FI62083C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera n-beta-substituerade benzilsyra-n-alkylnortropin-estrar - Google Patents
Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera n-beta-substituerade benzilsyra-n-alkylnortropin-estrar Download PDFInfo
- Publication number
- FI62083C FI62083C FI762590A FI762590A FI62083C FI 62083 C FI62083 C FI 62083C FI 762590 A FI762590 A FI 762590A FI 762590 A FI762590 A FI 762590A FI 62083 C FI62083 C FI 62083C
- Authority
- FI
- Finland
- Prior art keywords
- benzylic acid
- compound
- crystals
- acetonitrile
- moles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752540633 DE2540633A1 (de) | 1975-09-12 | 1975-09-12 | Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung |
DE2540633 | 1975-09-12 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI762590A FI762590A (cs) | 1977-03-13 |
FI62083B FI62083B (fi) | 1982-07-30 |
FI62083C true FI62083C (fi) | 1982-11-10 |
Family
ID=5956267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI762590A FI62083C (fi) | 1975-09-12 | 1976-09-09 | Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera n-beta-substituerade benzilsyra-n-alkylnortropin-estrar |
Country Status (22)
Country | Link |
---|---|
US (1) | US4042700A (cs) |
JP (2) | JPS5236693A (cs) |
AT (1) | AT353428B (cs) |
AU (1) | AU506286B2 (cs) |
BE (1) | BE846104A (cs) |
CA (1) | CA1079733A (cs) |
CH (1) | CH621349A5 (cs) |
DE (1) | DE2540633A1 (cs) |
DK (1) | DK142988C (cs) |
ES (1) | ES451467A1 (cs) |
FI (1) | FI62083C (cs) |
FR (1) | FR2323387A1 (cs) |
GB (1) | GB1517086A (cs) |
IE (1) | IE44166B1 (cs) |
LU (1) | LU75781A1 (cs) |
MX (1) | MX4053E (cs) |
NL (1) | NL187210C (cs) |
NO (1) | NO145199C (cs) |
NZ (1) | NZ182011A (cs) |
PT (1) | PT65571B (cs) |
SE (1) | SE428472B (cs) |
ZA (1) | ZA765426B (cs) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU174431B (hu) * | 1976-12-08 | 1980-01-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija novykh proizvodnykh nortropin-carbazata |
DE3320138A1 (de) * | 1983-06-03 | 1984-12-06 | Boehringer Ingelheim KG, 6507 Ingelheim | Neues nortropinderivat, verfahren zu seiner herstellung und seine verwendung |
DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
JPH0558911A (ja) * | 1991-08-27 | 1993-03-09 | N D Shinyaku Kaihatsu Kenkyusho:Kk | 鎮咳去痰剤 |
US5770738A (en) * | 1992-03-05 | 1998-06-23 | Boehringer Ingelheim Kg | Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions |
EE200200602A (et) * | 2000-04-27 | 2004-04-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pikatoimelised beetamimeetikumid, meetod nende valmistamiseks ja nende kasutamine ravimitena |
DK1292281T3 (da) * | 2000-10-12 | 2004-10-11 | Boehringer Ingelheim Pharma | Nye tiotropiumholdige inhalationspulvere |
US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
US6852728B2 (en) * | 2000-10-14 | 2005-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them |
US6706726B2 (en) | 2000-10-14 | 2004-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anticholinergics which may be used as medicaments as well as processes for preparing them |
DE10050995A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
US20020111363A1 (en) * | 2000-10-31 | 2002-08-15 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
US20020137764A1 (en) * | 2000-10-31 | 2002-09-26 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
DE10062712A1 (de) * | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
US20020151541A1 (en) * | 2000-10-31 | 2002-10-17 | Michel Pairet | Pharmaceutical compositions containing tiotropium salts and antihistamines and their use |
US20020193392A1 (en) * | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
US20100310477A1 (en) * | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
US20030013675A1 (en) * | 2001-05-25 | 2003-01-16 | Boehringer Ingelheim Pharma Kg | Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases |
US20030070679A1 (en) * | 2001-06-01 | 2003-04-17 | Boehringer Ingelheim Pharma Kg | Capsules containing inhalable tiotropium |
US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
DE10141377A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
US6919325B2 (en) * | 2001-09-14 | 2005-07-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts |
DE10200943A1 (de) | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
US7405224B2 (en) * | 2002-01-31 | 2008-07-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions |
US6790856B2 (en) * | 2002-01-31 | 2004-09-14 | Boehringer Ingelheim Pharma Kg | Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments |
US20030229227A1 (en) * | 2002-03-16 | 2003-12-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions |
US7309707B2 (en) * | 2002-03-20 | 2007-12-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
US7244415B2 (en) * | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
US7311894B2 (en) * | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
RU2004132222A (ru) * | 2002-04-04 | 2005-10-10 | Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг (De) | Порошковые композиции, пригодные для ингаляции |
US20030235538A1 (en) | 2002-04-09 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the administration of an anticholinergic by inhalation |
