FI62317C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla d-homosteroider - Google Patents
Foerfarande foer framstaellning av farmakologiskt vaerdefulla d-homosteroider Download PDFInfo
- Publication number
- FI62317C FI62317C FI781055A FI781055A FI62317C FI 62317 C FI62317 C FI 62317C FI 781055 A FI781055 A FI 781055A FI 781055 A FI781055 A FI 781055A FI 62317 C FI62317 C FI 62317C
- Authority
- FI
- Finland
- Prior art keywords
- hydroxy
- dione
- homopregna
- formula
- triene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (3)
1. Förfarande för framställning av farmakologiskt värdefulla D-homosteroider med formeln I Γ2"*21 R R17a I1 c 11 väri R är väte, fluor eller metyl; R är ((JvHy$OH) eller 0; R1^a är hydroxi eller alkanoyloxi och R2 3 4 5 är väte, klor hydroxi, alkanoyloxi eller en fosfatrest, och den streckade 1,2-bindningen är valfri, jämte salter därav, kännetecknat därav, att man ur en förening med den allmänna formeln fV»21 11 17a 21 2 väri substituenterna R , R , R , P. och den streckade 1 ,2-bindningen har ovannämnda betydelse, avspjälker bromväte och ifall önskvärt, förtvälar alkanoyloxigruppen, förestrar hydroxigruppen i 3 17a- och/eller 21-ställningen, oxiderar 11-hydroxigruppen, och/eller 4 överför den erhällna föreningen med formeln I i ett sait. 5
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man som utg&ngsmaterial använder en förening med formeln II, väri R6 är (Ο^Η,^ΟΗ), R21 är väte, hydroxi, alkanoyloxi eller en fosfatrest och R1 är metyl eller fluor. 6
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att man använder 21-acetoxi-9-brom-11, 17a-dihydroxi-D-homopregna-1,4-dien-3-20-dion som utgängsmaterial.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU77173A LU77173A1 (sv) | 1977-04-21 | 1977-04-21 | |
LU77173 | 1977-04-21 | ||
CH13978 | 1978-01-06 | ||
CH13978A CH632280A5 (en) | 1977-04-21 | 1978-01-06 | D-Homosteroids |
Publications (3)
Publication Number | Publication Date |
---|---|
FI781055A FI781055A (fi) | 1978-10-22 |
FI62317B FI62317B (fi) | 1982-08-31 |
FI62317C true FI62317C (fi) | 1982-12-10 |
Family
ID=25683635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI781055A FI62317C (fi) | 1977-04-21 | 1978-04-06 | Foerfarande foer framstaellning av farmakologiskt vaerdefulla d-homosteroider |
Country Status (23)
Country | Link |
---|---|
US (1) | US4131655A (sv) |
JP (1) | JPS53132553A (sv) |
AR (1) | AR220127A1 (sv) |
AT (1) | AT358748B (sv) |
AU (1) | AU515487B2 (sv) |
CA (1) | CA1114364A (sv) |
DE (1) | DE2817081A1 (sv) |
DK (1) | DK158678A (sv) |
ES (1) | ES468967A1 (sv) |
FI (1) | FI62317C (sv) |
FR (1) | FR2387997A1 (sv) |
GB (1) | GB1587032A (sv) |
GR (1) | GR72714B (sv) |
HU (1) | HU179486B (sv) |
IE (1) | IE46775B1 (sv) |
IL (1) | IL54508A (sv) |
IT (1) | IT1094923B (sv) |
NL (1) | NL7802905A (sv) |
NO (1) | NO147275C (sv) |
NZ (1) | NZ186988A (sv) |
PH (1) | PH15961A (sv) |
PT (1) | PT67927B (sv) |
SE (1) | SE7804552L (sv) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2950026C2 (de) * | 1979-12-10 | 1982-05-19 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 11-Ketosteroiden |
JPS60161914A (ja) * | 1984-02-02 | 1985-08-23 | Green Cross Corp:The | ステロイド脂肪酸エステル含有直腸投与製剤 |
DE3409554A1 (de) * | 1984-03-13 | 1985-09-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6(alpha)-methyl-d-homo-kortikoide |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1026160A (en) * | 1964-04-29 | 1966-04-14 | American Cyanamid Co | Pregnatrienes |
