ES432921A1 - Un procedimiento para la preparacion de acido 5-fluor-2-me- til-1-(p-metilsulfinilbenciliden)-inden-3-acetico o sus sa- les de adicion de acido). - Google Patents
Un procedimiento para la preparacion de acido 5-fluor-2-me- til-1-(p-metilsulfinilbenciliden)-inden-3-acetico o sus sa- les de adicion de acido).Info
- Publication number
- ES432921A1 ES432921A1 ES432921A ES432921A ES432921A1 ES 432921 A1 ES432921 A1 ES 432921A1 ES 432921 A ES432921 A ES 432921A ES 432921 A ES432921 A ES 432921A ES 432921 A1 ES432921 A1 ES 432921A1
- Authority
- ES
- Spain
- Prior art keywords
- acetic acid
- fluoro
- methyl
- methylsulphinyl
- methylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PTUSXMWNCXRKAX-UHFFFAOYSA-N 2-(1h-inden-1-yl)acetic acid Chemical class C1=CC=C2C(CC(=O)O)C=CC2=C1 PTUSXMWNCXRKAX-UHFFFAOYSA-N 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 abstract 2
- -1 methylsulphinyl Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/75—Reactions with formaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US426864A US3870753A (en) | 1973-12-20 | 1973-12-20 | Process for preparing indenyl acetic acids |
| US05/486,031 US3970693A (en) | 1974-07-05 | 1974-07-05 | Process for preparing indene acetic acids |
| US05/509,602 US3944600A (en) | 1973-12-20 | 1974-09-30 | Indenylidene-3-acetic acid process for preparing indene acetic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES432921A1 true ES432921A1 (es) | 1977-03-16 |
Family
ID=27411527
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES432921A Expired ES432921A1 (es) | 1973-12-20 | 1974-12-13 | Un procedimiento para la preparacion de acido 5-fluor-2-me- til-1-(p-metilsulfinilbenciliden)-inden-3-acetico o sus sa- les de adicion de acido). |
| ES455333A Expired ES455333A1 (es) | 1973-12-20 | 1977-01-25 | Un procedimiento de preparacion de acido 5-fluor-2-metil-(p-metilsulfenilbenciliden)-inden-3-acetico o sus sales. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES455333A Expired ES455333A1 (es) | 1973-12-20 | 1977-01-25 | Un procedimiento de preparacion de acido 5-fluor-2-metil-(p-metilsulfenilbenciliden)-inden-3-acetico o sus sales. |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5331153B2 (cs) |
| AR (2) | AR210484A1 (cs) |
| CA (1) | CA1044255A (cs) |
| CH (1) | CH616152A5 (cs) |
| DD (1) | DD116819A5 (cs) |
| DE (1) | DE2462380C2 (cs) |
| DK (1) | DK140835B (cs) |
| ES (2) | ES432921A1 (cs) |
| FI (1) | FI62287C (cs) |
| FR (1) | FR2255060B1 (cs) |
| GB (1) | GB1479519A (cs) |
| IE (1) | IE41529B1 (cs) |
| NL (1) | NL170534C (cs) |
| NO (2) | NO140857C (cs) |
| SE (2) | SE426818B (cs) |
| YU (2) | YU41017B (cs) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732292A (en) * | 1970-05-01 | 1973-05-08 | Merck & Co Inc | Indenyl compounds |
| US3822310A (en) * | 1971-01-21 | 1974-07-02 | Merck & Co Inc | Substituted indenyl acetic acids |
| NL7200058A (cs) * | 1971-01-21 | 1972-07-25 |
-
1974
- 1974-12-02 FI FI3489/74A patent/FI62287C/fi active
- 1974-12-02 SE SE7415063A patent/SE426818B/xx not_active IP Right Cessation
- 1974-12-02 NL NLAANVRAGE7415701,A patent/NL170534C/xx not_active IP Right Cessation
- 1974-12-04 DK DK629674AA patent/DK140835B/da not_active IP Right Cessation
- 1974-12-05 NO NO744395A patent/NO140857C/no unknown
- 1974-12-10 CA CA215,636A patent/CA1044255A/en not_active Expired
- 1974-12-12 IE IE2557/74A patent/IE41529B1/en unknown
- 1974-12-13 YU YU3316/74A patent/YU41017B/xx unknown
- 1974-12-13 ES ES432921A patent/ES432921A1/es not_active Expired
- 1974-12-14 DD DD183051A patent/DD116819A5/xx unknown
- 1974-12-16 GB GB54320/74A patent/GB1479519A/en not_active Expired
- 1974-12-17 FR FR7441519A patent/FR2255060B1/fr not_active Expired
- 1974-12-18 CH CH1682474A patent/CH616152A5/de not_active IP Right Cessation
- 1974-12-19 DE DE2462380A patent/DE2462380C2/de not_active Expired
- 1974-12-20 JP JP14580474A patent/JPS5331153B2/ja not_active Expired
-
1976
- 1976-01-30 AR AR262084A patent/AR210484A1/es active
- 1976-07-15 AR AR20633476D patent/AR206334A1/es active
-
1977
- 1977-01-25 ES ES455333A patent/ES455333A1/es not_active Expired
-
1979
- 1979-02-05 NO NO790360A patent/NO141892C/no unknown
-
1981
- 1981-03-05 YU YU00559/81A patent/YU55981A/xx unknown
- 1981-12-22 SE SE8107702A patent/SE440774B/sv not_active IP Right Cessation
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