DE10216427A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum |
US7084153B2 (en) * | 2002-04-12 | 2006-08-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising steroids and a novel anticholinergic |
US7417051B2 (en) * | 2002-04-12 | 2008-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising betamimetics and a novel anticholinergic |
US7094788B2 (en) * | 2002-04-13 | 2006-08-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions |
US7763280B2 (en) * | 2002-11-28 | 2010-07-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing powder formulation for inhalation |
DE10345065A1 (de) * | 2003-09-26 | 2005-04-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
TWI274641B (en) * | 2005-08-30 | 2007-03-01 | Rexon Ind Corp Ltd | Cutting machine |
USD831375S1 (en) | 2017-01-20 | 2018-10-23 | The Gillette Company Llc | Shaving razor stand |
EP3351138B1 (en) | 2017-01-20 | 2020-09-09 | The Gillette Company LLC | Personal care product docking system |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3505337A (en) * | 1967-12-22 | 1970-04-07 | Boehringer Sohn Ingelheim | N - hydrocarbyl-substituted noratropinium,haloalkylates and o-acyl derivatives thereof |
-
1975
- 1975-09-12 DE DE19752540633 patent/DE2540633A1/de active Granted
-
1976
- 1976-08-20 AT AT618676A patent/AT353428B/de not_active IP Right Cessation
- 1976-09-03 US US05/720,245 patent/US4042700A/en not_active Expired - Lifetime
- 1976-09-09 GB GB37447/76A patent/GB1517086A/en not_active Expired
- 1976-09-09 FI FI762590A patent/FI62083C/fi not_active IP Right Cessation
- 1976-09-09 FR FR7627151A patent/FR2323387A1/fr active Granted
- 1976-09-09 CH CH1145576A patent/CH621349A5/de not_active IP Right Cessation
- 1976-09-10 JP JP51108667A patent/JPS5236693A/ja active Granted
- 1976-09-10 MX MX764898U patent/MX4053E/es unknown
- 1976-09-10 IE IE2032/76A patent/IE44166B1/en not_active IP Right Cessation
- 1976-09-10 PT PT65571A patent/PT65571B/pt unknown
- 1976-09-10 NL NLAANVRAGE7610063,A patent/NL187210C/xx not_active IP Right Cessation
- 1976-09-10 SE SE7610070A patent/SE428472B/xx not_active IP Right Cessation
- 1976-09-10 AU AU17629/76A patent/AU506286B2/en not_active Expired
- 1976-09-10 ZA ZA00765426A patent/ZA765426B/xx unknown
- 1976-09-10 DK DK411576A patent/DK142988C/da active
- 1976-09-10 BE BE170555A patent/BE846104A/xx not_active IP Right Cessation
- 1976-09-10 LU LU75781A patent/LU75781A1/xx unknown
- 1976-09-10 NO NO763109A patent/NO145199C/no unknown
- 1976-09-10 NZ NZ182011A patent/NZ182011A/xx unknown
- 1976-09-11 ES ES451467A patent/ES451467A1/es not_active Expired
- 1976-09-13 CA CA261,037A patent/CA1079733A/en not_active Expired
-
1986
- 1986-06-18 JP JP61142449A patent/JPS625983A/ja active Granted
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI62083C (fi) | Foerfarande foer framstaellning av farmakologiskt vaerdefulla kvaternaera n-beta-substituerade benzilsyra-n-alkylnortropin-estrar | |
DD246995A5 (de) | Verfahren zur herstellung von neuen schwefelhaltigen 5-substituierten benzimidazol-derivaten | |
US4668786A (en) | P-fluorobenzoyl-piperidino alkyl theophylline derivatives | |
NO162176B (no) | Middel for bekjempelse av plantesykdommer og anvendelse derav. | |
NO154116B (no) | Fremgangsm¨te og lamellsepareringsapparat for tilf¯rsel og fordeling av en sammensatt v|ske til et lamellseparerings apparat. | |
DE2828529A1 (de) | Neue 5-phenylpyrazol-derivate, verfahren zu deren herstellung und arzneimittel | |
NO762661L (cs) | ||
DK163580B (da) | Analogifremgangsmaade til fremstilling af cyclohexancarboxylsyrederivater | |
CS226020B2 (en) | Method of preparing pyridine and pyrimidine derivatives | |
NO128608B (cs) | ||
FI56968B (fi) | Foerfarande foer framstaellning av hoegren kristallisk kenodesoxicholsyra | |
SU895291A3 (ru) | Способ получени производных 4-амино-2-пиперидинохиназолина или их солей с фармацевтически приемлимыми кислотами | |
JPS597720B2 (ja) | 新規なジアミノアンドロスタン誘導体、その酸付加塩及びその四級塩、並びにそれらの製造方法 | |
SU505358A3 (ru) | Способ получени производных пиперазина | |
EP0941992B1 (en) | Ipriflavone preparation process | |
Begtrup et al. | Studies on Methylated 1, 2, 3-Triazoles. II | |
NO140010B (no) | Analogifremgangsmaate til fremstilling av terapeutisk virksomme 6-substituerte 3-karbetoksyhydrazinopyridaziner | |
GB2067990A (en) | Cinnamyl moranoline derivatives | |
JPS5822107B2 (ja) | α↓−アミノメチレン↓−β↓−ホルミルアミノプロピオニトリル及びその製法 | |
HU180716B (en) | Process for preparing substituted amino-alkyl-guanidines | |
US4549021A (en) | N-(β-Fluoroethyl)-nortropine | |
US3076806A (en) | Quaternary ammonium salts of 1-carbolower-alkoxy-4-[(10-phenothiazinyl)-lower-alkyl]piperazines and preparation thereof | |
EP0182271B1 (de) | Neue Nb-quartäre Dibromderivate von Ajmalin, Isoajmalin, Sandwicin und Isosandwicin sowie diese Derivate enthaltende pharmazeutische Zubereitungen und Zwischenprodukte und Verfahren zu ihrer Herstellung | |
CS208746B2 (en) | Method of making the 3,6-disubstituted-1,2,4-triazin 5-ons | |
SU1250170A3 (ru) | Способ получени дихлоргидрата пирбутерола |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: C.H. BOEHRINGER SOHN |