US4036874A (en) * | 1972-03-29 | 1977-07-19 | Hoffmann-La Roche Inc. | D-homopregnanes |
GB1440064A (en) * | 1972-08-11 | 1976-06-23 | Glaxo Lab Ltd | Delta8-9- steroids of the pregnane series |
NO140672C (no) * | 1973-03-28 | 1979-10-17 | Hoffmann La Roche | Analogifremgangsmaate ved fremstilling av nye anti-inflammatorisk virksomme steroider |
DE2448662C2 (de) * | 1974-10-09 | 1983-07-21 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 6α-Fluor-16α-methyl-1,4,8-pregnatrien-3,20-dion-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
IL51468A (en) * | 1976-02-23 | 1981-01-30 | Sparamedica Ag | 17 -hydroxy- -d-homosteroid derivatives,their preparation and pharmaceutical compositions containing them |
-
1978
- 1978-03-16 NL NL7802905A patent/NL7802905A/xx not_active Application Discontinuation
- 1978-03-30 AR AR271612A patent/AR220127A1/es active
- 1978-04-06 FI FI781055A patent/FI62317C/fi not_active IP Right Cessation
- 1978-04-11 DK DK158678A patent/DK158678A/da not_active IP Right Cessation
- 1978-04-14 IL IL54508A patent/IL54508A/xx unknown
- 1978-04-14 AU AU35123/78A patent/AU515487B2/en not_active Expired
- 1978-04-17 NZ NZ186988A patent/NZ186988A/xx unknown
- 1978-04-17 IE IE750/78A patent/IE46775B1/en unknown
- 1978-04-18 GR GR56010A patent/GR72714B/el unknown
- 1978-04-19 HU HU78HO2065A patent/HU179486B/hu unknown
- 1978-04-19 JP JP4544478A patent/JPS53132553A/ja active Pending
- 1978-04-19 FR FR7811547A patent/FR2387997A1/fr active Granted
- 1978-04-19 DE DE19782817081 patent/DE2817081A1/de not_active Ceased
- 1978-04-20 SE SE7804552A patent/SE7804552L/sv unknown
- 1978-04-20 CA CA301,515A patent/CA1114364A/en not_active Expired
- 1978-04-20 AT AT281178A patent/AT358748B/de not_active IP Right Cessation
- 1978-04-20 NO NO781390A patent/NO147275C/no unknown
- 1978-04-20 PT PT67927A patent/PT67927B/pt unknown
- 1978-04-20 GB GB15669/78A patent/GB1587032A/en not_active Expired
- 1978-04-20 ES ES468967A patent/ES468967A1/es not_active Expired
- 1978-04-20 US US05/898,070 patent/US4131655A/en not_active Expired - Lifetime
- 1978-04-21 PH PH21037A patent/PH15961A/en unknown
- 1978-04-21 IT IT22628/78A patent/IT1094923B/it active
Also Published As
Publication number | Publication date |
---|---|
IL54508A0 (en) | 1978-07-31 |
US4131655A (en) | 1978-12-26 |
FR2387997A1 (fr) | 1978-11-17 |
GB1587032A (en) | 1981-03-25 |
SE7804552L (sv) | 1978-10-22 |
NL7802905A (nl) | 1978-10-24 |
AR220127A1 (es) | 1980-10-15 |
AU3512378A (en) | 1979-10-18 |
IT7822628A0 (it) | 1978-04-21 |
AU515487B2 (en) | 1981-04-09 |
IL54508A (en) | 1982-03-31 |
FR2387997B1 (sv) | 1980-01-18 |
NZ186988A (en) | 1980-05-27 |
DE2817081A1 (de) | 1978-11-09 |
PH15961A (en) | 1983-05-04 |
NO147275C (no) | 1983-03-16 |
JPS53132553A (en) | 1978-11-18 |
IT1094923B (it) | 1985-08-10 |
ATA281178A (de) | 1980-02-15 |
NO781390L (no) | 1978-10-24 |
PT67927B (en) | 1980-04-07 |
CA1114364A (en) | 1981-12-15 |
FI62317B (fi) | 1982-08-31 |
IE780750L (en) | 1978-10-21 |
GR72714B (sv) | 1983-12-01 |
DK158678A (da) | 1978-10-22 |
FI781055A (fi) | 1978-10-22 |
HU179486B (en) | 1982-10-28 |
NO147275B (no) | 1982-11-29 |
PT67927A (en) | 1978-05-01 |
AT358748B (de) | 1980-09-25 |
ES468967A1 (es) | 1979-09-16 |
IE46775B1 (en) | 1983-09-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: F. HOFFMANN-LA ROCHE & CO. |