820262A
Other languages
English (en)
Finnish (fi)
Other versions
FI820262L (fi
FI67544C (fi
Inventor
Christopher Bourne Chapleo
Peter Leslie Myers
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of FI820262L publication Critical patent/FI820262L/fi
Publication of FI67544B publication Critical patent/FI67544B/fi
Application granted granted Critical
Publication of FI67544C publication Critical patent/FI67544C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (3)

1. Förfarande för framställning av farmakologiskt värdefullt imidazolinderivat med formeln I R1 , oci^ ' där R1 är n-alkyl i-propyl, alkenyl C2_4, cykloalkenyl c4«7» cykloalkyl C4_7 eller fenyl, kännetecknat därav, att en förening med formeln II, rr+f
0 J 'or-hx (ii> där R är alkyl C^_4 och HX är en syra och R^ avser samma som ovan omsätts med minst en molekvivalent etylendiamin och därefter eventuellt hydreras en förening med formeln (I), där r! är alkenyl C2_4, eller cykloalkenyl C4_7, i närvaro av en palladium/kolkatalysator för erhällande av en förening med formeln (I) där R^ är alkyl C2_4 eller cykloalkyl C4_7.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att i föreningen med formeln (II) R är metyl eller etyl, HX är klorväte och att reaktionen utföres respektivt i metanol eller etanol.
FI820262A 1981-01-30 1982-01-27 Foerfarande foer framstaellning av farmakologiskt vaerdefullt imidazolinderivat FI67544C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8102906 1981-01-30
GB8102906 1981-01-30
GB8123277 1981-07-28
GB8123277 1981-07-28

Publications (3)

Publication Number Publication Date
FI820262L FI820262L (fi) 1982-07-31
FI67544B true FI67544B (fi) 1984-12-31
FI67544C FI67544C (fi) 1985-04-10

Family

ID=26278285

Family Applications (1)

Application Number Title Priority Date Filing Date
FI820262A FI67544C (fi) 1981-01-30 1982-01-27 Foerfarande foer framstaellning av farmakologiskt vaerdefullt imidazolinderivat

Country Status (22)

Country Link
US (1) US4397860A (sv)
EP (1) EP0058006B1 (sv)
AR (1) AR229957A1 (sv)
AU (1) AU545344B2 (sv)
CA (1) CA1176638A (sv)
CS (1) CS245766B2 (sv)
DE (1) DE3262919D1 (sv)
DK (1) DK40482A (sv)
ES (1) ES8302694A1 (sv)
FI (1) FI67544C (sv)
GB (1) GB2092139B (sv)
GR (1) GR75168B (sv)
HU (1) HU190983B (sv)
IE (1) IE52310B1 (sv)
IL (1) IL64880A (sv)
NO (1) NO156865C (sv)
NZ (1) NZ199469A (sv)
PH (1) PH17747A (sv)
PL (1) PL137716B1 (sv)
PT (1) PT74354B (sv)
SU (1) SU1197566A3 (sv)
ZW (1) ZW1882A1 (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ203680A (en) * 1982-04-17 1985-08-16 Reckitt & Colmann Prod Ltd Imidazolines and pharmaceutical compositions
US4634714A (en) * 1983-12-01 1987-01-06 American Home Products Corporation Inhibition of prolactin release by a benzodioxinylimidazoline derivative
FR2698789B1 (fr) * 1992-12-07 1995-03-03 Pf Medicament Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
FR2700113B1 (fr) * 1993-01-07 1995-03-24 Pf Medicament Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer.
US6162455A (en) * 1997-01-22 2000-12-19 American Cyanamid Company Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals
FR2766824B1 (fr) * 1997-07-30 1999-09-10 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6650943B1 (en) 2000-04-07 2003-11-18 Advanced Bionics Corporation Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction
US20050240229A1 (en) * 2001-04-26 2005-10-27 Whitehurst Tood K Methods and systems for stimulation as a therapy for erectile dysfunction
US6885895B1 (en) * 2001-04-26 2005-04-26 Advanced Bionics Corporation Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction
CN103030646B (zh) * 2011-09-29 2016-08-24 上海恒瑞医药有限公司 苯并二氧六环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2979511A (en) * 1959-03-25 1961-04-11 Olin Mathieson Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
PH16249A (en) * 1980-02-04 1983-08-16 Reckitt & Colmann Prod Ltd Imidazoline derivatives,its pharmaceutical composition and method of use

Also Published As

Publication number Publication date
NZ199469A (en) 1984-03-16
PL235152A1 (en) 1983-07-18
EP0058006A1 (en) 1982-08-18
ES509131A0 (es) 1983-01-16
NO820258L (no) 1982-08-02
NO156865C (no) 1987-12-09
IE52310B1 (en) 1987-09-02
CA1176638A (en) 1984-10-23
AR229957A1 (es) 1984-01-31
ES8302694A1 (es) 1983-01-16
AU7992682A (en) 1982-08-05
ZW1882A1 (en) 1982-06-23
PT74354A (en) 1982-02-01
PL137716B1 (en) 1986-07-31
GB2092139A (en) 1982-08-11
PT74354B (en) 1983-07-04
US4397860A (en) 1983-08-09
FI820262L (fi) 1982-07-31
CS245766B2 (en) 1986-10-16
GR75168B (sv) 1984-07-13
NO156865B (no) 1987-08-31
SU1197566A3 (ru) 1985-12-07
DK40482A (da) 1982-07-31
IE820209L (en) 1982-07-30
IL64880A (en) 1985-04-30
DE3262919D1 (en) 1985-05-15
PH17747A (en) 1984-11-27
IL64880A0 (en) 1982-03-31
HU190983B (en) 1986-12-28
GB2092139B (en) 1984-10-31
FI67544C (fi) 1985-04-10
EP0058006B1 (en) 1985-04-10
AU545344B2 (en) 1985-07-11

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Owner name: RECKITT & COLMAN PRODUCTS LIMITED