FI65621C - Foerfarande foer framstaellning av som cns-aktiva medel anvaendbara 2-(4,4-difluorfenyl-butyl)-6h-oktahydropyrazino-(1,2-c) pyrimidin-6-oner - Google Patents

Foerfarande foer framstaellning av som cns-aktiva medel anvaendbara 2-(4,4-difluorfenyl-butyl)-6h-oktahydropyrazino-(1,2-c) pyrimidin-6-oner Download PDF

Info

Publication number
FI65621C
FI65621C FI782370A FI782370A FI65621C FI 65621 C FI65621 C FI 65621C FI 782370 A FI782370 A FI 782370A FI 782370 A FI782370 A FI 782370A FI 65621 C FI65621 C FI 65621C
Authority
FI
Finland
Prior art keywords
formula
compound
hydrogen
substituted
iii
Prior art date
Application number
FI782370A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI782370A (fi
FI65621B (fi
Inventor
Anders Karl Konrad Bjoerk
Bengt Eric Sigvard Kjellberg
Aina Lisbeth Abramo
Sven Erik Harry Hernestam
Original Assignee
Ferrosan Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan Ab filed Critical Ferrosan Ab
Publication of FI782370A publication Critical patent/FI782370A/fi
Publication of FI65621B publication Critical patent/FI65621B/fi
Application granted granted Critical
Publication of FI65621C publication Critical patent/FI65621C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI782370A 1977-09-05 1978-08-01 Foerfarande foer framstaellning av som cns-aktiva medel anvaendbara 2-(4,4-difluorfenyl-butyl)-6h-oktahydropyrazino-(1,2-c) pyrimidin-6-oner FI65621C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3690477 1977-09-05
GB3690477 1977-09-05

Publications (3)

Publication Number Publication Date
FI782370A FI782370A (fi) 1979-03-06
FI65621B FI65621B (fi) 1984-02-29
FI65621C true FI65621C (fi) 1984-06-11

Family

ID=10392108

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782370A FI65621C (fi) 1977-09-05 1978-08-01 Foerfarande foer framstaellning av som cns-aktiva medel anvaendbara 2-(4,4-difluorfenyl-butyl)-6h-oktahydropyrazino-(1,2-c) pyrimidin-6-oner

Country Status (17)

Country Link
US (1) US4183933A (nl)
JP (1) JPS5452097A (nl)
AT (1) AT364365B (nl)
BE (1) BE870227A (nl)
CA (1) CA1102323A (nl)
CH (1) CH637133A5 (nl)
DE (1) DE2837089A1 (nl)
DK (1) DK149365C (nl)
ES (1) ES473070A1 (nl)
FI (1) FI65621C (nl)
FR (1) FR2401923A1 (nl)
IT (1) IT1159108B (nl)
LU (1) LU80192A1 (nl)
MX (1) MX5281E (nl)
NL (1) NL7809016A (nl)
NO (1) NO154194C (nl)
SE (1) SE442115B (nl)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560503A (en) * 1968-09-18 1971-02-02 Council Scient Ind Res Di-lower alkyl-substituted octahydropyrazinopyrimidinones
US3752816A (en) * 1969-06-10 1973-08-14 Sherwin Williams Co Certain 3-substituted-pyrido(3,2-d)pyrimidine 2,4-(1h,3h)-diones
GB1284582A (en) * 1969-11-10 1972-08-09 Council Scient Ind Res Substituted piperazinopyrimidinones
FR2103465A1 (en) * 1970-08-24 1972-04-14 Hokuriku Pharmaceutical Benzhydril-pyridodiazepines - as antihistaminics and anticholinergics from dihaloalkylpiperidines and arylalkylamines with condensing agent
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US3922275A (en) * 1972-11-09 1975-11-25 Hisamitsu Pharmaceutical Co Pyrido{8 2,3-D{9 {0 pyrimidine-2,4(1H,3H)-diones
DE2523730A1 (de) * 1974-06-12 1976-02-12 Hisamitsu Pharmaceutical Co Pyrido eckige klammer auf 2,3-d eckige klammer zu pyrimidinonen

