FI62287C - Foerfarande foer framstaellning av 5-fluor-2-metyl-1-(p-metylsulfinylbensyliden)-inden-3-aettiksyra - Google Patents

Foerfarande foer framstaellning av 5-fluor-2-metyl-1-(p-metylsulfinylbensyliden)-inden-3-aettiksyra Download PDF

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Publication number
FI62287C
FI62287C FI3489/74A FI348974A FI62287C FI 62287 C FI62287 C FI 62287C FI 3489/74 A FI3489/74 A FI 3489/74A FI 348974 A FI348974 A FI 348974A FI 62287 C FI62287 C FI 62287C
Authority
FI
Finland
Prior art keywords
acid
fluoro
methyl
compound
acetic acid
Prior art date
Application number
FI3489/74A
Other languages
English (en)
Finnish (fi)
Other versions
FI62287B (fi
FI348974A7 (cs
Inventor
Roger James Tull
Robert Francis Czaja
Richard Ferriss Shuman
Seemon Hayden Pines
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US426864A external-priority patent/US3870753A/en
Priority claimed from US05/486,031 external-priority patent/US3970693A/en
Priority claimed from US05/509,602 external-priority patent/US3944600A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI348974A7 publication Critical patent/FI348974A7/fi
Publication of FI62287B publication Critical patent/FI62287B/fi
Application granted granted Critical
Publication of FI62287C publication Critical patent/FI62287C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75—Reactions with formaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI3489/74A 1973-12-20 1974-12-02 Foerfarande foer framstaellning av 5-fluor-2-metyl-1-(p-metylsulfinylbensyliden)-inden-3-aettiksyra FI62287C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US42686473 1973-12-20
US426864A US3870753A (en) 1973-12-20 1973-12-20 Process for preparing indenyl acetic acids
US05/486,031 US3970693A (en) 1974-07-05 1974-07-05 Process for preparing indene acetic acids
US48603174 1974-07-05
US05/509,602 US3944600A (en) 1973-12-20 1974-09-30 Indenylidene-3-acetic acid process for preparing indene acetic acids
US50960274 1974-09-30

Publications (3)

Publication Number Publication Date
FI348974A7 FI348974A7 (cs) 1975-06-21
FI62287B FI62287B (fi) 1982-08-31
FI62287C true FI62287C (fi) 1982-12-10

Family

ID=27411527

Family Applications (1)

Application Number Title Priority Date Filing Date
FI3489/74A FI62287C (fi) 1973-12-20 1974-12-02 Foerfarande foer framstaellning av 5-fluor-2-metyl-1-(p-metylsulfinylbensyliden)-inden-3-aettiksyra

Country Status (16)

Country Link
JP (1) JPS5331153B2 (cs)
AR (2) AR210484A1 (cs)
CA (1) CA1044255A (cs)
CH (1) CH616152A5 (cs)
DD (1) DD116819A5 (cs)
DE (1) DE2462380C2 (cs)
DK (1) DK140835B (cs)
ES (2) ES432921A1 (cs)
FI (1) FI62287C (cs)
FR (1) FR2255060B1 (cs)
GB (1) GB1479519A (cs)
IE (1) IE41529B1 (cs)
NL (1) NL170534C (cs)
NO (2) NO140857C (cs)
SE (2) SE426818B (cs)
YU (2) YU41017B (cs)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732292A (en) * 1970-05-01 1973-05-08 Merck & Co Inc Indenyl compounds
NL7200058A (cs) * 1971-01-21 1972-07-25
US3822310A (en) * 1971-01-21 1974-07-02 Merck & Co Inc Substituted indenyl acetic acids

Also Published As

Publication number Publication date
SE7415063L (sv) 1975-06-23
NO140857C (no) 1979-11-28
YU55981A (en) 1982-06-30
DE2462380A1 (de) 1977-02-10
NO140857B (no) 1979-08-20
SE8107702L (sv) 1981-12-22
DD116819A5 (cs) 1975-12-12
GB1479519A (en) 1977-07-13
FR2255060B1 (cs) 1978-07-21
IE41529B1 (en) 1980-01-30
YU41017B (en) 1986-10-31
DE2462380C2 (de) 1982-11-11
FI62287B (fi) 1982-08-31
DE2460292B2 (de) 1977-06-16
DK629674A (cs) 1975-08-25
JPS5095254A (cs) 1975-07-29
NL170534C (nl) 1982-11-16
NO141892B (no) 1980-02-18
CA1044255A (en) 1978-12-12
CH616152A5 (en) 1980-03-14
ES455333A1 (es) 1978-05-01
NO790360L (no) 1975-06-23
IE41529L (en) 1975-06-20
AR206334A1 (es) 1976-07-15
JPS5331153B2 (cs) 1978-08-31
DK140835C (cs) 1980-04-28
DE2460292A1 (de) 1975-06-26
NL170534B (nl) 1982-06-16
AU7623674A (en) 1976-06-10
ES432921A1 (es) 1977-03-16
FR2255060A1 (cs) 1975-07-18
NO744395L (cs) 1975-07-14
SE426818B (sv) 1983-02-14
SE440774B (sv) 1985-08-19
FI348974A7 (cs) 1975-06-21
YU331674A (en) 1982-02-28
NL7415701A (nl) 1975-06-24
NO141892C (no) 1980-05-28
DK140835B (da) 1979-11-26
AR210484A1 (es) 1977-08-15

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