FI67212C - Foerfarande foer framstaellning av nya saosom laekemedel anvaendbara aziridin-derivat - Google Patents
Foerfarande foer framstaellning av nya saosom laekemedel anvaendbara aziridin-derivat Download PDFInfo
- Publication number
- FI67212C FI67212C FI770718A FI770718A FI67212C FI 67212 C FI67212 C FI 67212C FI 770718 A FI770718 A FI 770718A FI 770718 A FI770718 A FI 770718A FI 67212 C FI67212 C FI 67212C
- Authority
- FI
- Finland
- Prior art keywords
- carbamoylaziridinyl
- cyanoaziridinyl
- cyanaziridine
- group
- aziridinyl
- Prior art date
Links
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 title description 2
- PGZUFTROELAOMP-UHFFFAOYSA-N aziridine-2-carbonitrile Chemical group N#CC1CN1 PGZUFTROELAOMP-UHFFFAOYSA-N 0.000 claims description 60
- -1 5,6-dihydro-2H-pyranyl Chemical group 0.000 claims description 27
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 16
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- 238000000034 method Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- LZRVAAYXGFWSDY-UHFFFAOYSA-N aziridine-2-carboxamide Chemical compound NC(=O)C1CN1 LZRVAAYXGFWSDY-UHFFFAOYSA-N 0.000 claims description 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 7
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- 150000002825 nitriles Chemical group 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762610156 DE2610156A1 (de) | 1976-03-11 | 1976-03-11 | 1-eckige klammer auf 2-cyanaziridinyl-(1)eckige klammer zu-1-eckige klammer auf 2-carbamoyl-aziridinyl- (1)eckige klammer zu-cyclohexan |
| DE2610156 | 1976-03-11 | ||
| DE2632517 | 1976-07-20 | ||
| DE19762632517 DE2632517A1 (de) | 1976-07-20 | 1976-07-20 | 2- eckige klammer auf 2-cyanaziridinyl- (1) eckige klammer zu -2- eckige klammer auf 2-carbamoyl-aziridinyl-(1) eckige klammer zu -propan und verfahren zu dessen herstellung |
| DE19762656240 DE2656240C2 (de) | 1976-12-11 | 1976-12-11 | Neue Aziridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Mittel |
| DE2656240 | 1976-12-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI770718A7 FI770718A7 (en:Method) | 1977-09-12 |
| FI67212B FI67212B (fi) | 1984-10-31 |
| FI67212C true FI67212C (fi) | 1985-02-11 |
Family
ID=27186778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI770718A FI67212C (fi) | 1976-03-11 | 1977-03-07 | Foerfarande foer framstaellning av nya saosom laekemedel anvaendbara aziridin-derivat |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4370323A (en:Method) |
| JP (1) | JPS52111563A (en:Method) |
| AR (1) | AR214733A1 (en:Method) |
| AT (1) | AT351043B (en:Method) |
| CA (1) | CA1086321A (en:Method) |
| CH (1) | CH629770A5 (en:Method) |
| DD (1) | DD128615A5 (en:Method) |
| DK (1) | DK154832B (en:Method) |
| EG (1) | EG13513A (en:Method) |
| ES (1) | ES456632A1 (en:Method) |
| FI (1) | FI67212C (en:Method) |
| FR (1) | FR2343739A1 (en:Method) |
| GB (1) | GB1518494A (en:Method) |
| GR (1) | GR73009B (en:Method) |
| HU (1) | HU176646B (en:Method) |
| IE (1) | IE44640B1 (en:Method) |
| IL (1) | IL51602A (en:Method) |
| IT (1) | IT1076885B (en:Method) |
| LU (1) | LU76918A1 (en:Method) |
| NL (1) | NL177916C (en:Method) |
| NO (1) | NO147185C (en:Method) |
| NZ (1) | NZ183528A (en:Method) |
| OA (1) | OA05594A (en:Method) |
| PL (1) | PL106627B1 (en:Method) |
| PT (1) | PT66275B (en:Method) |
| SE (1) | SE436128B (en:Method) |
| SU (1) | SU673167A3 (en:Method) |
| YU (1) | YU63077A (en:Method) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT386195B (de) * | 1978-08-03 | 1988-07-11 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von neuen n-substituierten aziridin-2-carbonsaeurederivaten und ihren salzen |
| US4925835A (en) * | 1986-05-01 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | Aziridinyl putrescine containing compositions and their uses in treating prostate cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3828024A (en) * | 1970-12-21 | 1974-08-06 | Hercules Inc | Poly(aziridine)s |
-
1977
- 1977-03-03 CA CA273,107A patent/CA1086321A/en not_active Expired
- 1977-03-06 EG EG137/77A patent/EG13513A/xx active
- 1977-03-07 SE SE7702521A patent/SE436128B/xx not_active IP Right Cessation
- 1977-03-07 FI FI770718A patent/FI67212C/fi not_active IP Right Cessation
- 1977-03-07 GB GB9499/77A patent/GB1518494A/en not_active Expired
- 1977-03-07 DK DK098577AA patent/DK154832B/da not_active Application Discontinuation
- 1977-03-07 IL IL51602A patent/IL51602A/xx unknown
- 1977-03-07 IT IT21008/77A patent/IT1076885B/it active
- 1977-03-07 PT PT66275A patent/PT66275B/pt unknown
- 1977-03-08 AT AT154277A patent/AT351043B/de not_active IP Right Cessation
- 1977-03-08 NZ NZ183528A patent/NZ183528A/xx unknown
- 1977-03-08 ES ES456632A patent/ES456632A1/es not_active Expired
- 1977-03-08 DD DD7700197731A patent/DD128615A5/xx unknown
- 1977-03-09 LU LU76918A patent/LU76918A1/xx unknown
- 1977-03-09 YU YU00630/77A patent/YU63077A/xx unknown
- 1977-03-09 NL NLAANVRAGE7702527,A patent/NL177916C/xx not_active IP Right Cessation
- 1977-03-09 IE IE518/77A patent/IE44640B1/en unknown
- 1977-03-09 CH CH296577A patent/CH629770A5/de not_active IP Right Cessation
- 1977-03-09 PL PL1977196543A patent/PL106627B1/pl unknown
- 1977-03-09 GR GR52957A patent/GR73009B/el unknown
- 1977-03-09 JP JP2586777A patent/JPS52111563A/ja active Granted
- 1977-03-09 US US05/776,068 patent/US4370323A/en not_active Expired - Lifetime
- 1977-03-09 HU HU77BO1654A patent/HU176646B/hu unknown
- 1977-03-10 NO NO770847A patent/NO147185C/no unknown
- 1977-03-10 FR FR7707061A patent/FR2343739A1/fr active Granted
- 1977-03-11 OA OA56096A patent/OA05594A/xx unknown
- 1977-03-11 AR AR266818A patent/AR214733A1/es active
- 1977-03-11 SU SU772459152A patent/SU673167A3/ru active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: BOEHRINGER MANNHEIM GMBH |