Also Published As

Publication number Publication date
ES473070A1 (es) 1979-04-01
DK149365C (da) 1986-11-24
NO154194B (no) 1986-04-28
US4183933A (en) 1980-01-15
DK149365B (da) 1986-05-20
CA1102323A (en) 1981-06-02
FI782370A (fi) 1979-03-06
FI65621B (fi) 1984-02-29
ATA638178A (de) 1981-03-15
FR2401923B1 (nl) 1982-05-14
NO154194C (no) 1986-08-06
BE870227A (fr) 1979-03-05
MX5281E (es) 1983-06-02
IT7827103A0 (it) 1978-08-29
SE7809288L (sv) 1979-03-06
NL7809016A (nl) 1979-03-07
IT1159108B (it) 1987-02-25
LU80192A1 (de) 1979-06-01
SE442115B (sv) 1985-12-02
AT364365B (de) 1981-10-12
FR2401923A1 (fr) 1979-03-30
JPS5452097A (en) 1979-04-24
DK386778A (da) 1979-03-06
CH637133A5 (de) 1983-07-15
DE2837089A1 (de) 1979-03-22
NO782995L (no) 1979-03-06
JPS5725555B2 (nl) 1982-05-29

Similar Documents

Publication Publication Date Title
US3491093A (en) Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles
FI70576B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-amino-2-hydroxipropyl)-2-nitroimidazoler
US6127541A (en) Imidazoquinazoline derivatives
IE911683A1 (en) "New aminopiperidine, aminopyrrolidine and aminoperhydroazepine compounds processes for the preparation thereof and pharmaceutical compositions containing them"
US4730042A (en) Compounds 1 or 3-hydroxy-4-benzyl-6-methyl-7-(4-isopropylamino-butoxy)-1,3-dihydro[3,4-C]pyridine and 2-methyl-3-(4-isopropyl-aminobutoxy)-4-(1'-morphilinomethyl)-5-hydroxymethyl-6-benzyl pyridine, useful for treating cardiac arrhythmias
CS258150B2 (en) Method of arylcyclobutylalkylamines production
US5852019A (en) Pyrimidinylpyrazole derivatives
Biel et al. Antispasmodics. I. Substituted Acetic Acid Esters of 1-Alkyl-3-hydroxypiperidine1
FI77224B (fi) Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara aminopropanolderivat av 2-hydroxi- -fenylpropiofenoner.
IL98696A (en) 1,4-disubstituted piperazines their preparation and pharmaceutical compositions containing them
FI71936B (fi) Foerfarande foer framstaellning av neuroleptiskt aktiva 2-substituerade-8-fluor-5-(4-fluorfenyl)-2,3,4,4a 5,9b-hexahydro-4a 9b-trans-1h-pyrido/4,3-b/indolderivat
EP0414422A2 (en) 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof
IL97140A (en) Tricyclic-cyclic amines and cholinesterase inhibitors containing them
FI73428C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-aryl-8-(4-arylcyklohexyl)-1,3,8- triazaspiro/4,5/dekan-4-onderivater.
US5118693A (en) 4,4-disubstituted piperidine derivatives, pharmaceutical compositions containing them and process for preparing same
US4515944A (en) 1,5-Diphenyl-2-haloalkylpyrazolin-3-one intermediates
NO157931B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-(4-(difenylmethylen)-1-piperidinyl)-eddiksyrer samt deres amider og salter.
NZ238243A (en) Isochromane derivatives and pharmaceutical preparations
FI65621C (fi) Foerfarande foer framstaellning av som cns-aktiva medel anvaendbara 2-(4,4-difluorfenyl-butyl)-6h-oktahydropyrazino-(1,2-c) pyrimidin-6-oner
US4467094A (en) Precursors to ethylenediamine derivatives
KR840001775B1 (ko) 헤테로 사이클릭 유도체의 제조방법
US3282942A (en) Substituted cycloalkanoindoles
Gootjes et al. Derivatives of benzo‐and indolo‐quinolizines: I Synthesis of 2‐substituted hexahydro‐2H‐benzo [a] quinolizines and octahydroindolo [2, 3‐a] quinolizines from substituted glutaric acids
FI65427C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara xanten- eller furankarbonyloxipropanpiperazin-derivat
FR2558835A1 (fr) Derives d'hydantoine, leur procede de production et medicament les contenant

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: AB FERROSAN